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Soho

Soho is an area of the City of Westminster in the West End of London. Originally a fashionable district for the aristocracy, it has been one of the main entertainment districts in the capital since the 19th century.

The area was developed from farmland by Henry VIII in 1536, when it became a royal park. It became a parish in its own right in the late 17th century, when buildings started to be developed for the upper class, including the laying out of Soho Square in the 1680s. St Anne's Church was established during the late 17th century, and remains a significant local landmark; other churches are the Church of Our Lady of the Assumption and St Gregory and St Patrick's Church in Soho Square. The aristocracy had mostly moved away by the mid-19th century, when Soho was particularly badly hit by an outbreak of cholera in 1854. For much of the 20th century Soho had a reputation as a base for the sex industry in addition to its night life and its location for the headquarters of leading film companies. Since the 1980s, the area has undergone considerable gentrification. It is now predominantly a fashionable district of upmarket restaurants and media offices, with only a small remnant of sex industry venues. London's gay community is centred on Old Compton Street in Soho.

Soho's reputation as a major entertainment district of London stems from theatres such as the Windmill Theatre on Great Windmill Street and the Raymond Revuebar owned by entrepreneur Paul Raymond, and music clubs such as the 2i's Coffee Bar and the Marquee Club. Trident Studios was based in Soho, and the nearby Denmark Street has hosted numerous music publishing houses and instrument shops from the 20th century onwards. The independent British film industry is centred around Soho, including the British headquarters of Twentieth Century Fox and the British Board of Film Classification offices. The area has been popular for restaurants since the 19th century, including the long-standing Kettner's which was visited by numerous celebrities. Near to Soho is London's Chinatown, centred on Gerrard Street and containing several restaurants and shops.

Name
The name "Soho" first appears in the 17th century. The name is derived from a former hunting cry. James Scott, 1st Duke of Monmouth, used "soho" as a rallying call for his men at the Battle of Sedgemoor on 6 July 1685, half a century after the name was first used for this area of London.

The Soho name has been reused by other entertainment and restaurant districts such as the Soho, Hong Kong entertainment zone and the cultural and commercial area of Soho in Málaga, Spain. The New York City neighbourhood of SoHo, Manhattan, gets its name from its location south of Houston Street, but is also a reference to London's Soho. The Pittsburgh neighbourhood of Uptown was also formerly called Soho, most likely having been named by its founder James Tustin after the London district, though it may refer to Soho, West Midlands.

Location
Soho has never been an administrative unit with formally defined boundaries; it is about 1 sqmi in area, and is usually considered to be bounded by Shaftesbury Avenue to the south, Oxford Street to the north, Regent Street to the west, and Charing Cross Road to the east. Apart from Oxford Street, all of these roads are 19th-century metropolitan improvements. The area to the west is known as Mayfair, to the north Fitzrovia, to the east St Giles and Covent Garden, and to the south St James's. Soho is part of the West End electoral ward which elects three councillors to Westminster City Council.

The nearest London Underground stations are Oxford Circus, Piccadilly Circus, Tottenham Court Road, Leicester Square and Covent Garden.

Early history
During the Middle Ages, the area that is now Soho was farmland that belonged to the Abbot and Convent of Abingdon and the master of Burton St Lazar Hospital in Leicestershire, who managed a leper hospital in St Giles in the Fields. In 1536, the land was taken by Henry VIII as a royal park for the Palace of Whitehall. The area south of what is now Shaftesbury Avenue did not stay in the Crown possession for long; Queen Mary sold around 7 acre in 1554, and most of the remainder was sold between 1590 and 1623. A small 2 acre section of land remained, until sold by Charles II in 1676.

In the 1660s, ownership of Soho Fields passed to Henry Jermyn, 1st Earl of St Albans, who leased 19 out of the 22 acre of land to Joseph Girle. He was granted permission to develop property and quickly passed the lease and development to bricklayer Richard Frith. Much of the land was granted freehold in 1698 by William III to William Bentinck, 1st Earl of Portland, while the southern part of Soho was sold piecemeal in the 16th and 17th centuries, partly to Robert Sidney, Earl of Leicester.

Soho was part of the ancient parish of St Martin in the Fields, forming part of the Liberty of Westminster. As the population started to grow, a new church was provided, and in 1687 a new parish of St Anne was established for it. The parish stretched from Oxford Street in the north to Leicester Square in the south and from what is now Charing Cross Road in the east to Wardour Street in the west; it therefore included all of contemporary eastern Soho, including the Chinatown area. The western portion of modern Soho, around Carnaby Street, was part of the parish of St James, which was split off from St Martin in 1686.

Gentrification
Building progressed rapidly in the late 17th century, with large properties such as Monmouth House (built for James Scott, 1st Duke of Monmouth, Charles II's eldest illegitimate son), Leicester House, Fauconberg House, Carlisle House and Newport House.

Soho Square was first laid out in the 1680s on the former Soho Fields; by 1691, 41 houses had been completed there. It was originally called King Square in honour of Charles II, and a statue of him was based in the centre. Several upper-class families moved into the area, including those of Richard Graham, 1st Viscount Preston, and Edward Howard, 2nd Earl of Carlisle. The square had become known as Soho Square by 1720, at which point it had fashionable houses on all sides. Only No 10 and No 15 from this period have survived into the 21st century.

Though the Earls of Leicester and Portland had intended Soho to be an upper-class estate comparable to Bloomsbury, Marylebone and Mayfair, it never developed as such. Immigrants began to settle in the area from around 1680 onwards, particularly French Huguenots after 1688. The area became known as London's French quarter. The French church in Soho Square was founded by Huguenots and opened on 25 March 1893, with a façade of terracotta and coloured brick designed by Aston Webb.

Cholera outbreak
A significant event in the history of epidemiology and public health was John Snow's study of an 1854 outbreak of cholera in Soho. He identified the cause of the outbreak as water from the public pump at the junction of Broad Street (now Broadwick Street) and Cambridge Street (now Lexington Street), close to the rear wall of what is today the John Snow public house.

Snow mapped the addresses of the sick and noted that they were mostly people whose nearest access to water was the Broad Street pump. He persuaded the authorities to remove the handle of the pump, thus preventing any more of the infected water from being collected. The spring below the pump was later found to have been contaminated with sewage. This is an early example of epidemiology, public health medicine and the application of science—the germ theory of disease—in a real-life crisis. Science writer Steven Johnson has written about the changes related to the cholera outbreak, and notes that almost every building on the street that existed in 1854 has since been replaced. A replica of the pump, with a memorial plaque and without a handle (to signify Snow's action to halt the outbreak) was erected in 1992 near the location of the original.

Decline
By the mid-18th century, the aristocrats who had been living in Soho Square or Gerrard Street had moved away, as more fashionable areas such as Mayfair became available. The historian and topographer William Maitland wrote that the parish "so greatly abound with French that is an easy Matter for a Stranger to imagine himself in France." Soho's character stems partly from the ensuing neglect by rich and fashionable London, and the lack of the redevelopment that characterised the neighbouring areas.

The aristocracy had mostly disappeared from Soho by the 19th century, to be replaced by prostitutes, music halls and small theatres. The population increased significantly, reaching 327 inhabitants per acre by 1851, making the area one of the most densely populated areas of London. Houses became divided into tenements with chronic overcrowding and disease. The 1854 cholera outbreak caused the remaining upper-class families to leave the area. Numerous hospitals were built to cope with the health problem; six were constructed between 1851 and 1874. Businesses catering to household essentials were established at the same time.

The restaurant trade in Soho improved dramatically in the early 20th century. The construction of new theatres along Shaftesbury Avenue and Charing Cross Road improved the reputation of the area, and a meal for theatre-goers became common. Public houses in Soho increased in popularity during the 1930s and were frequented by struggling authors, poets and artists.

Recent history
Since the decline of the sex industry in Soho in the 1980s, the area has returned to being more residential. The Soho Housing Association was established in 1976 to provide reasonable rented accommodation. By the 21st century, it had acquired around 400 flats. St Anne's Church in Dean Street was refurbished after decades of neglect, and a Museum of Soho was established.

On 30 April 1999, the Admiral Duncan pub on Old Compton Street, which serves the gay community, was damaged by a nail bomb that left three dead and 30 injured. The bomb was the third that had been planted by David Copeland, a neo-Nazi who was attempting to stir up ethnic and homophobic tensions by carrying out a series of bombings.

In early February 2020, parts of an unexploded Second World War bomb was discovered by construction workers developing a new mixed residential building in Richmond Mews, near Dean Street. Residents, employees, and pedestrians on Richmond Mews, Dean Street, Meard Street and St Anne's Court were evacuated on both the 3rd and 4th of February 2020. All road junctions connecting to the streets closed during retrieval of the bomb fragments as well.

Theatre and film
Soho is near the heart of London's theatre area. It is home to the Soho Theatre, built in 2000 to present new plays and comedy.

The Windmill Theatre was based on Great Windmill Street, and was named after a windmill at this location that was demolished in the 18th century. It initially opened as the Palais de Luxe in 1910 as a small cinema, but was unable to compete with larger venues and was converted into a theatre by Howard Jones. It re-opened in December 1931, but was still unsuccessful. In 1932, the general manager Vivian Van Damm introduced a non-stop variety show throughout the afternoon and evening. It was famous for its nude tableaux vivants, in which the models had to remain motionless to avoid the censorship laws then in place. The theatre claimed that, aside from a compulsory closure between 4 and 16 September 1939, it was the only theatre in London which did not close during the Second World War; this led it to use the slogan "We never closed". Several prominent comedians including Harry Secombe, Jimmy Edwards and Tony Hancock began their careers at the Windmill. It closed on 31 October 1964 and was again turned into a cinema.

The Raymond Revuebar at No. 11 Walker's Court was a small theatre specialising in striptease and nude dancing. It was owned by Paul Raymond and opened in 1958. The facade supported a brightly lit sign declaring it to be the "World Centre of Erotic Entertainment". Raymond subsequently bought the lease of the Windmill and ran it as a "nude entertainment" venue until 1981. The upstairs became known as the Boulevard Theatre and in 1980 was adopted as a comedy club called "The Comic Strip" by a small group of alternative comedians including Rik Mayall, Dawn French, Jennifer Saunders, Alexei Sayle and Adrian Edmondson, before they found wider recognition with the series The Comic Strip Presents on Channel 4. The name and control of the theatre (but not the property itself) were bought by Raymond's business associate Gérard Simi in 1996. The theatre suffered financial difficulties owing to increasing rent, leading to its closure in 2004. It became a gay bar and cabaret venue called Too2Much; in 2005, Elton John staged a joint bachelor party there with his longtime partner David Furnish in anticipation of their civil partnership. The venue was subsequently renamed to the Soho Revue Bar, but closed in 2009.

Soho is a centre of the independent film and video industry as well as the television and film post-production industry. Audio post duo White Lightning (Robbie Weston and Rick Dzendzera) opened two audio post-production facilities in different parts of Soho in 1986: Silk Sound at 13 Berwick Street, and The Bridge Facilities at 55-57 Great Marlborough Street. Silk Sound is still in operation, but The Bridge was sold to Miloco Studios in 2009, and relocated to the Orinoco Studios Complex at 36 Leroy Street in Greater London. White Lightning also opened a third studio at 16 Dufours Place, named Space Facilities, in late 1995, but it closed in the same year The Bridge was sold. Twentieth Century House in Soho Square was built in 1937 for Twentieth Century Fox. The British Board of Film Classification, formerly known as the British Board of Film Censors, has been based in Soho Square since 1950. Soho's key fibre communications network has been managed by Sohonet since 1995, which connects the Soho media and post-production community to British film studios such as Pinewood and Shepperton, along with other locations worldwide include HBO and Warner Brothers. In the 2010s, research commissioned by Westminster City Council showed 23 per cent of the workforce in Soho worked in the creative industries.

Restaurants and clubs
Many small and easily affordable restaurants and cafes were established in Soho during the 19th century, particularly as a result of Greek and Italian immigration. The restaurants were not looked upon favourably at first, but their reputation changed at the start of the 20th century. In 1924, a guide reported "of late years, the inexpensive restaurants of Soho have enjoyed an extraordinary vogue." Arthur Ransome's Bohemia in London (1907) mentions Old and New Soho, including details about Soho coffee-houses including The Moorish Café and The Algerian.

Kettner's was a restaurant on Romilly Street, established in 1867 by Napoleon III's chef Auguste Kettner. It was frequently visited by Albert, Prince of Wales (where he is alleged to have dined with his mistress, Lillie Langtry) and Oscar Wilde. The restaurant survived both World Wars without incident, and was regularly visited by Agatha Christie and Bing Crosby.

In the 20th century, several Soho pubs and private members clubs gained notoriety for both their proprietors and clientele. Clive Jennings says of regular clientele such as Jeffrey Barnard and Francis Bacon that "the lethal triangle of The French, The Coach & Horses and The Colony were the staging points of the Dean Street shuffle, with occasional forays into other joints such as The Gargoyle or the Mandrake ... The Groucho or Blacks". Christopher Howse notes of the coterie of bohemian heavy drinkers that "There was no worry about pensions in Soho. People didn't live that long."

The Gargoyle Club opened at 69 Dean Street in 1925. It was founded by the socialite the Hon David Tennant as a place where writers, artists and musicians could mingle with the upper crust and eat and drink at affordable prices for the next three decades. In May 1979 the Gargoyle's uppermost room started hosting a weekly club-night on Saturdays called the Comedy Store, which made the reputations of many of the UK's upcoming "alternative comedians". Among the original lineup here were Alexei Sayle, Rik Mayall and Adrian Edmondson who broke away in 1980 to establish The Comic Strip team at Raymond's Revue Bar, before they found wider recognition with the series The Comic Strip Presents on Channel 4. The Gargoyle's success and Bohemian clientele led to other restaurants being founded around Soho, including the Eiffel Tower and Bellotti's.

During the 1970s the building at 69 Dean Street housed another nightspot in its cellars, initially known as Billy's, and run by Soho's only Jamaican club owner, Vince Howard. The Blitz Kids, a group of London clubgoers who spearheaded the New Romantic movement in the early 1980s, originally met at Billy's. The club changed its name to Gossip's and became part of London's clubland heritage by spawning several weekly club-nights that influenced British music and fashion during the 1980s.

Gerrard Street is the centre of London's Chinatown, and along with Lisle Street and Little Newport Street, house a mix of import companies, oriental food shops and restaurants. Street festivals are held throughout the year, particularly on the Chinese New Year. In March 2022, Cadbury opened a temporary vegan chocolate shop at 15 Bateman Street.

Radio
Soho Radio is an internet radio station on Great Windmill Street, next to the Windmill Theatre. Since May 2014 it has been streaming live and pre-recorded programming from its premises, which also function as a retail space and coffee shop. The station states on its website that it aims "to reflect the culture of Soho through our vibrant and diverse content". There is no playlist policy, and presenters are allowed to play any music they like. In 2016, it was voted the world's best radio station at Mixcloud's Online Radio Awards.

Religion
Soho is home to numerous religious and spiritual groups. St Anne's Church on Wardour Street was built between 1677 and 1686, possibly to the design of Sir Christopher Wren or William Talman. An additional tower was built in 1717 by Talman and reconstructed in 1803. The church was damaged by a V1 flying bomb during World War II in 1940, but the tower survived. In 1976, John Betjeman campaigned to save the building. The church was fully restored in the late 1980s and formally re-opened by the Princess Royal on 12 March 1990. The Church of Our Lady of the Assumption and St Gregory on Warwick Street was built in 1788 and is the only remaining 18th-century Roman Catholic embassy chapel in London and principal church of the Personal Ordinariate of Our Lady of Walsingham. St Patrick's Church in Soho Square was built in 1792 to accommodate Irish immigrants who had moved to the area.

Other religious buildings in Soho include the Hare Krishna Temple off Soho Square, which was part-funded by George Harrison and opened in 1979. There exists a small mosque on Berwick Street. The French Protestant Church of London, the only one of its kind in the city and constructed in the Flemish Gothic style, has been at Nos. 8–9 Soho Square since 1893.

Music
The music scene in Soho can be traced back to 1948 and Club Eleven, generally regarded as the first venue where modern jazz, or bebop, was performed in the UK. It closed in 1950 following a drugs raid. The Harmony Inn was a hang-out for musicians on Archer Street operating during the 1940s and 1950s.

The Ken Colyer Band's 51 Club, a venue for traditional jazz, opened on Great Newport Street in 1951. Blues guitarist and harmonica player Cyril Davies and guitarist Bob Watson launched the London Skiffle Centre, London's first skiffle club, on the first floor of the Roundhouse pub on Wardour Street in 1952. It was renamed the London Blues and Barrelhouse Club in the late 1950s, and closed in 1964.

In the early 1950s, Soho became the centre of the beatnik culture in London. The first coffee bar to open was Moka at No. 29 Frith Street. It was formally opened in 1953 by the film star Gina Lollobrigida, and the frothed coffee produced from stainless steel machines was pioneering in British culture. Le Macabre on Wardour Street, had coffin-shaped tables, fostered beat poetry, jive dance and political debate. The Goings On, in Archer Street, was a Sunday afternoon club organised by the beat poet Pete Brown, active in the mid-1960s. For the rest of the week, it operated as an illegal gambling den. Pink Floyd played at the club at the beginning of their career.

The 2i's Coffee Bar was one of the first rock clubs in Europe. It initially opened on No. 44 Gerard Street in 1956, but soon moved to its more famous venue of No. 59 Old Compton Street. Soho quickly became the centre of the fledgling rock scene in London. Clubs included the Flamingo Club, a regular gig for Georgie Fame, Ronan O'Rahilly's The Scene, which opened in 1963 and catered for the Mod movement with regular attendees including Steve Marriot and Andrew Loog Oldham, and jazz clubs like Ronnie Scott's, which opened in 1959 at 39 Gerrard Street and moved to 47 Frith Street in 1965.

Soho's Wardour Street was the home of the Marquee Club, which opened in 1958. In the 1960s, numerous major rock bands played at the venue, including early performances from the Rolling Stones in July 1962 and The Who in late 1964, Jimi Hendrix, David Bowie, Led Zeppelin, Pink Floyd, Jethro Tull, AC/DC and Iron Maiden. Eric Clapton and Brian Jones both lived for a time in Soho, sharing a flat with future rock publicist, Tony Brainsby.

Trident Studios was based at 17 St Anne's Court, Soho and was a major London recording studio. It was established by Norman and Barry Sheffield in 1968, who wanted to expand from the small studio they had above their music shop. It became immediately successful after The Beatles decided to record several tracks on The White Album there, as the facilities were better than Abbey Road studios. Queen were originally managed by the Sheffields, and recorded their first four albums and filmed the video for Bohemian Rhapsody at Trident. Other artists who recorded at Trident include David Bowie, Elton John, Free and Thin Lizzy. It closed as a general-purpose recording studio in 1981, but has since reopened in various guises, including providing sound and mixing services for television.

Although technically not part of Soho, the adjacent Denmark Street is known for its connections with British popular music, and is nicknamed the British Tin Pan Alley due to its large concentration of shops selling musical instruments. The Sex Pistols lived beneath No. 6 and recorded their first demos there. Jimi Hendrix, the Rolling Stones and David Bowie have all recorded at studios on Denmark Street and Elton John wrote his hit "Your Song" in the street. Led Zeppelin's first rehearsal in 1968 was in a basement studio on Gerrard Street.

Sex industry
The Soho area has been at the heart of London's sex industry for more than 200 years; between 1778 and 1801, 21 Soho Square was location of the White House, a brothel described by the magistrate Henry Mayhew as "a notorious place of ill-fame". Shortly before World War I, two rival gangs, one led by Chan Nan (also called "Brilliant Chang") and the other by Eddie Manning, controlled drugs and prostitution in Soho. Both were eventually arrested and imprisoned; Manning died midway through a three-year sentence in 1933. Following World War II, gangs set up rings of prostitutes in the area, concentrated around Brewer Street and Rupert Street. Photographers also visited Soho in the hope of being able to blackmail people caught in the act of visiting prostitutes.

When the Street Offences Act 1959 drove prostitution off the streets, many clubs such as the Blue Lagoon at No. 50 Carnaby Street became fronts for it. Gangs controlled the clubs and the prostitutes, and the police were bribed. In 1960 London's first sex cinema, the Compton Cinema Club (a members-only club to get around the law), opened at 56 Old Compton Street. It was owned by Michael Klinger and Tony Tenser who later produced two early Roman Polanski films, including Repulsion (1965). As post-war austerity relaxed into the "swinging '60s", clip joints also surfaced; these unlicensed establishments sold coloured water as champagne with the promise of sex to follow, thus fleecing tourists looking for a "good time". Harrison Marks, a "glamour photographer" and girlie magazine publisher, had a photographic gallery on Gerrard Street and published several magazines in the 1950s and '60s. The model Pamela Green prompted him to take up nude photography, and she remained the creative force in their business.

By the 1970s, the sex shops had grown from the handful opened by Carl Slack in the early 1960s. From 1976 to 1982, Soho had 54 sex shops, 39 sex cinemas and cinema clubs, 16 strip and peep shows, 11 sex-oriented clubs and 12 licensed massage parlours. The proliferation of sex shops dissuaded some people from visiting Soho. The growth of the sex industry in Soho during this time was partly caused by corruption in the Metropolitan Police. The vice squad at the time suffered from police officers enforcing against organised crime in the area, while simultaneously accepting bribes. This changed following the appointment of Robert Mark as chief constable, who began to crack down on corruption. In 1972 local residents started the Soho Society in order to control the increasing expansion of the sex industry in the area and improve it with a comprehensive redevelopment plan. This led to a series of corruption trials in 1975, following which several senior police officers were imprisoned. This caused a small recession in Soho which depressed property values at the time Paul Raymond had started buying freeholds there.

By the 1980s, purges of the police force along with pressure from the Soho Society and new and tighter licensing controls by the City of Westminster led to a crackdown on illegal premises. The number of sex industry premises dropped from 185 in 1982 to around 30 in 1991. By 2000, substantial relaxation of general censorship, the ready availability of non-commercial sex, and the licensing or closing of unlicensed sex shops had reduced the red-light area to just a small area around Berwick Street. Much of the business has been reported to have been run by Albanian gangs. By the end of 2014, gentrification and competition from the internet had reduced the number of flats in Soho used for prostitution (see Soho walk-up), but the area remains a red-light district and a centre of the sex industry in London.

Health and welfare
The National Hospital for Diseases of the Heart and Paralysis was established at No. 32 Soho Square in 1874. The property had previously been owned by the naturalist and botanist Sir Joseph Banks. It moved to Westmoreland Street in 1914, and then to Fulham Road in 1991.

In July 2019, Soho was reported to be the unhealthiest place to live in Britain. Researchers from the University of Liverpool found that the area had the greatest access to takeaways, pubs and off-licences and these were combined with high levels of air pollution and low levels of parks and green spaces.

Streets
Berwick Street was built between 1687 and 1703, and is probably named after James FitzJames, 1st Duke of Berwick, the illegitimate son of James II of England. It has held a street market since the early 18th century, which has been formally organised since 1892.

Carnaby Street was laid out in the late 17th century. It was named after Karnaby House, built on the street's eastern side in 1683. It was a popular residence for Huguenots at first, before becoming populated by shops in the 19th century. In 1957, a fashion boutique was opened, and Carnaby Street became the fashion centre of 1960s Swinging London, although it quickly became known for poor quality "kitsch" products.

D'Arblay Street was laid out between 1735 and 1744. It was originally known as Portland Street after William Bentinck, 2nd Duke of Portland, and given its current named in 1909 in commemoration of Frances Burney, Madame D'Arblay, who had lived in Poland Street nearby, when she was young. The George public house at No. 1 was opened in 1889, but there has been a tavern on this site since 1739. Several of the original houses have survived into the 21st century.

Dean Street was built in the 1680s and was originally settled by French immigrants. It is home to the Soho Theatre and a pub known as The French House, which during the Second World War was popular with the French government-in-exile. Karl Marx lived at No. 64 Dean Street around 1850. The Colony Club was founded by Muriel Belcher and based at No. 41 Dean Street from 1948 to 2008. It was frequented by several important artists including Francis Bacon, Lucian Freud and Frank Auerbach.

Frith Street was named after Richard Frith, a local builder. On Rocque's Map of London it is marked as Thrift Street. It was a popular aristocratic residence, although without as many foreign residents as some other streets. A plaque above the stage door of the Prince Edward Theatre identifies the site where Mozart lived as a child between 1764 and 1765. John Logie Baird first demonstrated television in his laboratory at No 22 in 1926; the site is now the location of Bar Italia. Ronnie Scott's Jazz Club is located at No 46 Frith Street, having moved there from Gerrard Street in 1965.

Greek Street was first laid out around 1680 and was named after a nearby Greek church. It initially housed several upper-class tenants including Arthur Annesley, 5th Earl of Anglesey, and Peter Plunket, 4th Earl of Fingall. Thomas De Quincey lived in the street after running away from Manchester Grammar School in 1802. Josiah Wedgwood ran his main pottery warehouse and showrooms at Nos. 12–13 between 1774 and 1797. The street now mostly contains restaurants, and several historical buildings from the early 18th century are still standing.

Gerrard Street was built between 1677 and 1685 on land, called the Military Ground, which was owned by Charles Gerard, 1st Earl of Macclesfield. The initial development contained a large house belonging to the Earl of Devonshire, which was subsequently occupied by Charles Montagu, 4th Earl of Manchester, Thomas Wharton, Baron Wharton, and Richard Lumley, 1st Earl of Scarbrough. Several foreign restaurants had become established on Gerrard Street by the end of the 19th century, including the Hotel des Etrangers and the Mont Blanc. Ronnie Scott's Jazz Club opened at 39 Gerrard Street in 1959 and remained there until its move to No 47 Frith Street in 1965. Scott kept 39 Gerrard Street open for up-and-coming British jazz musicians (referred to as 'the Old Place') until the lease ran out in 1967. The 43 Club was based on Gerrard Street. It was one of the most notorious clubs in Soho, run as a cover for organised crime and illegal after-hours selling of alcohol; following a police investigation, the owner Kate Meyrick was jailed in 1928. During the 1950s, the cheap rents on Gerrard Street attracted Chinese Londoners, many who moved from Poplar. By 1970, the street had become the centre of London's Chinatown, and it became pedestrianised and decorated with a Chinese gateway and lanterns. It continues to host numerous Chinese restaurants and shops into the 21st century.

Golden Square is a garden square to the southwest of Soho. Built over land formerly used for grazing, its name is a corruption of gelding. Building began in 1675 and it was complete by the early 18th century. It was originally home to several upper-class residents, including Barbara Villiers, Duchess of Cleveland, James Brydges (later to become 1st Duke of Chandos), and Henry St John, 1st Viscount St John. By the mid-18th century the aristocracy had moved west towards Mayfair, and a number of foreign embassies were established around the square. In the 19th century, it became a popular residence for local musicians and instrument makers, while by the 20th it had become an established centre of woollen merchants. A statue of King George II sits in the centre of the square, designed by John Van Nost and constructed in 1753.

Great Marlborough Street was first laid out in the early 18th century, and named after the military commander John Churchill, 1st Duke of Marlborough. The street was initially fashionable and was home to numerous peers. The London College of Music was based at No. 47 from 1896 to 1990, while the department store Liberty is on the corner with Regent Street. The street was the location of Philip Morris's original London factory and gave its name to the Marlboro brand of cigarettes. Marlborough Street Magistrates Court was based at No. 20–21 and had become one of the country's most important magistrates courts by the late 19th century. The Marquess of Queensbury's libel trial against Oscar Wilde took place here in 1895. The Rolling Stones' Mick Jagger and Keith Richards were tried for drugs possession at the court in 1967, with fellow band member Brian Jones being similarly charged a year later.

Great Windmill Street was named after a 17th-century windmill on this location. The Scottish anatomist William Hunter opened his anatomical theatre at No. 16 in 1766, running it until his death in 1783. It continued to be used for anatomical lectures until 1831. The principles of The Communist Manifesto were laid out by Karl Marx in 1850 at a meeting in the Red Lion pub.

Old Compton Street is named after the Bishop of London Henry Compton, and was first laid out in the 1670s, fully developed by 1683. During the late 18th and 19th centuries, it became a popular meeting place for French exiles. The street was the birthplace of Europe's rock club circuit (2i's club) and contained the first adult cinema in England (The Compton Cinema Club). Dougie Millings, who was the famous tailor for The Beatles, had his first shop at 63 Old Compton Street, which opened in 1962. Old Compton Street is now the core of London's main gay village, where there are several businesses catering for the gay community.

Poland Street was named for the King of Poland pub which stood at one end. It was destroyed by a bomb in 1940. Henry Howard, 6th Earl of Suffolk lived at No. 15 in 1717, while Percy Bysshe Shelley briefly lodged in the street in 1811. William Blake lived at No. 28 from 1785 to 1791, and wrote several works there, including Songs of Innocence and The Book of Thel. The street was the site of the St James Workhouse whose infirmary is believed to be the predecessor to the St. James Infirmary. The first multi-storey car park in London opened on Poland Street in 1934.

Wardour Street dates back to 1585, when it was known as Commonhedge Lane and connected Oxford Street to the King's Mews (now part of Trafalgar Square). It began to be built up in the 1680s and was named after local landowner Edward Wardour. Most of the original houses were rebuilt in the 18th century, and the street became known for antiques and furniture dealers. Several music publishers were established along Wardour Street in the early 20th century, including Novello and Co at Nos. 152–160. The most famous location of the Marquee Club was at No. 90 Wardour Street between 1964 and 1988. Another seventies rock hangout was The Intrepid Fox pub (at 97/99 Wardour Street), originally dedicated to Charles James Fox (who is featured on a relief on the outside of the building). It subsequently became a haven for the Goth subculture before closing in 2006.

Cultural references
A detailed mural depicting Soho characters, including writer Dylan Thomas and jazz musician George Melly, is in Broadwick Street, at the junction with Carnaby Street.

In fiction, Robert Louis Stevenson had Dr. Henry Jekyll set up a home for Edward Hyde in Soho in his novel, Strange Case of Dr Jekyll and Mr Hyde. Charles Dickens referred to Soho in several of his works; in A Tale of Two Cities, Lucie Manette and her father Dr. Alexandre Manette live on Soho Square, while Golden Square is mentioned in Nicholas Nickleby, in which Ralph Nickleby has a house on the square, and the George II statue in the centre is described as "mournful". Joseph Conrad used Soho as the home for The Secret Agent, a French immigrant who ran a pornography shop. Dan Kavanagh (Julian Barnes)'s 1980 novel Duffy is set in Soho.

Lee Ho Fook's, formerly in Gerrard Street, is mentioned in Warren Zevon's song "Werewolves of London". The Who song "Pinball Wizard", also covered by Elton John, contains the line "From Soho down to Brighton, I must've played them all", in reference to the locations frequented by the title character. The Pogues 1986 song "A Rainy Night in Soho", written and sung by Shane MacGowan (and covered by Bono and Johnny Depp) frames night-time in the district. "Lola" by The Kinks sees the story-teller of the song meeting a transgender woman by the name of Lola in a club in Soho.

The area is the setting for the 2021 film Last Night in Soho by Edgar Wright.

title: Soho


text:
Orders, decorations, and medals of the United Kingdom

In the United Kingdom and the British Overseas Territories, personal bravery, achievement, or service are rewarded with honours. The honours system consists of three types of award:

 * Honours are used to recognise merit in terms of achievement and service;
 * Decorations tend to be used to recognise specific deeds;
 * Medals are used to recognise service on a particular operation or in a specific theatre, long or valuable service, and good conduct.

Appointments to the various orders and awards of other honours are usually published in The London Gazette.

Brief history
Although the Anglo-Saxon monarchs are known to have rewarded their loyal subjects with rings and other symbols of favour, it was the Normans who introduced knighthoods as part of their feudal government. The first English order of chivalry, the Order of the Garter, was created in 1348 by Edward III. Since then, the system has evolved to address the changing need to recognise other forms of service to the United Kingdom.

Modern honours
As the head of state, the Sovereign is the fount of honour, but the system for identifying and recognising candidates to honour has changed considerably over time. Various orders of knighthood have been created (see below) as well as awards for military service, bravery, merit, and achievement which take the form of decorations or medals. Most medals are not graded. Each one recognises specific service so there are normally set criteria which must be met. These criteria may include a period of time and will often delimit a particular geographic region. Medals are not normally presented by the Sovereign. A full list is printed in the "order of wear", published (infrequently) by the London Gazette.

Orders of honours
Honours are split into classes ("orders") and are graded to distinguish different degrees of achievement or service, according to various criteria. Nominations are reviewed by honours committees made up of government officials and private citizens from different fields, who meet twice a year to discuss the candidates and make recommendations for appropriate honours to be awarded by the King.

New Year and Birthday honours
A list of approximately 1,350 names are published twice a year, at the New Year and on the date of the Sovereign's (official) birthday. Since decisions are inevitably subjective, the twice-yearly honours lists often provoke criticism from those who feel strongly about particular cases. Candidates are identified by public or private bodies, by government departments, or are nominated by members of the public. Depending on their roles, those people selected by the honours committee are submitted either to the Prime Minister, Secretary of State for Foreign, Commonwealth and Development Affairs, or Secretary of State for Defence for their approval before being sent to the Sovereign for final approval. Certain honours are conferred solely at the Sovereign's discretion, such as appointments to the Order of the Garter, the Order of the Thistle, the Royal Victorian Order, and the Order of Merit. The honours' insignia are then presented by the Sovereign or his representative at investitures held at Buckingham Palace, Windsor Castle or the Palace of Holyroodhouse; Prince William and Princess Anne deputised for Queen Elizabeth II and continue to do so for King Charles III.

Prime Minister's Resignation Honours
By convention, a departing prime minister is allowed to nominate Prime Minister's Resignation Honours, to reward political and personal service. In recent history, only Tony Blair and Gordon Brown have not taken up this privilege (although Brown did issue the 2010 Dissolution Honours to similar effect).

Special Honours
As part of the British honours system, Special Honours are issued at the Monarch's pleasure at any given time. The Special Honours refer to the awards made within royal prerogative, operational honours, political honours and other honours awarded outside the New Years Honours and Birthday Honours.

Current orders of chivalry
The current system is made up of six orders of chivalry and four orders of merit. The statutes of each order specify matters such as the size of the order, the use of post-nominal letters and insignia design and display. These are ordered by date of formation, which does not necessarily correspond to order of wear.

Dormant orders of chivalry
Orders were created for particular reasons at particular times. In some cases these reasons have ceased to have any validity and orders have fallen into abeyance, primarily due to the decline of the British Empire during the twentieth century. Reforms of the system have sometimes made other changes. For example, the British Empire Medal temporarily ceased to be awarded in the UK in 1993, as was the companion level award of the Imperial Service Order (although its medal is still used). The British Empire Medal was revived, however, in 2012 with 293 BEMs awarded for the 2012 Birthday Honours, and has continued to be awarded in some other Commonwealth nations.

Order of St Patrick
The Order of St Patrick was founded in 1783 by George III for the Kingdom of Ireland, and after the Acts of Union 1800 continued for Irish peers in the United Kingdom of Great Britain and Ireland. After the Irish Free State's secession in 1922, only members of the royal family were appointed to the order, the last in 1936. The last surviving knight was Prince Henry, Duke of Gloucester, who died on 10 June 1974. Although dormant, the order technically still exists, and may be used as an award at any time.

Imperial orders
These orders, relating to the British Raj or the British Indian Empire, are also dormant. The senior order, the Order of the Star of India, was divided into three grades, Knight Grand Commander, Knight Commander and Companion, of which the first and highest was conferred upon the Princes and Chiefs of Indian states and upon important British civil servants working in India. Women were not eligible to receive the award. The junior order, the Order of the Indian Empire, was divided into the same ranks and also excluded women. The third order, the Order of the Crown of India, was used exclusively to honour women. Its members, all sharing a single grade, consisted of the wives and close female relatives of Indian Princes or Chiefs; the Viceroy or Governor-General; the Governors of Bombay, Madras and Bengal; the Principal Secretary of State for India; and the Commander-in-Chief in India. Upon Indian independence in 1947, appointments to all these orders ceased.

HH Maharaja Tej Singh Prabhakar Bahadur of Alwar, who was a KCSI and the last surviving member of the Order of the Star of India, died in February 2009, aged 97. The last surviving member of the Order of the Indian Empire, HH Maharaja Meghrajji III of Dhrangadhra-Halvad, a KCIE died in August 2010, aged 87. Queen Elizabeth II was appointed to the Order of the Crown of India (then as Princess Elizabeth) and was the last surviving former member of that order until her death in September 2022, aged 96. The King still remains the Sovereign of the Indian orders as they have never been abolished.

The Order of Burma was created in May 1940 by King George VI of the United Kingdom to recognise subjects of the British colony of Burma (Myanmar) after it became a distinct colony, separate from British India. This order had one class which entitled the member to the postnominal letters OB but no title. It was originally intended to reward long and faithful service by military and police. In 1945 the Royal Warrant was altered to allow for membership for acts of gallantry as well as meritorious service. The Order was one of the rarest awarded with only 33 appointments by the time appointments were discontinued in 1948 when Burma declared independence.

Royal Guelphic Order
The Royal Guelphic Order, also known as the Hanoverian Guelphic Order, was an honour founded by George, Prince Regent in the name of his father King George III in 1815. In the United Kingdom, it was used only briefly, until the death of William IV in 1837. That is when the personal union with the Kingdom of Hanover ended due to the Hanover throne succession, which followed Salic Law, unlike the United Kingdom, where women could inherit the throne. The order continued for some time as a national order of Hanover, until the Kingdom of Prussia’s defeat and forced dissolution in 1866. Since then, it has been a house order to be awarded by the House of Hanover. The order's current head is Ernst August Prinz von Hanover, head of the House of Hanover. The Order includes two Divisions, Civil and Military. During the personal union of the United Kingdom and Hanover, it originally had three classes. Today, after several reorganizations since 1841, it is a house order with four classes and an additional Cross of Merit.

Decorations
Current awarded decorations in order of wear:

On 1 July 2009, BBC News reported that the Queen had approved a new posthumous award, the Elizabeth Cross, honouring members of the armed forces killed in action or by terrorist attack since World War II. The cross itself is given to the deceased's family.

Hereditary peerage
There are five ranks of hereditary peerage: duke, marquess, earl, viscount, and baron. Until the mid-20th century, peerages were usually hereditary. Until the end of the 20th century, English, Scottish, British, and UK peerages (except, until very recent times, those for the time being held by women) carried the right to a seat in the House of Lords.

Hereditary peerages are now normally given only to Royal Family members. The most recent were the grants to: then-Queen Elizabeth's youngest son, Prince Edward, Earl of Wessex, on his marriage in 1999; the Queen's grandson Prince William, made the Duke of Cambridge on the morning before his marriage to Catherine Middleton on 29 April 2011; and the Queen's grandson Prince Harry, made the Duke of Sussex on the morning before his marriage to Meghan Markle on 19 May 2018. No hereditary peerages were granted to commoners after the Labour Party came to power in 1964, until Margaret Thatcher tentatively reintroduced them by two grants to men with no sons in 1983: Speaker of the House of Commons George Thomas; and former deputy prime minister William Whitelaw. Both titles died with their holders. She followed this with an earldom in 1984 for former prime minister Harold Macmillan not long before his death, reviving a traditional honour for former prime ministers. Macmillan's grandson succeeded him on his death in 1986. No hereditary peerages have been created since, and Thatcher's own title was a life peerage (see further explanation below). The concession of a baronetcy (i.e., hereditary knighthood), was granted to her husband Denis following her resignation (explained below).

Hereditary peerages are not "honours under the crown" and cannot normally be withdrawn. A peerage can be revoked only by a specific Act of Parliament, and then only for the current holder, in the case of hereditary peerages. A hereditary peer can disclaim his peerage for his own lifetime under Peerage Act 1963 within a year of inheriting the title.

Life peerage
Modern life peerages were introduced under the Appellate Jurisdiction Act 1876, following a test case, the Wensleydale Peerage Case (1856), which established that non-statutory life peers would not have the right to sit in the House of Lords. At that time, life peerages were intended only for law lords, who would introduce appellate legal expertise into the chamber without conferring rights on future generations, which might not have legal experts.

Subsequently, under the Life Peerages Act 1958, life peerages became the norm for all new grants outside the Royal Family. This was viewed as a modest reform of the second legislative chamber. However, its effects were gradual because hereditary peers and their successors retained their rights to attend and vote with the life peers. All hereditary peers, except 92 chosen in a secret ballot of all hereditary peers, have now lost their rights to sit in the second chamber. All hereditary peers, however, retain dining rights to the House of Lords, viewed as "the best club in London".

All life peers hold the rank of baron and automatically have the right to sit in the House of Lords. The title exists only for the duration of their own lifetime and is not passed to their heirs, although the children of life peers enjoy the same courtesy titles as those of hereditary peers. Some life peerages are created as an honour for achievement, some for the specific purpose of introducing legislators from the various political parties (known as working peers), and some under the Appellate Jurisdiction Act 1876, with a view to judicial work. There is a discrete number appointed as "People's Peers", recommended by the general public. Twenty-six Church of England bishops have a seat in the House of Lords.

As a life peerage is not technically an "honour under the Crown", it cannot normally be withdrawn once granted. Thus, while knighthoods have been withdrawn as "honours under the Crown", convicted criminals who have served their sentences have returned to the House of Lords. In the case of Lord Archer of Weston-super-Mare, he has chosen only to exercise dining rights and has not spoken in Parliament since released from his perjury conviction.

Baronetcy
A baronetcy is the lowest hereditary title in the United Kingdom. It carries the title sir. In order of precedence, a Baronetcy is below a Barony but above most knighthoods. Baronetcies are not peerages. When a baronetcy becomes vacant on the holder's death, the heir is required to register the proofs of succession if he wishes to be addressed as "Sir". The Official Roll of Baronets is kept at the Ministry of Justice, transferred from the Home Office in 2001, by the Registrar of the Baronetage. Anyone who considers that he is entitled to be entered on the roll may petition the Crown through the Lord Chancellor. Anyone succeeding to a baronetcy must exhibit proofs of succession to the Lord Chancellor. A person who is not entered on the roll will not be addressed or mentioned as a baronet or accorded precedence as a baronet, effectively declining the honour. The baronetcy can be revived at any time on provision of acceptable proofs of succession. As of 2017, 208 baronetcies are listed as presumedly not extinct but awaiting proofs of succession.

As with hereditary peerages, baronetcies generally ceased to be granted after the Labour Party came to power in 1964. The sole subsequent exception was a baronetcy created in 1990 for the husband of Margaret Thatcher, Sir Denis Thatcher, later inherited by their son Mark Thatcher.

Knighthood
Descended from medieval chivalry, knights exist both within the orders of chivalry and in a class known as Knights Bachelor. Regular recipients include High Court judges and, to a lesser extent, Chief Constables of larger police forces. Knighthood carries the title Sir; the female equivalent Dame exists only within the orders of chivalry—Dame Commander of the Order of the British Empire (DBE) is usually awarded as an equivalent of a Knight Bachelor.

Order of St John
Members of the Most Venerable Order of the Hospital of St John of Jerusalem (founded 1888) may wear the Order's insignia, but the ranks within the Order of St John do not confer official rank in the order of precedence. Likewise, the abbreviations or post-nominal initials associated with the various grades of membership in the Order of St John do not indicate precedence among the other orders. Thus, someone knighted in the order does not take precedence over the knights of other British orders, nor should they be addressed as "Sir" or "Dame".

Other orders
Other British and Commonwealth orders, decorations, and medals exist that do not carry titles but entitle the holder to place post-nominal letters after his or her name, as do a small number of Royal Family Orders.

British honours in the Commonwealth realms
Until the mid-20th century, the British honours system was the primary—and generally the sole—honours system utilised across the various dominions and territories of the British Empire, which became the Commonwealth of Nations from 1949. Today, British honours and decorations continue to be awarded to citizens of Commonwealth realms and British Overseas Territories. Within the Commonwealth realms, however, the nature of the British honour or decoration awarded and the permissibility of its conferment varies from government to government. The British honours system comprises both dynastic honours, the personal gift of the Sovereign, and British state honours or decorations (known as imperial honours or decorations outside the UK), which are not. Dynastic honours continue to be conferred by the Sovereign across the Commonwealth realms, although outside the United Kingdom they are typically non-titular honours, such as the Order of Merit or the lower grades of the Royal Victorian Order.

In 1917 and 1919, the Canadian House of Commons passed the Nickle Resolutions, which although non-binding gradually ended the conferment of titular honours—peerages, baronetcies, and knighthoods—to Canadians. Occasional conferments of knighthoods (in 1934 and 1935) and imperial honours, notably after the Second World War, continued until 1955, when the Canadian government officially ended all awards of imperial honours to Canadians. In 1967, Canada established its own honours system with the Order of Canada, created its own system of bravery decorations in 1972, and its own system of military decorations for valour in 1993. Canadian service personnel remained eligible to receive the imperial Victoria Cross until 1993, when a Canadian version was instituted. Canadian citizens remain eligible for imperial honours, including peerages and knighthoods, presumably for achievements within Great Britain, however such conferment may involve individual approval by the Canadian government.

In 1975, the Australian government established its own honours system, creating the Order of Australia and its own system of bravery decorations. Indigenous police and fire service decorations followed from 1986, with a new system of military decorations created in 1991. Imperial honours continued to be conferred on Australians through 1989, when the last recommendations were made. With effect from 5 October 1992, the Australian government discontinued the awarding of imperial honours.

In 1975, New Zealand also instituted its first indigenous honour, the Queen's Service Order, followed by the Order of New Zealand in 1987. In 1996, it replaced imperial honours with the New Zealand Order of Merit, and replaced imperial gallantry and bravery decorations with New Zealand decorations in 1999.

Other Commonwealth realms have continued to apply the imperial honours system together with their own honours systems. Jamaica established its own honours system in 1969, passing the National Honours and Awards Act. Saint Lucia followed in 1980; the Solomon Islands in 1981; Belize in 1991; Antigua and Barbuda in 1998; Papua New Guinea in 2004; and Grenada in 2007. The government of the Bahamas continues to solely use imperial honours. In 2007, it passed a National Honours Act establishing a Bahamian honours system; however, it had not come into effect as of 2015.

In practice, legislation across the Commonwealth realms regulating the awarding of imperial honours to citizens of a realm, including knighthoods and damehoods, does not necessarily prevent a citizen of a Commonwealth realm from receiving a substantive award of an imperial honour for service in the United Kingdom or to its government. There continue to be numerous examples of Canadians, New Zealanders, and Australians who the British government have honored and can use the honour or its accompanying style when they are resident in their own nation or the United Kingdom.

Honorary awards
Citizens of countries that do not have the King as their head of state sometimes have honours conferred upon them, in which case the awards are "honorary". In the case of knighthoods, the holders are entitled to place initials after their name but not style themselves "Sir" as they are not entitled to receive the accolade. Examples of foreigners with honorary knighthoods are Billy Graham, Bill Gates, Bob Geldof, Bono and Rudolph Giuliani, while Arsène Wenger and Gérard Houllier are honorary OBEs. Honorary knighthoods are of Orders of Chivalry rather than as Knights Bachelor as the latter confers no postnominal letters.

Recipients of honorary awards who later become subjects of His Majesty may apply to convert their awards to substantive ones. Examples of this are Marjorie Scardino, American CEO of Pearson PLC, and Yehudi Menuhin, the American-born violinist and conductor. They were granted an honorary damehood and knighthood respectively while still American citizens, and converted them to substantive awards after they assumed British nationality, becoming Dame Marjorie and Sir Yehudi. Menuhin later accepted a life peerage with the title Lord Menuhin.

Sir Tony O'Reilly, who holds both British and Irish nationality, uses the style "Sir", but has also gained approval from the Irish Government to accept the award as is necessary under the Irish Constitution. Elisabeth Schwarzkopf, the German soprano, became entitled to be known as "Dame Elisabeth" when she took British nationality. Irish-born Sir Terry Wogan was initially awarded an honorary knighthood, but by the time he collected the accolade from the Queen in December 2005, he had obtained dual nationality and the award was upgraded to a substantive knighthood.

Bob Geldof is often erroneously referred to as "Sir Bob"; he is not entitled to this style as an honorary knight as he is a citizen of the Republic of Ireland (i.e., he is not a citizen of a Commonwealth realm).

There is no law in the UK preventing foreigners from holding a peerage (e.g., Newburgh), though only Commonwealth and Irish citizens may sit in the House of Lords. This has yet to be tested under the new arrangements. However, some other countries have laws restricting the acceptances of awards granted to would-be recipients by foreign powers. In Canada, where the House of Commons of Canada (but not the Senate of Canada) has opposed the granting of titular honours with its (non-binding) Nickle Resolution, then Prime Minister Jean Chrétien advised the Queen not to grant Conrad Black a titular honour while he remained a Canadian citizen (see Black v Chrétien).

Ceremony
Each year, around 2,600 people receive their awards personally from the monarch or another member of the Royal Family. The majority of investitures take place at Buckingham Palace, but an annual ceremony also takes place at the Palace of Holyroodhouse in Edinburgh (during Holyrood Week), and some happen at Windsor Castle. There are approximately 120 recipients at each Investiture. In recent years the King, the Prince of Wales and The Princess Royal have all held investitures.

During the ceremony, the monarch enters the ballroom of Buckingham Palace attended by two Gurkha orderly officers, a tradition begun in 1876 by Queen Victoria. On duty on the dais are five members of the King's Body Guard of the Yeomen of the Guard, which was created in 1485 by Henry VII; they are the oldest, but not most senior, military corps in the United Kingdom. Three Lady or Gentleman Ushers are on duty to help look after the recipients and their guests.

The King or his representative is escorted by either the Lord Chamberlain or the Lord Steward. After the national anthem has been played, he stands to the right of the King and announces the name of each recipient and the achievement for which they are being decorated. The King or his representative is provided with a brief background for each recipient by their equerry as they approach to receive their decorations.

Men who are to be knighted kneel on an investiture stool to receive the accolade, which the King bestows. Elizabeth II used the sword used by her father, George VI as Duke of York and Colonel of the Scots Guards. Only men are knighted. Women receive their honours in the same fashion as men receiving decorations or medals, even if they are receiving a damehood. Occasionally an award for gallantry may be made posthumously and in this case, the King or his representative presents the decoration or medal to the recipient's next-of-kin in private before the public investiture begins. The Elizabeth Cross was created especially for this purpose.

After the investiture ceremony, those honoured are ushered out of the ballroom into the Inner Quadrangle of Buckingham Palace, where the royal rota's photographers are stationed. Here recipients are photographed with their awards. In some cases, members of the press may interview some of the more well-known people who have been honoured.

Refusal
In 2003, Sunday Times published a list of almost 300 people who had declined an honour between 1951 and 1999. In 2020, the Guardian reported based on a Freedom of Information request, that the number of people refusing an honour had more than doubled in the previous nine years.

Notable examples

 * Outgoing prime ministers:
 * Neville Chamberlain declined an earldom and appointment as Knight of the Garter.
 * Sir Winston Churchill declined a dukedom in order to remain in the House of Commons and to allow his son Randolph Churchill a political career.
 * Sir Edward Heath declined a life peerage in order to remain in the House of Commons.
 * Sir John Major declined a life peerage, saying elevation to the House of Lords was incompatible with retirement from politics.
 * Sir Tony Blair declined a life peerage.
 * Gordon Brown declined a life peerage.
 * Joseph Conrad, novelist
 * John Cleese declined appointment as CBE and later declined a life peerage.
 * Frank Pick declined both a knighthood and a peerage.
 * T. E. Lawrence declined a knighthood as he felt that Britain had betrayed the Arabs.
 * David Bowie declined a knighthood.
 * Graham Greene, novelist
 * Stephen Hawking, physicist, reportedly turned down a knighthood because he "does not like titles."
 * Benjamin Zephaniah declined an OBE, describing it as a legacy of colonialism.
 * George Bernard Shaw declined an Order of Merit, replying that "merit" in authorship could only be determined by the posthumous verdict of history.
 * Honor Blackman declined a CBE as she was a republican.
 * Albert Finney, actor (in 2000; had previously declined CBE in 1980).
 * John Lennon returned his MBE (awarded in 1965) in 1969, although no official provision exists for renouncing an honour.
 * Geraldine McEwan declined a damehood.
 * Vanessa Redgrave declined a damehood in 1999, but accepted it in 2022. She also accepted a CBE in 1967.
 * Gareth Peirce declined a CBE.

Revocation
Honours are sometimes revoked (forfeited), for example if a recipient is subsequently convicted of a serious criminal offence. The Honours Forfeiture Committee is an ad hoc committee convened under the chairmanship of the Head of the Home Civil Service, to consider cases where information has been received which indicates an individual is unsuitable to hold an award. Sometimes the original decision to grant an honour was made on the basis of inaccurate information (including through manipulation of the public nominations system), but normally cases relate to actions that took place after the award was made. Recommendations are made to the monarch of the United Kingdom, who has the sole authority to rescind an honour.

In 2009, Gordon Brown confirmed that the process remains as set out in 1994 by the then Prime Minister John Major in a written answer to the House of Commons:"The statutes of most orders of knighthood and the royal warrants of decorations and medals include provision for the Queen to 'cancel and annul' appointments and awards. Cancellation is considered in cases where retention of the appointment or award would bring the honours system into disrepute. There are no set guidelines for cancellations, which are considered on a case-by-case basis. Since 1979, the London Gazette has published details of cancellations of 15 appointments and awards—three knighthoods, one CBE, five OBEs, four MBEs and two BEMs."

In October 2016, the House of Commons approved a motion to ask the Honours Forfeiture Committee to strip Sir Philip Green of his knighthood for his role in the downfall of British Home Stores. It was the first time MPs voted to recommend rescinding a knighthood.

Notable examples

 * Kaiser Wilhelm II was a Knight of the Garter prior to the start of the First World War, when it was revoked.
 * Roger Casement had been honoured for his human rights work while a British diplomat; however, upon being convicted on 30 June 1916 of High Treason for his role in the Irish 1916 Easter Rising, the King directed that Casement would cease to be a member of the Order of St Michael and St George, his name being stricken from the register, and letters patent were also issued "degrading" him "from the degree, title and dignity of Knight Bachelor". He was executed that August.
 * Benito Mussolini was stripped of his honorary knighthood after Italy declared war on the United Kingdom in 1940.
 * Anthony Blunt, knighted as Surveyor of the Queen's Pictures for his services to Art, lost his knighthood in the 1980s when he was revealed to be the "Fourth Man" in the early 1950s Burgess and Maclean spying scandal which also touched on the 1960s Philby spying affair, as a result of which he confessed to the security services. Although Blunt was never charged or convicted, the honour was withdrawn on the advice of the then Prime Minister, Margaret Thatcher.
 * Nicolae Ceaușescu forfeited his honorary knighthood that he earlier received for his friendship with Western democracies.
 * Albert Henry was the former Premier of the Cook Islands. He was later convicted of electoral fraud in the 1980s.
 * Terry Lewis, knighted for his services to Queensland police, was stripped of his knighthood in 1993 after being sentenced to prison on charges of corruption and forgery as a result of the findings of the Fitzgerald Inquiry.
 * Jack Lyons, who had received his knighthood for his huge charitable donations and services to industry, lost it when he was convicted of fraud in the 1980s.
 * Robert Mugabe was stripped of his honorary GCB after calls from the Government to the Royal Family due to the crisis in Zimbabwe under his régime, including hyperinflation, and violence in the 2008 presidential elections.
 * Lester Piggott, the high-profile jockey, had his OBE removed after being convicted and sentenced to imprisonment for tax evasion.
 * Fred Goodwin, the former CEO of Royal Bank of Scotland, had his knighthood annulled, after the Financial Services Authority found that the failure of RBS had an important role in the financial crisis of 2008–9, because Goodwin was the dominant decision maker at the time.
 * James Crosby, former CEO of HBOS and non-executive director of the Financial Services Authority, was stripped of his knighthood at his request in April 2013 as the result of the bank's collapse during the UK financial crisis.

Order of Wear
Honours, decorations and medals are arranged in the "Order of Wear", an official list which describes the order in which they should be worn. Updates to the Order of Wear are published in The London Gazette when necessary. The current Order of Wear was published on 11 January 2019. Additional information on the social events at which an award may be worn is contained in the insignia case given to each recipient.

The list places the Victoria Cross and George Cross at the top, followed by the orders of knighthood arranged in order of date of creation. Below the Knights of the Garter and Thistle, individuals of a higher rank precede those of a lower rank. For instance, a Knight Grand Cross of any order precedes any Knight Commander. For those of equal rank, members of the higher-ranked Order take precedence. Within the same Order, precedence is accorded to that individual who received the honour earlier.

Not all orders have the same number of ranks. The Order of Merit, the Order of the Companions of Honour, the Distinguished Service Order and the Imperial Service Order are slightly different, being single-rank honours, and have been placed at appropriate positions of seniority. The precedence of Knight Bachelor is below the knights of the different orders and above those with the rank of Commander or lower.

Decorations are followed by medals of various categories, being arranged in date order within each section. These are followed by Commonwealth and honorary foreign awards of any level. Miscellaneous details are explained in notes at the bottom of the list.

The order of wear is not connected to and should not be confused with the order of precedence.

Style
For peers, see forms of address in the United Kingdom.

For baronets, the style Sir John Smith, Bt (or Bart) is used. Their wives are styled Lady Smith. A baronetess is styled Dame Jane Smith, Btss.

For knights, the style Sir John Smith [ postnominals] is used, attaching the proper postnominal letters depending on rank and order (for knights bachelor, no postnominal letters are used). Their wives are styled Lady Smith, with no postnominal letters. A dame is styled Dame Jane Smith, [postnominals]. More familiar references or oral addresses use the first name only, e.g. Sir John, or Dame Joan.

Wives of knights and baronets are styled Lady Smith, although customarily no courtesy title is automatically reciprocated to male consorts.

Recipients of orders, decorations and medals receive no styling of Sir or Dame, but they may attach the according postnominal letters to their name, e.g., John Smith, VC. Recipients of gallantry awards may be referred to in Parliament as "gallant", in addition to "honourable", "noble", etc.: The honourable and gallant Gentleman.

Bailiffs or Dames Grand Cross (GCStJ), Knights/Dames of Justice/Grace (KStJ/DStJ), Commander Brothers/Sisters (CStJ), Officer Brothers/Sisters (OStJ), Serving Brothers/Sisters (SBStJ/SSStJ), and Esquires (EsqStJ) of the Order of St John do not receive any special styling with regards to prenominal address i.e. Sir or Dame. They may, however, attach the relevant postnominal initials (solely) within internal correspondence of the Order. In the Priory of Australia, Canada and the United States, the rank of Serving Brother/Sister is no longer granted. The rank now awarded is referred to as Member of the Order of St John for both men and women.

For honours bestowed upon those in the entertainment industry (e.g., Anthony Hopkins, Maggie Smith), it is an accepted practice to omit the title for professional credits.

Reform
Reforms of the system occur from time to time. In the last century notable changes to the system have included a Royal Commission in 1925 following the scandal in which Prime Minister David Lloyd George was found to be selling honours. The sale of British Honours, including titles, is now prohibited by the Honours (Prevention of Abuses) Act 1925.

A significant set of reforms were enacted in 1993 under the Conservative Prime Minister John Major, with the intention of providing a more merits-based system for honouring service and achievement. Among other outcomes, this removed the rank distinctions that were explicitly linked to certain military awards, and ended (with the exception of High Court Judges) the awarding of ex officio honours. The reforms also provided for people to be nominated for an honour by members of the public, as well as placing more emphasis within the system on recognising and rewarding voluntary service in particular.

In July 2004, the Public Administration Select Committee (PASC) of the House of Commons and, concurrently, Sir Hayden Phillips, Permanent Secretary at the Department of Constitutional Affairs, both concluded reviews of the system. The PASC recommended some radical changes; Sir Hayden concentrated on issues of procedure and transparency. In February 2005, the Government responded to both reviews by issuing a Command paper detailing which of the proposed changes it had accepted. These included diversifying and opening up the system of honours selection committees for the Prime Minister's list and also the introduction of a miniature badge. Furthermore, the 2004 review suggested a regular report on the transparency and operation of the system at a suggested frequency of every 3 years. These reviews have taken place in 2008, 2011, 2014, 2018 and 2023. The most recent review covers the period 2019 to 2023 and shows a notable shift towards community and voluntary recognition, and a continued emphasis on ensuring that the Honours System reflects British societal diversity.

As of 2012, same-sex civil partners of individual recipients of British honours are not themselves granted honours by way of their partnered relation. In July 2012, Conservative MP Oliver Colvile introduced a private member's bill, titled "Honours (Equality of Titles for Partners) Bill", to amend the honours system to both allow husbands of those made dames and for civil partners of recipients to receive honours by their relationship statuses.

In May 2020, a special COVID nomination process was introduced to provide a more streamlined consideration process and accessible route for the public to nominate those in society who had responded to the COVID-19 pandemic. Compared with the existing public nomination form, it required substantially less information in order to be accepted and processed. This process was ended in May 2022.

Controversies
A scandal in the 1920s was the sale by Maundy Gregory of honours and peerages to raise political funds for David Lloyd George.

In 1976, the Harold Wilson era was mired by controversy over the 1976 Prime Minister's Resignation Honours, which became known as the "Lavender List".

In 2006, The Sunday Times newspaper revealed that every donor who had given £1,000,000 or more to the Labour Party since 1997 was given a Knighthood or a Peerage (see Cash-for-Honours scandal). Moreover, the government had given honours to 12 of the 14 individuals who have donated more than £200,000 to Labour and of the 22 who donated more than £100,000, 17 received honours. An investigation by the Crown Prosecution Service did not lead to any charges being made.

The Times published an analysis of the recipients of honours in December 2015 which showed that 46% of those getting knighthoods and above in 2015 had been to fee-paying public schools. In 1955 it was 50%. Only 6.55% of the population attends such schools. 27% had been to Oxford or Cambridge universities (18% in 1955).

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Electroporation

Electroporation, or electropermeabilization, is a technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane. This may allow chemicals, drugs, electrode arrays or DNA to be introduced into the cell (also called electrotransfer).

In microbiology, the process of electroporation is often used to transform bacteria, yeast, or plant protoplasts by introducing new coding DNA. If bacteria and plasmids are mixed together, the plasmids can be transferred into the bacteria after electroporation, though depending on what is being transferred, cell-penetrating peptides or cell squeeze could also be used. Electroporation works by passing thousands of volts (~8 kV/cm) across suspended cells in an electroporation cuvette. Afterwards, the cells have to be handled carefully until they have had a chance to divide, producing new cells that contain reproduced plasmids. This process is approximately ten times more effective in increasing cell membrane's permeability than chemical transformation, although many laboratories lack the specialized equipment needed for electroporation.

Electroporation is also highly efficient for the introduction of foreign genes into tissue culture cells, especially mammalian cells. For example, it is used in the process of producing knockout mice, as well as in tumor treatment, gene therapy, and cell-based therapy. The process of introducing foreign DNA into eukaryotic cells is known as transfection. Electroporation is highly effective for transfecting cells in suspension using electroporation cuvettes. Electroporation has proven efficient for use on tissues in vivo, for in utero applications as well as in ovo transfection. Adherent cells can also be transfected using electroporation, providing researchers with an alternative to trypsinizing their cells prior to transfection. One downside to electroporation, however, is that after the process the gene expression of over 7,000 genes can be affected. This can cause problems in studies where gene expression has to be controlled to ensure accurate and precise results.

Although bulk electroporation has many benefits over physical delivery methods such as microinjections and gene guns, it still has limitations, including low cell viability. Miniaturization of electroporation has been studied, leading to microelectroporation and nanotransfection of tissue utilizing electroporation-based techniques via nanochannels to minimally invasively deliver cargo to the cells.

Electroporation has also been used as a mechanism to trigger cell fusion. Artificially induced cell fusion can be used to investigate and treat different diseases, like diabetes,  regenerate axons of the central nerve system, and produce cells with desired properties, such as in cell vaccines for cancer immunotherapy. However, the first and most known application of cell fusion is production of monoclonal antibodies in hybridoma technology, where hybrid cell lines (hybridomas) are formed by fusing specific antibody-producing B lymphocytes with a myeloma (B lymphocyte cancer) cell line.

Laboratory practice
Electroporation is performed with electroporators, purpose-built appliances that create an electrostatic field in a cell solution. The cell suspension is pipetted into a glass or plastic cuvette which has two aluminium electrodes on its sides. For bacterial electroporation, typically a suspension of around 50 microliters is used. Prior to electroporation, this suspension of bacteria is mixed with the plasmid to be transformed. The mixture is pipetted into the cuvette, the voltage and capacitance are set, and the cuvette is inserted into the electroporator. The process requires direct contact between the electrodes and the suspension. Immediately after electroporation, one milliliter of liquid medium is added to the bacteria (in the cuvette or in an Eppendorf tube), and the tube is incubated at the bacteria's optimal temperature for an hour or more to allow recovery of the cells and expression of the plasmid, followed by bacterial culture on agar plates.

The success of the electroporation depends greatly on the purity of the plasmid solution, especially on its salt content. Solutions with high salt concentrations might cause an electrical discharge (known as arcing), which often reduces the viability of the bacteria. For a further detailed investigation of the process, more attention should be paid to the output impedance of the porator device and the input impedance of the cells suspension (e.g. salt content).

Since the cell membrane is not able to pass current (except in ion channels), it acts as an electrical capacitor. Subjecting membranes to a high-voltage electric field results in their temporary breakdown, resulting in pores that are large enough to allow macromolecules (such as DNA) to enter or leave the cell.

Additionally, electroporation can be used to increase permeability of cells during in Utero injections and surgeries. Particularly, the electroporation allows for a more efficient transfection of DNA, RNA, shRNA, and all nucleic acids into the cells of mice and rats. The success of in vivo electroporation depends greatly on voltage, repetition, pulses, and duration. Developing central nervous systems are most effective for in vivo electroporation due to the visibility of ventricles for injections of nucleic acids, as well as the increased permeability of dividing cells. Electroporation of injected in utero embryos is performed through the uterus wall, often with forceps-type electrodes to limit damage to the embryo.

In vitro and animal studies
In vivo gene electrotransfer was first described in 1991 and today there are many preclinical studies of gene electrotransfer. The method is used to deliver large variety of therapeutic genes for potential treatment of several diseases, such as: disorders in immune system, tumors, metabolic disorders, monogenetic diseases, cardiovascular diseases, analgesia....

With regards to irreversible electroporation, the first successful treatment of malignant cutaneous tumors implanted in mice was completed in 2007 by a group of scientists who achieved complete tumor ablation in 12 out of 13 mice. They accomplished this by sending 80 pulses of 100 microseconds at 0.3 Hz with an electrical field magnitude of 2500 V/cm to treat the cutaneous tumors. Currently, a number of companies, including AngioDynamics, Inc. and VoltMed, Inc., are continuing to develop and deploy irreversible electroporation-based technologies within clinical environments.

The first group to look at electroporation for medical applications was led by Lluis M Mir at the Institute Gustave Roussy. In this case, they looked at the use of reversible electroporation in conjunction with impermeable macromolecules. The first research looking at how nanosecond pulses might be used on human cells was conducted by researchers at Eastern Virginia Medical School and Old Dominion University, and published in 2003.

Medical applications
The first medical application of electroporation was used for introducing poorly permeant anticancer drugs into tumor nodules. Soon also gene electrotransfer became of special interest because of its low cost, easiness of realization and safety. Namely, viral vectors can have serious limitations in terms of immunogenicity and pathogenicity when used for DNA transfer.

Irreversible electroporation is being used and evaluated as cardiac ablation therapy to kill very small areas of heart muscle. This is done to treat irregularities of heart rhythm. A cardiac catheter delivers trains of high-voltage ultra-rapid electrical pulses that form irreversible pores in cell membranes, resulting in cell death. It is thought to allow better selectivity than the previous techniques, which used heat or cold to kill larger volumes of muscle.

A higher voltage of electroporation was found in pigs to irreversibly destroy target cells within a narrow range while leaving neighboring cells unaffected, and thus represents a promising new treatment for cancer, heart disease and other disease states that require removal of tissue. Irreversible electroporation (IRE) has since proven effective in treating human cancer, with surgeons at Johns Hopkins and other institutions now using the technology to treat pancreatic cancer previously thought to be unresectable.

Also first phase I clinical trial of gene electrotransfer in patients with metastatic melanoma was reported. Electroporation mediated delivery of a plasmid coding gene for interleukin-12 (pIL-12) was performed and safety, tolerability and therapeutic effect were monitored. Study concluded, that gene electrotransfer with pIL-12 is safe and well tolerated. In addition partial or complete response was observed also in distant non treated metastases, suggesting the systemic treatment effect. Based on these results they are already planning to move to Phase II clinical study. There are currently several ongoing clinical studies of gene electrotransfer where safety, tolerability and effectiveness of immunization with DNA vaccine, which is administered by the electric pulses is monitored.

Although the method is not systemic, but strictly local one, it is still the most efficient non-viral strategy for gene delivery.

N-TIRE
A recent technique called non-thermal irreversible electroporation (N-TIRE) has proven successful in treating many different types of tumors and other unwanted tissue. This procedure is done using small electrodes (about 1mm in diameter), placed either inside or surrounding the target tissue to apply short, repetitive bursts of electricity at a predetermined voltage and frequency. These bursts of electricity increase the resting transmembrane potential (TMP), so that nanopores form in the plasma membrane. When the electricity applied to the tissue is above the electric field threshold of the target tissue, the cells become permanently permeable from the formation of nanopores. As a result, the cells are unable to repair the damage and die due to a loss of homeostasis. N-TIRE is unique to other tumor ablation techniques in that it does not create thermal damage to the tissue around it.

Reversible electroporation
Contrastingly, reversible electroporation occurs when the electricity applied with the electrodes is below the electric field threshold of the target tissue. Because the electricity applied is below the cells' threshold, it allows the cells to repair their phospholipid bilayer and continue on with their normal cell functions. Reversible electroporation is typically done with treatments that involve getting a drug or gene (or other molecule that is not normally permeable to the cell membrane) into the cell. Not all tissue has the same electric field threshold; therefore careful calculations need to be made prior to a treatment to ensure safety and efficacy.

One major advantage of using N-TIRE is that, when done correctly according to careful calculations, it only affects the target tissue. Proteins, the extracellular matrix, and critical structures such as blood vessels and nerves are all unaffected and left healthy by this treatment. This allows for a quicker recovery, and facilitates a more rapid replacement of dead tumor cells with healthy cells.

Before doing the procedure, scientists must carefully calculate exactly what needs to be done and treat each patient on an individual case-by-case basis. To do this, imaging technology such as CT scans and MRI's are commonly used to create a 3D image of the tumor. From this information, they can approximate the volume of the tumor and decide on the best course of action including the insertion site of electrodes, the angle they are inserted in, the voltage needed, and more, using software technology. Often, a CT machine will be used to help with the placement of electrodes during the procedure, particularly when the electrodes are being used to treat tumors in the brain.

The entire procedure is very quick, typically taking about five minutes. The success rate of these procedures is high and is very promising for future treatment in humans. One disadvantage to using N-TIRE is that the electricity delivered from the electrodes can stimulate muscle cells to contract, which could have lethal consequences depending on the situation. Therefore, a paralytic agent must be used when performing the procedure. The paralytic agents that have been used in such research are successful; however, there is always some risk, albeit slight, when using anesthetics.

H-FIRE
A more recent technique has been developed called high-frequency irreversible electroporation (H-FIRE). This technique uses electrodes to apply bipolar bursts of electricity at a high frequency, as opposed to unipolar bursts of electricity at a low frequency. This type of procedure has the same tumor ablation success as N-TIRE. However, it has one distinct advantage, H-FIRE does not cause muscle contraction in the patient and therefore there is no need for a paralytic agent. Furthermore, H-FIRE has been demonstrated to produce more predictable ablations due to the lesser difference in the electrical properties of tissues at higher frequencies.

Drug and gene delivery
Electroporation can also be used to help deliver drugs or genes into the cell by applying short and intense electric pulses that transiently permeabilize cell membrane, thus allowing transport of molecules otherwise not transported through a cellular membrane. This procedure is referred to as electrochemotherapy when the molecules to be transported are chemotherapeutic agents or gene electrotransfer when the molecule to be transported is DNA. Scientists from Karolinska Institute and the University of Oxford use electroporation of exosomes to deliver siRNAs, antisense oligonucleotides, chemotherapeutic agents and proteins specifically to neurons after inject them systemically (in blood). Because these exosomes are able to cross the blood brain barrier, this protocol could solve the problem of poor delivery of medications to the central nervous system, and potentially treat Alzheimer's disease, Parkinson's disease, and brain cancer, among other conditions.

Bacterial transformation is generally the easiest way to make large amounts of a particular protein needed for biotechnology purposes or in medicine. Since gene electrotransfer is very simple, rapid and highly effective technique it first became very convenient replacement for other transformation procedures.

Recent research has shown that shock waves could be used for pre-treating the cell membrane prior to electroporation. This synergistic strategy has shown to reduce external voltage requirement and create larger pores. Also application of shock waves allow scope to target desired membrane site. This procedure allows to control the size of the pore.

Physical mechanism

Electroporation allows cellular introduction of large highly charged molecules such as DNA which would never passively diffuse across the hydrophobic bilayer core. This phenomenon indicates that the mechanism is the creation of nm-scale water-filled holes in the membrane. Electropores were optically imaged in lipid bilayer models like droplet interface bilayers and giant unilamellar vesicles, while addition of cytoskeletal proteins such as actin networks to the giant unilamellar vesicles seem to prevent the formation of visible electropores. Experimental evidences for actin networks in regulating the cell membrane permeability has also emerged. Although electroporation and dielectric breakdown both result from application of an electric field, the mechanisms involved are fundamentally different. In dielectric breakdown the barrier material is ionized, creating a conductive pathway. The material alteration is thus chemical in nature. In contrast, during electroporation the lipid molecules are not chemically altered but simply shift position, opening up a pore which acts as the conductive pathway through the bilayer as it is filled with water.

Electroporation is a dynamic phenomenon that depends on the local transmembrane voltage at each point on the cell membrane. It is generally accepted that for a given pulse duration and shape, a specific transmembrane voltage threshold exists for the manifestation of the electroporation phenomenon (from 0.5 V to 1 V). This leads to the definition of an electric field magnitude threshold for electroporation (Eth). That is, only the cells within areas where E≧Eth are electroporated. If a second threshold (Eir) is reached or surpassed, electroporation will compromise the viability of the cells, i.e., irreversible electroporation (IRE).

Electroporation is a multi-step process with several distinct phases. First, a short electrical pulse must be applied. Typical parameters would be 300–400 mV for < 1 ms across the membrane (note- the voltages used in cell experiments are typically much larger because they are being applied across large distances to the bulk solution so the resulting field across the actual membrane is only a small fraction of the applied bias). Upon application of this potential the membrane charges like a capacitor through the migration of ions from the surrounding solution. Once the critical field is achieved there is a rapid localized rearrangement in lipid morphology. The resulting structure is believed to be a "pre-pore" since it is not electrically conductive but leads rapidly to the creation of a conductive pore. Evidence for the existence of such pre-pores comes mostly from the "flickering" of pores, which suggests a transition between conductive and insulating states. It has been suggested that these pre-pores are small (~3 Å) hydrophobic defects. If this theory is correct, then the transition to a conductive state could be explained by a rearrangement at the pore edge, in which the lipid heads fold over to create a hydrophilic interface. Finally, these conductive pores can either heal, resealing the bilayer or expand, eventually rupturing it. The resultant fate depends on whether the critical defect size was exceeded which in turn depends on the applied field, local mechanical stress and bilayer edge energy.

Gene electroporation
Application of electric pulses of sufficient strength to the cell causes an increase in the trans-membrane potential difference, which provokes the membrane destabilization. Cell membrane permeability is increased and otherwise nonpermeant molecules enter the cell. Although the mechanisms of gene electrotransfer are not yet fully understood, it was shown that the introduction of DNA only occurs in the part of the membrane facing the cathode and that several steps are needed for successful transfection: electrophoretic migration of DNA towards the cell, DNA insertion into the membrane, translocation across the membrane, migration of DNA towards the nucleus, transfer of DNA across the nuclear envelope and finally gene expression. There are a number of factors that can influence the efficiency of gene electrotransfer, such as: temperature, parameters of electric pulses, DNA concentration, electroporation buffer used, cell size and the ability of cells to express transfected genes. In in vivo gene electrotransfer, DNA diffusion through extracellular matrix, properties of tissue and overall tissue conductivity are also crucial.

History
In the 1960s it was known that by applying an external electric field, a large membrane potential at the two pole of a cell can be created. In the 1970s it was discovered that when a membrane potential reached a critical level, the membrane would break down and that it could recover. By the 1980s, this opening was being used to introduce various materials/molecules into the cells.

title: Electroporation