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Achduart

Achduart (Gaelic: Achadh Dhubhaird ) is a coastal hamlet in Coigach, Wester Ross in northwestern Scotland, now within the Highland council area. It is situated about 4 km southeast of the village of Achiltibuie, at the end of a minor road. A footpath continues on to the hamlet of Culnacraig, then along the coast past Ben More Coigach to Strathcanaird. Achduart has accommodation facilities for tourists, who come for its proximity to the sea and its seclusion and remoteness. There is a hostel in Acheninver, a short distance to the north, formerly run by the Scottish Youth Hostels Association. The name of Achduart comes from the Gaelic for "the field at the black headland". Achduart was part of the Estate of Coigach, Lochbroom, belonging to the Countess of Cromartie.

The dominant geographical feature in the area is Cairn Conmheall, which rises to 541 metres.

Notable people

 * Kenny John Macleod -fiddler

license: Creative Commons - Attribution Share-Alike - https://creativecommons.org/licenses/by-sa/4.0/

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Achiltibuie

Achiltibuie (Achd Ille Bhuidhe or Field of the yellow-haired boy ) is a long linear village in Ross and Cromarty, Highland, on the Coigach coast of northwestern Scotland, overlooking Badentarbet Bay to the west. Loch Broom and the Summer Isles lie to the south. Located 10 miles (16 km) northwest of Ullapool as the crow flies. Achiltibuie is the central community of a series of townships and communities stretching from Culnacraig, through Badenscallie and Polglass (where the community hall, the primary school and the Piping School Cafe are located), Polbain, and Reiff to Achnahaird.

History
The first post office in the village opened on 28 July 1884.

Smokehouse
For a time the Summer Isles Smokehouse attracted visitors. In 2013 the community had hopes to re-establish the business.

Hydroponicum
The Hydroponicum, a facility for growing fresh fruit and vegetables indoors using hydroponics, was built in the village in the 1980s by Robert Irvine, then owner of the Summer Isles Hotel. The Hydroponicum was known for growing exotic fruit such as bananas all year round. It attracted up to 10,000 visitors a year until it was sold in 2007 to a company based in the Isle of Man. New greenhouses have since been built apart from the original hydroponicum buildings, and the new owners continue to grow fruit and vegetables for local businesses and residents. A community buyout attempt in 2011 by the Coigach Community Development Company fell through when the site's sellers pulled out. The building has now been demolished. Some of the former staff of the Hydroponicum run a small-scale activity known as The Achiltibuie Garden, situated nearby.

Notable residents

 * Tom Longstaff (1875-1964), mountaineer.
 * Lucy Irvine (b. 1956), writer, lived very briefly in the Summer Isles Hotel with her father, who owned it and the Hydroponicum.
 * de:Reiner Luyken (b.1951), former foreign correspondent of the German weekly paper Die Zeit

Notable recent achievements
'Coigach Community Rowing' the crew members of which coastal rowing club are all local, won the World St. Ayles Skiff Rowing Championships in July 2013 and a mixed crew from the club won the Alan Spong Trophy for 1st Mixed crew 4-oar rowing at the Thames Great River Race in September 2013. Coigach Community Rowing hand-built their two St Ayles rowing skiffs, the 'Coigach Lass' and the 'Lily~Rose' and race under the auspices of the Scottish Coastal Rowing Association, which is the governing body of St Ayles class coastal rowing around the world.

The Brochs of Coigach designed by SBA Architects Ltd were shortlisted in 2011 for the RIAS Andrew Doolan Best Building in Scotland Award. They are two unique buildings landscaped into a hillside. They were Regional Finalist of the Civic Trust Awards 2013. In 2015, they were highly commended in the inaugural Scottish Rural Awards.

Cultural connections
The Roman epic movie The Eagle, based on the 1954 novel The Eagle of the Ninth by Rosemary Sutcliff, was filmed on location in Achiltibuie for a week in October 2009. The main location was Fox Point, Old Dornie. The Pictish village which was constructed at Fox Point was used on most days of the filming. Other sites included Achnahaird beach where a horse chase was filmed and Loch Lurgainn.

The village and its residents featured in The Wee Mad Road (2008) by Jack and Barbara Maloney.

Achiltibuie is also the setting of a humorous German book about Scotland by Reiner Luyken, Schotten dicht (2015) published by Ullstein Verlag, Berlin.

title: Achiltibuie


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Adaptive expectations

In economics, adaptive expectations is a hypothesized process by which people form their expectations about what will happen in the future based on what has happened in the past. For example, if people want to create an expectation of the inflation rate in the future, they can refer to past inflation rates to infer some consistencies and could derive a more accurate expectation the more years they consider.

One simple version of adaptive expectations is stated in the following equation, where $$p^e$$ is the next year's rate of inflation that is currently expected; $$p^e_{-1}$$is this year's rate of inflation that was expected last year; and $$p$$ is this year's actual rate of inflation:

 * $$p^e = p^{e}_{-1} + \lambda (p - p^{e}_{-1})$$

where $$\lambda$$ is between 0 and 1. This says that current expectations of future inflation reflect past expectations and an "error-adjustment" term, in which current expectations are raised (or lowered) according to the gap between actual inflation and previous expectations. The error-adjustment term, also called partial adjustment, allows for variations in inflation rates over the previous years, especially years that have abnormally high or low rates.

 * $$ \lambda(p - p^{e}_{-1})$$

The above term is the partial adjustment error term, this term allows for variances that occur between actual values and expected values. The importance of considering the error prevents over and under expecting values of in the above example inflation rates. The adjustment means that the expectation can tend toward the direction of the future expected value that would be closer to the actual value, this allows a prediction to be made and consideration to be added or removed so as to be accurate of the future expectation. This consideration or error term is what allows the predicted value to be adaptable, thus creating an equation that is adaptive of the expectation being inferred.

The theory of adaptive expectations can be applied to all previous periods so that current inflationary expectations equal:

 * $$p^e_t = \lambda \sum_{j = 0}^{\infty} (1 - \lambda)^j p_{t-j}$$

where $$p_{t-j}$$ equals actual inflation $$j$$ years in the past. The adding of a time series portion to the expectation equations accounts for multiple previous years and their respective rates in forecasting like the above example of the future inflation rate. Thus, current expected inflation reflects a weighted average of all past inflation rates, where the weights get smaller and smaller as we move further in to the past. The initial previous year has the highest weighting and the subsequent years take lesser weighting the further back the equation accounts for.

When an agent makes a forecasting error (as in incorrectly recording a value or mistyping), the stochastic shock will cause the agent to incorrectly forecast the price expectation level again even if the price level experiences no further shocks, since the previous expectations only ever incorporates part of their errors. The backward nature of expectation formulation and the resultant systematic errors made by agents (see cobweb model) had become unsatisfactory to economists such as John Muth, who was pivotal in the development of an alternative model of how expectations are formed, called rational expectations. The use of rational expectations have largely replaced adaptive expectations in macroeconomic theory since its assumptions rely on an optimal expectations approach which is consistent with economic theory. However, it must be stressed that confronting adaptive expectations and rational expectations aren't necessarily justified by either use, in other words, there are situations in which following the adaptive scheme is a rational response.

The first use adaptive expectations hypothesis was to describe agent behavior in The Purchasing Power of Money by Irving Fisher (1911), then later used to describe models such as hyperinflation by Philip Cagan (1956). Adaptive expectations were instrumental in the consumption function (1957) and Phillips curve outlined by Milton Friedman. Friedman suggests that workers form adaptive expectations of the inflation rate, the government can easily surprise them through unexpected monetary policy changes. As agents are trapped by the money illusion, they are unable to correctly perceive price and wage dynamics, so based on Friedman's theory, unemployment can always be reduced through monetary expansions. If the government chooses to fix a low unemployment rate the result is an increasing level of inflation for an extended period of time. However, in this framework, it is clear why and how adaptive expectations are problematic. Agents are arbitrarily supposed to ignore sources of information which, otherwise, would affect their expectations. For example, government announcements are such sources. Agents are expected to modify their expectations and break with the former trends when changes in economic policy necessitate it. This is the reason why the theory of adaptive expectations is often regarded as a deviation from the rational tradition of economics.

title: Adaptive expectations


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Talk:Afterlife

Source/Citation Improvement
This topic is off to a great start, but needs citation improvement, especially secondary citations for multiple religions and topics. This is extremely important due to the controversy that comes from this topic, and to remain unopinionated on any specific religious belief of the afterlife. Smerblah (talk) 23:31, 30 April 2023 (UTC)

Afterlife
The entire Afterlife section is filled with Christian conceptions of the afterlife presented uncritically and projected into other belief systems in ways that are wildly inaccurate. Valhalla, for example, is not equal to "Heaven." Strikingly, a link in this section that is presented as Hades is covertly piped to Christian views on Hades. Darker Dreams (talk) 13:17, 28 June 2023 (UTC)

The Chinese Religions
Can we add Taoism and perhaps Confucianism as Chinese religions that also have a perspective of the concept of an afterlife? MateoFrayo (talk) 14:21, 14 July 2023 (UTC)

 * @MateoFrayo I have not checked for archives of this talk page but this Short description|Continued existence after death in the article suggests the article is not limited for any specific belief systems and you can add info about more belief systems with WP:RS.
 * On side note: There is lot of information gap in this and related articles. IMO article deserves some info about Grave goods culture analysis by anthropology and archeology; a little more detail view from Eternal oblivion along with atheist vs. theist polemics. Of course all with RS. --  Bookku   (talk) 14:29, 27 July 2023 (UTC)
 * Of course—I completely agree @Bookku.
 * I may add a few descriptions of certain topics in the upcoming months and fill in some information gaps with a few religions (especially some of the Abrahamic ones and Grave goods, like you said), but unfortunately I am currently working on a separate project. I'll definitely watchlist this page and hopefully see it expand a lot more in the near future.
 * Do you think plan on adding information to this article, or will you leave that to someone else? - MateoFrayo (talk) 17:17, 7 September 2023 (UTC)
 * Nice to see your reply. This article topic remains on back of my mind. For me too hands are already full enough with other stuff so not sure I would be able to devote enough time for this and related articles. But many times while searching google books and google scholar etc if I come across interesting citations I keep adding up and time permits I do update articles randomly. Besides I do actively encourage users working on similar topics by referring them to various information and gap areas time to time.  Bookku    (talk) 07:03, 8 September 2023 (UTC)

Scope for revisit and improvement
@Vice regent

This has ref to.

 * Previous sentence

 * strike out is deleted part by the next edit dif

 * Dif after change

 * Present article short description

As such this article does not seem to be reserved for any particular belief systems and even atheist views may have space as belief system though they have an entire article Eternal oblivion  still summary of the same and atheist vs. theist polemics against and for after life may have scope in this article.

For a while if we leave scope of atheism outside for a while, and visit entire article the above sentence in the does not seem to represent just Abrahamic tradition but along with is inclusive of other belief systems when it says 'some belief systems'. Because of some belief systems I am not sure even 'divine judgment' wording is enough, but still inclusion of 'divine judgment' seems needed for some belief systems. Hopefully upon reading the whole article you may get my point. Hence this suggestion to revisit deletion and deliberate further improvements as and when you feel to come back to this topic.

Wish you happy editing and cheers.  Bookku   (talk) 14:54, 27 July 2023 (UTC)
 * Hello . I was under the impression that all Abrahamic belief systems believe in God as the sole deity. Please correct me i I'm wrong.VR talk 03:18, 28 July 2023 (UTC)
 * See only for 'Abrahamic belief systems'  ..in the Abrahamic tradition, hold that the dead go to a specific place after death, as determined by God, .." this much part of the sentence is enough. Whoever wrote summary sentence actually clubbed 'Abrahamic belief systems' with other belief systems. Reading with 'or other divine judgment,' seem to make two different meanings depending upon how one reads it. And one reading can give feeling of whether sentence is ascribing 'or other divine judgment,' with God. Hence I can see your point.
 * But just removing part we do not want makes to cease representation of other systems in the lede. That leads to inadvertent obscurantism. We would need to deal with editorial neutrality by writing more proper paraphrasing that will summarize for all belief systems mentioned in the article body.
 * I do not have issues if you want to have separate sentences for all belief systems, though that would not be best lede summary.
 * Whoever wrote the sentence seem to have taken some care but may have missed some inadvertent meaning which you read in the sentence.
 * 'Some belief systems,' means not all the belief systems since many other belief systems have different presumptions about afterlife.
 * such as those in the Abrahamic tradition, -- here wording 'such as' is used for not only to give example of 'Abrahamic tradition' but also other beliefs systems believing in God.
 * 'as determined by God, or other divine judgment,' You seem to be reading this together like if not God or along with God other divine judgment. But who paraphrased sentence might have wished to read as this or that. ('or That' part for other belief systems which believe in divine judgements other that God.
 * This can remain complex and confusing for the readers. So no issues in splitting sentences and covering different different belief systems in the lede.
 * In fact we can TNT and write the lede again but even for that effort these articles do not seem to be at their minimum best.
 * I think we might need to read t/p archives to see previous discussions too.
 * I am not in hurry - rather bit busy to spare enough time on this as of now. Just came across while replying earlier message so just wanted to keep you informed so in due course we can form better lede.  Bookku   (talk) 04:49, 28 July 2023 (UTC)

title: Talk:Afterlife


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Mexican tetra

The Mexican tetra (Astyanax mexicanus), also known as the blind cave fish, blind cave characin or the blind cave tetra, is a freshwater fish in the Characidae family (tetras and relatives) of the order Characiformes. The type species of its genus, it is native to the Nearctic realm, originating in the lower Rio Grande, and the Neueces and Pecos Rivers in Texas, into the Central Plateau and eastern states of Mexico.

Maturing at a total length of about 12 cm, the Mexican tetra is of typical characin form, albeit with silvery, unremarkable scalation, likely an evolutionary adaptation to its natural environment. By comparison, the species' blind "cave" form has scales which evolved a pale, pinkish-white color, somewhat resembling an albino, as it inhabits pitch-black caverns and subterranean streams and has no need for a colorful appearance (i.e. for attracting mates).

Likewise, the blind cave tetra has fully "devolved" (lost) the use of its eyes by living in an environment completely devoid of natural light, with only empty sockets in their place. The blind tetra instead has sensory organs along its body, as well as a heightened nervous system (and senses of smell and touch), and can immediately detect where objects or other animals are located by slight changes in the surrounding water pressure, a process vaguely similar to echolocation—another adaptation known from cave-dwelling, as well as aquatic, species, such as the bats and cetaceans.

The Mexican tetra's blind variant has experienced a steady surge in popularity among modern aquarists.

A. mexicanus is a peaceful, sociable schooling species, like most tetras, that spends most of its time in midlevel waters above the rocky and sandy bottoms of pools, and backwaters of creeks and streams. Coming from an environment somewhere between subtropical climate, it prefers water with 6.5–8 pH, a hardness of up to 30 dGH, and a temperature range of 20 to 25 C. In the winter, some populations migrate to warmer waters. The species' natural diet consists largely of crustaceans, annelids and arthropods and their larvae, including both aquatic insects, such as water beetles, and those that land on or fall in the water, like flies or arachnids. It will also supplement its diet with algae or aquatic vegetation; in captivity, it is largely omnivorous, often doing well on a variety of foods such as frozen/thawed or live cultured blackworms, bloodworms, brine shrimp, daphnia, and mysis shrimp, among other commercially-available fish foods.

The Mexican tetra has been treated as a subspecies of A. fasciatus, though this is not widely accepted. Additionally, the hypogean blind cave form is sometimes recognized as a separate species, A. jordani, but this directly contradicts the phylogenetic evidence.

Blind cave form
A. mexicanus is famous for its blind cave form, which is known by such names as blind cave tetra, blind tetra (leading to easy confusion with the Brazilian Stygichthys typhlops), blind cave characin and blind cavefish. Depending on the exact population, cave forms can have degenerated sight or have total loss of sight and even their eyes, due to down-regulation of the protein αA-crystallin and consequent lens cell death. The fish in the Pachón caves have lost their eyes completely whilst the fish from the Micos cave only have limited sight. Cave fish and surface fish are able to produce fertile offspring.

These fish can still, however, find their way around by means of their lateral lines, which are highly sensitive to fluctuating water pressure. Blindness in A. mexicanus induces a disruption of early neuromast patterning, which further causes asymmetries in cranial bone structure. One such asymmetry is a bend in the dorsal region of their skull, which is propounded to increase water flow to the opposite side of the face, functionally enhancing sensory input and spatial mapping in the dark waters of caves. Scientists suggest that gene cystathionine beta synthase-a mutation restricts blood flow to cavefish eyes during a critical stage of growth so the eyes are covered by skin.

Currently, about 30 cave populations are known, dispersed over three geographically distinct areas in a karst region of San Luis Potosí and far southern Tamaulipas, northeastern Mexico. Among the various cave population are at least three with only full cave forms (blind and without pigment), at least eleven with cave, "normal" and intermediate forms, and at least one with both cave and "normal" forms but no intermediates. Studies suggest at least two distinct genetic lineages occur among the blind populations, and the current distribution of populations arose by at least five independent invasions. Furthermore, cave populations have a very recent origin (< 20,000 years) in which blindness or reduced vision evolved convergently after surface ancestors populated several caves independently and at different times. This recent origin suggests that the phenotypic changes in cavefish populations, namely eye degeneration, arose as a result of the high fixation of genetic variants present in surface fish populations in a short period of time.

The eyed and eyeless forms of A. mexicanus, being members of the same species, are closely related and can interbreed making this species an excellent model organism for examining convergent and parallel evolution, regressive evolution in cave animals, and the genetic basis of regressive traits. This, combined with the ease of maintaining the species in captivity, has made it the most studied cavefish and likely also the most studied cave organism overall.

The blind and colorless cave form of A. mexicanus is sometimes recognized as a separate species, A. jordani, but this leaves the remaining A. mexicanus as a paraphyletic species and A. jordani as polyphyletic. The Cueva Chica Cave in the southern part of the Sierra del Abra system is the type locality for A. jordani. Other blind populations were initially also recognized as separate species, including antrobius described in 1946 from the Pachón Cave and hubbsi described in 1947 from the Los Sabinos Cave (both subsequently merged into jordani/mexicanus). The most divergent cave population is the one in Los Sabinos.

Another cave-adapted population of Astyanax, varying from blind and depigmented to individuals showing intermediate features, is known from the Granadas Cave, part of the Balsas River drainage in Guerrero, southern Mexico, but it is a part of A. aeneus (itself sometimes included in A. mexicanus).

Evolution research
The surface and cave forms of the Mexican tetra have proven powerful subjects for scientists studying evolution. When the surface-dwelling ancestors of current cave populations entered the subterranean environment, the change in ecological conditions rendered their phenotype—which included many biological functions dependent on the presence of light—subject to natural selection and genetic drift. One of the most striking changes to evolve was the loss of eyes. This is referred to as a "regressive trait" because the surface fish that originally colonized caves possessed eyes. In addition to regressive traits, cave forms evolved "constructive traits". In contrast to regressive traits, the purpose or benefit of constructive traits is generally accepted. Active research focuses on the mechanisms driving the evolution of regressive traits, such as the loss of eyes, in A. mexicanus. Recent studies have produced evidence that the mechanism may be direct selection, or indirect selection through antagonistic pleiotropy, rather than genetic drift and neutral mutation, the traditionally favored hypothesis for regressive evolution.

The blind form of the Mexican tetra is different from the surface-dwelling form in a number of ways, including having unpigmented skin, having a better olfactory sense by having taste buds all over its head, and by being able to store four times more energy as fat, allowing it to deal with irregular food supplies more effectively.

Darwin said of sightless fish: "By the time that an animal had reached, after numberless generations, the deepest recesses, disuse will on this view have more or less perfectly obliterated its eyes, and natural selection will often have effected other changes, such as an increase in the length of antennae or palpi, as compensation for blindness."

Modern genetics has made clear that the lack of use does not, in itself, necessitate a feature's disappearance. In this context, the positive genetic benefits have to be considered, i.e., what advantages are obtained by cave-dwelling tetras by losing their eyes? Possible explanations include:
 * Not developing eyes allows the individual more energy for growth but not egg production. However the species does use other methods to locate food and detect danger, which also consume energy that would be conserved if it had eyes or transparent eyelids.
 * There remains less chance of accidental damage and infection, since the previously useless and exposed organ is sealed with a flap of protective skin. It is unknown why this species did not develop transparent skin or eyelids instead, as some species of reptiles did.
 * The lack of eyes disables the "body clock", which is controlled by periods of light and dark, conserving energy. However sunlight does have minimal impact on the "body clock" in caves.

Another likely explanation for the loss of its eyes is that of selective neutrality and genetic drift; in the dark environment of the cave, the eyes are neither advantageous nor disadvantageous and thus any genetic factors that might impair the eyes (or their development) can take hold with no consequence on the individual or species. Because there is no selection pressure for sight in this environment, any number of genetic abnormalities that give rise to the damage or loss of eyes could proliferate among the population with no effect on the fitness of the population.

Among some creationists, the cave tetra is seen as evidence 'against' evolution. One argument claims this is an instance of "devolution"—showing an evolutionary trend of decreasing complexity. But evolution is a non-directional process, and while increased complexity is a common effect, there is no reason why evolution cannot tend towards simplicity if that makes an organism better suited to its environment.

Inhibition of the HSP90 protein has a dramatic effect in the development of the blind tetra.

In the aquarium
The blind cave tetras seen in the aquarium trade are all based on stock collected in the Cueva Chica Cave in the southern part of the Sierra del Abra system in 1936. These were sent to an aquarium company in Texas, who soon started to distribute them to aquarists. Since then, these have been selectively bred for their troglomorphic traits. Today large numbers are bred at commercial facilities, especially in Asia.

The blind cave tetra is a hardy species. Their lack of sight does not hinder their ability to get food. They prefer subdued lighting with a rocky substrate, like gravel, mimicking their natural environment. They become semi-aggressive as they age, and are by nature schooling fish. Experiments have shown that keeping these fish in bright aquarium set-ups has no effect on the development of the skin flap that forms over their eyes as they grow.

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Atom probe

The atom probe was introduced at the 14th Field Emission Symposium in 1967 by Erwin Wilhelm Müller and J. A. Panitz. It combined a field ion microscope with a mass spectrometer having a single particle detection capability and, for the first time, an instrument could “... determine the nature of one single atom seen on a metal surface and selected from neighboring atoms at the discretion of the observer”.

Atom probes are unlike conventional optical or electron microscopes, in that the magnification effect comes from the magnification provided by a highly curved electric field, rather than by the manipulation of radiation paths. The method is destructive in nature removing ions from a sample surface in order to image and identify them, generating magnifications sufficient to observe individual atoms as they are removed from the sample surface. Through coupling of this magnification method with time of flight mass spectrometry, ions evaporated by application of electric pulses can have their mass-to-charge ratio computed.

Through successive evaporation of material, layers of atoms are removed from a specimen, allowing for probing not only of the surface, but also through the material itself. Computer methods are used to rebuild a three-dimensional view of the sample, prior to it being evaporated, providing atomic scale information on the structure of a sample, as well as providing the type atomic species information. The instrument allows the three-dimensional reconstruction of up to billions of atoms from a sharp tip (corresponding to specimen volumes of 10,000-10,000,000 nm3).

Overview
Atom probe samples are shaped to implicitly provide a highly curved electric potential to induce the resultant magnification, as opposed to direct use of lensing, such as via magnetic lenses. Furthermore, in normal operation (as opposed to a field ionization modes) the atom probe does not utilize a secondary source to probe the sample. Rather, the sample is evaporated in a controlled manner (field evaporation) and the evaporated ions are impacted onto a detector, which is typically 10 to 100 cm away.

The samples are required to have a needle geometry and are produced by similar techniques as TEM sample preparation electropolishing, or focused ion beam methods. Since 2006, commercial systems with laser pulsing have become available and this has expanded applications from metallic only specimens into semiconducting, insulating such as ceramics, and even geological materials. Preparation is done, often by hand, to manufacture a tip radius sufficient to induce a high electric field, with radii on the order of 100 nm.

To conduct an atom probe experiment a very sharp needle shaped specimen is placed in an ultra high vacuum chamber. After introduction into the vacuum system, the sample is reduced to cryogenic temperatures (typically 20-100 K) and manipulated such that the needle's point is aimed towards an ion detector. A high voltage is applied to the specimen, and either a laser pulse is applied to the specimen or a voltage pulse (typically 1-2 kV) with pulse repetition rates in the hundreds of kilohertz range is applied to a counter electrode. The application of the pulse to the sample allows for individual atoms at the sample surface to be ejected as an ion from the sample surface at a known time. Typically the pulse amplitude and the high voltage on the specimen are computer controlled to encourage only one atom to ionize at a time, but multiple ionizations are possible. The delay between application of the pulse and detection of the ion(s) at the detector allow for the computation of a mass-to-charge ratio.

Whilst the uncertainty in the atomic mass computed by time-of-flight methods in atom probe is sufficiently small to allow for detection of individual isotopes within a material this uncertainty may still, in some cases, confound definitive identification of atomic species. Effects such as superposition of differing ions with multiple electrons removed, or through the presence of complex species formation during evaporation may cause two or more species to have sufficiently close time-of-flights to make definitive identification impossible.

Field ion microscopy
Field ion microscopy is a modification of field emission microscopy where a stream of tunneling electrons is emitted from the apex of a sharp needle-like tip cathode when subjected to a sufficiently high electric field (~3-6 V/nm). The needle is oriented towards a phosphor screen to create a projected image of the work function at the tip apex. The image resolution is limited to (2-2.5 nm), due to quantum mechanical effects and lateral variations in the electron velocity.

In field ion microscopy the tip is cooled by a cryogen and its polarity is reversed. When an imaging gas (usually hydrogen or helium) is introduced at low pressures (< 0.1 Pascal) gas ions in the high electric field at the tip apex are field ionized and produce a projected image of protruding atoms at the tip apex. The image resolution is determined primarily by the temperature of the tip but even at 78 Kelvin atomic resolution is achieved.

10-cm Atom Probe
The 10-cm Atom Probe, invented in 1973 by J. A. Panitz was a “new and simple atom probe which permits rapid, in depth species identification or the more usual atom-by atom analysis provided by its predecessors ... in an instrument having a volume of less than two liters in which tip movement is unnecessary and the problems of evaporation pulse stability and alignment common to previous designs have been eliminated.” This was accomplished by combining a time of flight (TOF) mass spectrometer with a proximity focussed, dual channel plate detector, an 11.8 cm drift region and a 38° field of view. An FIM image or a desorption image of the atoms removed from the apex of a field emitter tip could be obtained. The 10-cm Atom Probe has been called the progenitor of later atom probes including the commercial instruments.

Imaging Atom Probe
The Imaging Atom-Probe (IAP) was introduced in 1974 by J. A. Panitz. It incorporated the features of the 10-cm Atom-Probe yet “... departs completely from [previous] atom probe philosophy. Rather than attempt to determine the identity of a surface species producing a preselected ion-image spot, we wish to determine the complete crystallographic distribution of a surface species of preselected mass-to-charge ratio. Now suppose that instead of operating the [detector] continuously, it is turned on for a short time coincidentally with the arrival of a preselected species of interest by applying a gate pulse a time T after the evaporation pulse has reached the specimen. If the duration of the gate pulse is shorter than the travel time between adjacent species, only that surface species having the unique travel time T will be detected and its complete crystallographic distribution displayed.” It was patented in 1975 as the Field Desorption Spectrometer. The Imaging Atom-Probe moniker was coined by A. J. Waugh in 1978 and the instrument was described in detail by J. A. Panitz in the same year.

Atom Probe Tomography (APT)
Modern day atom probe tomography uses a position sensitive detector aka a FIM in a box to deduce the lateral location of atoms. The idea of the APT, inspired by J. A. Panitz's Field Desorption Spectrometer patent, was developed by Mike Miller starting in 1983 and culminated with the first prototype in 1986. Various refinements were made to the instrument, including the use of a so-called position-sensitive (PoS) detector by Alfred Cerezo, Terence Godfrey, and George D. W. Smith at Oxford University in 1988. The Tomographic Atom Probe (TAP), developed by researchers at the University of Rouen in France in 1993, introduced a multichannel timing system and multianode array. Both instruments (PoSAP and TAP) were commercialized by Oxford Nanoscience and CAMECA respectively. Since then, there have been many refinements to increase the field of view, mass and position resolution, and data acquisition rate of the instrument. The Local Electrode Atom Probe was first introduced in 2003 by Imago Scientific Instruments. In 2005, the commercialization of the pulsed laser atom probe (PLAP) expanded the avenues of research from highly conductive materials (metals) to poor conductors (semiconductors like silicon) and even insulating materials. AMETEK acquired CAMECA in 2007 and Imago Scientific Instruments (Madison, WI) in 2010, making the company the sole commercial developer of APTs with more than 110 instruments installed around the world in 2019.

The first few decades of work with APT focused on metals. However, with the introduction of the laser pulsed atom probe systems applications have expanded to semiconductors, ceramic and geologic materials, with some work on biomaterials. The most advanced study of biological material to date using APT involved analyzing the chemical structure of teeth of the radula of chiton Chaetopleura apiculata. In this study, the use of APT showed chemical maps of organic fibers in the surrounding nano-crystalline magnetite in the chiton teeth, fibers which were often co-located with sodium or magnesium. This has been furthered to study elephant tusks, dentin and human enamel.

Field evaporation
Field evaporation is an effect that can occur when an atom bonded at the surface of a material is in the presence of a sufficiently high and appropriately directed electric field, where the electric field is the differential of electric potential (voltage) with respect to distance. Once this condition is met, it is sufficient that local bonding at the specimen surface is capable of being overcome by the field, allowing for evaporation of an atom from the surface to which it is otherwise bonded.

Ion flight
Whether evaporated from the material itself, or ionised from the gas, the ions that are evaporated are accelerated by electrostatic force, acquiring most of their energy within a few tip-radii of the sample.

Subsequently, the accelerative force on any given ion is controlled by the electrostatic equation, where n is the ionisation state of the ion, and e is the fundamental electric charge.

 * $$F=ne \nabla \phi$$

This can be equated with the mass of the ion, m, via Newton's law (F=ma):

 * $$ ma = q \nabla \phi$$

 * $$ a = \frac{q}{m} \nabla \phi$$

Relativistic effects in the ion flight are usually ignored, as realisable ion speeds are only a very small fraction of the speed of light.

Assuming that the ion is accelerated during a very short interval, the ion can be assumed to be travelling at constant velocity. As the ion will travel from the tip at voltage V1 to some nominal ground potential, the speed at which the ion is travelling can be estimated by the energy transferred into the ion during (or near) ionisation. Therefore, the ion speed can be computed with the following equation, which relates kinetic energy to energy gain due to the electric field, the negative arising from the loss of electrons forming a net positive charge.

 * $$E = \frac{1}{2}mU_{\mathrm{ion}}^2 = -neV_1$$

Where U is the ion velocity. Solving for U, the following relation is found:

 * $$ U =\sqrt{ \frac{ 2neV_1}{m}}$$

Let's say that for at a certain ionization voltage, a singly charged hydrogen ion acquires a resulting velocity of 1.4x10^6 ms−1 at 10~kV. A singly charged deuterium ion under the sample conditions would have acquired roughly 1.4x10^6/1.41 ms−1. If a detector was placed at a distance of 1 m, the ion flight times would be 1/1.4x10^6 and 1.41/1.4x10^6 s. Thus, the time of the ion arrival can be used to infer the ion type itself, if the evaporation time is known.

From the above equation, it can be re-arranged to show that

 * $$ \frac{m}{n} = -\frac{2eV_1}{U^2} $$

given a known flight distance. F, for the ion, and a known flight time, t,

 * $$ U = \frac{f}{t}$$

and thus one can substitute these values to obtain the mass-to-charge for the ion.

 * $$ \frac{m}{n} = -2eV_1 \left(\frac{t}{f}\right)^2 $$

Thus for an ion which traverses a 1 m flight path, across a time of 2000 ns, given an initial accelerating voltage of 5000 V (V in Si units is kg.m^2.s^-3.A^-1) and noting that one amu is 1×10−27 kg, the mass-to-charge ratio (more correctly the mass-to-ionisation value ratio) becomes ~3.86 amu/charge. The number of electrons removed, and thus net positive charge on the ion is not known directly, but can be inferred from the histogram (spectrum) of observed ions.

Magnification
The magnification in an atom is due to the projection of ions radially away from the small, sharp tip. Subsequently, in the far-field, the ions will be greatly magnified. This magnification is sufficient to observe field variations due to individual atoms, thus allowing in field ion and field evaporation modes for the imaging of single atoms.

The standard projection model for the atom probe is an emitter geometry that is based upon a revolution of a conic section, such as a sphere, hyperboloid or paraboloid. For these tip models, solutions to the field may be approximated or obtained analytically. The magnification for a spherical emitter is inversely proportional to the radius of the tip, given a projection directly onto a spherical screen, the following equation can be obtained geometrically.

 * $$M = \frac{r_{screen}}{r_{tip}}. $$

Where rscreen is the radius of the detection screen from the tip centre, and rtip the tip radius. A practical tip to screen distances may range from several centimeters to several meters, with increased detector area required at larger to subtend the same field of view.

Practically speaking, the usable magnification will be limited by several effects, such as lateral vibration of the atoms prior to evaporation.

Whilst the magnification of both the field ion and atom probe microscopes is extremely high, the exact magnification is dependent upon conditions specific to the examined specimen, so unlike for conventional electron microscopes, there is often little direct control on magnification, and furthermore, obtained images may have strongly variable magnifications due to fluctuations in the shape of the electric field at the surface.

Reconstruction
The computational conversion of the ion sequence data, as obtained from a position-sensitive detector to a three-dimensional visualisation of atomic types, is termed "reconstruction". Reconstruction algorithms are typically geometrically based and have several literature formulations. Most models for reconstruction assume that the tip is a spherical object, and use empirical corrections to stereographic projection to convert detector positions back to a 2D surface embedded in 3D space, R3. By sweeping this surface through R3 as a function of the ion sequence input data, such as via ion-ordering, a volume is generated onto which positions the 2D detector positions can be computed and placed three-dimensional space.

Typically the sweep takes the simple form of advancement of the surface, such that the surface is expanded in a symmetric manner about its advancement axis, with the advancement rate set by a volume attributed to each ion detected and identified. This causes the final reconstructed volume to assume a rounded-conical shape, similar to a badminton shuttlecock. The detected events thus become a point cloud data with attributed experimentally measured values, such as ion time of flight or experimentally derived quantities, e.g. time of flight or detector data.

This form of data manipulation allows for rapid computer visualisation and analysis, with data presented as point cloud data with additional information, such as each ion's mass to charge (as computed from the velocity equation above), voltage or other auxiliary measured quantity or computation therefrom.

Data features
The canonical feature of atom probe data, is its high spatial resolution in the direction through the material, which has been attributed to an ordered evaporation sequence. This data can therefore image near atomically sharp buried interfaces with the associated chemical information.

The data obtained from the evaporative process is however not without artefacts that form the physical evaporation or ionisation process. A key feature of the evaporation or field ion images is that the data density is highly inhomogeneous, due to the corrugation of the specimen surface at the atomic scale. This corrugation gives rise to strong electric field gradients in the near-tip zone (on the order of an atomic radii or less from the tip), which during ionisation deflects ions away from the electric field normal.

The resultant deflection means that in these regions of high curvature, atomic terraces are belied by a strong anisotropy in the detection density. Where this occurs due to a few atoms on a surface is usually referred to as a "pole", as these are coincident with the crystallographic axes of the specimen (FCC, BCC, HCP) etc. Where the edges of an atomic terrace causes deflection, a low density line is formed and is termed a "zone line".

These poles and zone-lines, whilst inducing fluctuations in data density in the reconstructed datasets, which can prove problematic during post-analysis, are critical for determining information such as angular magnification, as the crystallographic relationships between features are typically well known.

When reconstructing the data, owing to the evaporation of successive layers of material from the sample, the lateral and in-depth reconstruction values are highly anisotropic. Determination of the exact resolution of the instrument is of limited use, as the resolution of the device is set by the physical properties of the material under analysis.

Systems
Many designs have been constructed since the method's inception. Initial field ion microscopes, precursors to modern atom probes, were usually glass blown devices developed by individual research laboratories.

System layout
At a minimum, an atom probe will consist of several key pieces of equipment.
 * A vacuum system for maintaining the low pressures (~10−8 to 10−10 Pa) required, typically a classic 3 chambered UHV design.
 * A system for the manipulation of samples inside the vacuum, including sample viewing systems.
 * A cooling system to reduce atomic motion, such as a helium refrigeration circuit - providing sample temperatures as low as 15K.
 * A high voltage system to raise the sample standing voltage near the threshold for field evaporation.
 * A high voltage pulsing system, use to create timed field evaporation events
 * A counter electrode that can be a simple disk shape (like earlier generation atom probes), or a cone-shaped Local Electrode. The voltage pulse (negative) is typically applied to the counter electrode.
 * A detection system for single energetic ions that includes XY position and TOF information.

Optionally, an atom probe may also include laser-optical systems for laser beam targeting and pulsing, if using laser-evaporation methods. In-situ reaction systems, heaters, or plasma treatment may also be employed for some studies as well as a pure noble gas introduction for FIM.

Performance
Collectable ion volumes were previously limited to several thousand, or tens of thousands of ionic events. Subsequent electronics and instrumentation development has increased the rate of data accumulation, with datasets of hundreds of million atoms (dataset volumes of 107 nm3). Data collection times vary considerably depending upon the experimental conditions and the number of ions collected. Experiments take from a few minutes, to many hours to complete.

Metallurgy
Atom probe has typically been employed in the chemical analysis of alloy systems at the atomic level. This has arisen as a result of voltage pulsed atom probes providing good chemical and sufficient spatial information in these materials. Metal samples from large grained alloys may be simple to fabricate, particularly from wire samples, with hand-electropolishing techniques giving good results.

Subsequently, atom probe has been used in the analysis of the chemical composition of a wide range of alloys.

Such data is critical in determining the effect of alloy constituents in a bulk material, identification of solid-state reaction features, such as solid phase precipitates. Such information may not be amenable to analysis by other means (e.g. TEM) owing to the difficulty in generating a three-dimensional dataset with composition.

Semiconductors
Semi-conductor materials are often analysable in atom probe, however sample preparation may be more difficult, and interpretation of results may be more complex, particularly if the semi-conductor contains phases which evaporate at differing electric field strengths.

Applications such as ion implantation may be used to identify the distribution of dopants inside a semi-conducting material, which is increasingly critical in the correct design of modern nanometre scale electronics.

Limitations

 * Materials implicitly control achievable spatial resolution.
 * Specimen geometry during the analysis is uncontrolled, yet controls projection behaviour, hence there is little control over the magnification. This induces distortions into the computer generated 3D dataset. Features of interest might evaporate in a physically different manner to the bulk sample, altering projection geometry and the magnification of the reconstructed volume. This yields strong spatial distortions in the final image.
 * Volume selectability can be limited. Site specific preparation methods, e.g. using Focussed ion beam preparation, although more time-consuming, may be used to bypass such limitations.
 * Ion overlap in some samples (e.g. between oxygen and sulfur) resulted in ambiguous analysed species. This may be mitigated by selection of experiment temperature or laser input energy to influence the ionisation number (+, ++, 3+ etc.) of the ionised groups. Data analysis can be used in some cases to statistically recover overlaps.
 * Low molecular weight gases (Hydrogen & Helium) may be difficult to be removed from the analysis chamber, and may be adsorbed and emitted from the specimen, even though not present in the original specimen. This may also limit identification of Hydrogen in some samples. For this reason, deuterated samples have been used to overcome limitations.
 * Results may be contingent on the parameters used to convert the 2D detected data into 3D. In more problematic materials, correct reconstruction may not be done, due to limited knowledge of the true magnification; particularly if zone or pole regions cannot be observed.

title: Atom probe


text:
Al Capone

Alphonse Gabriel Capone (January 17, 1899 – January 25, 1947), sometimes known by the nickname "Scarface", was an American gangster and businessman who attained notoriety during the Prohibition era as the co-founder and boss of the Chicago Outfit from 1925 to 1931. His seven-year reign as a crime boss ended when he went to prison at the age of 33.

Capone was born in New York City in 1899 to Italian immigrants. He joined the Five Points Gang as a teenager and became a bouncer in organized crime premises such as brothels. In his early twenties, Capone moved to Chicago and became a bodyguard and trusted factotum for Johnny Torrio, head of a criminal syndicate that illegally supplied alcohol—the forerunner of the Outfit—and was politically protected through the Unione Siciliana. A conflict with the North Side Gang was instrumental in Capone's rise and fall. Torrio went into retirement after North Side gunmen almost killed him, handing control to Capone. Capone expanded the bootlegging business through increasingly violent means, but his mutually profitable relationships with Mayor William Hale Thompson and the Chicago Police Department meant he seemed safe from law enforcement.

Capone apparently reveled in attention, such as the cheers from spectators when he appeared at baseball games. He made donations to various charities and was viewed by many as a "modern-day Robin Hood". However, the Saint Valentine's Day Massacre, in which seven gang rivals were murdered in broad daylight, damaged the public image of Chicago and Capone, leading influential citizens to demand government action and newspapers to dub Capone "Public Enemy No. 1".

Federal authorities became intent on jailing Capone and charged him with twenty-two counts of tax evasion. He was convicted of five counts in 1931. During a highly publicized case, the judge admitted as evidence Capone's admissions of his income and unpaid taxes, made during prior (and ultimately abortive) negotiations to pay the government taxes he owed. He was convicted and sentenced to eleven years in federal prison. After conviction, he replaced his defense team with experts in tax law, and his grounds for appeal were strengthened by a Supreme Court ruling, but his appeal ultimately failed. Capone showed signs of neurosyphilis early in his sentence and became increasingly debilitated before being released after almost eight years of incarceration. In 1947, he died of cardiac arrest after a stroke.

Early life
Alphonse Gabriel Capone was born in Brooklyn, a borough of New York City, on January 17, 1899. His parents were Italian immigrants Gabriele Capone (1865–1920) and Teresa Capone (née Raiola; 1867–1952). His father was a barber and his mother was a seamstress, both born in Angri, a small comune outside of Naples in the Province of Salerno. Capone's family had immigrated to the United States in 1893 by ship, first going through Fiume (modern-day Rijeka, Croatia), a port city in what was then Austria-Hungary. The family settled at 95 Navy Street, in the Navy Yard section of Brooklyn. When Al was aged 11, he and his family moved to 38 Garfield Place in Park Slope, Brooklyn.

Capone's parents had eight other children: James Vincenzo Capone, who later changed his name to Richard Hart and became a Prohibition agent in Homer, Nebraska; Raffaele James Capone, also known as Ralph Capone or "Bottles", who took charge of his brother's beverage industry; Salvatore "Frank" Capone; Ermina Capone, who died at the age of one; Ermino "John" Capone; Albert Capone; Matthew Capone and Mafalda Capone. Ralph and Frank worked with Al Capone in his criminal empire. Frank did so until his death on April 1, 1924. Ralph ran Capone's bottling companies (both legal and illegal) early on and was also the front man for the Chicago Outfit until he was imprisoned for tax evasion in 1932.

Al Capone showed promise as a student but had trouble with the rules at his strict parochial Catholic school. His schooling ended at the age of 14 after he was expelled for hitting a female teacher in the face. Capone worked at odd jobs around Brooklyn, including a candy store and a bowling alley. From 1916 to 1918 he played semi-professional baseball. Following this, Capone was influenced by gangster Johnny Torrio, whom he came to regard as a mentor.

Capone married Mae Josephine Coughlin at age 19, on December 30, 1918. She was Irish Catholic and earlier that month had given birth to their son Albert Francis "Sonny" Capone (1918–2004). Albert lost most of his hearing in his left ear as a child. Capone was under the age of 21, and his parents had to consent in writing to the marriage. By all accounts, the two had a happy marriage.

New York City
Capone initially became involved with small-time gangs that included the Junior Forty Thieves and the Bowery Boys. He then joined the Brooklyn Rippers, and then the powerful Five Points Gang based in Lower Manhattan. During this time he was employed and mentored by fellow racketeer Frankie Yale, a bartender in a Coney Island dance hall and saloon called the Harvard Inn. Capone inadvertently insulted a woman while working the door, and he was slashed with a knife three times on the left side of his face by her brother, Frank Galluccio; the wounds led to the nickname "Scarface", which Capone loathed. The date when this occurred has been reported with inconsistencies. When Capone was photographed, he hid the scarred left side of his face, saying that the injuries were war wounds. He was called "Snorky" by his closest friends, a term for a sharp dresser.

Move to Chicago
In 1919, Capone left New York City for Chicago at the invitation of Torrio, who was imported by crime boss James "Big Jim" Colosimo as an enforcer. Capone began in Chicago as a bouncer in a brothel, which is thought to be most likely where he contracted syphilis. Capone was aware of being infected at an early stage and timely use of Salvarsan probably could have cured the infection, but he apparently never sought treatment. In 1923, Capone purchased a small house at 7244 South Prairie Avenue in the Park Manor neighborhood in Chicago's South Side for US$5500.

As originally reported in the Chicago Tribune, hijacker Joe Howard was killed on May 8, 1924, after he tried to interfere with the Capone-Torrio bootlegging business. (In a 1936 article highlighting Capone's criminal career, the Tribune erroneously reported the date as May 7, 1923.) In the early years of the decade, Capone's name began appearing in newspaper sports pages where he was described as a boxing promoter. Torrio took over Colosimo's criminal empire after the latter's murder on May 11, 1920, in which Capone was suspected of being involved.

Torrio headed an essentially Italian organized crime group that was the biggest in Chicago, with Capone as his right-hand man. Torrio was wary of being drawn into gang wars and tried to negotiate agreements over territory between rival crime groups. The smaller North Side Gang, led by Dean O'Banion, came under pressure from the Genna brothers who were allied with Torrio. O'Banion found that Torrio was unhelpful with the Gennas' encroachment, despite his pretensions to be a settler of disputes. In a fateful step, Torrio arranged the murder of O'Banion at his flower shop on November 10, 1924. This placed Hymie Weiss at the head of the gang, backed by Vincent Drucci and Bugs Moran. Weiss had been a close friend of O'Banion, and the North Siders made it a priority to get revenge on his killers.

During Prohibition, Capone was involved with Canadian bootleggers who helped him smuggle liquor into the U.S. When Capone was asked if he knew Rocco Perri, billed as Canada's "King of the Bootleggers", he replied: "Why, I don't even know which street Canada is on." Other sources, however, claim that Capone had certainly visited Canada, where he maintained some hideaways, but the Royal Canadian Mounted Police states that there is no "evidence that he ever set foot on Canadian soil."

Boss
An ambush in January 1925 left Capone shaken but unhurt. Twelve days later, Torrio was returning from a shopping trip when he was shot several times. After recovering, he effectively resigned and handed control to Capone, aged 26, who became the new boss of an organization that took in illegal breweries and a transportation network that reached to Canada, with political and law-enforcement protection. In turn, he was able to use more violence to increase revenue. Any establishment that refused to purchase liquor from Capone often got blown up, and as many as 100 people were killed in such bombings during the 1920s. Rivals saw Capone as responsible for the proliferation of brothels in the city.

Capone often enlisted the help of local members of the black community into his operations; jazz musicians Milt Hinton and Lionel Hampton had uncles who worked for Capone on Chicago's South Side. A fan of jazz as well, Capone once asked clarinetist Johnny Dodds to play a number that Dodds did not know; Capone split a $100 bill in half and told Dodds that he would get the other half when he learned it. Capone also sent two bodyguards to accompany jazz pianist Earl Hines on a road trip.

Capone indulged in custom suits, cigars, gourmet food and drink, and female companionship. He was particularly known for his flamboyant and costly jewelry. His favorite responses to questions about his activities were: "I am just a businessman, giving the people what they want"; and, "All I do is satisfy a public demand." Capone had become a national celebrity and talking point.

Capone based himself in Cicero, Illinois, after using bribery and widespread intimidation to take over town council elections, making it difficult for the North Siders to target him. Capone's driver was found tortured and murdered, and there was an attempt on Weiss' life in the Chicago Loop. On September 20, 1926, the North Siders used a ploy outside Capone's headquarters at the Hawthorne Inn aimed at drawing him to the windows. Gunmen in several cars then opened fire with Thompson submachine guns and shotguns at the windows of the first-floor restaurant. Capone was unhurt and called for a truce, but the negotiations fell through. Three weeks later, on October 11, Weiss was killed outside the North Siders' headquarters at O'Banion's former flower shop. The owner of Hawthorne's restaurant was a friend of Capone's, and he was kidnapped and killed by Moran and Drucci in January 1927.

Capone became increasingly security-minded and desirous of getting away from Chicago. As a precaution, he and his entourage would often show up suddenly at one of Chicago's train depots and buy up an entire Pullman sleeper car on a night train to Cleveland, Omaha, Kansas City, Little Rock or Hot Springs, Arkansas, where they would spend a week in luxury hotel suites under assumed names.

In 1928, Capone paid $40,000 to Clarence Busch of the Anheuser-Busch brewing family for a 10000 sqfoot home at 93 Palm Avenue on Palm Island, Florida, between Miami and Miami Beach.

Feud with Aiello
In November 1925, Capone's consigliere, Antonio Lombardo, was named head of the Unione Siciliana, a Sicilian-American benevolent society that had been corrupted by gangsters. An infuriated Joe Aiello, who had wanted the position himself, believed Capone was responsible for Lombardo's ascension and resented the non-Sicilian's attempts to manipulate affairs within the Unione. Aiello severed all personal and business ties with Lombardo and entered into a feud with Capone.

Aiello allied himself with several other Capone enemies, including Jack Zuta, who ran vice and gambling houses together. Aiello plotted to eliminate both Lombardo and Capone, and starting in the spring of 1927 made several attempts to assassinate Capone. On one occasion, Aiello offered money to the chef of Joseph "Diamond Joe" Esposito's Bella Napoli Café, Capone's favorite restaurant, to put prussic acid in Capone's and Lombardo's soup; reports indicated he offered between $10,000 and $35,000. Instead, the chef exposed the plot to Capone, who responded by dispatching men to destroy Aiello's bakery on West Division Street with machine-gun fire. More than 200 bullets were fired into the bakery on May 28, 1927, wounding Joe's brother Antonio.

During the summer and autumn of 1927, a number of hitmen Aiello hired to kill Capone were themselves slain. Among them were Anthony Russo and Vincent Spicuzza, each of whom had been offered $25,000 by Aiello to kill Capone and Lombardo. Aiello eventually offered a $50,000 bounty to anyone who eliminated Capone. At least ten gunmen tried to collect on the bounty but ended up dead. Capone's ally Ralph Sheldon attempted to kill both Capone and Lombardo for Aiello's reward, but Capone henchman Frank Nitti's intelligence network learned of the transaction and had Sheldon shot in front of a West Side hotel, although he survived the incident.

In November 1927, Aiello organized machine-gun ambushes across from Lombardo's home and a cigar store frequented by Capone, but those plans were foiled after an anonymous tip led police to raid several addresses and arrest Milwaukee gunman Angelo La Mantio and four other Aiello gunmen. After the police discovered receipts for the apartments in La Mantio's pockets, he confessed that Aiello had hired him to kill Capone and Lombardo, leading the police to arrest Aiello himself and bring him to the South Clark Street police station. Upon learning of the arrest, Capone dispatched nearly two dozen gunmen to stand guard outside the station and await Aiello's release. The men made no attempt to conceal their purpose there, and reporters and photographers rushed to the scene to observe Aiello's expected murder. When released, Aiello was given a police escort out of the station to safety. He later failed to make a court appearance after his attorney claimed he suffered a nervous breakdown. Aiello disappeared with some family members to Trenton, NJ, from whence he continued his campaign against Capone and Lombardo.

Political alliances
Chicago politicians had long been associated with questionable methods, and even newspaper circulation "wars", but the need for bootleggers to have protection in city hall introduced a far more serious level of violence and graft. Capone is generally seen as having an appreciable effect in bringing about the victory of Republican mayoral candidate William Hale Thompson, who had campaigned on a platform of not enforcing Prohibition and at one time hinted that he'd reopen illegal saloons. Thompson allegedly accepted a contribution of $250,000 from Capone. Thompson beat Democratic candidate William Emmett Dever in the 1927 mayoral race by a relatively slim margin.

On the day of the so-called Pineapple Primary on April 10, 1928, voting booths were targeted by Capone's bomber, James Belcastro, in wards where Thompson's opponents were thought to have support, causing the deaths of at least fifteen people. Belcastro was accused of the murder of lawyer Octavius Granady, an African-American who challenged Thompson's candidate for the Black vote, and was chased through the streets on polling day by cars of gunmen before being shot dead. Four policemen were among those charged along with Belcastro, but all charges were dropped after key witnesses recanted their statements. An indication of the attitude of local law enforcement toward Capone's organization came in 1931 when Belcastro was wounded in a shooting; police suggested to skeptical journalists that Belcastro was an independent operator.

A 1929 report by The New York Times connected Capone to the 1926 murder of Assistant State Attorney William H. McSwiggin, the 1928 murders of chief investigator Ben Newmark and former mentor Frankie Yale.

Saint Valentine's Day Massacre
Capone was widely assumed to have been responsible for ordering the 1929 Saint Valentine's Day Massacre, despite being at his Florida home at the time of the massacre. The massacre was an attempt to eliminate Bugs Moran, head of the North Side Gang, and the motivation for the plan may have been the fact that some expensive whisky illegally imported from Canada via the Detroit River had been hijacked while it was being transported to Cook County, Illinois.

Moran was the last survivor of the North Side gunmen; his succession had come about because his similarly aggressive predecessors, Weiss and Vincent Drucci, had been killed in the violence that followed the murder of original leader Dean O'Banion.

To monitor their targets' habits and movements, Capone's men rented an apartment across from the trucking warehouse and garage at 2122 North Clark Street, which served as Moran's headquarters. On the morning of Thursday, February 14, 1929, Capone's lookouts signaled four gunmen disguised as police officers to initiate a "police raid". The faux police lined the seven victims along a wall and signaled for accomplices armed with machine guns and shotguns. Moran was not among the victims. Photos of the slain victims shocked the public and damaged Capone's image. Within days, Capone received a summons to testify before a Chicago grand jury on charges of federal Prohibition violations, but he claimed to be too unwell to attend. In an effort to clean up his image, Capone donated to charities and sponsored a soup kitchen in Chicago during the Depression.

The Saint Valentine's Day Massacre led to public disquiet about Thompson's alliance with Capone and was a factor in Anton J. Cermak winning the mayoral election on April 6, 1931.

Feud with Aiello ends
Capone was primarily known for ordering other men to do his dirty work for him. In May 1929, one of Capone's bodyguards, Frank Rio, uncovered a plot by three of his men, Albert Anselmi, John Scalise and Joseph Giunta, who had been persuaded by Aiello to depose Capone and take over the Chicago Outfit. Capone later beat the men with a baseball bat and then ordered his bodyguards to shoot them, a scene that was included in the 1987 film The Untouchables. Deirdre Bair, along with writers and historians such as William Elliot Hazelgrove, have questioned the veracity of the claim. Bair questioned why "three trained killers could sit quietly and let this happen", while Hazelgrove stated that Capone would have been "hard pressed to beat three men to death with a baseball bat" and that he would have instead let an enforcer perform the murders. However, despite claims that the story was first reported by author Walter Noble Burns in his 1931 book The One-way Ride: The red trail of Chicago gangland from prohibition to Jake Lingle, Capone biographers Max Allan Collins and A. Brad Schwartz have found versions of the story in press coverage shortly after the crime. Collins and Schwartz suggest that similarities among reported versions of the story indicate a basis in truth and that the Outfit deliberately spread the tale to enhance Capone's fearsome reputation. George Meyer, an associate of Capone's, also claimed to have witnessed both the planning of the murders and the event itself.

In 1930, upon learning of Aiello's continued plotting against him, Capone resolved to finally eliminate him. In the weeks before Aiello's death, Capone's men tracked him to Rochester, New York, where he had connections through Buffalo crime family boss Stefano Magaddino, and plotted to kill him there, but Aiello returned to Chicago before the plot could be executed. Aiello, angst-ridden from the constant need to hide out and the killings of several of his men, set up residence in the Chicago apartment of Unione Siciliana treasurer Pasquale "Patsy Presto" Prestogiacomo at 205 N. Kolmar Ave. On October 23, upon exiting Prestogiacomo's building to enter a taxicab, a gunman in a second-floor window across the street started firing at Aiello with a submachine gun. Aiello was said to have been shot at least 13 times before he toppled off the building steps and moved around the corner, attempting to move out of the line of fire. Instead, he moved directly into the range of a second submachine gun positioned on the third floor of another apartment block, and was subsequently gunned down.

Federal intervention
In the wake of the Saint Valentine's Day Massacre, Walter A. Strong, publisher of the Chicago Daily News, asked his friend President Herbert Hoover for federal intervention to stem Chicago's lawlessness. He arranged a secret meeting at the White House, just two weeks after Hoover's inauguration. On March 19, 1929, Strong, joined by Frank Loesch of the Chicago Crime Commission, and Laird Bell, made their case to the President. In Hoover's 1952 Memoir, the former President reported that Strong argued "Chicago was in the hands of the gangsters, that the police and magistrates were completely under their control, …that the Federal government was the only force by which the city's ability to govern itself could be restored. At once I directed that all the Federal agencies concentrate upon Mr. Capone and his allies."

That meeting launched a multi-agency attack on Capone. Treasury and Justice Departments developed plans for income tax prosecutions against Chicago gangsters, and a small, elite squad of Prohibition Bureau agents (whose members included Eliot Ness) were deployed against bootleggers. In a city used to corruption, these lawmen were incorruptible. Charles Schwarz, a writer for the Chicago Daily News, dubbed them Untouchables. To support Federal efforts, Strong secretly used his newspaper's resources to gather and share intelligence on the Capone outfit.

Trials

On March 27, 1929, Capone was arrested by FBI agents as he left a Chicago courtroom after testifying to a grand jury that was investigating violations of federal prohibition laws. He was charged with contempt of court for feigning illness to avoid an earlier appearance. On May 16, 1929, Capone was arrested in Philadelphia, Pennsylvania, for carrying a concealed weapon. On May 17, 1929, Capone was indicted by a grand jury and a trial was held before Philadelphia Municipal Court Judge John E Walsh. Following the entering of a guilty plea by his attorney, Capone was sentenced to a prison term of one year. On August 8, 1929, Capone was transferred to Philadelphia's Eastern State Penitentiary. A week after his release in March 1930, Capone was listed as the number one "Public Enemy" on the unofficial Chicago Crime Commission's widely publicized list.

In April 1930, Capone was arrested on vagrancy charges when visiting Miami Beach; the governor had ordered sheriffs to run him out of the state. Capone claimed that Miami police had refused him food and water and threatened to arrest his family. He was charged with perjury for making these statements, but was acquitted after a three-day trial in July. In September, a Chicago judge issued a warrant for Capone's arrest on charges of vagrancy and then used the publicity to run against Thompson in the Republican primary. In February 1931, Capone was tried on the contempt of court charge. In court, Judge James Herbert Wilkerson intervened to reinforce questioning of Capone's doctor by the prosecutor. Wilkerson sentenced Capone to six months, but he remained free while on appeal of the contempt conviction.

In February 1930, Capone's organization was linked to the murder of Julius Rosenheim, who served as a police informant in the Chicago Outfit for 20 years.

Tax evasion

Assistant Attorney General Mabel Walker Willebrandt is said to have originated the tactic of charging obviously wealthy crime figures with federal tax evasion on the basis of their luxurious lifestyles. In 1927, the Supreme Court ruled in United States v. Sullivan that the approach was legally sound: illegally earned income was subject to income tax.

The key to Capone's conviction on tax charges was not his spending, but proving his income, and the most valuable evidence in that regard originated in his offer to pay tax. Ralph, his brother and a gangster in his own right, was tried for tax evasion in 1930. Ralph spent the next 18 months in prison after being convicted in a two-week trial over which Wilkerson presided. Seeking to avoid the same fate, Al Capone ordered his lawyer to regularize his tax position, and although it was not done, his lawyer made crucial admissions when stating the income that Capone was willing to pay tax on for various years, admitting income of $100,000 for 1928 and 1929, for instance. Hence, without any investigation, the government had been given a letter from a lawyer acting for Capone conceding his large taxable income for certain years he had paid no tax on. On March 13, 1931, Capone was charged with income tax evasion for 1924, in a secret grand jury. On June 5, 1931, Capone was indicted by a federal grand jury on 22 counts of income tax evasion from 1925 through 1929; he was released on $50,000 bail. Capone was then indicted on 5,000 violations of the Volstead Act (Prohibition laws).

On June 16, 1931, at the Chicago Federal Building in the courtroom of Wilkerson, Capone pleaded guilty to income tax evasion and the 5,000 Volstead Act violations as part of a $2 1/2$-year prison sentence plea bargain. However, on July 30, 1931, Wilkerson refused to honor the plea bargain, and Capone's counsel rescinded the guilty pleas. On the second day of the trial, Wilkerson deemed that the 1930 letter to federal authorities could be admitted into evidence, overruling objections that a lawyer could not confess for his client. Wilkerson later tried Capone only on the income tax evasion charges as he determined they took precedence over the Volstead Act charges.

Much was later made of other evidence, such as witnesses and ledgers, but these strongly implied Capone's control rather than stating it. Capone's lawyers, who had relied on the plea bargain Wilkerson refused to honor and therefore had mere hours to prepare for the trial, ran a weak defense focused on claiming that essentially all his income was lost to gambling. This would have been irrelevant regardless, since gambling losses can only be subtracted from gambling winnings, but it was further undercut by Capone's expenses, which were well beyond what his claimed income could support; Wilkerson allowed Capone's spending to be presented at very great length. The government charged Capone with evasion of $215,000 in taxes on a total income of $1,038,654, during the five-year period. Capone was convicted on five counts of income tax evasion on October 17, 1931,  and was sentenced a week later to 11 years in federal prison, fined $50,000 plus $7,692 for court costs, and was held liable for $215,000 plus interest due on his back taxes. The contempt of court sentence was served concurrently. New lawyers hired to represent Capone were Washington-based tax experts. They filed a writ of habeas corpus based on a Supreme Court ruling that tax evasion was not fraud, which apparently meant that Capone had been convicted on charges relating to years that were actually outside the time limit for prosecution. However, a judge interpreted the law so that the time that Capone had spent in Miami was subtracted from the age of the offences, thereby denying the appeal of both Capone's conviction and sentence.

Imprisonment

Capone was sent to Atlanta U.S. Penitentiary in May 1932, aged 33. Upon his arrival at Atlanta, Capone was officially diagnosed with syphilis and gonorrhea. He was also experiencing withdrawal symptoms from cocaine addiction, the use of which had perforated his nasal septum. Capone was competent at his prison job of stitching soles on shoes for eight hours a day, but his letters were barely coherent. He was seen as a weak personality, and so out of his depth dealing with bullying at the hands of fellow inmates that his cellmate, seasoned convict Red Rudensky, feared that Capone would have a breakdown. Rudensky was formerly a small-time criminal associated with the Capone gang and found himself becoming a protector for Capone. The conspicuous protection by Rudensky and other prisoners drew accusations from less friendly inmates and fueled suspicion that Capone was receiving special treatment. No solid evidence ever emerged, but it formed part of the rationale for moving Capone to the recently opened Alcatraz Federal Penitentiary off the coast of San Francisco, in August 1934. On June 23, 1936, Capone was stabbed and superficially wounded by fellow Alcatraz inmate James C. Lucas.

Due to his good behavior, Capone was permitted to play banjo in the Alcatraz prison band, the Rock Islanders, which gave regular Sunday concerts for other inmates. Capone also transcribed the song "Madonna Mia" creating his own arrangement as a tribute to his wife Mae. At Alcatraz, Capone's decline became increasingly evident, as neurosyphilis progressively eroded his mental faculties; his formal diagnosis of syphilis of the brain was made in February 1938. He spent the last year of his Alcatraz sentence in the hospital section, confused and disoriented. Capone completed his term in Alcatraz on January 6, 1939, and was transferred to the Federal Correctional Institution at Terminal Island in California to serve out his sentence for contempt of court. He was paroled on November 16, 1939, after his wife Mae appealed to the court, based on his reduced mental capabilities.

Chicago aftermath
The main effect of Capone's conviction was that he ceased to be boss immediately on his imprisonment, but those involved in the jailing of Capone portrayed it as a considerable undermining of the city's organized crime syndicate. Capone's underboss, Frank Nitti, took over as boss of the Outfit after he was released from prison in March 1932, having also been convicted of tax evasion charges. Far from being smashed, the Outfit continued without being troubled by the Chicago police, but at a lower level and without the open violence that had marked Capone's rule. Organized crime in the city had a lower profile once Prohibition was repealed, already wary of attention after seeing Capone's notoriety bring him down, to the extent that there is a lack of consensus among writers about who was actually in control and who was a figurehead "front boss". Prostitution, labor union racketeering, and gambling became moneymakers for organized crime in the city without incurring serious investigation. In the late 1950s, FBI agents discovered an organization led by Capone's former lieutenants reigning supreme over the Chicago underworld.

Some historians have speculated that Capone ordered the 1939 murder of Edward J. O'Hare a week before his release, for helping federal prosecutors convict Capone of tax evasion, though there are other theories for O'Hare's death.

Illness and death
Due to his failing health, Capone was released from prison on November 16, 1939, and referred to Johns Hopkins Hospital in Baltimore for the treatment of syphilitic paresis. Because of his unsavory reputation, Johns Hopkins refused to treat him, but Baltimore's Union Memorial Hospital did. Capone was grateful for the compassionate care that he received and donated two Japanese weeping cherry trees to Union Memorial Hospital in 1939. After a few weeks of inpatient and outpatient care, on March 20, 1940, a very sickly Capone left Baltimore and travelled to his mansion in Palm Island, Florida. In 1942, after mass production of penicillin was started in the United States, Capone was one of the first American patients treated by the new drug. Though it was too late for him to reverse the damage to his brain, it did slow down the progression of the disease.

In 1946, his physician and a Baltimore psychiatrist examined him and concluded that Capone had the mentality of a 12-year-old child. He spent the last years of his life at his Palm Island mansion, spending time with his wife and grandchildren. On January 21, 1947, Capone had a stroke. He regained consciousness and started to improve, but contracted bronchopneumonia. He suffered a cardiac arrest on January 22, and on January 25, surrounded by his family in his home, died after his heart failed as a result of apoplexy. His body was transported back to Chicago a week later and a private funeral was held. He was originally buried at Mount Olivet Cemetery in Chicago. In 1950, Capone's remains, along with those of his father, Gabriele, and brother, Frank, were moved to Mount Carmel Cemetery in Hillside, Illinois.

In popular culture
Capone is one of the most notorious American gangsters of the 20th century and has been the major subject of numerous articles, books, and films. Particularly, from 1925 to 1929, shortly after he moved to Chicago, he enjoyed his status as the most notorious mobster in the country. He cultivated a certain image of himself in the media that made him a subject of fascination.

title: Al Capone


text:
Talk:Antidepressant

Edits regarding references to the Management of depression article
Hi I made another edit to that sentence in the lede. Please let me know what you think.

I'm curious about why you removed the link from the "see also" section to the Management of depression article. I think that the link is good to include there. ↠Pine  (✉)  01:40, 24 April 2020 (UTC)
 * Hey User:Pine hope all is well. Since we link to management of depression in the lead IMO we do not need to put that in the see also section aswell. Doc James  (talk · contribs · email) 01:47, 24 April 2020 (UTC)
 * Hi I think that the link is good to include there for the benefit of readers who go take time to read the entire article and may want to read related pages after they get to the bottom of the article. Also, I use the "see also" section  to find related articles in a way that is similar to how I use categories, and from my admittedly non-expert perspective the article Management of depression is closely related to the topic of antidepressants, so I think that including the link in the "see also" section is preferable.  ↠Pine   (✉)  01:57, 24 April 2020 (UTC)
 * Yah. We have WP:See also "As a general rule, the "See also" section should not repeat links that appear in the article's body". I am easy either way if you want to return it. Doc James  (talk · contribs · email) 02:56, 24 April 2020 (UTC)

Complete inefficacy
According to a rich line of research by Kirsch, Burns and others, there are systematic biases in most research about antidepressants. Keeping in mind that all current research finds tiny effects barely above statistical significance, and definitely below clinical significance, that means that probably all so-called antidepressants are just placebos with underestimated adverse effects.

I tried to add a small paragraph with sources about that in articles on common SSRIs and SNRIs but it keeps getting deleted with little or no explanation. Can I add it here or will someone get offended (or maybe hurt in his/her economic interests)? AndreaGMonaco (talk) 17:03, 8 March 2021 (UTC).

 * It would definitely deserve at least a subsection's worth of mention. Calling them just placebos isn't correct though, Kirsch noted that they do have a true effect in severely depressed patients, if I recall correctly. Regardless, try to avoid sourcing his studies directly, because Wikipedia prefers secondary sources. Using primary sources allows for some very easy cherry-picking of studies, plus it doesn't establish notability well enough. So yeah, go ahead and find a reliable secondary medical source or two and add it.--Megaman en m (talk) 20:22, 8 March 2021 (UTC)

 * But "Should antidepressants be used for major depressive disorder?" by Jakobsen, Gluud and Kirsch (https://ebm.bmj.com/content/25/4/130) is a meta-analysys, that is a secondary source, and other sources I used are secondary too. In the Conclusions of that study they say that "The benefits of antidepressants seem to be minimal and possibly without any importance to the average patient with major depressive disorder. Antidepressants should not be used for adults with major depressive disorder before valid evidence has shown that the potential beneficial effects outweigh the harmful effects." Also, there is no mention of different results for severe depression: they write that "Despite biases inflating beneficial effects of review results, they still show only negligible differences between antidepressants and placebo on depressive symptoms, and the ‘true’ effect of antidepressants might not even be statistically significant." AndreaGMonaco (talk) 14:21, 13 March 2021 (UTC)
 * The Jakobsen, Gluud and Kirsch article also states: "Several reviews have assessed the effects of antidepressants compared with placebo for depression.30 All these previous reviews show that antidepressants have statistically significant effects on depressive symptoms." That is certainly not "complete inefficacy" of antidepressants. Andrea seems to be cherry-picking the quotations confirming his POV. Remember, Neutral point of view requires that your writing "must be written from a neutral point of view (NPOV), which means representing fairly, proportionately, and, as far as possible, without editorial bias" the views of the sources.The Sceptical Chymist (talk) 15:32, 13 March 2021 (UTC)
 * That quote appears in the middle of the article and is immediately and thoroughly challenged. The Findings section instead summarises that: "Several reviews have assessed the effects of antidepressants compared with placebo for depression. Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients. Antidepressants seem to have minimal beneficial effects on depressive symptoms and increase the risk of both serious and non-serious adverse events.". Also remember that statistical significance has arguably no meaning; a stronger proof of clinical significance is required in clinical settings AndreaGMonaco (talk) 14:39, 16 March 2021 (UTC).

 * Exactly, we need to present both to sum up the Kirsch article fairly. Also, I suggest not putting your suggested revision into a separate chapter Research or subchapter Lack of Efficacy but as a new paragraph to the chapter depression. Also I have no problems with you adding the first paragraph starting Research by Irving Kirsch, and ending with journal=Psychotherapy and Psychosomatics, 68}}. The criticisms, I think, are summed up fairly. You can go ahead and add it, if there are no other objections. It is the second paragraph (the summation of 2019 review) that I have problems with (as I wrote above), and non-encyclopedic language like "so-called antidepressants". The Sceptical Chymist (talk) 16:24, 16 March 2021 (UTC)

 * To make it clear, adding the following two paragraphs by AndreaGMonaco to the article is being discussed The Sceptical Chymist (talk) 02:39, 17 March 2021 (UTC)

Research by Irving Kirsch, David D. Burns and many others contends that most studies on so-called antidepressant medication are confounded by several biases: for example the lack of an active placebo, which means that many people in the placebo arm of a double-blind study may figure out that they are not getting any true treatment, thus destroying double-blindness; a short follow up after termination of treatment; studies being paid for by the industry; selective publication of results.

Most studies on antidepressant medication find small positive effects, barely above statistical significance and clearly below clinical significance. Taking into account all of the aforementioned biases, which all play in favor of the drugs, this line of research contends that all currently existing so-called antidepressants have no beneficial effect and have worse adverse effects than is currently thought. In the conclusions of a 2019 meta-review by Jakobsen, Gluud and Kirsch: "The benefits of antidepressants seem to be minimal and possibly without any importance to the average patient with major depressive disorder. Antidepressants should not be used for adults with major depressive disorder before valid evidence has shown that the potential beneficial effects outweigh the harmful effects."
 * This point of view is represented in the article at this point by a single sentence at the end of Depression subchapter: "Some reviews of antidepressants in adults with depression find benefits[19][13] while others do not.[14]" This certainly can be expanded. It would be nice, though, if you can support your expansion by direct quotations from Kirsch et al writings (here at the Talk). Please avoid going beyond what Kirsch says in his articles: it is "original research", a mortal sin on Wikipedia - No original research. The Sceptical Chymist (talk) 23:32, 8 March 2021 (UTC)

Flaws in Antidepressant Research
It has by now been well-documented that there are a number of unacceptable and significant flaws in the antidepressant research literature, particularly in the early trials conducted in the 90s/00s. In some cases this has led to significant public scandals, as in Study 329 or in Lilly's practice of misclassifying suicides. The flaws in the original trials mean that in many cases the prominent meta-analyses (such as Cipriani's) have had to use low-quality or uncertain evidence. Considering the magnitude of the problem, it is not well-represented in the article, given only a few sentences under MDD and a well-sourced but incomplete treatment in pharmacology. Some issues, such as widespread misreporting and ghostwriting, are mentioned only in passing or not at all. The problems with the literature should be substantially explicated somewhere in the article, possibly even with its own section or at least subsection. When I have the time I will try to do so. Feline negativity (talk) 08:04, 16 January 2023 (UTC)

 * @Medgirl131 Your contribution is excellent but I wonder whether some of it would be better-suited to a "Controversy" section. I'm currently drafting one and a lot of the points you've added also belong there. There should certainly be something about the active placebo theory under pharmacology, but I think some of it should be moved up to this new section. If you have any thoughts they'd be very welcome. Feline negativity (talk) 09:39, 22 January 2023 (UTC)
 * Have now added a "Controversy" section. It needs a bit of work, including a more detailed presentation on the case for why the efficacy of antidepressants is underestimated, but I think it's a fair summary. In the past it seems there was more information on the controversy, it's unclear why there no longer is given that the debate remains alive and well. Feline negativity (talk) 15:45, 23 January 2023 (UTC)

Akathisia
There appears to have been a bit of edit-warring about akathisia as a common side effect. Akathisia doesn't seem to be mentioned elsewhere in the article. It is well-known that akathisia can be a side effect of antidepressants, there are countless case reports and I believe the package inserts also mention it. The trouble is that as far as I can tell there are no reliable estimates of how common akithisia actually is. I'll keep looking but if someone does have a source on how often it occurs it would be very helpful. Feline negativity (talk) 14:12, 24 February 2023 (UTC)

 * There is a real paucity of research on this. Again it's well-known they can cause akathisia, but very hard to estimate how often. A 2016 BMJ systematic review found doubled odds of akathisia, but the results were not statistically significant, authors also say likely underestimated due to misreporting. A 2009 review in BJPsych found the incidence of what they termed "jitteriness/anxiety syndrome" to be between 4 to 65 percent, which really underscores the difficulty of knowing how common it is. Loonen and Stahl cite Lipinski et al.'s paper (on fluoxetine) to put the incidence between 9.8 and 25 percent. Given that it's a known side effect it should appear somewhere in the article, but since the incidence estimates are unreliable I don't know that it should be in the list of common side effects right at the start. Worth noting perhaps that agitation (of which akathisia is an extreme manifestation) does appear as a "common side effect." Feline negativity (talk) 12:41, 17 March 2023 (UTC)

pharmacology section
The pharmacology section seems to mainly be about addressing the criticisms of the monoamine hypothesis and antidepressants in general. It is relevant to reference these, but I think it would be fair to mention other documented indirect effects of (certain) antidepressants such as increased BDNF expression and down-regulation of certain serotonin receptors as well. I am not a medical professional so maybe someone who knows about neuropsychopharmacology could provide some information/sources. 83.233.200.105 (talk) 18:25, 12 March 2023 (UTC)

 * @83.233.200.105 Agreed, section definitely in need of work/updating. BDNF very popular now, this review could be a good source: https://doi.org/10.1016/j.biopsych.2021.05.008 Feline negativity (talk) 11:56, 17 March 2023 (UTC)

title: Talk:Antidepressant