President Michel Cosnard

Chairman Franz Jakob

Ms Martine Cohen-Solal

Mr Franz

Seiamak Mr

Bahram

Ms Véronique Breuil

Jean-Paul Mr

Lallès

Raymond Mr

Bazin

Ms Laurence Lomme

The president of Hcéres "countersigns the evaluation reports set up by the expert committees and signed by their chairman." (Article 8, paragraph 5); 2 The evaluation reports "are signed by the chairman of the expert committee". (Article 11, paragraph 2). This report is the sole result of the unit's evaluation by the expert committee

INTRODUCTION HISTORY AND GEOGRAPHICAL LOCATION OF THE UNIT

BIOSCAR is a young unit created in 2014 by INSERM (U1132) and Paris-Diderot University. It is situated directly in the hospital Lariboisière, close to the rheumatology department.

MANAGEMENT TEAM

BIOSCAR unit is led by Ms Martine COHEN-SOLAL.

HCERES NOMENCLATURE

SVE5-1.

SCIENTIFIC DOMAIN

The unit develops cutting-edge translational and fundamental research in severe bone and joint diseases. Its main interests are: i) bone fragility in osteoporosis and bone tumours, and ii) joint related diseases and notably osteoarthritis and microcrystals diseases.

UNIT WORKFORCE

GLOBAL ASSESSMENT OF THE UNIT

Based in the hospital, BIOSCAR main strategy is to link basic science and translational clinical research. Both the interest in the mutual interaction between bone and joints and between clinical needs and basic science renders this unit somehow unique in the European scenery of musculoskeletal research, and also worldwide. The Unit has been completely restructured since its last evaluation without any loss in scientific strength and publication output, which are both rated excellent. Not only has it published in highest ranked journals of bone and joint research, but also in highly ranked journals beyond this field. Its translational activity yielded highly ranked clinical papers as well as publication of guidelines and ad-hoc clinical recommendations for patient care. Scientists of the unit serve in editorial boards of esteemed journals and in advisory and program boards of national and international scientific societies. The unit is strongly involved in international research networks and also very active in teaching and education programs. The visibility of the unit is excellent both at the national and international levels, and it is steadily increasing. The future potential of this Unit is rated very high.

Unit workforce Number 30/06/2017 Number 01/01/2019 Permanent staff

	PhD Students	9
	TOTAL non-permanent staff	21
	TOTAL unit	41
	Full professors and similar positions	7	9
	Assistant professors and similar positions	1	1
	Full time research directors (Directeurs de recherche) and similar positions	1	1
	Full time research associates (Chargés de recherche) and similar positions	2	2
	Other scientists ("Conservateurs, cadres scientifiques des EPIC, fondations, industries, etc.")	0	0
	High school teachers	0	0
	Supporting personnel (ITAs, BIATSSs and others, notably of EPICs)	8	9
	TOTAL permanent staff	20	22
	Non-permanent staff
	Non-permanent professors and associate professors, including emeritus	2

The evaluation reports of Hceres are available online : www.hceres.com

Evaluation of clusters of higher education and research institutions Evaluation of higher education and research institutions Evaluation of research Evaluation of doctoral schools Evaluation of programmes International evaluation and accreditation


President Michel Cosnard

Jeremy Hughes

This report is the sole result of the unit's evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee.

UNIT PRESENTATION

SCIENTIFIC DOMAIN

Although the focus of the CRI is inflammation, the current and proposed teams have a broad range of research interests including: inflammation of various organs (kidney, gut, liver); the regulation of antigen presentation; the role of mast cells and basophils in autoimmune and sterile inflammation; the contribution of phagocytes and NADPH-oxidases as well as heme-iron to inflammatory disease; the interface between inflammation and liver and pancreas cancer; viral hepatitis; the response of the gut to surgery; and novel imaging methods to detect and quantify the severity of inflammation and fibrosis as well as cancer. Within many of these domains there is work that involves both preclinical basic science and clinical research that aims to translate key findings to patients.

UNIT WORKFORCE

GLOBAL ASSESSMENT OF THE UNIT

The research interests within the CRI are broad with some areas of significant overlap and potential synergy. The CRI is composed of 2 departments: Nephrology and Immuno-Haematology (NIH) and Hepatology and Gastroenterology (HGE). Areas of research include sterile and immune inflammation in multiple organs, the regulation of immune response initiation and the roles of particular leukocytes (e.g. mast cells, basophils) in disease. The contribution of NADPH-oxidases and heme-iron interactions to inflammatory disease is studied as well as viral infection of the liver. The relationship between inflammation and the transition to cancer is examined together with gut inflammation and the gut response to surgery. Novel imaging methods using MRI to detect and quantify inflammation, fibrosis and cancer are used in both experimental and clinical research. The teams within the CRI have discrete research interests but also undertake bench-to bedside research that cuts across multiples disciplines and themes (inflammation, imaging, immunity, metabolism experimental models, human disease etc.). As a result, the totality of the CRI is significantly greater than the sum of the individual teams. The CRI has exhibited significant progress since the last evaluation with an excellent publication record, strong research grant funding, the successful generation of patents and licenses and solid research training for students. In addition, 2 start-up companies have been created including Inatherys focused on developing therapeutic monoclonal antibodies for the fields of inflammation and cancer and Inception IBD that focuses upon new therapeutic approaches to inflammatory bowel disease.

The evaluation reports of Hceres are available online : www.hceres.com

Evaluation of clusters of higher education and research institutions Evaluation of higher education and research institutions Evaluation of research Evaluation of doctoral schools Evaluation of programmes International evaluation and accreditation

INTRODUCTION

  HISTORY AND GEOGRAPHICAL LOCATION OF THE UNITThe CRI was created on the Bichat and Beaujon sites in 2014 following a merger of 3 previous research units (UMRS699, Inserm U773 and Inserm U843) and became the first research centre to focus upon the study of medical inflammation in France.MANAGEMENT TEAMDirector: Mr Renato MONTEIRO. Deputy Director: Mr Richard MOREAU.HCERES NOMENCLATURESVE3_4; SVE5_1; SVE5_3.

Unit workforce Number 30/06/2017 Number 01/01/2019 Permanent staff

	Non-permanent professors and associate professors, including emeritus	19
	Non-permanent full time scientists, including emeritus, post-docs	68
	Non-permanent supporting personnel	17
	PhD Students	99
	TOTAL non-permanent staff	203
	TOTAL unit	369
	Full professors and similar positions	53	57
	Assistant professors and similar positions	23	24
	Full time research directors (Directeurs de recherche) and similar positions	8	12
	Full time research associates (Chargés de recherche) and similar positions	18	17
	Other scientists ("Conservateurs, cadres scientifiques des EPIC, fondations, industries, etc.")	0	0
	High school teachers	0	0
	Supporting personnel (ITAs, BIATSSs and others, notably of EPICs)	64	18
	TOTAL permanent staff	166	128
	Non-permanent staff

HCERES scientific officer:

Mr Jean-Paul LALLES

Representatives of supervising institutions and bodies:

Mr Nicolas DE ROUX, Université Paris Diderot Mr Bruno LUCAS, CNRS Ms Sabrina SAHOUN, Inserm


This report is the sole result of the unit's evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee.

UNIT PRESENTATION

MANAGEMENT TEAM

The UMR 7154 IPGP is organized under the umbrella of the GE IPGP and contains all of the research activities supported by the GE IPGP. The UMR is jointly operated with the GE IPGP and with the "Unité Mixte de Service" (UMS) 3454 that groups the 5 observatories run by the GE IPGP. There is one director and one general secretary for the GE, the UMR and the UMS. The five deputy directors of the GE are members of the UMR and their work benefits the UMR. Director: Mr Marc CHAUSSIDON; deputy director in charge of industrial relations: Mr Marc BENEDETTI; deputy director in charge of research and space activities: Mr Gauthier HULOT; deputy director in charge of the observatories: Ms Anne LE FRIANT; deputy director in charge of studies division: Mr François MÉTIVIER; deputy director in charge of international relations: Mr Jean-Paul MONTAGNER; general director of services: Mr Antoine CHARLOT.

HCERES NOMENCLATURE

ST3: earth and space sciences.

SCIENTIFIC DOMAIN

The UMR 7154 (IPGP) provides the structure for all of the research activities in Earth, environment and planetary sciences supported by the "grand établissement de recherche et d'enseignement supérieur" (GE) "Institut de Physique du Globe de Paris -IPGP". The GE IPGP is one of the very few institutions worldwide associating Earth, geophysical and geochemical observatories and intensive research. GE IPGP is strongly involved in all fields of Earth science (including geobiology and planetary sciences) at all scales in time and space. GE IPGP undertakes Earth observation (on continents, at sea and from space) of seismic, tectonic, magnetic and volcanic activities, and of erosion and the critical zone. It ensures permanent observations of various natural phenomena in the French overseas territories and abroad, and makes temporary observations on land, at sea and in space; these observations can contribute to the understanding and mitigation of seismic and volcanic hazards. IPGP provides the national and international community with services related to the research activity of the establishment.

For the next 5 years, the 16 teams will be organized around 4 themes (Earth and Planetary Interiors, Natural Hazards, Earth System Science, Origins). Research teams are Environmental Biogeochemistry, CAGE (Cosmochimie, astophysique et géophysique expérimentale), Geological Fluid Dynamics, Geochemistry of the External Earth, Stable Isotope Geochemistry, Geomagnetism, Geomaterials, Geomicrobiology, Marine Geosciences, Gravity and Space Geodesy, Paleomagnetism, Physics of Natural Site, Planetary and Space Science, Seismology, Volcanic System, Tectonic.

UNIT WORKFORCE

INTRODUCTION

  HISTORY AND GEOGRAPHICAL LOCATION OF THE UNITThe IPGP was created as an institute in 1921 and became a "Grand Établissement" (GE) in 1990. The first geophysical activities started in 1883 with the development of the measurement and monitoring of the Earth's magnetic field in St-Maur-des-Fossés. The UMR 7154 (Unité Mixte de Recherche) was created in 2006 as a result of the merger of 7 smaller pre-existing UMRs. The UMR is housed on two campuses. The Cuvier campus (1 rue Jussieu, 75005 Paris) belongs to the "grand établissement" IPGP, hosts 14 of the 16 research teams and all of the master teaching. The Paris Rive Gauche (PRG) campus (Lamark building, 35 rue Hélène Brion, 75013 Paris) belongs to the university Paris Diderot (P7), includes 2 research groups, and hosts all of the undergraduate teaching activities of UFR STEP (Unité de Formation et de Recherche Sciences de la Terre de l'Environnement et des Planètes) of P7.

Unit workforce Number 30/06/2017 Number 01/01/2019 Permanent staff

	Full professors and similar positions	41	41
	Assistant professors and similar positions	49	49
	Full time research directors (Directeurs de recherche) and similar positions	17	24
	Full time research associates (Chargés de recherche) and similar positions	18	21
	Other scientists ("Conservateurs, cadres scientifiques des EPIC, fondations, industries, etc.")	0	0
	High school teachers	0	0
	Supporting personnel (ITAs, BIATSSs and others, notably of EPICs)	115	119
	TOTAL permanent staff	240	254
	Non-permanent staff
	Non-permanent professors and associate professors, including emeritus	12
	Non-permanent full time scientists, including emeritus, post-docs	35
	Non-permanent supporting personnel	55
	PhD Students	93

TOTAL non-permanent staff 195 TOTAL unit

Institut de Physique du Globe de Paris, IPGP, IPGP, CNRS, U Paris 7, U La Réunion, IGN, Mr Marc CHAUSSIDON

GLOBAL ASSESSMENT OF THE UNIT

IPGP is a flagship research unit in the field of Earth and Planetary Sciences, at the national and international levels. In recent years, it has greatly reinforced its field of expertise (of the Earth internal to the environment and solar system). The research carried out within the IPGP is generally based on a multidisciplinary, by using the most powerful tools and methods coming from the physics, chemistry, geology, mathematics and computer science.

IPGP beneficiates of numerous experimental equipments and instruments for chemical characterization and physics of geological objects. If the quantitative models are based on theoretical developments, the data experimental and analytical work and numerical intensive calculations are the backbone of many studies. The field study also plays an important role in several teams.

The IPGP presents a very positive general assessment with a scientific production of very high quality, illustrated by a large number of publications in the most prestigious multidisciplinary journals (Nature, Science, Nature Geoscience, Proceedings of the National Academy of Sciences …) and international distinctions.

His project for the next contract is relevant, realistic and in line with its areas of expertise.

The evaluation reports of Hceres are available online : www.hceres.com

Evaluation of clusters of higher education and research institutions Evaluation of higher education and research institutions Evaluation of research Evaluation of doctoral schools Evaluation of programmes International evaluation and accreditation


President Michel Cosnard

Chairman Richard Edward Randall

The president of HCERES "countersigns the evaluation reports set up by the experts committees and signed by their chairman." (Article 8, paragraph 5); 2 The evaluation reports "are signed by the chairman of the expert committee". (Article 11, paragraph 2).

This report is the sole result of the unit's evaluation by the expert committee, the composition of which is specified below. The assessments contained herein are the expression of an independent and collegial reviewing by the committee.

UNIT PRESENTATION

MANAGEMENT TEAM

The department is headed by Ms Monique LAFON with Mr Francis DELPEYROUX as deputy-head.

HCERES NOMENCLATURE SVE3_2 Virologie.

SCIENTIFIC DOMAIN

The research teams work on viruses that are a present and continuing threat to human health and wellbeing, including, HIV, HTLV, influenza, rabies, HBV, HCV, Zika, arboviruses and viral hemorrhagic viruses, such as Ebola, Lassa fever and yellow fever viruses.

UNIT WORKFORCE

GLOBAL ASSESSMENT OF THE UNIT

The department of Virology of the Institute Pasteur is one of the largest Virology Departments in the world. It is a member of the Global Virus Network and has a world-wide reputation for the excellence of its research. In general, within the department there is an excellent balance between fundamental, applied, and public health programmes. Research topics range from structural studies on virus glycoproteins and antibody-mediated virus neutralization to virus-host cell interactions, including the interaction of arboviruses with mammalian and insect cells, virus evolution, innate mammalian and insect immunity, adaptive immunity and vaccine design. Personnel from a number of the research teams were heavily involved in containing and monitoring the Ebola, Chikungunya and Zika virus outbreaks, and a number of research teams house national reference centres, World Health Organization (WHO) collaborative centres for influenza, viral hemorrhagic fevers, hantaviruses, enteroviruses, arboviruses, and a World Organisation for Animal Health (OIE) reference laboratory for Rift and Crimea Congo virus. Overall the department has a very impressive publication record and has been able to attract significant national and international funding. The department plays an important role in training the next generation of virologists. It plans to use advanced structural, molecular and biochemical techniques to dissect the molecular pathogenesis of virus infections, to apply the knowledge gained from such studies to improve human health and well-being by developing novel vaccines and therapies, and to further understand the factors that influence the emergence and re-emergence of virus disease and the epidemiology of virus infections.

INTRODUCTION

  HISTORY AND GEOGRAPHICAL LOCATION OF THE UNITThe department of Virology is one of 11 research departments of the Institute Pasteur (Paris). There are 16 research teams, which are located on the Paris campus, apart from one which has moved to the Gerland Pole, Lyon, to be close to BSL4 containment facilities.

HCERES scientific officer:

Ms Catherine SCHUSTER

Representatives of supervising institutions and bodies:

Ms Evelyne JOUVIN-MARCHE, INSERM Mr Frank LAFONT, CNRS Mr Reiner VEITIA, Université Paris-Diderot