Marie S T Morin

Thomas Vives

Olivier Baslé

Christophe Crévisy

Virginie Ratovelomanana-Vidal

Marc Mauduit
email: marc.mauduit@ensc-rennes.fr

Efficiency of Industrially Relevant Atropisomeric Diphosphines in Copper-Catalyzed 1,4-Asymmetric Conjugate Addition of Dialkylzincs to Cyclic or Acyclic Enones or Dienones

Keywords: -Aryl enones, Dienones, Conjugate addition, Copper, Dialkylzinc reagents, BINAP, SYNPHOS, DIFLUORPHOS

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Scheme 1 Copper-catalyzed conjugate additions involving atropisomeric ligands

The screening of atropisomeric ligands L1-3 was started with the conjugate addition of diethylzinc to the sterically hindered cyclohexyl-substituted -phenyl enone 1a (Table 1), a challenging Michael acceptor that has been scarcely studied to date. [START_REF]To the best of our knowledge, only two reports disclose the 1,4-adduct 2a with a maximum of 77% yield and 96% ee, with Cu-ACA processes involving phosphino-based BINOL or SPINOL ligands[END_REF] Under optimized reaction conditions (copper-thiophene-2-carboxylate (CuTc)/L-X 5 mol%, THF, room temperature, Table 1, entry 1), (R)-BINAP (L-1) afforded the expected 1,4-adduct 2a in 92% isolated yield and high enantioselectivity (97% ee). At lower catalyst loading, the enantioselectivity of the addition decreased to 88% ee (Table 1, entry 2). a Reaction conditions: 1a-f (0.5 mmol), Et2Zn (1.5 mmol), CuTc (0.025 mmol), L-X (0.025 mmol), THF (0.5 mL), rt, 14 to 36 h. b Isolated yield. c Determined by GC on 2 (see ESI). d Reaction performed with 2 mol% of CuTc/L-1 . e A 1:1.5 MeTHF/Cyclohexane ratio was used at -40°C, see ref. 7.

f A 1:1.5 MeTHF/Cyclohexane ratio was used at 0°C, see ref. 7. g 1 H NMR yield with internal standard (see ESI).

In the case of (S)-SYNPHOS (L-2) and (R)-DIFLUORPHOS (L-3), similar excellent yields were reached (up to 98%) but with slightly lower enantioselectivity (90% and 93% ee, respectively, entries 2-3). One should note that the results obtained for 2a are equivalent to the best results reported in the literature both in term of isolated yield and enantioselectivity. 11 Moreover, in comparison with the less hindered substrate 1b bearing a methyl group, 7 the erosion of enantioselectivity remained exceptionally quite low (entry 4, 99% ee vs entry 1, 97% ee). On the other hand, the replacement of the phenyl ketone function by the more bulky 2-naphthyl ketone fragment only led to a slight decrease of the efficiency to form the corresponding adduct 2c with excellent 89% isolated yield and 94% enantiomeric excess (entry 6). In view of these studies, we decided to extend the scope by attempting the addition of a bulkier alkyl nucleophile such as i-Pr2Zn (entry 7). The corresponding 1,4-adduct 2d was isolated for the first time with a moderate isolated yield of 54%, despite a prolonged reaction time (36 h). Unfortunately, the enantioselectivity of the addition was quite low (12% ee). The latter result illustrated a limit of the BINAP ligand (L1) toward sterically-demanding ACA involving organozinc reagents as nucleophiles. We pursued our ligand screening in the addition of Et2Zn to the newly synthesized -phenyl enone 1d bearing a tert-butylCH2 side chain (entries 8-10). Again, the BINAP ligand (L-1) appeared to be the most efficient one, affording the 1,4-adduct 2e in excellent 96% isolated yield and 91% ee, while (S)-SYNPHOS (L-2) and (R)-DIFLUORPHOS (L-3) reached 89 and 83% ee, respectively. The steric hindrance from the CH2t-Bu group had slightly altered the enantioselectivity of the addition in comparison with adduct 2f bearing an isobutyl side chain (91 vs 94% ee, entries 8 and 11). Noteworthy, the addition of the less reactive dimethylzinc to enone 1d was less productive, affording the corresponding 1,4-adduct 2g in 44% isolated yield, while the enantioselectivity remained excellent reaching 93% ee, in the same range as the previously reported adduct 2h (entries 12-13).

Unfortunately, the addition of diethylzinc to the more sterically-demanding enone 1f bearing a t-Bu moiety was unsuccessful leading only to racemic product 2i in 22% yield (entry 14). 11 In comparison with previously reported copper-catalytic systems involving BINAP-type ligands for the 1,4-ACA of alkyl Grignard 3,4 or trialkylaluminum 6 reagents to electron deficient unsaturated systems, our methodology gave similar efficiency both in term of isolated yields and enantioselectivities.

The capacity to control both the regio-and the enantioselectivity in metal-catalyzed conjugate addition involving electrophilic extended unsaturated systems remains a challenge for organic chemists and the development of new catalytic systems is highly desirable. [START_REF] Csaky | ACA on extended Michael acceptors[END_REF] Therefore, having proved the efficiency of BINAP (L-1) toward simple aliphatic -aryl enones, we then decided to extend this method to the more challenging acyclic and cyclic dienic Michael acceptors to produce either 1,6-or 1,4-adducts. [START_REF] Fillion | For examples of Cu-catalyzed ACA on conjugated dienones[END_REF] First, we tried the addition of diethylzinc to -phenyl dienone 1g (Table 2). We were pleased to observe that BINAP (L-1) promoted an excellent regioselectivity in favor of the 1,4adduct 2j (96/4 ratio) with 82% isolated yield after 3 h at room temperature and up to 92% ee (entry 1). This 1,4selectivity was also recently observed with L-1 for the addition of AlMe3 on an -ketoester analogue, as reported by Alexakis and Gremaud (98% ee). 6 When (S)-SYNPHOS (L-2) and (R)-DIFLUORPHOS (L-3) were used, the additions were completed after 5 to 6 h to furnish 2j with a similarly high level of regioselectivity (97/3 and 95/5 respectively, entries 2-3) but with lower ees (54% and 80% respectively). It is important to notice that enantioenriched 1,4-adducts such as 2j could be easily transformed into valuable synthetic intermediates through the post-oxidation of the phenylketone as reported by Coates and Sowerby during the synthesis of Zizaene 14 or the styrenyl side chain as described by Zhang and co-workers. 13f L-3 6 95/5 66 80 a Reaction conditions: 1g (0.5 mmol), Et2Zn (1.5 mmol), CuTc (0.025 mmol), L-X (0.025 mmol), THF (0.5 mL), 0 °C, 3 to 6 h. b Determined by 1 H NMR spectroscopy. c Isolated yield of 2j/2j'. d Determined by GC on 2 (see ESI).

We finally focused our attention on the enantioselective addition of diethylzinc to the cyclic dienone 1h (Table 3). Although the relative steric hindrances at the  and  positions should favour the 1,6-addition, it was previously observed that the regioisomeric outcome of such a reaction is also under strong dependence of the nature of both the nucleophile and the chiral ligand. [START_REF]For instance, it was observed that the Cu/phosphoramidite catalysed addition of Et2Zn or Et3Al to a cyclic dienone structurally close to 1h gave the 1,6-adduct, whereas the Cu/NHC catalysed addition of a Grignard reagent led to the 1,4-adduct[END_REF] Using a Cu/diphosphine L1-3 catalytic system, a complete regioselectivity in favour of the 1,6-adduct 2k was observed (after reconjugation in the presence of DBU). With (R)-BINAP (L-1), complete conversion occurred after 5 h at room temperature, furnishing 2k in 60% isolated yield and 82% ee (entry 1). At lower temperature, the enantioselectivity was not improved and the yield decreased significantly to 26% despite 21 h of reaction (entry 2). A similar level of enantio-induction was reached with (S)-SYNPHOS (L-2), however the addition was less productive after 14 h of reaction at room temperature (54% of yield, entry 3). (R)-DIFLUORPHOS (L-3) appeared also less efficient under the same reaction conditions, yielding the 1,6-adduct in only 14% yield with 74% of enantioselectivity (entry 4).

In conclusion, we have demonstrated the efficiency of atropoisomeric diphosphines ligands in the enantioselective conjugate addition of dialkylzinc reagents onto -aryl enones, -aryl dienones as well as cyclic dienones by using CuTc as a catalyst. The industrially relevant (R)-BINAP proved superior to both (S)-SYNPHOS and (R)-DIFLUORPHOS as a ligand for this transformation both in terms of productivity and enantioselectivity, providing valuable 1,4-and 1,6-adducts in relatively good isolated yields and up to 97% ee. Unfortunately, highly sterically demanding enones or bulky organozinc reagents remain problematic leading only to moderate yields and low enantioselection. Further developments for such challenging reactions are currently under investigation in our group and will be applied in the enantioselective synthesis of bio-relevant targets. In that context, BINAP is a commercially available and rather inexpensive chiral ligand that has already demonstrated its potential for industrial applications. [START_REF] Noyori | For industrial enantioselective metal-catalytic processes using BINAP[END_REF] Consequently, the fact that a Cu/BINAP system catalyses efficiently and selectively various ACA of dialkylzincs to both enones and dienones is of a great interest in organic synthesis.

All reactions were performed under an argon atmosphere using oven-dried glassware. Et2Zn and i-Pr2Zn were purchased from Aldrich and used without further purification. Me2Zn was purchased from Acros and used without further purification. Substrates 1a 17 , 1f 18 , 1g 19 and 1h 13b were synthesized as reported in the literature. THF was distilled from Na/benzophenone under argon and dichloromethane was distilled from calcium hydride under nitrogen. All other chemical reagents and solvents were obtained from commercial sources and used without further purification. 1 H (400 MHz), [START_REF] Fillion | For examples of Cu-catalyzed ACA on conjugated dienones[END_REF] C (100 MHz), NMR spectra were recorded on a Bruker ARX400 spectrometer with complete proton decoupling for nuclei other than 1 H. Chemical shifts are reported in ppm with the solvent resonance as the internal standard (CDCl3, 1 H: δ 7.26 ppm, [START_REF] Fillion | For examples of Cu-catalyzed ACA on conjugated dienones[END_REF] C: δ 77.16 ppm,). Data are reported as follows: chemical shift (δ in ppm, multiplicity (s = singlet, d = doublet, t = triplet, q = quartet, quint = quintuplet, sept = septuplet, m = multiplet), coupling constants (Hz) and integration. Optical rotations were recorded using a polarimeter Perkin-Elmer 341. High resolution mass spectrometry analyses were performed at the Centre Régional de Mesures Physiques de l'Ouest (CRMPO), Université de Rennes 1. Enantiomeric excesses were measured using gas chromatography (capillary column -Chiraldex Beta-dex, 30 m x 0.25 mm id, 0.25 μm or G-TA, 30 m x 0.25 mm id, 0.12 μm) or HPLC (Chiralcel OJ-H or IA columns).

(E)-3-cyclohexyl-1-(naphthalene-2-yl)prop-2-en-1-one (1c)

According the literature procedure 17 and starting from cyclohexanecarboxaldehyde (5 mmol), the desired enone 1c was obtained in 61% yield (806 mg). 1 H NMR (400 MHz; CDCl3): δ 8.44 (s, 1H), 8.02 (dd, J = 8.6 Hz, 1.7 Hz, 1H), 7.97 (d, J = 8.0 Hz, 1H), 7.90 (t, J = 9.0 Hz, 2H), 7.62-7.53 (m, 2H), 7.09 (dd, J = 15.5 Hz, 6.5 Hz, 1H), 6.99 (dd, J = 15.5 Hz, 1.0 Hz, 1H), 2.35-2.26 (m, 1H), 1.90-1.71 (m, 5H), 1.41-1.19 (m, 5H). 13 C NMR (101 MHz; CDCl3): δ 191. 2, 155.0, 135.6, 135.5, 132.6, 130.0, 129.6, 128.5, 128.3, 127.9, 126.8, 124.7, 123.4, 41.2, 32.0, 26.11, 25.9. HRMS (ESI) : m/z calcd for C19H21O: 265.15924; [M+H] + found 265.1593 (0 ppm).

(E)-5,5-dimethyl-1-phenylhex-2-en-1-one (1d)

According the literature procedure 17 and starting from 3,3-dimethylbutyraldehyde (4 mmol), the desired enone 1d was obtained in 56% yield (457 mg). 6, 147.4, 138.0, 132.5, 128.48, 128.46, 127.9, 47.3, 31.6, 29.5. HRMS (ESI) : m/z calcd for C14H18ONa: 225.12554; [M+Na] + found 225.1253 (1 ppm).

1,4-asymmetric conjugate addition on aryl enones: Typical Procedure

A flame dried Schlenk flask, under an argon atmosphere, was charged with (R)-BINAP ligand (12.5 mg, 0.02 mmol, 5 mol%), CuTc (3.8 mg, 0.02 mmol, 5 mol%) and dry THF (0.5 mL). The resulting mixture was stirred for 10 min at room temperature and to this solution was added dropwise a solution of dialkylzinc reagent (3 equiv.) The reaction mixture was stirred for 10 min at room temperature and a solution of substrate 1 (0.4 mmol, 1 equiv.) in 0.5 mL of dry THF was added. The reaction mixture was stirred at room temperature for 14 h for the product 2a, 16 h for 2c and 2e, 36 h for 2d and 24 h for 2g and 2i. The reaction was quenched by the addition of ethanol (4 mL). The mixture was stirred for 15 min and filtered through a short column of silica gel with EtOAc. The solvents were removed under reduced pressure. The crude mixtures were purified by flash chromatography on silica gel (pentane/Et2O: 98/2) to afford the corresponding products as colorless oils. Ee was obtained by GC or HPLC analysis of the purified product.

3-cyclohexyl-1-phenylpentan-1-one (2a)

Using the typical procedure with (R)-BINAP, (S)-2a was obtained in 92% yield (90 mg) and 97% ee (HPLC: Chiralcel IA column, n-Hexane/i-PrOH: 99/1, 0.5 mL/min, RT1(major) = 11.8 min, RT2(minor) = 13.2 min.). [α] CHCl3). Data were in accordance with the literature. 10b,20

3-cyclohexyl-1-(naphthalen-2-yl)pentan-1-one (2c)

Using the typical procedure with (R)-BINAP, 2c was obtained in 89% yield (105 mg) and 94% ee (HPLC: Chiralcel OJ-H column, n-Hexane, 0.5 mL/min., RT1(major) = 38.2 min., RT2(minor) = 44.3 min.). [α] D 20 = -15.6 (c 1, CHCl3). 1 H NMR (400 MHz; CDCl3): δ 8.47 (s, 1H), 8.04 (dd, J = 8.6 Hz, 1.8 Hz, 1H), 7.98 (d, J = 7.9 Hz, 1H), 7.90 (t, J = 7.8 Hz, 2H), 7.63-7.54 (m, 2H), 3.11 (dd, J = 16.1 Hz, 5.6 Hz, 1H), 2.91 (dd, J = 16.1 Hz, 7.5 Hz, 1H), 2.07-2.00 (m, 1H), 1.78-1.53 (m, 5H), 1.49-1.44 (m, 2H), 1.38-1.05 (m, 6H), 0.90 (t, J = 7.4 Hz, 3H). 13 C NMR (101 MHz; CDCl3): δ 201. 1, 135.6, 135.0, 132.7, 129.69, 129.67, 128.5, 128.4, 127.9, 126.8, 124.2, 41.4, 40.5, 40.4, 30.5, 29.5, 27.0, 26.95, 26.92, 24.2, 12.1. HRMS (ESI) : m/z calcd for C21H26ONa: 317.18814; [M+Na] + found 317.1877 (1 ppm).

3-cyclohexyl-4-methyl-1-phenylpentan-1-one (2d)

Using the typical procedure with (R)-BINAP, 2d was obtained in 54% yield (56 mg) and 12% ee (HPLC: Chiralcel IA column, n-Hexane/i-PrOH: 99/1, 0.5 mL/min., RT1(major) = 11.6 min, RT2(minor) = 13.4 min.). [α] D 20 = -0.7 (c 1, CHCl3). 1 H NMR (400 MHz; CDCl3): δ 8.00-7.97 (m, 2H), 7.57-7.53 (m, 1H), 7.49-7.44 (m, 2H), 2.88 (dd, J = 17.7 Hz, 5.9 Hz, 1H), 2.80 (dd, J = 17.7 Hz, 5.1 Hz, 1H), 2.04 (quint, J = 5.6 Hz, 1H), 1.92-1.80 (m, 1H), 1.75-1.66 (m, 3H), 1.65-1.52 (m, 2H), 1.43-1.34 (m, 1H), 1.27-0.93 (m, 5H), 0.90 (d, J = 6.8 Hz, 3H), 0.81 (d, J = 6.8 Hz, 3H). 13 C NMR (101 MHz; CDCl3): δ 200. 7, 137.6, 132.8, 128.6, 128.1, 44.1, 40.3, 37.7, 31.8, 30.1, 28.8, 26.94, 26.91, 26.8, 21.6, 18.9. HRMS (ESI) : m/z calcd for C18H26ONa: 281.18814; [M+Na] + found 281.1883 (1 ppm).

3-ethyl-5,5-dimethyl-1-phenylhexan-1-one (2e)

Using the typical procedure with (R)-BINAP, 2e was obtained in 96% yield (84 mg) and 91% ee (HPLC: Chiralcel OJ-H column, n-Hexane, 0.2 mL/min, RT1(major) = 38.4 min., RT2(minor) = 43.9 min.). [α] CHCl3). 1 H NMR (400 MHz; CDCl3): δ 7. 97-7.94 (m, 2H), 7.57-7.52 (m, 1H), 7.48-7.43 (m, 2H), 2.99 (dd, J = 16.3 Hz, 7.5 Hz, 1H), 2.83 (dd, J = 16.3 Hz, 5.6 Hz, 1H), 2.13-2.05 (m, 1H), 1.40-1.33 (m, 2H), 1.29 (dd, J = 13.6 Hz, 5.2 Hz, 1H), 1.19 (dd, J = 14.2 Hz, 5.3 Hz, 1H), 0.91-0.88 (m, 12H). 13 C NMR (101 MHz; CDCl3): δ 200. 6, 137.7, 132.9, 128.7, 128.2, 47.8, 45.4, 32.3, 31.2, 30.1, 29.3, 11.3. HRMS (ESI) : m/z calcd for C16H24ONa: 255.17249; [M+Na] + found : 255.1726 (0 ppm).

3,5,5-trimethyl-1-phenylhexan-1-one (2g)

Using the typical procedure with (R)-BINAP, 2g was obtained in 44% yield (38 mg) and 93% ee (GC: G-TA column, helium (40 cm/sec), 100 ˚C -150 min. -5 ˚C/min. -160 ˚C -10 min., Rt1(minor) = 135.3 min., Rt2(major) = 140.9 min.). [α] D 20 = -13.2 (c 1, CHCl3). 1 H NMR (400 MHz; CDCl3): δ 7.96-7.93 (m, 2H), 7.57-7.53 (m, 1H), 7.48-7.44 (m, 2H), 2.92 (dd, J = 15.9, 5.7 Hz, 1H), 2.82 (dd, J = 15.9, 8.0 Hz, 1H), 2.32-2.21 (m, 1H), 1.32 (dd, J = 14.0, 4.0 Hz, 1H), 1.18 (dd, J = 14.0, 6.5 Hz, 1H), 1.00 (d, J = 6.6 Hz, 3H), 0.91 (s, 9H). 13 C NMR (101 MHz; CDCl3): δ 200.4, 137.6, 132.9, 128.7, 128.2, 51.2, 48.3, 31.3, 30.2, 26.5, 23.1. HRMS (ESI) : m/z calcd for C15H22ONa: 241.15684; [M+Na] + found : 241.1567 (1 ppm).

3-ethyl-4,4-dimethyl-1-phenylpentan-1-one (2i)

Using the typical procedure with (R)-BINAP, 2i was obtained in 22% yield (determined by 1 H NMR using mesitylene as an internal standard) and 0% ee (HPLC: Chiralcel OJ column, n-Hexane, 0.2 mL/min., RT1 = 28.9 min., RT2 = 38.1 min.). Data were in accordance with the literature. [START_REF] Csaky | ACA on extended Michael acceptors[END_REF] 1,4-asymmetric conjugate addition on aryl dienone (1g): Typical Procedure A flame dried Schlenk flask, under an argon atmosphere, was charged with diphosphine ligand (0.025 mmol, 5 mol%), CuTc (4.8 mg, 0.025 mmol, 5 mol%) and dry THF (0.5 mL). The resulting mixture was stirred for 10 min at room temperature and to this solution was added dropwise a 1M solution of diethylzinc in hexanes (1.5 mL, 1.5 mmol, 3 equiv.). The reaction mixture was stirred for 10 min at room temperature and a solution of substrate 1g (117 mg, 0.5 mmol, 1 equiv.) in 0.5 mL of dry THF was added. The reaction mixture was stirred at 0 °C until the completion. The reaction was quenched by the addition of ethanol (4 mL). The mixture was stirred for 15 min and filtered through a short column of silica gel with EtOAc. The solvents were removed under reduced pressure. The crude mixtures were purified by flash chromatography on silica gel (pentane/Et2O: 98/2) to afford the corresponding mixture of adducts 2j/2j' as colorless oils. Data were in accordance with literature. 7 Ee was obtained by chiral HPLC analysis of the purified product (Chiralcel OJ-H column, n-Hexane/i-PrOH: 99/1, 1 mL/min, RT1(1,4 adduct, minor) = 18.1 min, RT2(1,4 adduct, major) = 20.0 min.).

With (R)-BINAP: After 3h of reaction, a 96/4 mixture of adducts 2j/2j' was isolated in 82% yield (109 mg) and 92% ee. With (S)-SYNPHOS: After 5h of reaction, a 97/3 mixture of adducts 2j/2j' was isolated in 70% yield (92 mg) and -54% ee. With (R)-DIFLUORPHOS: After 6h of reaction, a 95/5 mixture of adducts 2j/2j' was isolated in 66% yield (87 mg) and 80% ee.

1,6-asymmetric conjugate addition on dienone (1h): Typical Procedure

A flame dried Schlenk flask, under an argon atmosphere, was charged with diphosphine ligand (0.025 mmol, 5 mol%), CuTc (4.8 mg, 0.025 mmol, 5 mol%) and dry THF (1 mL). The resulting mixture was stirred for 10 min. A 1M solution of diethylzinc in hexanes (1.5 mL, 1.5 mmol, 3 equiv.) was added and the reaction mixture was stirred for 10 min. Finally, a solution of substrate 1h (90 mg, 0.5 mmol, 1 equiv.) in 0.5 mL of THF was added. The reaction mixture was stirred at room temperature until the completion. The reaction was quenched by the addition of solid NH4Cl (500 mg). The solution was stirred for 1 h and then filtered on a small pad of silica, washed with EtOAc, and concentrated under vacuo. The residue was dissolved in 4 mL of dry CH2Cl2 and DBU (100 mL, 0.7 mmol, 1.4 equiv) was added to the solution. The reaction was stirred for 5 h and then filtered on a small pad of silica, washed with EtOAc, and concentrated under vacuo. The crude product was purified by flash chromatography on silica gel (pentane/Et2O: 85/15) to afford 2k. Data were in accordance with literature. 13b Ee was obtained by GC analysis of the purified product (Beta-dex column, helium (40 cm/sec), 100 ˚C-400 min-5 ˚C/min-170 ˚C-10 min, Rt1(minor) = 380.5 min, Rt2(major) = 385.4 min.) With (R)-BINAP: After 5 h of reaction, 2k was isolated in 60% yield (63 mg) and 82% ee. With (S)-SYNPHOS: After 14 h of reaction, 2k was isolated in 54% yield (56 mg) and -82% ee. With (R)-DIFLUORPHOS: After 14 h of reaction, 2k was isolated in 14% yield (determined by 1 H NMR using mesitylene as an internal standard) and 74% ee.

1 H

 1 NMR (400 MHz; CDCl3): δ 7.95-7.92 (m, 2H), 7.57-7.53 (m, 1H), 7.49-7.44 (m, 2H), 7.10 (dt, J = 15.4 Hz, 7.7 Hz, 1H), 6.86 (dt, J = 15.3 Hz, 1.3 Hz, 1H), 2.21 (dd, J = 7.8 Hz, 1.3 Hz, 2H), 0.97 (s, 9H). 13 C NMR (101 MHz; CDCl3): δ 190.

Table 1

 1 Screening of atropisomeric ligands in 1,4 Cu-ACA of dialkylzinc to -aryl enones a

	Entr y	1	Ar	R	Alk	L-X	Product	Yield (%) b	ee (%) c
	1					L-1		92	97 (S)
	2 d 3	1a	Ph	Cy	Et	L-1 L-2		91 92	88 (S) 90 (R)
	4					L-3		98	93 (S)
	5 e 1b	Ph	Me	Et	L-1		74	99
	6	1c 2-Nph Cy	Et	L-1		89	94
	7	1a	Ph	Cy	i-Pr L-1		54	12
	8 9 10	1d	Ph	CH2 t-Bu	Et	L-1 L-2 L-3		96 96 98	91 -89 83
	11 e 1e	Ph	i-Bu	Et	L-1		85	94
	12 1d	Ph	CH2 t-Bu	Me L-1		44	93
	13 f 1e	Ph	i-Bu	Me L-1		30	91
	14 1f	Ph	t-Bu	Et	L-1		22 g	0

Table 2

 2

	Entry	L-X	Time (h)	Ratio 2j/2j' b	Yield (%) c	ee (%) d
	1	L-1	3	96/4	82	92
	2	L-2	5	97/3	70	-54
	3

Screening of atropisomeric ligands in 1,4 Cu-ACA of Et2Zn to -aryl dienone 1g a

Table 3

 3 Screening of atropisomeric ligands in 1,6 Cu-ACA of Et2Zn to cyclic dienone 1h a Reaction conditions: 1h (0.5 mmol), Et2Zn (1.5 mmol), CuTc (0.025 mmol), L-X (0.025 mmol), THF (0.5 mL), rt, 5 to 21 h. b Determined by 1 H NMR spectroscopy. c Isolated yield of 2k. d Determined by GC on 2 (see ESI). e 1 H NMR yield with internal standard (see ESI).

	Entry	L-X	T (°C)	Time (h)	Ratio 2k/2k' b	Yield (%) c	ee (%) d
	1	L-1	rt	5	>98/2	60	82
	2	L-1	0	21	>98/2	26	82
	3	L-2	rt	14	>98/2	54	-82
	4	L-3	rt	14	>98/2	14 e	74
	a

Acknowledgement

This work was supported by the Agence Nationale de la Recherche (SCATE, n° ANR-12-B507-0009-01; grant to MSTM). MM and OB also thank the CNRS.

Supporting Information

Supporting information for this article is available online at http://dx.doi.org/.