text:
Pratt & Whitney

Pratt & Whitney is an American aerospace manufacturer with global service operations. It is a subsidiary of RTX Corporation (formerly Raytheon Technologies). Pratt & Whitney's aircraft engines are widely used in both civil aviation (especially airlines) and military aviation. Its headquarters are in East Hartford, Connecticut. The company is the world's second largest commercial aircraft engine manufacturer, with a 35% market share. In addition to aircraft engines, Pratt & Whitney manufactures gas turbine engines for industrial use, marine propulsion, and power generation. In 2017, the company reported that it supported more than 11,000 customers in 180 countries around the world.

Early history
In April 1925, Frederick Rentschler, an Ohio native and former executive at Wright Aeronautical, was determined to start an aviation-related business of his own. His social network included Edward Deeds, another prominent Ohioan of the early aviation industry, and Frederick's brother Gordon Rentschler, both of whom were on the board of Niles Bement Pond, then one of the largest machine tool corporations in the world. Frederick Rentschler approached these men as he sought capital and assets for his new venture. Deeds and G. Rentschler persuaded the board of Niles Bement Pond that their Pratt & Whitney Machine Tool (P&WMT) subsidiary of Hartford, Connecticut, should provide the funding and location to build a new aircraft engine being developed by Rentschler, George J. Mead, and colleagues, all formerly of Wright Aeronautical. Conceived and designed by Mead, the new engine would be a large, air-cooled, radial design. Pratt & Whitney Machine Tool was going through a period of self-revision at the time to prepare itself for the post-World War I era, discontinuing old product lines and incubating new ones. World War I had been profitable to P&WMT, but the peace brought a predictable glut to the machine tool market, as contracts with governments were canceled and the market in used, recently-built tools competed against new ones. P&WMT's future growth would depend on innovation. Having idle factory space and capital available at this historical moment, to be invested wherever good return seemed available, P&WMT saw the post-war aviation industry, both military and civil (commercial, private), as one with some of the greatest growth and development potential available anywhere for the next few decades. It lent Rentschler US$250,000, the use of the Pratt & Whitney name, and space in their building. This was the beginning of the Pratt & Whitney Aircraft Company. Pratt & Whitney Aircraft's first engine, the 425 horsepower (317 kW) R-1340 Wasp, was completed on Christmas Eve 1925. On its third test run it easily passed the U.S. Navy qualification test in March 1926; by October 1926, the U.S. Navy had ordered 200. The Wasp exhibited performance and reliability that revolutionized American aviation. The R-1340 powered the aircraft of Wiley Post, Amelia Earhart, and many other record flights.

The R-1340 was followed by another very successful engine, the R-985 Wasp Junior. Eventually a whole Wasp series was developed. Both engines are still in use in agricultural aircraft around the world and produce more power than their original design criteria.

George Mead soon led the next step in the field of large, state-of-the-art, air-cooled, radial aircraft engines (which the Wasp dominated) when Pratt & Whitney released its R-1690 Hornet. It was basically "a bigger Wasp".

In 1929, Rentschler ended his association with Pratt & Whitney Machine Tool and merged Pratt & Whitney Aircraft with Boeing and other companies to form the United Aircraft and Transport Corporation (UATC). His agreement allowed him to carry the Pratt & Whitney name with him to his new corporation. Only five years later, in 1934, the federal government of U.S. banned common ownership of airplane manufacturers and airlines. Pratt & Whitney was merged with UATC's other manufacturing interests east of the Mississippi River as United Aircraft Corporation, with Rentschler as president. In 1975, United Aircraft Corporation became United Technologies.

21st century
In October 2014, Pratt & Whitney was awarded a $592 million contract with Department of Defense (DoD) to supply 36 F135 engines for the F-35 fighter.

In January 2017, ten employees, including the head of the F135 engine program, reportedly left the company after expenses incurred to transport South Korean officials to the company's West Palm Beach, Florida facility in 2012 were deemed unethical.

In 2020, United Technologies merged with Raytheon Company to form Raytheon Technologies, with Pratt & Whitney becoming one of the new corporation's four main subsidiaries.

In November 2022, Pratt & Whitney was awarded a contract for nearly $4.4 billion by the US DoD to build 100 jet engines for the U.S. military's Air Force, Navy, and Marine Corps branches.

As of May 2023, Pratt & Whitney was "struggling to support its fleet of passenger jets with enough spare parts and engines" which had consequences for airlines worldwide who had to ground their Airbus A320 Neo and Airbus A220. The durability of the Pratt & Whitney PW1000G geared turbofan engine since its inception in 2016 has been the central issue.

In July 2023, Pratt & Whitney issued a product recall that would affect hundreds of jet engines. The recall was issued due to a concern of metal parts being contaminated that could lead to cracking over time. In August 2023, airlines in the US, Europe and Asia announced that they would be temporarily reducing some flights so they could inspect aircraft affected by the recall. , it was estimated that around 3,000 engines might have been manufactured with flawed components.

Headquarters
Pratt & Whitney is headquartered in East Hartford, Connecticut and also has plants in Londonderry, New Hampshire; Springdale, Arkansas; Columbus, Georgia; Middletown, Connecticut; Middletown, Pennsylvania; Dallas, Texas; Palm Beach County, Florida; North Berwick, Maine; Aguadilla, Puerto Rico; Asheville, North Carolina and Bridgeport, West Virginia.

Pratt & Whitney holds the naming rights for the home stadium for the University of Connecticut Huskies football team, Rentschler Field, which is located adjacent to Pratt & Whitney's East Hartford, Connecticut campus, on Pratt's company-owned former airfield of the same name. In 2015, the stadium was renamed to Pratt & Whitney Stadium at Rentschler Field in time for the 2015–2016 University of Connecticut football season.

Divisions
Pratt & Whitney is a business unit of aerospace conglomerate Raytheon Technologies, making it a sister company to Collins Aerospace, Raytheon Missiles & Defense and Raytheon Intelligence & Space. It is also involved in two major joint ventures, the Engine Alliance with GE which manufactures engines for the Airbus A380, and International Aero Engines company with Rolls-Royce, MTU Aero Engines, and the Japanese Aero Engines Corporation which manufactures engines for the Airbus A320 and the McDonnell Douglas MD-90 aircraft.

Commercial engines
Pratt & Whitney's large commercial engines power more than 25 percent of the world's passenger aircraft fleet and serve more than 800 customers in 160 countries. With more than 16,000 large commercial engines installed today, Pratt & Whitney provides power to hundreds of airlines and operators, from narrow-bodied airplanes to wide-bodied jumbo jetliners. In June 2007, Pratt & Whitney's fleet of large commercial engines surpassed 1 billion flight hours of service.

Global Material Solutions
Pratt & Whitney's Global Material Solutions (GMS) makes parts for the CFM56 engine thus giving customers an alternative in new CFM56 engine materials. In addition to engine parts, GMS provides customers with fleet management and customized maintenance service programs. United Airlines was the GMS launch customer.

GMS received its first part certification in July 2007, when the Federal Aviation Administration (FAA) granted Parts Manufacturing Approval (PMA) certification for the GMS high-pressure turbine (HPT) shroud for the CFM56-3 engine. In March 2008, the FAA certified the GMS fan and booster with a Supplemental Type Certificate (STC) with FAA Chapter 5 life limits equal to the original type certificate holder. The STC was the first FAA certification ever granted for alternative life-limited engine parts. In May 2008, Global Material Solutions received FAA STCs for its remaining life limited parts for CFM56-3 engines.

Global Service Partners
Pratt & Whitney Global Service Partners (GSP) offers overhaul, maintenance and repair services for Pratt & Whitney, International Aero Engines, General Electric, Rolls-Royce, and CFMI engines. In addition to engine overhaul and repair services, GSP provides services including line maintenance, engine monitoring and diagnostics, environmentally friendly on-wing water washes, leased engines, custom engine service programs and new and repaired parts.

Pratt & Whitney maintains one of the largest service center networks in the world, with more than 40 engine overhaul and maintenance centers located around the globe.

The Global Service Partners includes Japan Turbine Technologies (JTT). JTT started in 2000 as a joint venture between Pratt and Japan Airlines, with Japan Airlines owning 33.4 percent of the venture, and Pratt & Whitney owning the rest. In July 2011 Pratt bought out Japan Airlines' share in the venture. The facility is located in the town of Taiei near the city of Narita in the Chiba Prefecture and it primarily repairs V2500, JT8D engine parts.

Military Engines
Pratt & Whitney's Military Engines power 27 air forces around the globe, with nearly 11,000 military engines in service with 23 customers in 22 nations. Pratt & Whitney military engines include the F135 for the F-35 Lightning II, the F119 for the F-22 Raptor, the F100 family that powers the F-15 Eagle and F-16 Falcon, the F117 for the C-17 Globemaster III, the J52 for the EA-6B Prowler, the TF33 powering E-3 AWACS, E-8 Joint STARS, B-52, and KC-135 aircraft, and the TF30 for the F-111 and F-14A. In addition, Pratt & Whitney offers a global network of maintenance, repair, and overhaul facilities and military aviation service centers focused on maintaining engine readiness for their customers.

Pratt & Whitney Canada
Pratt & Whitney Canada (PWC), originally Canadian Pratt & Whitney Aircraft Company, and later United Aircraft of Canada, provides a large range of products, including turbofan, turboprop and turboshaft engines targeted for the regional, business, utility and military aircraft and helicopter markets. The company also designs and manufactures engines for auxiliary power units and industrial applications. Its headquarters are located in Longueuil, Quebec (just outside Montreal).

Speaking to Reuters June 16, 2013, ahead of the Paris Airshow 2013, Pratt & Whitney President David Hess said he was confident that Canada would decide to stick with the F-35 program despite its recent discussions about having a new competition. If the orders did shift to another company, Pratt & Whitney could decide to move some of the industrial base work it is currently doing in Canada, Hess said. "We might reallocate the work elsewhere", he said, adding that reduced order volumes would likely trigger changes in Canada.

The division admitted in July 2012 to providing engines and engine software for China's first attack helicopter, the Z-10. This violated U.S. export laws and resulted in a multimillion-dollar fine.

Pratt & Whitney Space Propulsion
Pratt & Whitney Space Propulsion consisted of liquid space propulsion at the Liquid Space Propulsion Division (West Palm Beach, Florida) and solid rocket propulsion at the Chemical Systems Division (San Jose, California), as well as refurbishment and integration of the non-motor elements of the Space Shuttle's solid rocket boosters at the USBI Co. Division (NASA Kennedy Space Center, Florida). Pratt & Whitney Space Propulsion provided advanced technology solutions to commercial, government and military customers for more than four decades. Products included the RL10, the upper stage rocket engine used on the Boeing Delta and Lockheed Martin Atlas rockets, high-pressure turbopumps for the Space Shuttle Main Engines (SSME) and the RD-180 booster engine, offered by RD Amross, a partnership between Pratt & Whitney and NPO Energomash of Russia, for the Atlas III and V programs. The West Palm Beach site consisted of an engineering division and manufacturing division which designed and manufactured the high-pressure turbopumps (fuel and LOX) for the Space Shuttle's Main Engines (SSME) which were manufactured by the former Rocketdyne Corporation.

Pratt & Whitney Rocketdyne
Pratt & Whitney Rocketdyne (PWR) was formed in 2005 when Pratt & Whitney Space Propulsion and Rocketdyne Propulsion & Power were merged following the latter's acquisition from Boeing.

P&W Rocketdyne engines powered the Space Shuttle, and the company also supplies booster engines for Delta II rockets and boosters and upper stage engines for Atlas III and V and Delta IV rockets.

In 2013, PWR was sold to GenCorp, which merged it with Aerojet to become Aerojet Rocketdyne.

Pratt & Whitney Power Systems
Pratt & Whitney Power Systems (PWPS) designs, builds, furnishes and supports aero-derivative gas turbine and geothermal power systems for customers worldwide. These industrial gas turbines power everything from small businesses to small cities. PWPS’ industrial turbines not only generate electrical power, but provide variable speed mechanical drive for marine propulsion, gas compression, and liquid pumping. PWPS has over 2,000 industrial gas turbines installed in more than 40 countries worldwide. PWPS also provides parts and repairs for heavy-duty frame gas turbines as an OEM alternative.

In May 2013, United Technologies Corporation (UTC) sold its Pratt & Whitney Power Systems unit to Mitsubishi Heavy Industries (MHI).

International Aero Engines
International Aero Engines is a joint venture that develops, builds and services the V2500 aero engine family, which powers the Airbus A320 family and McDonnell Douglas MD-90 aircraft. The four founding engine manufacturers that make up IAE each contribute an individual module to the V2500 engine. Pratt & Whitney produces the combustor and high-pressure turbine, Rolls-Royce the high-pressure compressor, JAEC the fan and low-pressure compressor and MTU the low-pressure turbine.

Engine Alliance
Engine Alliance, a 50/50 joint venture between General Electric and Pratt & Whitney, was formed in August 1996 to develop, manufacture, and support a family of modern technology engines for new high-capacity, long-range aircraft. The main application is the GP7200, which has been designed for use on the Airbus A380. It competes with the Rolls-Royce Trent 900, the launch engine for the aircraft.

The first GP7200-powered Airbus A380 entered service with Emirates on August 1, 2008, on a non-stop flight from Dubai to New York City.

Motorsports
Between 1967 and 1971, Pratt & Whitney turbine engines were used in American Championship Car Racing and Formula One. The STP-Paxton Turbocar dominated the 1967 Indianapolis 500 until a transmission bearing failed four laps from the finish. STP entered four Lotus 56s in the 1968 Indianapolis 500. One car crashed during qualifying. Two of the remaining cars qualified fastest and second fastest, but all three retired from the race. Turbine cars were deemed illegal before the following year's race, so Lotus chief Colin Chapman developed the car for use in Formula One and an updated 56B competed in half a dozen Formula One races in 1971.

Aeroderivative industrial and marine gas turbines

 * PW FT-12 from JT12
 * Pratt & Whitney GG3/FT3 from JT3D JT3C
 * Pratt & Whitney GG4/FT4 from J75
 * Pratt & Whitney FT8 from JT8D
 * PW ST16 from JT8D PWC
 * Pratt & Whitney ST18M – based on Pratt & Whitney Canada PW100
 * Pratt & Whitney ST40M – based on Pratt & Whitney Canada PW150A. Used, for example, on private yachts.

Engine maintenance systems
Pratt & Whitney now markets its Ecopower pressure-washing service, which uses a high-pressure water spray run through several nozzles to clean grime and contaminants from jet engine parts, most notably turbine blades, to prevent overheating, improve engine operating efficiency and reduce fuel burn. The system collects the runoff from the washing process for appropriate disposal. The washing is accomplished at the airport tarmac in about one hour. Customers include United Airlines, Air India, Martinair, Thai Airways International, Virgin Atlantic, and JetBlue.

title: Pratt & Whitney


text:
Low-density lipoprotein

Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall density naming convention), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL delivers fat molecules to cells. LDL has been associated with the progression of atherosclerosis.

Overview
Lipoproteins transfer lipids (fats) around the body in the extracellular fluid, making fats available to body cells for receptor-mediated endocytosis. Lipoproteins are complex particles composed of multiple proteins, typically 80–100 proteins per particle (organized by a single apolipoprotein B for LDL and the larger particles). A single LDL particle is about 220–275 angstroms in diameter, typically transporting 3,000 to 6,000 fat molecules per particle, and varying in size according to the number and mix of fat molecules contained within. The lipids carried include all fat molecules with cholesterol, phospholipids, and triglycerides dominant; amounts of each vary considerably.

A good clinical interpretation of blood lipid levels is that high LDL, in combination with a high amount of triglycerides, which indicates a high likelihood of the LDL being oxidised, is associated with increased risk of cardiovascular diseases.

Structure
Each native LDL particle enables emulsification, i.e. surrounding the fatty acids being carried, enabling these fats to move around the body within the water outside cells. Each particle contains a single apolipoprotein B-100 molecule (Apo B-100, a protein that has 4536 amino acid residues and a mass of 514 kDa), along with 80 to 100 additional ancillary proteins. Each LDL has a highly hydrophobic core consisting of polyunsaturated fatty acid known as linoleate and hundreds to thousands (about 1500 commonly cited as an average) of esterified and unesterified cholesterol molecules. This core also carries varying numbers of triglycerides and other fats and is surrounded by a shell of phospholipids and unesterified cholesterol, as well as the single copy of Apo B-100. LDL particles are approximately 22 nm (0.00000087 in.) to 27.5 nm in diameter and have a mass of about 3 million daltons. Since LDL particles contain a variable and changing number of fatty acid molecules, there is a distribution of LDL particle mass and size. Determining the structure of LDL has been a tough task because of its heterogeneous structure. However, the structure of LDL at human body temperature in native condition, with a resolution of about 16 Angstroms using cryogenic electron microscopy, has been described in 2011.

Physiology
LDL particles are formed when triglycerides are removed from VLDL by the lipoprotein lipase enzyme (LPL) and they become smaller and denser (i.e. fewer fat molecules with same protein transport shell), containing a higher proportion of cholesterol esters.

Transport into the cell
When a cell requires additional cholesterol (beyond its current internal HMGCoA production pathway), it synthesizes the necessary LDL receptors as well as PCSK9, a proprotein convertase that marks the LDL receptor for degradation. LDL receptors are inserted into the plasma membrane and diffuse freely until they associate with clathrin-coated pits. When LDL receptors bind LDL particles in the bloodstream, the clathrin-coated pits are endocytosed into the cell.

Vesicles containing LDL receptors bound to LDL are delivered to the endosome. In the presence of low pH, such as that found in the endosome, LDL receptors undergo a conformation change, releasing LDL. LDL is then shipped to the lysosome, where cholesterol esters in the LDL are hydrolysed. LDL receptors are typically returned to the plasma membrane, where they repeat this cycle. If LDL receptors bind to PCSK9, however, transport of LDL receptors is redirected to the lysosome, where they are degraded.

Role in the innate immune system
LDL interferes with the quorum sensing system that upregulates genes required for invasive Staphylococcus aureus infection. The mechanism of antagonism entails binding apolipoprotein B to a S. aureus autoinducer pheromone, preventing signaling through its receptor. Mice deficient in apolipoprotein B are more susceptible to invasive bacterial infection.

LDL size patterns
LDL can be grouped based on its size: large low density LDL particles are described as pattern A, and small high density LDL particles are pattern B. Pattern B has been associated by some with a higher risk for coronary heart disease. This is thought to be because the smaller particles are more easily able to penetrate the endothelium of arterial walls. Pattern I, for intermediate, indicates that most LDL particles are very close in size to the normal gaps in the endothelium (26 nm). According to one study, sizes 19.0–20.5 nm were designated as pattern B and LDL sizes 20.6–22 nm were designated as pattern A. Other studies have shown no such correlation at all.

Some evidence suggests the correlation between Pattern B and coronary heart disease is stronger than the correspondence between the LDL number measured in the standard lipid profile test. Tests to measure these LDL subtype patterns have been more expensive and not widely available, so the common lipid profile test is used more often.

There has also been noted a correspondence between higher triglyceride levels and higher levels of smaller, denser LDL particles and alternately lower triglyceride levels and higher levels of the larger, less dense ("buoyant") LDL.

With continued research, decreasing cost, greater availability and wider acceptance of other lipoprotein subclass analysis assay methods, including NMR spectroscopy, research studies have continued to show a stronger correlation between human clinically obvious cardiovascular events and quantitatively measured particle concentrations.

Oxidized LDL
Oxidized LDL is a general term for LDL particles with oxidatively modified structural components. As a result, from free radical attack, both lipid and protein parts of LDL can be oxidized in the vascular wall. Besides the oxidative reactions taking place in vascular wall, oxidized lipids in LDL can also be derived from oxidized dietary lipids. Oxidized LDL is known to associate with the development of atherosclerosis, and it is therefore widely studied as a potential risk factor of cardiovascular diseases. Atherogenicity of oxidized LDL has been explained by lack of recognition of oxidation-modified LDL structures by the LDL receptors, preventing the normal metabolism of LDL particles and leading eventually to development of atherosclerotic plaques. Of the lipid material contained in LDL, various lipid oxidation products are known as the ultimate atherogenic species. Acting as a transporter of these injurious molecules is another mechanism by which LDL can increase the risk of atherosclerosis.

Testing
Blood tests commonly report LDL-C: the amount of cholesterol which is estimated to be contained with LDL particles, on average, using a formula, the Friedewald equation. In clinical context, mathematically calculated estimates of LDL-C are commonly used as an estimate of how much low density lipoproteins are driving progression of atherosclerosis. The problem with this approach is that LDL-C values are commonly discordant with both direct measurements of LDL particles and actual rates of atherosclerosis progression.

Direct LDL measurements are also available and better reveal individual issues but are less often promoted or done due to slightly higher costs and being available from only a couple of laboratories in the United States. In 2008, the ADA and ACC recognized direct LDL particle measurement by NMR as superior for assessing individual risk of cardiovascular events.

Estimation of LDL particles via cholesterol content
Chemical measures of lipid concentration have long been the most-used clinical measurement, not because they have the best correlation with individual outcome, but because these lab methods are less expensive and more widely available.

The lipid profile does not measure LDL particles. It only estimates them using the Friedewald equation by subtracting the amount of cholesterol associated with other particles, such as HDL and VLDL, assuming a prolonged fasting state, etc.:
 * $$L \approx C - H - kT$$
 * where H is HDL cholesterol, L is LDL cholesterol, C is total cholesterol, T are triglycerides, and k is 0.20 if the quantities are measured in mg/dL and 0.45 if in mmol/L.

There are limitations to this method, most notably that samples must be obtained after a 12 to 14 h fast and that LDL-C cannot be calculated if plasma triglyceride is >4.52 mmol/L (400 mg/dL). Even at triglyceride levels 2.5 to 4.5 mmol/L, this formula is considered inaccurate. If both total cholesterol and triglyceride levels are elevated then a modified formula, with quantities in mg/dL, may be used
 * $$L = C - H - 0.16T$$

This formula provides an approximation with fair accuracy for most people, assuming the blood was drawn after fasting for about 14 hours or longer, but does not reveal the actual LDL particle concentration because the percentage of fat molecules within the LDL particles which are cholesterol varies, as much as 8:1 variation. There are several formulas published addressing the inaccuracy in LDL-C estimation. The inaccuracy is based on the assumption that VLDL-C (Very low density lipoprotein cholesterol) is always one-fifth of the triglyceride concentration. Another formulae addresses this issue by using an adjustable factor or by using a regression equation. There are few studies which have compared the LDL-C values derived from this formula and values obtained by direct enzymatic method. Direct enzymatic method are found to be accurate and it has to be the test of choice in clinical situations. In the resource poor settings, the option of using the formula has to be considered.

However, the concentration of LDL particles, and to a lesser extent their size, has a stronger and consistent correlation with individual clinical outcome than the amount of cholesterol within LDL particles, even if the LDL-C estimation is approximately correct. There is increasing evidence and recognition of the value of more targeted and accurate measurements of LDL particles. Specifically, LDL particle number (concentration), and to a lesser extent size, have shown slightly stronger correlations with atherosclerotic progression and cardiovascular events than obtained using chemical measures of the amount of cholesterol carried by the LDL particles. It is possible that the LDL cholesterol concentration can be low, yet LDL particle number high and cardiovascular events rates are high. Correspondingly, it is possible that LDL cholesterol concentration can be relatively high, yet LDL particle number low and cardiovascular events are also low.

Normal ranges
In the US, the American Heart Association, NIH, and NCEP provide a set of guidelines for fasting LDL-Cholesterol levels, estimated or measured, and risk for heart disease. As of about 2005, these guidelines were:

Over time, with more clinical research, these recommended levels keep being reduced because LDL reduction, including to abnormally low levels, was the most effective strategy for reducing cardiovascular death rates in one large double blind, randomized clinical trial of men with hypercholesterolemia; far more effective than coronary angioplasty/stenting or bypass surgery.

For instance, for people with known atherosclerosis diseases, the 2004 updated American Heart Association, NIH and NCEP recommendations are for LDL levels to be lowered to less than 70 mg/dL. This low level of less than 70 mg/dL was recommended for primary prevention of 'very-high risk patients' and in secondary prevention as a 'reasonable further reduction'. This position was disputed. Statin drugs involved in such clinical trials have numerous physiological effects beyond simply the reduction of LDL levels.

From longitudinal population studies following progression of atherosclerosis-related behaviors from early childhood into adulthood, the usual LDL in childhood, before the development of fatty streaks, is about 35 mg/dL. However, all the above values refer to chemical measures of lipid/cholesterol concentration within LDL, not measured low-density lipoprotein concentrations, the accurate approach.

A study was conducted measuring the effects of guideline changes on LDL cholesterol reporting and control for diabetes visits in the US from 1995 to 2004. It was found that although LDL cholesterol reporting and control for diabetes and coronary heart disease visits improved continuously between 1995 and 2004, neither the 1998 ADA guidelines nor the 2001 ATP III guidelines increased LDL cholesterol control for diabetes relative to coronary heart disease.

Direct measurement of LDL particle concentrations
There are several competing methods for measurement of lipoprotein particle concentrations and size. The evidence is that the NMR methodology (developed, automated & greatly reduced in costs while improving accuracy as pioneered by Jim Otvos and associates) results in a 22-25% reduction in cardiovascular events within one year, contrary to the longstanding claims by many in the medical industry that the superiority over existing methods was weak, even by statements of some proponents.

Since the later 1990s, because of the development of NMR measurements, it has been possible to clinically measure lipoprotein particles at lower cost [under $80 US (including shipping) & is decreasing; versus the previous costs of >$400 to >$5,000] and higher accuracy. There are two other assays for LDL particles, however, like LDL-C, most only estimate LDL particle concentrations.

Direct LDL particle measurement by NMR was mentioned by the ADA and ACC, in a 28 March 2008 joint consensus statement, as having advantages for predicting individual risk of atherosclerosis disease events, but the statement noted that the test is less widely available, is more expensive [about $13.00 US (2015 without insurance coverage) from some labs which use the Vantera Analyzer ]. Debate continues that it is "...unclear whether LDL particle size measurements add value to measurement of LDL-particle concentration", though outcomes have always tracked LDL particle, not LDL-C, concentrations.

Using NMR, the total LDL particle concentrations, in nmol/L plasma, are typically subdivided by percentiles referenced to the 5,382 men and women, not on any lipid medications, who are participating in the MESA trial.

LDL particle concentration can also be measured by measuring the concentration of the protein ApoB, based on the generally accepted principle that each LDL or VLDL particle carries one ApoB molecule.

Optimal ranges
The LDL particle concentrations are typically categorized by percentiles, <20%, 20–50%, 50th–80th%, 80th–95% and >95% groups of the people participating and being tracked in the MESA trial, a medical research study sponsored by the United States National Heart, Lung, and Blood Institute.

The lowest incidence of atherosclerotic events over time occurs within the <20% group, with increased rates for the higher groups. Multiple other measures, including particle sizes, small LDL particle concentrations, large total and HDL particle concentrations, along with estimations of insulin resistance pattern and standard cholesterol lipid measurements (for comparison of the plasma data with the estimation methods discussed above) are also routinely provided.

Lowering LDL-cholesterol
The mevalonate pathway serves as the basis for the biosynthesis of many molecules, including cholesterol. The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) is an essential component and performs the first of 37 steps within the cholesterol production pathway, and is present in every animal cell.

LDL-C is not a measurement of actual LDL particles. LDL-C is only an estimate (not measured from the individual's blood sample) of how much cholesterol is being transported by all LDL particles, which is either a smaller concentration of large particles or a high concentration of small particles. LDL particles carry many fat molecules (typically 3,000 to 6,000 fat molecules per LDL particle); this includes cholesterol, triglycerides, phospholipids and others. Thus even if the hundreds to thousands of cholesterol molecules within an average LDL particle were measured, this does not reflect the other fat molecules or even the number of LDL particles.

Pharmaceutical

 * PCSK9 inhibitors, in clinical trials, by several companies, are more effective for LDL reduction than the statins, including statins alone at high dose (though not necessarily the combination of statins plus ezetimibe).
 * Statins reduce high levels of LDL particles by inhibiting the enzyme HMG-CoA reductase in cells, the rate-limiting step of cholesterol synthesis. To compensate for the decreased cholesterol availability, synthesis of LDL receptors (including hepatic) is increased, resulting in an increased clearance of LDL particles from the extracellular water, including of the blood.
 * Ezetimibe reduces intestinal absorption of cholesterol, thus can reduce LDL particle concentrations when combined with statins.
 * Niacin (B3), lowers LDL by selectively inhibiting hepatic diacylglycerol acyltransferase 2, reducing triglyceride synthesis and VLDL secretion through a receptor HM74 and HM74A or GPR109A.
 * Several CETP inhibitors have been researched to improve HDL concentrations, but so far, despite dramatically increasing HDL-C, have not had a consistent track record in reducing atherosclerosis disease events. Some have increased mortality rates compared with placebo.
 * Clofibrate is effective at lowering cholesterol levels, but has been associated with significantly increased cancer and stroke mortality, despite lowered cholesterol levels. Other developed and tested fibrates, e.g. fenofibric acid have had a better track record and are primarily promoted for lowering VLDL particles (triglycerides), not LDL particles, yet can help some in combination with other strategies.
 * Some tocotrienols, especially delta- and gamma-tocotrienols, are being promoted as statin alternative non-prescription agents to treat high cholesterol, having been shown in vitro to have an effect. In particular, gamma-tocotrienol appears to be another HMG-CoA reductase inhibitor, and can reduce cholesterol production. As with statins, this decrease in intra-hepatic (liver) LDL levels may induce hepatic LDL receptor up-regulation, also decreasing plasma LDL levels. As always, a key issue is how benefits and complications of such agents compare with statins—molecular tools that have been analyzed in large numbers of human research and clinical trials since the mid-1970s.
 * Phytosterols are widely recognized as having a proven LDL cholesterol lowering efficacy' A 2018 review found a dose-response relationship for phytosterols, with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%, but reviews as of 2017 had found no data indicating that the consumption of phytosterols may reduce the risk of CVD. Current supplemental guidelines for reducing LDL recommend doses of phytosterols in the 1.6-3.0 grams per day range (Health Canada, EFSA, ATP III, FDA) with a 2009 meta-analysis demonstrating an 8.8% reduction in LDL-cholesterol at a mean dose of 2.15 gram per day.

Lifestyle
LDL cholesterol can be lowered by through dietary intervention by limiting foods with saturated fat and avoiding foods with trans fat. Saturated fats are found in meat products (including poultry), full-fat dairy, eggs, and refined tropical oils like coconut and palm. Added trans fat (in the form of partially hydrogenated oils) has been banned in the USA since 2021. However, trans fat can still be found in red meat and dairy products as it is produced in small amounts by ruminants such as sheep and cows. LDL cholesterol can also be lowered by increasing consumption of soluble fiber and plant-based foods.

Another lifestyle approach to reduce LDL cholesterol has been minimizing total body fat, in particular fat stored inside the abdominal cavity (visceral body fat). Visceral fat, which is more metabolically active than subcutaneous fat, has been found to produce many enzymatic signals, e.g. resistin, which increase insulin resistance and circulating VLDL particle concentrations, thus both increasing LDL particle concentrations and accelerating the development of diabetes mellitus.

Gene editing
In 2021, scientists demonstrated that CRISPR gene editing can decrease blood levels of LDL cholesterol in Macaca fascicularis monkeys for months by 60% via knockout of PCSK9 in the liver.

license: Creative Commons - Attribution Share-Alike - https://creativecommons.org/licenses/by-sa/4.0/

title: Low-density lipoprotein


text:
Fokker

Fokker (N.V. Koninklijke Nederlandse Vliegtuigenfabriek Fokker; lit. 'Royal Dutch Aircraft Factory Fokker'), was a Dutch aircraft manufacturer that operated from 1912 to 1996. The company was founded by the Dutch aviator Anthony Fokker and became famous during World War I for its fighter aircraft. During its most successful period in the 1920s and 1930s, Fokker dominated the civil aviation market. The company's fortunes declined over the course of the late 20th century. It declared bankruptcy in 1996, and its operations were sold to competitors.

Fokker in Germany
At age 20, while studying in Germany, Anthony Fokker built his initial aircraft, the Spin (Spider)—the first Dutch-built plane to fly in his home country. Taking advantage of better opportunities in Germany, he moved to Berlin, where in 1912, he founded his first company, Fokker Aeroplanbau, later moving to the Görries suburb just southwest of Schwerin (at 53.61275°N, 11.37544°W), where the current company was founded, as Fokker Aviatik GmbH, on 12 February 1912.

World War I
Fokker capitalized on having sold several Fokker Spin monoplanes to the German government and set up a factory in Germany to supply the German Army in World War I. His first new design for the Germans to be produced in any numbers was the Fokker M.5, which was little more than a copy of the Morane-Saulnier G, built with steel tube instead of wood for the fuselage, and with minor alterations to the outline of the rudder and undercarriage and a new aerofoil section. When it was realized that arming these scouts with a machine gun firing through the arc of the propeller was desirable, Fokker developed a synchronization gear similar to that patented by Franz Schneider.

Fitted with a developed version of this gear, the M.5 became the Fokker Eindecker, which due to its revolutionary armament, became one of the most feared aircraft over the western front, its introduction leading to a period of German air superiority known as the Fokker Scourge which only ended with the introduction of new aircraft such as the Nieuport 11 and Airco DH.2.

During World War I, Fokker engineers worked on the Fokker-Leimberger, an externally powered 12-barrel Gatling gun in the 7.92×57mm round claimed to be capable of firing over 7200 rounds per minute.

Later in the war, after the Fokker D.V (the last design by earlier chief designer Martin Kreutzer), had failed to gain acceptance with the Luftstreitkräfte the German government forced Fokker (for their aircraft production expertise) and Junkers (for their pioneering all-metal airframe construction techniques, and advanced design concepts) to cooperate more closely, which resulted in the foundation of the Junkers-Fokker Aktiengesellschaft, or Jfa, on 20 October 1917. As this partnership proved to be troublesome, it was eventually dissolved. By then, former Fokker welder and new designer Reinhold Platz, who had taken the late Martin Kreutzer's place with the firm, had adapted some of Prof. Junkers' design concepts, that resulted in a visual similarity between the aircraft of those two manufacturers during the next decade.

Some of the noteworthy types produced by Fokker during the second half of the war, all designed primarily by Platz, included the Fokker D.VI biplane, Fokker Dr.I triplane or Dreidecker (remembered as a mount of the Red Baron), Fokker D.VII biplane (the only aircraft ever referred to directly in a treaty: all D.VII's were singled out for handover to the allies in their terms of the armistice agreement) and the Fokker D.VIII parasol monoplane.

Return to the Netherlands
In 1919, Fokker, owing large sums in back taxes (including 14,250,000 marks of income tax), returned to the Netherlands and founded a new company near Amsterdam with the support of Steenkolen Handels Vereniging, now known as SHV Holdings. He chose the name Nederlandse Vliegtuigenfabriek (Dutch Aircraft Factory) to conceal the Fokker brand because of his involvement in World War I. Despite the strict disarmament conditions of the Treaty of Versailles, Fokker did not return home empty-handed. In 1919, he arranged an export permit and brought six entire trains of parts, and 180 types of aircraft across the Dutch-German border, among them 117 Fokker C.Is, D.VIIs, and D.VIIIs. This initial stock enabled him to set up shop quickly.

After his company's relocation, many Fokker C.I and C.IV military airplanes were delivered to Russia, Romania, and the still-clandestine German air force. Success came on the commercial market, too, with the development of the Fokker F.VII, a high-winged aircraft capable of taking on various types of engines. Fokker continued to design and build military aircraft, delivering planes to the Royal Netherlands Air Force. Foreign military customers eventually included Finland, Sweden, Denmark, Norway, Switzerland, Hungary, and Italy. These countries bought substantial numbers of the Fokker C.V reconnaissance aircraft, which became Fokker's main success in the late 1920s and early 1930s.

1920s and 30s: Fokker's glory period

In the 1920s, Fokker entered its glory years, becoming the world's largest aircraft manufacturer by the late 1920s. Its greatest success was the 1925 F.VIIa/3m trimotor passenger aircraft, which was used by 54 airline companies worldwide and captured 40% of the American market in 1936. It shared the European market with the Junkers all-metal aircraft, but dominated the American market until the arrival of the Ford Trimotor which copied the aerodynamic features of the Fokker F.VII, and Junkers structural concepts.

In 1923, Anthony Fokker moved to the United States, where in 1927, he established an American branch of his company, the Atlantic Aircraft Corporation, which was renamed the Fokker Aircraft Corporation of America. In 1930, this company merged with General Motors Corporation and the company's name became General Aviation Manufacturing Corporation, which in turn merged with North American Aviation and was divested by GM in 1948. In 1931, discontented at being totally subordinate to GM management, Fokker resigned.

A serious blow to Fokker's reputation came after the 1931 crash of a Transcontinental & Western Air Fokker F-10 in Kansas, when it became known that the crash was caused by a structural failure caused by wood rot. Notre Dame legendary football coach Knute Rockne was among the fatalities, prompting extensive media coverage and technical investigation. As a result, all Fokkers were grounded in the US, along with many other types that had copied Fokker's wings.

In 1934 Nevil Shute of Airspeed Ltd (England) negotiated with Fokker himself for a manufacturing licensing agreement. In January 1935 Airspeed signed an agreement for the Douglas DC-2 and a number of Fokker types, with Fokker to be a consultant for seven years. Shute found him "genial, shrewd and helpful" but "already a sick man"; and he was difficult to deal with as "his domestic life was irregular". Airspeed considered making the Fokker D.XVII for Greece, as Greece wanted to buy from Britain for currency reasons, but the proposal did not "come off"; Shute recommended reading his novel Ruined City on Balkan methods of business. And after a year the drift to war meant that Dutchmen could not go to the Airspeed factory or to board meetings.

On December 23, 1939, Fokker died in New York City after a three-week illness.

World War II
At the outset of World War II, the few G.Is and D.XXIs of the Dutch Air Force were able to score a respectable number of victories against the Luftwaffe, but many were destroyed on the ground before they could be used.

The Fokker factories were confiscated by the Germans and were used to build Bücker Bü 181 Bestmann trainers and parts for the Junkers Ju 52 transport. At the end of the war, the factories were completely stripped by the Germans and destroyed by Allied bombing.

Post-World War II rebuilding

Rebuilding after the war proved difficult. The market was flooded with cheap surplus planes from the war. The company cautiously started building gliders and autobuses and converting Dakota transport planes to civilian versions. A few F25s were built. Nevertheless, the S-11 trainer was a success, being purchased by several air forces. The S-14 Machtrainer became one of the first jet trainers, and although not an export success, it served for over a decade with the Royal Netherlands Air Force.

A new factory was built next to Schiphol Airport near Amsterdam in 1951. A number of military planes were built there under license, among them the Gloster Meteor twin-jet fighter and Lockheed's F-104 Starfighter. A second production and maintenance facility was established at Woensdrecht.

In 1958, the F-27 Friendship was introduced, Fokker's most successful postwar airliner. The Dutch government contributed 27 million guilders to its development. Powered by the Rolls-Royce Dart, it became the world's best-selling turboprop airliner, reaching almost 800 units sold by 1986, including 206 under licence by Fairchild. Also, a military version of the F-27, the F-27 Troopship, was built.

In 1962, the F-27 was followed by the jet-powered F-28 Fellowship. Until production stopped in 1987, a total of 241 were built in various versions. Both an F-27 and later an F-28 served with the Dutch Royal Flight, Prince Bernhard himself being a pilot.

In 1969, Fokker agreed to an alliance with Bremen-based Vereinigte Flugtechnische Werke under control of a transnational holding company. They collaborated on an unsuccessful regional jetliner, the VFW-614, of which only 19 were sold. This collaboration ended in early 1980.

Fokker was one of the main partners in the F-16 Fighting Falcon consortium (European Participating Air Forces), which was responsible for the production of these fighters for the Belgian, Danish, Dutch and Norwegian Air Forces. It consisted of companies and government agencies from these four countries and the United States. F-16s were assembled at Fokker and at SABCA in Belgium with parts from the five countries involved.

Aerospace
In 1967, Fokker started a modest space division building parts for European satellites. A major advance came in 1968 when Fokker developed the first Dutch satellite (the Astronomical Netherlands Satellite) together with Philips and Dutch universities. This was followed by a second major satellite project, IRAS, successfully launched in 1983. The European Space Agency in June 1974 named a consortium headed by ERNO-VFW-Fokker GmbH to build pressurized modules for Spacelab.

Subsequently, Fokker contributed to many European satellite projects, as well as to the Ariane rocket in its various models. Together with a Russian contractor, they developed the huge parachute system for the Ariane 5 rocket boosters which would allow the boosters to return to Earth safely and be reused.

The space division became more and more independent, until just before Fokker's bankruptcy in 1996, it became a fully stand-alone corporation, known successively as Fokker Space and Systems, Fokker Space, and Dutch Space. On 1 January 2006, it was taken over by EADS-Space Transportation.

Fokker 50, Fokker 100, and Fokker 70

After a brief and unsuccessful collaboration effort with McDonnell Douglas in 1981, Fokker began an ambitious project to develop two new aircraft concurrently. The Fokker 50 was to be a completely modernised version of the F-27, and the Fokker 100 a new airliner based on the F-28. Development costs were allowed to spiral out of control, almost forcing Fokker out of business in 1987. The Dutch government bailed the company out with 212 million guilders, but demanded Fokker look for a "strategic partner", British Aerospace and DASA being named most likely candidates.

Initial sales of the Fokker 100 were good, leading Fokker to begin development of the Fokker 70, a smaller version of the F100, in 1991, but sales of the F70 were below expectations and the F100 had strong competition from Boeing and Airbus by then. The Dutch government aircraft between 1996 and 2017 was a Fokker 70.

In 1992, after a long and arduous negotiation process, Fokker signed an agreement with DASA. This did not solve Fokker's problems, though, mostly because DASA's parent company Daimler-Benz also had to deal with its own organisational problems.

Bankruptcy
On 22 January 1996, the board of directors of Daimler-Benz decided to focus on its core automobile business and cut ties with Fokker. The next day, an Amsterdam court extended temporary creditor protection.

Discussions were initiated with Bombardier on 5 February 1996. After having reviewed and evaluated the opportunities and challenges Fokker represented at the time, Bombardier renounced its acquisition on 27 February. On 15 March, the Fokker company was declared bankrupt.

Differences in national culture could have played a role in the failed takeover of Fokker by Deutsche Aerospace (DASA).

Those divisions of the company that manufactured parts and carried out maintenance and repair work were taken over by Stork N.V.; it is now known as Stork Aerospace Group. Stork Fokker exists to sustain remarketing of the company's existing aircraft: it refurbishes and resells F 50s and F 100s, and has converted a few F 50s to transport aircraft. Special projects included the development of an F50 maritime patrol variant and an F100 executive jet. For this project, Stork received the 2005 "Aerospace Industry Award" in the Air Transport category from Flight International magazine.

Other divisions of the company that were profitable continued as separate companies: Fokker Space (later Dutch Space) and Fokker Control Systems.

In November 2009, Stork Aerospace changed its name to Fokker Aerospace Group. As of 2011, the Fokker Aerospace Group changed its name to Fokker Technologies. The five individual business units within Fokker Technologies all carry the Fokker name:
 * Fokker Aerostructures
 * Fokker Landing Gear
 * Fokker Elmo
 * Fokker Techniek
 * Fokker Services

The former Fokker aircraft facilities at Schiphol were redeveloped into the Fokker Logistics Park. One of the former Fokker tenants is Fokker Services.

In 1996, a new company named Rekkof Aircraft ("Fokker" backwards) attempted to restart production of the Fokker F70 and F100, supported by suppliers and airlines. The company was later renamed to Netherlands Aircraft Company, and started to focus on developing a new aircraft named F130NG. This attempt was not successful either, and the project came to a standstill in 2010. In 2023, after years of no updates, the company was renamed Fokker Next Gen. Along with the new name reveal, the company announced that they are developing a new hydrogen-powered regional airliner. Visualisations have been provided, but the name of the aircraft is yet not publicly disclosed.

In 2015, GKN considers Fokker Technologies as a possible acquisition to supply for the hybrid car market. The British automotive and aerospace supplier plans to buy the Netherlands-based Fokker for €706 million.

In 2021, Fokker Services and Fokker Techniek are acquired by Panta Holdings, a Dutch investment fund. The acquisition sought to strengthen Panta Holdings’ aerospace footprint. Panta Holdings also owns Fokker Next Gen.

Famous Fokker aircraft and pilots

 * In 1915, the Fokker E.I was the first fighter armed with a synchronized machine gun firing through the propeller, achieving air superiority during the Fokker Scourge.
 * Manfred von Richthofen ("The Red Baron," the top scoring World War I ace) is associated with an all-red Fokker Dr.I triplane, at least for some of his 80 victories (1917–1918)
 * The 1918 Fokker D.VII performed so well that surrender of all examples of the type was demanded when Germany capitulated.
 * In 1923, Oakley George Kelly and John Arthur Macready completed the first non-stop flight spanning the North American continent in a Fokker T-2.
 * In 1927, Richard E. Byrd completed his trans-Atlantic flight from New York City to Paris in the Fokker F.VII America.
 * In 1928, Amelia Earhart became the first woman to fly across the Atlantic as a passenger in a Fokker F.VII.
 * In 1928, Charles Kingsford Smith completed the first trans-Pacific flight in another F.VII, the Southern Cross.
 * Finnish pilot Jorma Sarvanto shot down six Soviet Ilyushin DB-3s in a quick succession using a Fokker D.XXI fighter during the Winter War, drawing international attention.
 * The 1951 Fokker S.14 Machtrainer was one of the first purpose-built jet training aircraft in the world.
 * King Willem-Alexander of the Netherlands was a co-pilot about twice per month for 21 years on commercial KLM Cityhopper and Martinair flights flying Fokker 70 aircraft.

1912–1921
• Fokker Spin

• Fokker M.1 – M.4 Spin (military version)

• Fokker W.1 – W.2

• Fokker M.5

• Fokker M.6

• Fokker B.I (M.7)

• Fokker W.3/W.4

• Fokker A.I (M.8)

• Fokker K.I (M.9)

• Fokker B.I (M.10E)

• Fokker B.II (M.10Z)

• Fokker M.11

• Fokker M.12

• Fokker Eindecker fighters

• * Fokker E.I (M.14)

• * Fokker E.II (M.14)

• * Fokker E.III (M.14)

• * Fokker E.IV (M.15)

• Fokker M.16E (prototype) and M.16Z

• Fokker D.I/B.III (M.18)

• Fokker D.II (M.17)

• Fokker D.III (M.19)

• Fokker M.20

• Fokker D.IV (M.21)

• Fokker D.V (M.22)

• Fokker V.1

• Fokker V.2 and V.3

• Fokker V.4

• Fokker F.I (V.5)

• Fokker Dr.I ('Dreidecker')

• Fokker V.6

• Fokker V.7

• Fokker V.8

• Fokker V.9, V.12, V.14, V.16 and V.33

• Fokker V.10

• Fokker D.VI (V.11)

• Fokker D.VII (V.13)

• Fokker V.17-V.25

• Fokker E.V/D.VIII (V.26)

• Fokker V.27 and V.37

• Fokker V.28

• Fokker V.29

• Fokker V.30

• Fokker V.31

• Fokker V.32

• Fokker V.34

• Fokker V.35

• Fokker V.36

• Fokker C.I (V.38)

• Fokker V.39 and V.40

• Fokker V.42

• Fokker F.I (V.44)

• Fokker C.I

• Fokker F.VI

• Fokker F.II (V.45)

• Fokker F.III

• Fokker F.IV

• Fokker T.II

• Fokker S.I (V.43)

• Fokker D.IX

• Fokker D.X (V.41)

1922–1940
• Fokker B.I

• Fokker S.II

• Fokker S.III

• Fokker F.V

• Fokker C.IV

• Fokker D.XI

• Fokker DC.I

• Fokker T.III

• Fokker B.II

• Fokker D.XII

• Fokker F.VII

• Fokker C.V

• Fokker D.XIII

• Fokker S.IV

• Fokker D.XIV

• Fokker F.X

• Fokker B.III

• Fokker F.XI "Universal"

• Fokker F.VIII

• Fokker T.IV & T.IVa

• Fokker B.V

• Fokker C.VII-W

• Fokker C.VIII

• Fokker B.IV

• Fokker F.XIII

• Fokker D.XV

• Fokker F.XIV

• Fokker D.XVI

• Fokker F.IX

• Fokker B.VI

• Fokker C.IX

• Fokker F.XI

• Fokker S.V

• Fokker D.XVII

• Fokker F.XII

• Fokker F.XV

• Fokker F.XVI

• Fokker F.XVII

• Fokker F.XXI

• Fokker F.XIX

• Fokker D.XVIII

• Fokker F.XVIII

• Fokker S.VI

• Fokker F.XX

• Fokker C.X

• Fokker S.VII

• Fokker F.36

• Fokker Model 118

• Fokker D.XIX

• Fokker D.XX

• Fokker DC.II

• Fokker T.VI (Model 115)

• Fokker F.22

• Fokker C.XI-W

• Fokker F.23

• Fokker B.V (Model 109)

• Fokker F.40 (Model 160)

• Fokker T.VII

• Fokker F.56 (Model 127)

• Fokker C.XII

• Fokker C.13W

• Fokker D.XXI

• Fokker F.37

• Fokker G.1

• Fokker T.V

• Fokker S.IX

• Fokker T.VI (Model 152)

• Fokker D.22

• Fokker G.2

• Fokker T.VIII

• Fokker T.10

• Fokker D.23

• Fokker F.24 (Model 193)

• Fokker T.IX

• Fokker D.24

• Fokker G.3

• Fokker S.X

• Fokker C.14W

• Fokker C.15W

• Fokker F.60

Fokker-Atlantic designs
• Fokker A-2 Ambulance

• Fokker AO-1 Artillery Observation / Atlantic Observation

• Fokker C-2

• Fokker C-5

• Fokker C-7

• Fokker C-14

• Fokker C-15

• Fokker C-16

• Fokker C-20

• Fokker CO-4

• Fokker CO-4 Mailplane

• Fokker CO-8

• Fokker LB-2 Light Bomber

• Fokker O-27

• Fokker FLB/PJ (AF.15)

• Fokker PW-5

• Fokker PW-6

• Fokker PW-7

• Fokker RA

• Fokker T-2

• Fokker XA-7 Attack

• Fokker XB-8 Bomber

• Fokker XJA-1

• Fokker XLB-2 Light Bomber

• Fokker B.11 Sport/Trainer

• Fokker F-7

• Fokker F-9 Universal Airliner & freighter

• Fokker F-10

• Fokker F-11

• Fokker F-12

• Fokker F-13

• Fokker F-14

• Fokker F-18 Super Universal Airliner & freighter

• Fokker F-32

• Fokker DH-4M

• Fokker-Hall H-51

1945–1996
• Fokker F.25 Promotor

• Fokker S-11 & S-12 Instructor

• Fokker S-13 Universal Trainer

• Fokker S.14 Machtrainer

• Fokker S.15

• Fokker S.16

• Fokker F26 Phantom

• Fokker F27 Friendship

• Fokker F28 Fellowship

• Fokker F.29

• Fokker 50

• Fokker 60 Utility

• Fokker 70

• Fokker 80

• Fokker 100

• Fokker 120NG (in development)

• Fokker 130 (concept stage only)

• VFW-Fokker/Republic Aviation D-24 Alliance Variable sweep wing VTOL aircraft

title: Fokker


text:
The Pink Panther

The Pink Panther is an American media franchise primarily focusing on a series of comedy-mystery films featuring an inept French police detective, Inspector Jacques Clouseau. The franchise began with the release of the film The Pink Panther in 1963. The role of Clouseau was originated by and is most closely associated with Peter Sellers. Most of the films were written and directed by Blake Edwards, with theme music composed by Henry Mancini. Elements and characters inspired by the films were adapted into other media, including books, comic books, video games and animated series.

The first film in the series derives its name from a pink diamond that has enormous size and value. The diamond is called the "Pink Panther" because the flaw at its center, when viewed closely, is said to resemble a leaping pink panther. The phrase reappears in the title of the fourth film The Return of the Pink Panther, in which the theft of the diamond is again the center of the plot. The phrase was used for all the subsequent films in the series, even when the jewel did not figure in the plot. The jewel ultimately appeared in six of the eleven films.

The first film in the series had an animated opening sequence, created by DePatie–Freleng Enterprises, featuring "The Pink Panther Theme" by Mancini, as well as the Pink Panther character. Designed by Hawley Pratt and Friz Freleng, the animated Pink Panther character was subsequently featured in a series of theatrical cartoons, starting with The Pink Phink in 1964. The cartoon series gained its highest profile on television, aired on Saturday mornings as The Pink Panther Show. The character returned to the film series opening sequences in 1975.

The Pink Panther (1963)
The Pink Panther (1963), the original film of the series, centered on the Phantom/Sir Charles Lytton, portrayed by David Niven. It is set in the ski resort of Cortina d'Ampezzo. Peter Sellers's performance was so popular that the resulting series was built on the Clouseau character, rather than the Phantom character. Niven and Sellers's co-stars included Capucine, Robert Wagner, and Claudia Cardinale.

A Shot in the Dark (1964)
A Shot in the Dark (1964) was released less than a year after The Pink Panther, and was the first to feature the Clouseau character as the protagonist of the film, investigating a murder set in a mansion in Paris. This film marked the first appearance of many of the tropes and supporting characters long associated with the series, including Commissioner Dreyfus (portrayed by Herbert Lom), his assistant François (portrayed by André Maranne), and Clouseau's manservant, Cato (portrayed by Burt Kwouk). Elke Sommer, George Sanders, Graham Stark, Tracy Reed and Douglas Wilmer also appeared in the film.

Inspector Clouseau (1968)
The 1968 film Inspector Clouseau stars Alan Arkin as Clouseau, and does not feature any other recurring characters from the rest of the series. Although it was produced by the Mirisch Corporation (who owned the rights to the Pink Panther and Clouseau characters), key people associated with the earlier films, such as Peter Sellers, Blake Edwards, and Henry Mancini, were not involved in the making of this film.

The Return of the Pink Panther (1975)
More than a decade after his previous portrayal, Peter Sellers returned as Clouseau in 1975's The Return of the Pink Panther. The film marked the return of the famous "Pink Panther" diamond as well as most of the creative team associated with the prior films, including director Blake Edwards, composer Henry Mancini, Herbert Lom as Dreyfus, Burt Kwouk as Cato and André Maranne as François. David Niven did not reprise the role of Sir Charles Lytton, who is portrayed in the film by Christopher Plummer instead. The film also co-starred Catherine Schell, Peter Arne, and Graham Stark.

The Pink Panther Strikes Again (1976)
In The Pink Panther Strikes Again (1976), Dreyfus' insanity reached its zenith, as he tried to blackmail the rest of the world into killing Clouseau. It co-starred Leonard Rossiter, Lesley-Anne Down, Michael Robbins, Colin Blakely, and featured an uncredited cameo by Omar Sharif.

Revenge of the Pink Panther (1978)
Revenge of the Pink Panther (1978) pitted Clouseau against the French Connection. It is the last in which Sellers played Clouseau. It co-starred Dyan Cannon, Robert Webber, Robert Loggia and Graham Stark.

Trail of the Pink Panther (1982)
Trail of the Pink Panther (1982) was the first Pink Panther film made after Peter Sellers' death in 1980. Sellers' role is created by using scenes cut from Strikes Again, as well as flashbacks from the previous Pink Panther films. This movie was intended as a tribute to Sellers, but after its release, Sellers' widow Lynne Frederick successfully sued Edwards and Metro-Goldwyn-Mayer for tarnishing her late husband's memory. David Niven and Capucine reprise their original roles from the first Pink Panther film. Trail was a critical and commercial failure.

Curse of the Pink Panther (1983)
1983's Curse of the Pink Panther is the first to feature a different lead character, blundering American detective Sgt. Clifton Sleigh, portrayed by Ted Wass. Inspector Clouseau and the Pink Panther diamond, both of which had disappeared in Trail, are pursued by Sleigh. Clouseau returns, after having plastic surgery to disguise his identity, in a cameo appearance by Roger Moore (who is credited as "Turk Thrust II"). Although intended to spawn a new series of misadventures for the inept Sergeant Sleigh, the film's dismal box-office performance and critical drubbing, along with a complicated series of lawsuits between Edwards and Metro-Goldwyn-Mayer, led to a decade-long hiatus of the series. The lawsuit was eventually settled out of court in 1988, around the time Edwards came up with one final film idea that would ultimately become the unofficial series finale.

Son of the Pink Panther (1993)
In Son of the Pink Panther (1993), Blake Edwards made one final attempt to revive the Pink Panther series, this time by casting Italian actor Roberto Benigni as Gendarme Jacques Gambrelli, Inspector Clouseau's illegitimate son by Maria Gambrelli, the murder suspect from A Shot in the Dark (1964). Once again, regular Panther co-stars return – Herbert Lom, Burt Kwouk, and Graham Stark, and a star of the original 1963 film, Claudia Cardinale. Although intended to relaunch the series with the blundering Jacques as a lead, Son failed both critically and commercially and became the final installment in the original Pink Panther series. It was also the final film for both retiring director Blake Edwards and composer Henry Mancini, who died in 1994.

The Pink Panther (2006)
This reboot launches a new Pink Panther film series starring Steve Martin as Inspector Clouseau and Kevin Kline as Chief Inspector Dreyfus. Not a remake of the original film, it forms a new starting point for a contemporary series, introducing the Clouseau and Dreyfus characters along with the famous diamond to a new generation. The film was panned by most critics, and grossed $164.1 million against an $80 million budget.

The Pink Panther 2 (2009)
The sequel to Steve Martin's 2006 film. Martin reprises his role, but John Cleese replaces Kevin Kline as Chief Inspector Dreyfus. This film received negative reviews and meager box office, grossing a worldwide total of $76 million against a budget of $70 million.

Future
In March 2014, Metro-Goldwyn-Mayer announced plans to develop a new live-action/CGI hybrid feature film starring the Pink Panther, which was to be directed by David Silverman, with Walter Mirisch and Julie Andrews serving as producers. Andrews, who is the widow of Blake Edwards, would be creatively involved in the process of developing the new project, which unlike previous installments would focus on the titular character instead of the franchise's main character, Inspector Jacques Clouseau. By November 2020, Jeff Fowler had joined the production replacing Silverman as director. Chris Bremner was hired to write the script, while Lawrence Mirisch will serve as an additional producer. The plot will center around the Pink Panther character and Inspector Clouseau.

By April 2023, it was announced that after acquiring MGM, Amazon is developing new additions to the franchise in the form of a movie and television series through their subsidiary Amazon Studios (now called Amazon MGM Studios). It was later reported that Eddie Murphy was in talks to star in the film as Clouseau.

20th-century film series
Most of the films in the series starred Peter Sellers as Inspector Clouseau and were directed and co-written by Blake Edwards. As detailed in the director's commentary for the first film, the Inspector Clouseau character was originally conceived as a vehicle for David Niven, but once written it was decided he should play the raconteur/thief. Then the role was offered to Peter Ustinov, with Ava Gardner to play his wife. When Gardner dropped out, so did Ustinov, so the role of Clouseau went to Sellers. Apparently, the tone of the film changed after Edwards picked up Sellers from the airport, and during the ride to the hotel, they bonded over their mutual love of old film comedians like Harold Lloyd, Buster Keaton and Laurel & Hardy. The role was then modified to include elements of slapstick. The jazz-based Pink Panther Theme was composed by Henry Mancini. In addition to the credits sequences, the theme often accompanies any suspenseful sequence in the first film and in most of the subsequent films featuring the character of Clouseau.

The "Pink Panther" of the title is a diamond supposedly containing a flaw that forms the image of a "leaping panther" which can be seen if held up to the light in a certain way. This is explained at the beginning of the first film, and the camera zooms in on the diamond to reveal the blurry flaw, which focuses on the cartoon Panther (though not actually leaping) to begin the opening credits sequence. (This is also done in The Return of the Pink Panther [1975].) The plot of the first film is based on the theft of this diamond. The diamond reappears in several later films in the series, The Return of the Pink Panther (1975), Trail of the Pink Panther (1982) and Curse of the Pink Panther (1983). It also appears in the revival of the Inspector Clouseau character in the Steve Martin reboot films The Pink Panther (2006), and its sequel The Pink Panther 2 (2009). The name "the Pink Panther" became attached to Inspector Clouseau in much the same way that Frankenstein has been used in film titles to refer to Dr. Frankenstein's creation, or The Thin Man was used in a series of detective films.

A Shot in the Dark, the second film in the series, was not originally intended to feature Clouseau and is the first of two films in the series (the other being Inspector Clouseau) that features neither the diamond nor the distinctive animated Pink Panther character in the opening credits and ending. Many critics, including Leonard Maltin, regard A Shot in the Dark as the best film in the series.

In the original film, released in 1963, the main focus was on David Niven's role as Sir Charles Litton, the infamous jewel thief nicknamed "the Phantom", and his plan to steal the Pink Panther diamond. Inspector Clouseau was only a secondary character as Litton's incompetent antagonist and provided slapstick to an otherwise subtle, lighthearted caper film, a somewhat jarring contrast of styles which is typical of Edwards's films. The popularity of Clouseau caused him to become the main character in subsequent Pink Panther films, which were more straightforward slapstick comedies.

Mancini's theme, with variations in arrangement, is used at the start of all but the first two of the subsequent films. Mancini's other themes for the first film include an Italian-language set-piece called "Meglio stasera", whose purpose seems primarily to introduce young actress Fran Jeffries. Portions of an instrumental version also appear in the film's musical score several times. Other segments include "Shades of Sennett", a "honky-tonk" piano number introducing the film's climactic chase scene through the streets of Rome. Most of the remaining tracks on the soundtrack album are the early 1960s orchestral jazz pieces, matching the style of the era. Although variations of the main theme would reprise for many of the Pink Panther series entries, as well as the cartoon series, Mancini composed different theme music for A Shot in the Dark; this theme was later adopted by the animated spin-off series The Inspector.

Although official, the live-action film Inspector Clouseau (1968) starring Alan Arkin as Clouseau, is generally not considered by fans to be part of the series canon, since it involved neither Sellers nor Edwards. However, some elements of Arkin's performance and costuming of Clouseau were retained when Peter Sellers resumed the role of Return in 1975. Despite speculation, Alan Arkin does not appear in Trail of the Pink Panther.

2000s film series
The film that launched the second Pink Panther series, The Pink Panther, starring Steve Martin as Clouseau, directed by Shawn Levy and produced by Robert Simonds, was released in February 2006 by Metro-Goldwyn-Mayer and was co-produced with Columbia Pictures. It is set in the present day and introduces different main characters, therefore belonging to a different continuity. Martin also stars in the sequel, The Pink Panther 2, released in 2009.

Cartoons
The opening title sequence in the original 1963 The Pink Panther film was such a success with the United Artists executives that they decided to adapt the title sequence into a series of theatrical animated shorts. DePatie–Freleng Enterprises, run by former Warner Bros. Cartoons personnel David H. DePatie and Isadore "Friz" Freleng, produced the opening sequences, with Freleng as director. United Artists commissioned a long series of The Pink Panther shorts, the first of which, 1964's The Pink Phink, won the 1964 Academy Award for Animated Short Film. This was the first (and to date only) time a studio's first work won an Oscar.

By the autumn of 1969, the shorts were being broadcast on NBC during Saturday mornings on The Pink Panther Show; after 1969, new shorts were produced for both television broadcast and theatrical release. A number of sister series also joined the Pink Panther character on movie screens and on the airwaves, including The Inspector, featuring a comical French police officer based on the Jacques Clouseau character. Traditionally mute, the Pink Panther was given the voice of actor Matt Frewer for a 1993-1995 animated TV series.

The animated Pink Panther character has also appeared in computer and console video games, as well as advertising campaigns for several companies, most notably for Owens Corning Fiberglass insulation. There was also a short-lived animated series called Pink Panther and Pals (2010) which is aimed at younger children. In 2014, MGM announced (see above) that it was planning an animation / live-action hybrid film reboot of the franchise, to be directed by David Silverman and produced by Walter Mirisch and Julie Andrews. But in November 2020, it was later announced that Jeff Fowler will direct the movie instead with Mirisch and Andrews still producing. The animated Pink Panther character also appeared in a short animated segment on the educational TV series Sesame Street, demonstrating his karate skills to carve the letter K out of a block of stone, only for it to crumble quickly afterward.

Romance of the Pink Panther
Romance of the Pink Panther would have been the seventh film in the franchise, and written by Peter Sellers and Jim Moloney. Due to a rift between Blake Edwards and Sellers, Edwards would not have directed the film. The basic plot was to involve Inspector Clouseau becoming smitten with a cat burglar called "the Frog", played by Pamela Stephenson. Shortly after Sellers' death in July 1980, it was reported that Dudley Moore might play Clouseau, but Blake Edwards instead chose to introduce a new character in the series, rather than recast the role of Clouseau. Both Clive Donner and Sidney Poitier were reported at various times to be directing the movie, with Donner's name in that role on the cover sheet of the July 1980 'final draft' script.

Pink Panther television series
In the late 1980s, MGM/UA had been developing a live action/animation hybrid Pink Panther TV series, focusing on a young reporter to be portrayed by Charlie Schlatter who is helped in his investigations by the Pink Panther. The series was encouraged by the success of Who Framed Roger Rabbit, but for unknown reasons, it was not greenlit.

title: The Pink Panther


text:
Haganah

Haganah (הַהֲגָנָה, lit. 'The Defense') was the main Zionist paramilitary organization that operated for the Yishuv in the British Mandate for Palestine. It was founded in 1920 to defend the Yishuv's presence in the region, and was formally disbanded in 1948, when it became the core force integrated into the Israel Defense Forces shortly after the Israeli Declaration of Independence.

Formed out of previous existing militias, Haganah's original purpose was to defend Jewish settlements against Arab attacks; this was the case during the 1920 Nebi Musa riots, the 1921 Jaffa riots, the 1929 Palestine riots, the 1936 Jaffa riots, and the 1936–1939 Arab revolt in Palestine, among others. The paramilitary was under the control of the Jewish Agency, the official governmental body in charge of Palestine's Jewish community during the British era. Until the end of World War II, Haganah's activities were moderate, in accordance with the strategic policy of havlagah (lit. 'self-restraint'), which caused the breakaway of the more radical paramilitaries: Irgun and Lehi. Haganah militants received clandestine military support from Poland and sought cooperation with the United Kingdom in the event of an Axis-led invasion of Palestine through North Africa, prompting the creation of the Palmach, their elite fighting force, in 1941.

Following the end of World War II, the British refused to lift the restrictions on Jewish immigration that they had imposed with the 1939 White Paper. This resulted in Haganah leading a Jewish insurgency against the British authorities in Palestine; the campaign included the paramilitaries' bombing of bridges, railways, and ships used to deport illegal Jewish immigrants, as well as assisting in bringing more diaspora Jews to Palestine in defiance of British policies. After the adoption of the United Nations Partition Plan for Palestine in 1947, Haganah came into the open as the biggest fighting force among the Palestinian Jews, successfully overcoming Arab militias during the Palestinian Civil War. Shortly after the beginning of the 1948 Arab–Israeli War, Haganah was merged with other paramilitary groups and reorganized into the official military force of the State of Israel.

Overview
The evolution of Jewish defense organizations in Palestine and later Israel went from small self-defense groups active during Ottoman rule, to ever larger and more sophisticated ones during the British Mandate, leading through the Haganah to the national army of Israel, the IDF. The evolution went step by step from Bar-Giora, to Hashomer, to Haganah, to IDF.

The Jewish paramilitary organizations in the New Yishuv (the Zionist enterprise in Palestine) started with the Second Aliyah (1904 to 1914). The first such organization was Bar-Giora, founded in September 1907. It consisted of a small group of Jewish immigrants who guarded settlements for an annual fee. It was converted to Hashomer (השומר; "The Watchman") in April 1909, which operated until the British Mandate of Palestine came into being in 1920. Hashomer was an elitist organization which never had more than 100 members. During World War I, the forerunners of the Haganah/IDF were the Zion Mule Corps and the Jewish Legion, both of which were part of the British Army. After the Arab riots against Jews in April 1920, the Yishuv's leadership saw the need to create a nationwide underground defense organization, and the Haganah was founded in June of the same year. The Haganah became a full-scale defense force after the 1936–1939 Arab revolt in Palestine with an organized structure, consisting of three main units—the Field Corps, Guard Corps, and the Palmach strike force. During World War II the successor to the Jewish Legion of World War I was the Jewish Brigade, which was joined by many Haganah fighters. During the 1947–48 civil war between the Arab and Jewish communities in what was still Mandatory Palestine, a reorganized Haganah managed to defend or wrestle most of the territory it was ordered to hold or capture. At the beginning of the ensuing 1948–49 full-scale conventional war against regular Arab armies, the Haganah was reorganized to become the core of the new Israel Defense Forces.

1920 Palestine riots and 1921 Jaffa riots
After the 1920 Nebi Musa riots and 1921 Jaffa riots by Palestinians, the Jewish leadership in Palestine believed that the British, to whom the League of Nations had given a mandate over Palestine in 1920, had no desire to confront local Arab groups that frequently attacked Palestinian Jews. Believing that they could not rely on the British administration for protection from these gangs, the Jewish leadership created the Haganah to protect Jewish farms and kibbutzim. The first head of the Haganah was a 28-year-old named Yosef Hecht, a veteran of the Jewish Legion.

In addition to guarding Jewish communities, the role of the Haganah was to warn the residents of and repel attacks by Palestinians. In the period between 1920 and 1929, the Haganah lacked a strong central authority or coordination. Haganah "units" were very localized and poorly armed: they consisted mainly of Jewish farmers who took turns guarding their farms or their kibbutzim.

Following the 1929 Palestine riots, the Haganah's role changed dramatically. It became a much larger organization encompassing nearly all the youth and adults in the Jewish settlements, as well as thousands of members from the cities. It also acquired foreign arms and began to develop workshops to create grenades and simple military equipment, transforming from an untrained militia to a capable underground army.

1931 Irgun split
Many Haganah fighters objected to the official policy of havlagah (restraint) that Jewish political leaders (who had become increasingly controlling of the Haganah) had imposed on the militia. Fighters had been instructed to only defend communities and not initiate counterattacks against Arab gangs or their communities. This policy appeared defeatist to many who believed that the best defense is a good offense. In 1931, the more militant elements of the Haganah splintered off and formed the Irgun Tsva'i-Leumi (National Military Organization), better known as "Irgun" (or by its Hebrew acronym, pronounced "Etzel").

1936–1939 Arab revolt in Palestine
During the 1936–1939 Arab revolt in Palestine, the Haganah worked to protect British interests and to quell the rebellion using the Posh and then the Hish units. At that time, the Haganah fielded 10,000 mobilized men along with 40,000 reservists. Although the British administration did not officially recognize the Haganah, the British security forces cooperated with it by forming the Jewish Settlement Police, Jewish Supernumerary Police and Special Night Squads, which were trained and led by Colonel Orde Wingate. The battle experience gained during the training was useful in the 1948 Arab–Israeli War.

Support from the Second Polish Republic
During the interwar period, as part of its policy of supporting a Jewish state in Palestine in order to facilitate mass Jewish emigration from its territory, the Second Polish Republic provided military training and weapons to Zionist paramilitary groups, including Haganah. Envoys from Haganah headed by Yehuda Arazi received dozens of shipments with military supplies, including 2750 Mauser rifles, 225 RKM machine guns, 10,000 hand grenades, two million bullets for rifles and machine guns, and a large number of pistols with ammunition. The British exerted heavy pressure on the Polish government to stop these deliveries. One of the last purchases of Arazi were two airplanes and two gliders. When he fled Poland to France, around 500 rifles were abandoned in a Warsaw warehouse. Members of the Haganah were also trained in a military camp in Rembertow along with Betar members between the years 1931 and 1937; it is estimated that training courses at the camp were attended by around 8,000 to 10,000 participants during their existence.

1939 White Paper
By 1939, the British had issued the White Paper, which severely restricted Jewish immigration to Palestine, deeply angering the Zionist leadership. David Ben-Gurion, then chairman of the Jewish Agency, set the policy for the Zionist relationship with the British: "We shall fight the war against Hitler as if there were no White Paper, and we shall fight the White Paper as if there were no war."

In reaction to the White Paper, the Haganah built up the Palmach as the Haganah's elite strike force and organized illegal Jewish immigration to Palestine. Approximately 100,000 Jews were brought to Palestine in over one hundred ships during the final decade of what became known as Aliyah Bet. The Haganah also organized demonstrations against British immigration quotas.

Bombing of the SS Patria in Haifa
In 1940 the Haganah sabotaged the Patria, an ocean liner being used by the British to deport 1,800 Jews to Mauritius, with a bomb intended to cripple the ship. However the ship sank, killing 267 people and injuring 172.

World War II
In the first years of World War II, the British authorities asked Haganah for cooperation again, due to the fear of an Axis breakthrough in North Africa. After Rommel was defeated at El Alamein in 1942, the British stepped back from their all-out support for Haganah. In 1943, after a long series of requests and negotiations, the British Army announced the creation of the Jewish Brigade Group. While Palestinian Jews had been permitted to enlist in the British army since 1940, this was the first time an exclusively Jewish military unit served in the war under a Jewish flag. The Jewish Brigade Group consisted of 5,000 soldiers and was initially deployed with the 8th Army in North Africa and later in Italy in September 1944. The brigade was disbanded in 1946. All in all, some 30,000 Palestinian Jews served in the British army during the war.

On May 14, 1941, the Haganah created the Palmach (an acronym for Plugot Mahatz—strike companies), an elite commando section, in preparation against the possibility of a British withdrawal and Axis invasion of Palestine. Its members, young men and women, received specialist training in guerilla tactics and sabotage. During 1942 the British gave assistance in the training of Palmach volunteers but in early 1943 they withdrew their support and attempted to disarm them. The Palmach, then numbering over 1,000, continued as an underground organization with its members working half of each month as kibbutz volunteers, the rest of the month spent training. It was never large—by 1947 it amounted to merely five battalions (about 2,000 men)—but its members had not only received physical and military training, but also acquired leadership skills that would subsequently enable them to take up command positions in Israel's army.

"The Saison" post-assassination of Lord Moyne
In 1944, after the assassination of Lord Moyne (the British Minister of State for the Middle East) by members of the Lehi, the Haganah worked with the British to kidnap, interrogate, and, in some cases, deport Irgun members. This action, which lasted from November 1944 to February 1945, was called the Saison, or the Hunting Season, and was directed against the Irgun and not the Lehi. Future Jerusalem mayor Teddy Kollek was later revealed to be a Jewish Agency liaison officer working with the British authorities who had passed on information that led to the arrest of many Irgun activists.

Many Jewish youth, who had joined the Haganah in order to defend the Jewish people, were greatly demoralized by operations against their own people. The Irgun, paralyzed by the Saison, were ordered by their commander, Menachem Begin, not to retaliate in an effort to avoid a full blown civil war. Although many Irgunists objected to these orders, they obeyed Begin and refrained from fighting back. The Saison eventually ended due to perceived British betrayal of the Yishuv becoming more obvious to the public and increased opposition from Haganah members.

Post–World War II
The Saison officially ended when the Haganah, Irgun and the Lehi formed the Jewish Resistance Movement, in 1945. Within this new framework, the three groups agreed to operate under a joint command. They had different functions, which served to drive the British out of Palestine and create a Jewish state.

The Haganah was less active in the Jewish Rebellion than the other two groups, but the Palmach did carry out anti-British operations, including a raid on the Atlit detainee camp that released 208 illegal immigrants, the Night of the Trains, the Night of the Bridges, and attacks on Palestine Police bases. The Haganah withdrew on 1 July 1946, but "remained permanently unco-operative" with the British authorities. It continued to organize illegal Jewish immigration as part of the Aliyah Bet program, in which ships carrying illegal immigrants attempted to breach the British blockade of Palestine and land illegal immigrants on the shore (most were intercepted by the Royal Navy), and the Palmach performed operations against the British to support the illegal immigration program. The Palmach repeatedly bombed British radar stations being used to track illegal immigrant ships, and sabotaged British ships being used to deport illegal immigrants, as well as two British landing and patrol craft. The Palmach performed a single assassination operation in which a British official who had been judged to be excessively cruel to Jewish prisoners was shot dead. The Haganah also organized the Birya affair. Following the expulsion of the residents of the Jewish settlement of Birya for illegal weapons possession, thousands of Jewish youth organized by the Haganah marched to the site and rebuilt the settlement. They were expelled by British shortly afterward while showing passive resistance, but after they returned a third time, the British backed off and allowed them to remain.

In addition to its operations, the Haganah continued to secretly prepare for a war with the Arabs once the British left by building up its arms and munitions stocks. It maintained a secret arms industry, with the most significant facility being an underground bullet factory underneath Ayalon, a kibbutz that had been established specifically to cover it up.

British estimates of the Haganah's strength at this time were a paper strength of 75,000 men and women with an effective strength of 30,000. After the British army, the Haganah was considered the most powerful military force in the Middle East. Research by Amos Perlmutter estimated that the Haganah budget in 1946 was £400,000, and by October 1947 its budget had reached £3.3 million. The same source estimated that the membership of the Haganah was 7% of the Jewish population in Palestine.

In July 1947, eager to maintain order with the visit of UNSCOP to Palestine and under heavy pressure from the British authorities to resume collaboration, the Jewish Agency reluctantly came into brief conflict with the Irgun and Lehi, and ordered the Haganah to put a stop to the operations of the other two groups for the time being. As Palmach members refused to participate, a unit of about 200 men from regular Haganah units was mobilized, and foiled several operations against the British, including a potentially devastating attack on the British military headquarters at Citrus House in Tel Aviv, in which a Haganah member was killed by an Irgun bomb. The Haganah also joined the search for two British sergeants abducted by the Irgun as hostages against the death sentences of three Irgun members in what became known as the Sergeants' affair. The Jewish Agency leadership feared the damage this act would do to the Jewish cause, and also believed that holding the hostages would only jeopardize the fates of the three condemned Irgun members. The attempts to free the sergeants failed, and following the executions of the three Irgun members, the two sergeants were killed and hanged in a eucalyptus grove. However, the campaign soon disintegrated into a series of retaliatory abductions and beatings of each other's members by the Haganah and Irgun, and eventually petered out. The campaign was dubbed the "Little Season" by the Irgun.

Reorganization
After "having gotten the Jews of Palestine and of elsewhere to do everything that they could, personally and financially, to help Yishuv," Ben-Gurion's second greatest achievement was his having successfully transformed Haganah from being a clandestine paramilitary organization into a true army. Ben-Gurion appointed Israel Galili to the position of head of the High Command counsel of Haganah and divided Haganah into 6 infantry brigades, numbered 1 to 6, allotting a precise theatre of operation to each one. Yaakov Dori was named Chief of Staff, but it was Yigael Yadin who assumed the responsibility on the ground as chief of Operations. Palmach, commanded by Yigal Allon, was divided into 3 elite brigades, numbered 10–12, and constituted the mobile force of Haganah. Ben-Gurion's attempts to retain personal control over the newly formed IDF culminated with The Generals' Revolt.

On 19 November 1947, obligatory conscription was instituted for all men and women aged between 17 and 25. By end of March 21,000 people had been conscripted. On 30 March the call-up was extended to men and single women aged between 26 and 35. Five days later a General Mobilization order was issued for all men under 40.

"From November 1947, the Haganah, (...) began to change from a territorial militia into a regular army. (...) Few of the units had been well trained by December. (...) By March–April, it fielded still under-equipped battalion and brigades. By April–May, the Haganah was conducting brigade size offensive.

The brigades of the Haganah which merged into the IDF once this was created on 26 May 1948:

The northern Levanoni Brigade, located in the Galilee, was split on February 22, 1948 into the 1st and 2nd Brigades. To the initial six brigades, three were added later during the war:
 * The 1st or Golani Brigade – was deployed in the Lower Galilee
 * The 2nd or Carmeli Brigade – was deployed in the north and took its name after its commander, Moshe Carmel
 * The 3rd or Alexandroni Brigade – headquartered in Netanya, it covered the area from Tel Aviv to Zichron Ya'akov
 * The 4th or Kiryati Brigade – formed in 1948 in the Tel Aviv area
 * The 5th or Givati Brigade – formed in December 1947. During civil war the Givati Brigade was deployed in the central region, and during the conventional war in the south as the 5th Brigade
 * The 6th or Etzioni or Jerusalem Brigade – formed on December 1, 1947 and dismantled in the summer of 1949 Flickr - Government Press Office (GPO) - TRAINING FOR THE HAGANA.jpg
 * The 7th Brigade, in Hebrew "Hativat Sheva" – formed in 1948, manned mainly with Holocaust survivors and including a number of Machal troops. Almost annihilated at Latrun, then re-formed in the north. It had tanks and mounted infantry.
 * The 8th Brigade – founded on May 24, 1948, and subordinated to Yitzhak Sadeh as the IDF's first armoured brigade, headquartered near Jerusalem.
 * The 9th or Oded Brigade – headquartered in Jerusalem.

The Palmach brigades which merged into the IDF:
 * The 10th or Harel Brigade – established on 16 April 1948
 * The 11th or Yiftach Brigade
 * The 12th or Negev Brigade – established in March 1948

1948 Arab-Israeli War
After the British announced they would withdraw from Palestine, and the United Nations approved the partition of Palestine, the 1947-48 Civil War in Mandatory Palestine broke out. The Haganah played the leading role in the Yishuv's war with the Palestinian Arabs. Initially, it concentrated on defending Jewish areas from Arab raids, but after the danger of British intervention subsided as the British withdrew, the Haganah went on the offensive and seized more territory. Following the Israeli Declaration of Independence and the start of the 1948 Arab–Israeli War on May 15, 1948, the Haganah, now the army of the new state, engaged the invading armies of the surrounding Arab states.

On May 28, 1948, less than two weeks after the creation of the state of Israel on May 15, the provisional government created the Israel Defense Forces, merging the Haganah, Irgun, and Lehi, although the other two groups continued to operate independently in Jerusalem and abroad for some time after. The reorganization led to several conflicts between Ben-Gurion and the Haganah leadership, including what was known as The Generals' Revolt and the dismantling of the Palmach.

Famous members of the Haganah included Yitzhak Rabin, Ariel Sharon, Rehavam Ze'evi, Dov Hoz, Moshe Dayan, Yigal Allon and Dr. Ruth Westheimer.

The Museum of Underground Prisoners in Jerusalem commemorates the activity of the underground groups in the pre-state period, recreating the everyday life of those imprisoned there.

Pal-Heib Unit for Bedouins
Some Bedouins had longstanding ties with nearby Jewish communities. They helped defend these communities in the 1936–1939 Arab revolt in Palestine. During the 1948 Arab–Israeli War, some Bedouins of Tuba formed an alliance with the Haganah defending Jewish communities in the Upper Galilee against Syria. Some were part of a Pal-Heib unit of the Haganah. Sheik Hussein Mohammed Ali Abu Yussef of Tuba was quoted in 1948 as saying, "Is it not written in the Koran that the ties of neighbors are as dear as those of relations? Our friendship with the Jews goes back for many years. We felt we could trust them and they learned from us too".

title: Haganah