Philippe Helluy

Jean-Marc Hérard

Nicolas Seguin

Keywords: Workshop on compressible multiphase flows: derivation, closure laws, thermodynamics

Workshop on Compressible Multiphase Flows

Derivation, closure laws, thermodynamics

The first Workshop on Compressible Multiphase Flows was held in Strasbourg (France), in May 2018, 23rd-25th. The goal was to address the modelling of compressible multiphase flows, gathering specialists of this subject, who came from math departments of universities but also from the industry.

The participants shared modelling methods, difficulties, (rigorous or more phenomenological) analysis, allowing for the description of multiphase flows with exchanges (mass transfer, energy exchange…) and apparition of shock waves. The main topics were:

• The Physics of multiphase flows with mass transfer and high energy exchanges;

• The derivation and analysis of PDE models for compressible multiphase flows;

• The Construction of coherent thermodynamical laws.

Note that one-velocity and multi-velocity models were considered, while numerical aspects were disregarded in order to focus on fruitful discussions on the modelling issues.

The details of the workshop, such as the list of speakers and the title of their talks, can be found here: http://gdr-manu.math.cnrs.fr/Thermo2018.php

The workshop received financial support from EDF R&D, GdR MaNu, Université de Strasbourg.

As co-editors of these ESAIM Proceedings, we are grateful to all the authors who have contributed to this volume. We also thank all the referees for their valuable comments which helped improving the final version of the papers. The ESAIM editorial team is also warmly acknowledged.

Philippe Helluy, Jean-Marc Hérard, Nicolas Seguin. 1


Philippe Helluy

Jean-Marc Hérard

Nicolas Seguin

Second Workshop on Compressible Multiphase Flows: Derivation, closure laws, thermodynamics

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Second Workshop on Compressible Multiphase Flows Derivation, closure laws, thermodynamics

During the Workshop on Compressible Multiphase Flows which held in May 2018, many interesting questions have been raised and the organizers decided to continue and open the discussion by proposing a second worshop on the same subject.

The second Workshop on Compressible Multiphase Flows has been staged in Strasbourg (France), in May 2019, 27-29th. The goal was to address the modelling of compressible multiphase flows, gathering specialists of this subject, which may come from math departments of universities but also from the industry.

The participants have shared modelling methods, difficulties, (rigorous or more phenomenological) analysis, allowing the description of multiphase flows with exchanges (mass transfer, energy exchange. . . ) and apparition of shock waves. The main topics have been:

• The Physics of multiphase flows with mass transfer and high energy exchanges;

• The derivation and analysis of PDE models for compressible multiphase flows;

• The construction of coherent thermodynamical laws.

Note that one-velocity and multi-velocity models have been considered, while numerical aspects were disregarded in order to focus on fruitful discussions on the modelling issues.

The details of the workshop, such as the list of speakers and the title of their talks, can be found here:

https://indico.math.cnrs.fr/event/4674/

The workshop has received financial support from EDF R&D, GdR MaNu, Université de Strasbourg.

As co-editors of these ESAIM Proceedings, we are grateful to all the authors who have contributed to this volume. We also thank all the referees for their valuable comments which helped improving the final version of the papers. The ESAIM editorial team is also warmly acknowledged.

Philippe Helluy, Jean-Marc Hérard, Nicolas Seguin.


CONTEXT

→ Long non-coding RNAs (lncRNAs), with at least 200 nt & low potential coding capabilities are a major component of regulatory elements in genomes. More than 15,000 loci have been modeled in human. → However, the role of most of them remains to be clarified.

• Exploring lncRNA conservation between species is an approach to strengthen the annotation of lncRNAs by inferring function in one species from another one more studied such as human or mouse, as has been done previously for protein coding genes (PCGs).

• However, unlike PCGs, lncRNA sequences are not well conserved across species [1]. Therefore, no lncRNA orthologs are reported in reference databases such as Ensembl BioMart, regardless of species.

• In this context, we have developed a workflow combining 3 approaches (Method 1, 2 and 3) that can be used for any species of interest and have applied it on 11 species covering a large phylogenetic scale from mammals to chicken.

RESULTS -FUNCTIONAL ANNOTATION

Fig. 1 :

 1 Fig. 1: One of the 23 lncRNAs in HSA identified as orthologous in 9 species by at least one method.

Fig. 4 :

 4 Fig. 4: Several tissue-specific orthologous lncRNAs had co-expressed genes associated to the same enriched terms related to the tissue function.

Table 1 : Orthologous lncRNAs between HSA & 10 species (mammals, birds & fish).

 1

Acknowledgments: We thank Thomas Derrien (CNRS, IGDR, Rennes), Sylvain Foissac (INRAE, UMR GenPhySe, Toulouse) and Hervé Acloque (INRAE, UMR GABI, Paris) for discussions.

The results presented here consider annotations and/or genome assemblies that may have been updated, such as the enriched annotation for the chicken genome (see poster P63). New analyses are currently in progress to include the major modifications.

fabien.degalez@inrae.fr