est destinée au dépôt

  cell imbalance in patients with rheumatoid arthritis. Maxime Samson, Sylvain Audia, Nona Janikashvili, Marion Ciudad, Malika Trad, Jennifer Fraszczak, Paul Ornetti, Jean-Francis Maillefert, Pierre Miossec, Bernard Bonnotte To cite this version:

Figure 1 :

 1 Figure 1: Circulating Th17 are increased in RA patients whereas Treg are decreased but functional. A, B: Flow cytometry analysis of Th17 (CD4 + IL-17 + ), Th1 (CD4 + IL-17 -IFN-γ + ) and Treg (CD4 + CD25 high Foxp3 + ) cells in RA patients (n=15) and healthy subjects (n=17). C: Functional analysis of Treg (CD4 + CD25 high ). The proliferation index was measured with the ModFit LT TM 3.0 software. The percentage of inhibition was calculated using the proliferation index of stimulated T effectors without Treg as reference. Percentages of inhibition were compared ratio to ratio. Active RA patients (n=6), TCZ treated RA (n=3) and healthy controls (n=6). D: Th17/Treg ratio. RA patients (n=15), healthy subjects (n=17). The Mann Whitney U test (Kruskall-Wallis test for 1C) was used for statistical analysis. NS: not statistically significant. Whiskers are as follow: the median (horizontal bar), the IQ range (box) and the extreme values (error bars).

Maxime Samson, Sylvain Audia, Nona Janikashvili, Marion Ciudad, Malika Trad, et al.. Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis.: modulation of the Th17/Treg balance with anti-IL-6R. Arthritis and Rheumatism, 2012,