President Michel Cosnard

Jean-Luc Imler

Georges Lacaud

Martine Laville

This report is the sole result of the unit's evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee.

UNIT PRESENTATION

GLOBAL ASSESSMENT OF THE UNIT

The Institute carries research deciphering molecular mechanisms of human physiopathology in the broad fields of endocrinology and metabolism, development and cancer, infection and immunology. It involves basic fundamental research on experimental models as well as clinical research with strong translational development.

During the past term, the Institute has implemented the recommendation issued in 2013 to recruit young talented promising group leaders. The Institute also organizes an international symposium (J.C. Dreyfus) every year on a strategic theme of interest, which has started to contribute to the international visibility of the Institute. However, financial means to attract and consolidate young teams are still limiting.

The scientific output of the Institute is excellent, and results from contributions by teams from all three departments. To conduct this high level research, one asset of the Institute is the quality of the core facilities. Close association with the Cochin hospital and back and forth exchanges between bench and bedside provide unique opportunities for discovery and valorisation. The impact of the work conducted could further be improved by focusing on fewer topics per team. Animal housing continues to be a weakness, although plans are made to improve the situation.

Overall, the Institut Cochin conducts excellent research, well balanced between the three departments. The important relation with translational and clinical research is remarkable.

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INTRODUCTION

  HISTORY AND GEOGRAPHICAL LOCATION OF THE UNITThe Institut Cochin was created in 2002. It is affiliated to INSERM, CNRS and the University Paris Descartes. Located in downtown Paris, within the campus of the Cochin-Broca-Hotel Dieu Hospital, it offers excellent opportunity to develop interactions between the research teams and the clinical departments of the hospital. The Institut Cochin, which occupies 5 buildings and a total of 17,000m 2 , hosts some 540 staff members, 60% of them with permanent position.MANAGEMENT TEAMThe director of Institut Cochin is Mr Pierre-Olivier Couraud. He is assisted by a deputy director, who was Ms Hélène Gilgenkrantz until 2017, when Ms Sophie Vaulont took over the position. investigates the biological mechanisms associated with physiological and pathophysiological situations in humans and animal models. The 38 teams evaluated are grouped in three scientific departments focusing on distinct aspects of physiology and associated sets of diseases: (i) Development, Reproduction and Cancer (DRC department); (ii) Endocrinology, Metabolism and Diabetes (EMD department); (iii) Infection, Immunity and Inflammation (3I department). personnel (ITAs, BIATSSs and others, notably of EPICs)

signed by their chairman.