President Michel Cosnard

Jacques Neefjes

The president of HCERES "countersigns the evaluation reports set up by the experts committees and signed by their chairman." (Article 8, paragraph 5); 2 The evaluation reports "are signed by the chairman of the expert committee". (Article 11, paragraph 2).

This report is the sole result of the unit's evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee.

UNIT PRESENTATION

SCIENTIFIC DOMAIN

The teams from Immunology Infection and Hematology department focus on the immunological mechanisms involved in lymphoid differentiation and immunoregulation in normal and pathologic conditions, as well as on the mechanisms of antigen presentation. In the infectious domain, the teams develop programs on pathogenesis and genome plasticity of bacterial infections.

The teams from the Cell biology department focus on cell signalling and metabolism in different organ dysfunctions.

Basic research programs are completed by applied research for therapeutics in most of the teams.

UNIT WORKFORCE

GLOBAL ASSESSMENT OF THE UNIT

The unit will assemble 13 different units that vary in size from small teams run by a single PI to very large teams run by 2-3 PIs. The labs are organized in two departments ('Cell Biology: Growth and Signalling' and 'Immunology, Haematology & Infectiology') that are both scientifically excellent. The research is in general excellent according to international standards, which is best reflected by the many ERC grants obtained at the Institute and the various publications in Nature and similar top journals. In general, the INEM performs fundamental research with a close link to translation and, in many teams, actual clinical translation occurs. This could be at the level of (kidney) transplantation, new therapies for (juvenile) T-ALL, control of B cell responses and new immune cell types, detection of cancer, bacterial infection and sepsis, autophagy, CFTR mutant manipulation and human lysosomal storage diseases. The move and assembly in the new building at the Neckar campus close to the hospital is expected to further the interactions with the clinic. Yet, translation requires an excellent basis of top fundamental scientific research and various teams within INEM are performing top innovative research.

When assembled, and given the excellent research of the teams that form INEM, INEM will have the potential to become one of the leading research centres in France and possibly in Europe. It is critical for INEM to communicate on this adequately. This is currently not the case, in part because the different research units are spread over multiple locations in Paris. At the new site, this should be possible and allow make INEM and the Necker campus visible and attractive to foreign PhD students and post-docs.

The training through research is excellent considering the numbers of defended Theses and the implication of members in M2 programs. The interactions with the non-academic world are outstanding and the unit communicates to public through different media.

The evaluation reports of Hceres are available online: www.hceres.com

Evaluation of clusters of higher education and research institutions Evaluation of higher education and research institutions Evaluation of research Evaluation of doctoral schools Evaluation of programmes International evaluation and accreditation

INTRODUCTION

  HISTORY AND GEOGRAPHICAL LOCATION OF THE UNIT INEM was founded in 2014 through the assembly of a number of research units active in biomedical research at the Necker and the Broussais campus. The INEM is at present spread over different locations in Paris. In 2019, all the groups will assemble in a new building at the Necker campus in Paris. This building will be close to the Necker hospital and the Imagine institute and the various labs have tight interactions with the Necker clinic for translational research. They also strongly collaborate with the Imagine institute, with which they share various facilities. MANAGEMENT TEAM INEM is directed by Mr Xavier Nassif and deputy directors are Ms Fabiola Terzi for the department of Cell Biology (BC) and Mr Peter Van Endert for the Immunology Infection Hematology (I2H) department. HCERES NOMENCLATURE SVE1-LS3, SVE1-LS4, SVE1-LS6.

Unit workforce Number 30/06/2017 Number 01/01/2019 Permanent staff

	Supporting personnel (ITAs, BIATSSs and others, notably of EPICs)	41	39
	TOTAL permanent staff	113	116
	Non-permanent staff
	Non-permanent professors and associate professors, including emeritus	10
	Non-permanent full time scientists, including emeritus, post-docs	40
	Non-permanent supporting personnel	24
	PhD Students	36
	TOTAL non-permanent staff	110
	TOTAL unit	223
	Full professors and similar positions	19	25
	Assistant professors and similar positions	20	17
	Full time research directors (Directeurs de recherche) and similar positions	13	16
	Full time research associates (Chargés de recherche) and similar positions	20	19
	Other scientists ("Conservateurs, cadres scientifiques des EPIC, fondations, industries, etc.")	0	0
	High school teachers	0	0

Representatives of supervising institutions and bodies:

Mr