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George III

George III (George William Frederick; 4 June 1738 –29 January 1820) was King of Great Britain and Ireland from 25 October 1760 until his death in 1820. The Acts of Union 1800 unified Great Britain and Ireland into the United Kingdom of Great Britain and Ireland, with George as its king. He was concurrently Duke and Prince-elector of Hanover in the Holy Roman Empire before becoming King of Hanover on 12 October 1814. He was a monarch of the House of Hanover, who, unlike his two predecessors, was born in Great Britain, spoke English as his first language, and never visited Hanover.

George was born during the reign of his paternal grandfather, King George II, as the first son of Frederick, Prince of Wales, and Princess Augusta of Saxe-Gotha. Following his father's death in 1751, Prince George became heir apparent and Prince of Wales. He succeeded to the throne on George II's death in 1760. The following year, he married Princess Charlotte of Mecklenburg-Strelitz, with whom he had 15 children. George III's life and reign were marked by a series of military conflicts involving his kingdoms, much of the rest of Europe, and places farther afield in Africa, the Americas and Asia. Early in his reign, Great Britain defeated France in the Seven Years' War, becoming the dominant European power in North America and India. However, Britain lost 13 of its North American colonies in the American War of Independence. Further wars against revolutionary and Napoleonic France from 1793 concluded in the defeat of Napoleon at the Battle of Waterloo in 1815. In 1807, the transatlantic slave trade was banned from the British Empire.

In the later part of his life, George had recurrent and eventually permanent mental illness. The exact nature of the mental illness is not known definitively, but historians and medical experts have suggested that his symptoms and behaviour traits were consistent with either bipolar disorder or porphyria. In 1810, George suffered a final relapse, and his eldest son, the Prince of Wales, was named Prince Regent the following year. The King died aged 81, at which time the Regent succeeded him as George IV. George III reigned during much of the Georgian and Regency eras. At the time of his death, he was the longest-lived and longest-reigning British monarch, having reigned for 59 years and 96 days; he remains the and longest-reigning male monarch in British history.

Early life

George was born in Norfolk House in St James's Square, London, on 4 June 1738. He was a grandson of King George II and the eldest son of Frederick, Prince of Wales, and Augusta of Saxe-Gotha. As he was born two months prematurely, and thought unlikely to survive, he was baptised the same day by Thomas Secker, who was both Rector of St James's Church, Piccadilly, and Bishop of Oxford. One month later, he was publicly baptised at Norfolk House, again by Secker. His godparents were King Frederick I of Sweden (for whom Lord Baltimore stood proxy), his uncle Frederick III, Duke of Saxe-Gotha (for whom Lord Carnarvon stood proxy), and his great-aunt Sophia Dorothea, Queen in Prussia (for whom Lady Charlotte Edwin stood proxy).

George grew into a healthy, reserved and shy child. The family moved to Leicester Square, where George and his younger brother Edward (later Duke of York and Albany) were educated together by private tutors. Family letters show that he could read and write in both English and German, as well as comment on political events of the time, by the age of eight. He was the first British monarch to study science systematically.

Apart from chemistry and physics, his lessons included astronomy, mathematics, French, Latin, history, music, geography, commerce, agriculture and constitutional law, along with sporting and social accomplishments such as dancing, fencing and riding. His religious education was wholly Anglican. At the age of 10, George took part in a family production of Joseph Addison's play Cato and said in the new prologue: "What, tho' a boy! It may with truth be said, A boy in England born, in England bred." Historian Romney Sedgwick argued that these lines appear "to be the source of the only historical phrase with which he is associated".

King George II disliked Prince Frederick and took little interest in his grandchildren. However, in 1751, Frederick died unexpectedly from a lung injury at the age of 44, and his son George became heir apparent to the throne and inherited his father's title of Duke of Edinburgh. The King now took more interest in his grandson and created him Prince of Wales three weeks later.

In the spring of 1756, as George approached his eighteenth birthday, the King offered him a grand establishment at St James's Palace, but George refused the offer, guided by his mother and her confidant, Lord Bute, who later served as prime minister. George's mother, now the Dowager Princess of Wales, preferred to keep George at home where she could imbue him with her strict moral values.

Accession and marriage
In 1759, George was smitten with Lady Sarah Lennox, sister of Charles Lennox, 3rd Duke of Richmond, but Lord Bute advised against the match and George abandoned his thoughts of marriage. "I am born for the happiness or misery of a great nation," he wrote, "and consequently must often act contrary to my passions." Nevertheless, George and his mother resisted attempts by the King to marry George to Princess Sophie Caroline of Brunswick-Wolfenbüttel. Sophie Caroline instead married Frederick, Margrave of Bayreuth.

The following year, at the age of 22, George succeeded to the throne when his grandfather George II died suddenly on 25 October 1760, at age 76. The search for a suitable wife intensified: after giving consideration to a number of Protestant German princesses, George's mother sent Colonel David Graeme with, on her son's behalf, an offer of marriage to Princess Charlotte of Mecklenburg-Strelitz. Charlotte accepted. While a royal household and staff were assembled for Charlotte in London, Lord Harcourt, the royal Master of the Horse, escorted her from Strelitz to London. Charlotte arrived in the afternoon of 8 September 1761 and the marriage ceremony was conducted that same evening in the Chapel Royal, St James's Palace. George and Charlotte's coronation was held at Westminster Abbey a fortnight later on 22 September. George never took a mistress (in contrast with his grandfather and his sons), and the couple enjoyed a happy marriage until his mental illness struck.

The King and Queen had 15 children—nine sons and six daughters. In 1762, George purchased Buckingham House (on the site now occupied by Buckingham Palace) for use as a family retreat. His other residences were Kew Palace and Windsor Castle. St James's Palace was retained for official use. He did not travel extensively and spent his entire life in southern England. In the 1790s, the King and his family took holidays at Weymouth, Dorset, which he thus popularised as one of the first seaside resorts in England.

Early regnal years
George, in his accession speech to Parliament, proclaimed: "Born and educated in this country, I glory in the name of Britain." He inserted this phrase into the speech, written by Lord Hardwicke, to demonstrate his desire to distance himself from his German forebears, who were perceived as caring more for Hanover than for Britain. During George III's lengthy reign, Britain was a constitutional monarchy, ruled by his ministerial government and prominent men in Parliament. Although his accession was at first welcomed by politicians of all parties, the first years of his reign were marked by political instability, largely as a result of disagreements over the Seven Years' War. George came to be perceived as favouring Tory ministers, which led to his denunciation by the Whigs as an autocrat.

On his accession, the Crown lands produced relatively little income; most revenue was generated through taxes and excise duties. George surrendered the Crown Estate to Parliamentary control in return for a civil list annuity for the support of his household and the expenses of civil government. Claims that he used the income to reward supporters with bribes and gifts are disputed by historians who say such claims "rest on nothing but falsehoods put out by disgruntled opposition". Debts amounting to over £3 million over the course of George's reign were paid by Parliament, and the civil list annuity was increased from time to time. He aided the Royal Academy of Arts with large grants from his private funds, and may have donated more than half of his personal income to charity. Of his art collection, the two most notable purchases are Johannes Vermeer's Lady at the Virginals and a set of Canalettos, but it is as a collector of books that he is best remembered. The King's Library was open and available to scholars and was the foundation of a new national library.

Legislation and politics
In May 1762, the incumbent Whig government of Thomas Pelham-Holles, 1st Duke of Newcastle, was replaced with one led by Lord Bute, a Scottish Tory. Bute's opponents worked against him by spreading the calumny that he was having an affair with the King's mother, and by exploiting anti-Scottish sentiment amongst the English. John Wilkes, a member of parliament, published The North Briton, which was both inflammatory and defamatory in its condemnation of Bute and the government. Wilkes was eventually arrested for seditious libel but he fled to France to escape punishment; he was expelled from the House of Commons and found guilty in absentia of blasphemy and libel. In 1763, after concluding the Peace of Paris which ended the war, Lord Bute resigned, allowing the Whigs under George Grenville to return to power. Britain received enormous concessions, including West Florida. Britain restored to France lucrative slave-sugar islands in the West Indies, including Guadeloupe and Martinique. France ceded Canada to Britain, in addition to all land between the Allegheny Mountains and the Mississippi River, except New Orleans, which was ceded to Spain.

Later that year, the Royal Proclamation of 1763 placed a limit upon the westward expansion of the American colonies and created an Indian reserve. The Proclamation aimed to divert colonial expansion to the north (to Nova Scotia) and to the south (Florida), and protect the British fur trade with the Indians. The Proclamation Line did not bother the majority of settled farmers, but it was unpopular with a vocal minority. This discontent ultimately contributed to conflict between the colonists and the British government. With the American colonists generally unburdened by British taxes, the government thought it appropriate for them to pay towards the defence of the colonies against native uprisings and the possibility of French incursions.

The central issue for the colonists was not the amount of taxes but whether Parliament could levy a tax without American approval, for there were no American seats in Parliament. The Americans protested that like all Englishmen they had rights to "no taxation without representation". In 1765, Grenville introduced the Stamp Act, which levied a stamp duty on every document in the British colonies in North America. Since newspapers were printed on stamped paper, those most affected by the introduction of the duty were the most effective at producing propaganda opposing the tax.

Meanwhile, George had become exasperated at Grenville's attempts to reduce the King's prerogatives, and tried, unsuccessfully, to persuade William Pitt the Elder to accept the office of prime minister. After a brief illness, which may have presaged his illnesses to come, George settled on Lord Rockingham to form a ministry, and dismissed Grenville.

Lord Rockingham, with the support of Pitt and the King, repealed Grenville's unpopular Stamp Act. Rockingham's government was weak, and he was replaced as prime minister in 1766 by Pitt, whom George created Earl of Chatham. The actions of Lord Chatham and George III in repealing the Act were so popular in America that statues of them both were erected in New York City. Lord Chatham fell ill in 1767, and Augustus FitzRoy, 3rd Duke of Grafton, took over the government. Grafton did not formally become prime minister until 1768. That year, John Wilkes returned to England, stood as a candidate in the general election, and came top of the poll in the Middlesex constituency. Wilkes was again expelled from Parliament. He was re-elected and expelled twice more, before the House of Commons resolved that his candidature was invalid and declared the runner-up as the victor. Grafton's government disintegrated in 1770, allowing the Tories led by Lord North to return to power.

Family issues and discontent in America
George was deeply devout and spent hours in prayer, but his piety was not shared by his brothers. George was appalled by what he saw as their loose morals. In 1770, his brother Prince Henry, Duke of Cumberland and Strathearn, was exposed as an adulterer. The following year, Henry married a young widow, Anne Horton. The King considered her inappropriate as a royal bride: she was from a lower social class and German law barred any children of the couple from the Hanoverian succession.

George insisted on a new law that essentially forbade members of the royal family from legally marrying without the consent of the sovereign. The subsequent bill was unpopular in Parliament, including among George's own ministers, but passed as the Royal Marriages Act 1772. Shortly afterwards, another of George's brothers, Prince William Henry, Duke of Gloucester and Edinburgh, revealed he had been secretly married to Maria, Countess Waldegrave, the illegitimate daughter of Sir Edward Walpole. The news confirmed George's opinion that he had been right to introduce the law: Maria was related to his political opponents. Neither lady was ever received at court.

Lord North's government was chiefly concerned with discontent in America. To assuage American opinion most of the custom duties were withdrawn, except for the tea duty, which in George's words was "one tax to keep up the right [to levy taxes]". In 1773, the tea ships moored in Boston Harbor were boarded by colonists and the tea was thrown overboard, an event that became known as the Boston Tea Party. In Britain, opinion hardened against the colonists, with Chatham now agreeing with North that the destruction of the tea was "certainly criminal".

With the clear support of Parliament, Lord North introduced measures, which were called the Intolerable Acts by the colonists: the Port of Boston was shut down and the charter of Massachusetts was altered so that the upper house of the legislature was appointed by the Crown instead of elected by the lower house. Up to this point, in the words of Professor Peter Thomas, George's "hopes were centred on a political solution, and he always bowed to his cabinet's opinions even when sceptical of their success. The detailed evidence of the years from 1763 to 1775 tends to exonerate George III from any real responsibility for the American Revolution." Though both the Americans and older British historians characterised George as a tyrant, in these years he acted as a constitutional monarch supporting the initiatives of his ministers.

American War of Independence

The American War of Independence was the culmination of the civil and political American Revolution. In the 1760s, a series of acts by Parliament was met with resistance in Britain's Thirteen Colonies in America. In particular they rejected new taxes levied by Parliament, a body in which they had no direct representation. The colonies had previously enjoyed a high level of autonomy in their internal affairs and viewed Parliament's acts as a denial of their rights as Englishmen. Armed conflict began between British regulars and colonial militiamen at the Battles of Lexington and Concord in April 1775. The Second Continental Congress sent petitions to the Crown for intervention with Parliament, but the King and Parliament ignored them. George declared the American leaders to be traitors and a year of fighting ensued. Thomas Paine's book Common Sense referred to George III as "the Royal Brute of Great Britain".

The colonies declared their independence in July 1776, listing twenty-seven grievances against the British king and legislature while asking the support of the populace. Among George's other offenses, the declaration charged, "He has abdicated Government here ... He has plundered our seas, ravaged our coasts, burnt our towns, and destroyed the lives of our people." The gilded equestrian statue of the King in New York was pulled down. The British captured the city in 1776 but lost Boston, and the grand strategic plan of invading from Canada and cutting off New England failed with the surrender of British Lieutenant-General John Burgoyne following the battles of Saratoga.

Prime Minister Lord North was not an ideal war leader, but George III managed to give Parliament a sense of purpose to fight, and North was able to keep his cabinet together. North's cabinet ministers the Earl of Sandwich, First Lord of the Admiralty, and Lord George Germain, Secretary of State for the Colonies, proved to lack leadership skills suited for their positions.

George III is often accused of obstinately trying to keep Great Britain at war with the rebels, despite the opinions of his own ministers. In the words of British historian George Otto Trevelyan, the King was determined "never to acknowledge the independence of the Americans, and to punish their contumacy by the indefinite prolongation of a war which promised to be eternal." He wanted to "keep the rebels harassed, anxious, and poor, until the day when, by a natural and inevitable process, discontent and disappointment were converted into penitence and remorse". Later historians defend George by saying that, in the context of the times, no king would willingly surrender such a large territory, and his conduct was far less ruthless than contemporaneous monarchs in Europe. After Saratoga, both Parliament and the British people were in favour of the war; recruitment ran at high levels and political opponents, though vocal, remained a small minority.

With the setbacks in America, Lord North asked to transfer power to Lord Chatham, whom he thought more capable, but George refused to do so; he suggested instead that Chatham serve as a subordinate minister in North's administration, but Chatham refused; he died later in the same year. North was allied to the "King's Friends" in Parliament and believed that George III had the right to exercise powers. In early 1778, Louis XVI of France (Britain's chief rival) signed a treaty of alliance with the United States. The French fleet outran the British naval blockade of the Mediterranean and sailed to America. The conflict now affected America, Europe, and India. Charles III of Spain had misgivings because of his own colonies but decided to side with France in the war in limited fashion in 1779. One faction of the Dutch Republic aided the Americans, whereas another aided Britain, whose allies included Loyalists and German auxiliaries. Lord Gower and Lord Weymouth both resigned from the government. Lord North again requested that he also be allowed to resign, but he stayed in office at George III's insistence.

During the summer of 1779, a combined French-Spanish naval fleet threatened to invade England and transport 31,000 French troops across the English Channel. George III said that Britain was confronted by the "most serious crisis the nation ever knew". In August, 66 warships entered the English channel, but sickness, hunger, and adverse winds forced the French-Spanish armada to withdraw, ending the invasion threat.

In late 1779, George III advocated sending more British warships and troops across the Atlantic to the West Indies. He boldly said: "We must risk something, otherwise we will only vegetate in this war. I own I wish either with spirit to get through it, or with a crash be ruined." In January 1780, 7,000 British troops under General Sir John Vaughan were transported to the West Indies. Nonetheless, opposition to the costly war was increasing, and in June 1780 contributed to disturbances in London known as the Gordon riots.

As late as the siege of Charleston in 1780, Loyalists could still believe in their eventual victory, as British troops inflicted defeats on the Continental forces at the Battle of Camden and the Battle of Guilford Court House. In late 1781, the news of Lord Cornwallis's surrender at the siege of Yorktown reached London; North's parliamentary support ebbed away and he resigned the following year. George drafted an abdication notice, which was never delivered. He finally accepted the defeat in America and authorized peace negotiations. Britain formally recognized the independence of the United States in the Treaties of Paris signed in 1782 and 1783. In early 1783, George III privately conceded "America is lost!" He reflected that the Northern colonies had developed into Britain's "successful rivals" in commercial trade and fishing. Up to 70,000 Loyalists fled to Canada, the Caribbean, or England.

John Adams was appointed American minister to London in 1785, by which time George had become resigned to the new relationship between his country and the former colonies. He told Adams, "I was the last to consent to the separation; but the separation having been made and having become inevitable, I have always said, as I say now, that I would be the first to meet the friendship of the United States as an independent power."

Government
With the collapse of Lord North's ministry in 1782, the Whig Lord Rockingham became prime minister for the second time, but died within months. The King then appointed Lord Shelburne to replace him. Charles James Fox, however, refused to serve under Shelburne, and demanded the appointment of William Cavendish-Bentinck, 3rd Duke of Portland. In 1783, the House of Commons forced Shelburne from office and his government was replaced by the Fox–North Coalition. Portland became prime minister, with Fox and Lord North, as foreign secretary and home secretary respectively.

The King disliked Fox intensely, for his politics as well as his character: he thought Fox unprincipled and a bad influence on the Prince of Wales. George III was distressed at having to appoint ministers not of his liking, but the Portland ministry quickly built up a majority in the House of Commons, and could not be displaced easily. He was further dismayed when the government introduced the India Bill, which proposed to reform the government of India by transferring political power from the East India Company to Parliamentary commissioners. Although George actually favoured greater control over the company, the proposed commissioners were all political allies of Fox. Immediately after the House of Commons passed it, George authorised Lord Temple to inform the House of Lords that he would regard any peer who voted for the bill as his enemy. The bill was rejected by the Lords; three days later, the Portland ministry was dismissed, and William Pitt the Younger was appointed prime minister, with Temple as his secretary of state. On 17 December 1783, Parliament voted in favour of a motion condemning the influence of the monarch in parliamentary voting as a "high crime" and Temple was forced to resign. Temple's departure destabilised the government, and three months later the government lost its majority and Parliament was dissolved; the subsequent election gave Pitt a firm mandate.

Pitt's appointment was a great victory for George. It proved that the King could appoint prime ministers on the basis of his own interpretation of the public mood without having to follow the choice of the current majority in the House of Commons. Throughout Pitt's ministry, George supported many of Pitt's political aims and created new peers at an unprecedented rate to increase the number of Pitt's supporters in the House of Lords. During and after Pitt's ministry, George was extremely popular in Britain. The British people admired him for his piety and for remaining faithful to his wife. He was fond of his children and was devastated at the death of two of his sons in infancy, in 1782 and 1783 respectively. Nevertheless, he set his children a strict regimen. They were expected to attend rigorous lessons from seven in the morning and to lead lives of religious observance and virtue. When his children strayed from George's principles of righteousness, as his sons did as young adults, he was dismayed and disappointed.

Illness
By this time, George's health was deteriorating. He had a mental illness characterised by acute mania. Until the mid-20th century, the King's illness was generally considered to be psychological. In 1966, a study by Ida Macalpine and Richard Hunter suggested that the illness was physiological, caused by the liver disorder porphyria. Although meeting with some contemporary opposition, the view gained widespread scholarly acceptance. A study of samples of George's hair published in 2005 revealed high levels of arsenic, a cause of metabolic blood disorders and thus a possible trigger for porphyria. The source of the arsenic is not known, but it could have been a component of medicines or cosmetics. The theory was also established in the public mind through influential dramatisations, such as Alan Bennett's play The Madness of George III, and in Nicholas Hytner's subsequent film. From 2010 this view has been increasingly challenged, and Macalpine and Hunter's study criticised. Recent scholarship discounts the porphyria theory and contends that George's illness was psychiatric, most probably bipolar disorder.

George may have had a brief episode of disease in 1765, and a longer episode began in the summer of 1788. At the end of the parliamentary session, he went to Cheltenham Spa to recuperate and in August visited the Bishop of Worcester at Hartlebury Castle and Viscount Mount Edgcumbe at Cotehele, Cornwall, with the Queen, and their daughters the Princess Royal and Princesses Augusta and Elizabeth. It was the furthest he had ever been from London, but his condition worsened. In November of that year, he became seriously deranged, sometimes speaking for many hours without pause, causing him to foam at the mouth and his voice to become hoarse. George would frequently repeat himself and write sentences with over 400 words at a time, and his vocabulary became "more complex, creative and colourful", possible symptoms of bipolar disorder. His doctors were largely at a loss to explain his illness, and spurious stories about his condition spread, such as the claim that he had shaken hands with a tree in the mistaken belief that it was the King of Prussia. Treatment for mental illness was primitive by modern standards; George's doctors, who included Francis Willis, treated the King by forcibly restraining him until he was calm, or applying caustic poultices to draw out "evil humours".

In the reconvened Parliament, Fox and Pitt wrangled over the terms of a regency during the King's incapacity. While both agreed that it would be most reasonable for the Prince of Wales to act as regent, Fox suggested, to Pitt's consternation, that it was the Prince's absolute right to act on his ill father's behalf with full powers. Pitt, fearing he would be removed from office if the Prince of Wales were empowered, argued that it was for Parliament to nominate a regent, and wanted to restrict the regent's authority. In February 1789, the Regency Bill, authorising the Prince of Wales to act as regent, was introduced and passed in the House of Commons, but before the House of Lords could pass the bill, George recovered.

War in Europe
After George's recovery, his popularity, and that of Pitt, continued to increase at the expense of Fox and the Prince of Wales. His humane and understanding treatment of two insane assailants, Margaret Nicholson in 1786 and John Frith in 1790, contributed to his popularity. James Hadfield's failed attempt to shoot George in the Theatre Royal, Drury Lane, on 15 May 1800 was not political in origin but motivated by the apocalyptic delusions of Hadfield and Bannister Truelock. George seemed unperturbed by the incident, so much so that he fell asleep in the interval.

The French Revolution of 1789, in which the French monarchy had been overthrown, worried many British landowners. France declared war on Great Britain in 1793; in response to the crisis, George allowed Pitt to increase taxes, raise armies, and suspend the right of habeas corpus. Pitt prosecuted British radicals for treason in 1794, and in October 1795, crowds attacked George's carriage on his way to opening Parliament, demanding an end to the war and lower bread prices. In response, Parliament passed the Treason and Seditious Meetings Acts a month later. The First Coalition to oppose revolutionary France, which included Austria, Prussia, and Spain, broke up in 1795 when Prussia and Spain made separate peace with France. The Second Coalition, which included Austria, Russia, and the Ottoman Empire, was defeated in 1800. Only Great Britain was left fighting Napoleon Bonaparte, the First Consul of the French Republic.

A brief lull in hostilities allowed Pitt to concentrate effort on Ireland, where there had been an uprising and attempted French landing in 1798. In 1800, the British and Irish Parliaments passed an Act of Union that took effect on 1 January 1801 and united Great Britain and Ireland into a single state, known as the "United Kingdom of Great Britain and Ireland". George used the opportunity to abandon the title "king of France", which English and British sovereigns had maintained since the reign of Edward III. It was suggested that George adopt the title "Emperor of the British Isles", but he refused. As part of his Irish policy, Pitt planned to remove certain legal disabilities that applied to Roman Catholics. George III claimed that to emancipate Catholics would be to violate his coronation oath, in which sovereigns promise to maintain Protestantism. Faced with opposition to his religious reform policies from both the King and the British public, Pitt threatened to resign. At about the same time, George had a relapse of his previous illness, which he blamed on worry over the Catholic question. On 14 March 1801, Pitt was formally replaced by the Speaker of the House of Commons, Henry Addington. Addington opposed emancipation, instituted annual accounts, abolished income tax and began a programme of disarmament. In October 1801, he made peace with the French, and in 1802 signed the Treaty of Amiens.

George did not consider the peace with France as real; in his view it was an "experiment". The war resumed in 1803, but public opinion distrusted Addington to lead the nation in war, and instead favoured Pitt. An invasion of England by Napoleon seemed imminent, and a massive volunteer movement arose to defend England against the French. George's review of 27,000 volunteers in Hyde Park, London, on 26 and 28 October 1803 and at the height of the invasion scare, attracted an estimated 500,000 spectators on each day. The Times said: "The enthusiasm of the multitude was beyond all expression." A courtier wrote on 13 November that "The King is really prepared to take the field in case of attack, his beds are ready and he can move at half an hour's warning." George wrote to his friend Bishop Hurd, "We are here in daily expectation that Bonaparte will attempt his threatened invasion ... Should his troops effect a landing, I shall certainly put myself at the head of mine, and my other armed subjects, to repel them." After Admiral Lord Nelson's famous naval victory at the Battle of Trafalgar, the possibility of invasion was extinguished.

In 1804, George's recurrent illness returned; after his recovery, Addington resigned and Pitt regained power. Pitt sought to appoint Fox to his ministry, but George refused. Lord Grenville perceived an injustice to Fox, and refused to join the new ministry. Pitt concentrated on forming a coalition with Austria, Russia, and Sweden. This Third Coalition, however, met the same fate as the First and Second Coalitions, collapsing in 1805. The setbacks in Europe took a toll on Pitt's health, and he died in 1806, reopening the question of who should serve in the ministry. Grenville became prime minister, and his "Ministry of All the Talents" included Fox. Grenville pushed through the Slave Trade Act 1807, which passed both houses of Parliament with large majorities. George was conciliatory towards Fox, after being forced to capitulate over his appointment. After Fox's death in September 1806, the King and ministry were in open conflict. To boost recruitment, the ministry proposed a measure in February 1807 whereby Roman Catholics would be allowed to serve in all ranks of the armed forces. George instructed them not only to drop the measure, but also to agree never to set up such a measure again. The ministers agreed to drop the measure then pending, but refused to bind themselves in the future. They were dismissed and replaced by the Duke of Portland, as the nominal prime minister, with actual power being held by the Chancellor of the Exchequer, Spencer Perceval. Parliament was dissolved, and the subsequent election gave the ministry a strong majority in the House of Commons. George III made no further major political decisions during his reign; the replacement of Portland by Perceval in 1809 was of little real significance.

Final years
In late 1810, at the height of his popularity, King George, already virtually blind with cataracts and in pain from rheumatism, suffered a relapse into his mental disorder and became dangerously ill. In his view, the malady had been triggered by stress over the death of his youngest and favourite daughter, Princess Amelia. The princess's nurse reported that "the scenes of distress and crying every day... were melancholy beyond description." George accepted the need for the Regency Act 1811, and the Prince of Wales (later George IV) acted as regent for the remainder of the King's life. Despite signs of a recovery in May 1811, by the end of the year, George III had become permanently insane, and lived in seclusion at Windsor Castle until his death.

Prime Minister Spencer Perceval was assassinated in 1812 and was replaced by Lord Liverpool. Liverpool oversaw British victory in the Napoleonic Wars. The subsequent Congress of Vienna led to significant territorial gains for Hanover, which was elevated from an electorate to a kingdom. Meanwhile, George's health deteriorated. He developed dementia, and became completely blind and increasingly deaf. He was incapable of knowing or understanding that he was declared King of Hanover in 1814, or that his wife died in 1818. At Christmas 1819, he spoke nonsense for 58 hours, and for the last few weeks of his life was unable to walk.

He died of pneumonia at Windsor Castle at 8:38 pm on 29 January 1820, six days after the death of his fourth son Prince Edward, Duke of Kent and Strathearn. His favourite son, Prince Frederick, Duke of York and Albany, was with him. George III lay in state for two days, and his funeral and interment took place on 16 February in St George's Chapel, Windsor Castle.

Slavery
Over the course of George's reign, a coalition of abolitionists and Atlantic slave uprisings caused the British public to spurn slavery. According to the historian Andrew Roberts, "George never bought or sold a slave in his life. He never invested in any of the companies that did such a thing. He signed legislation to abolish slavery." George wrote a document in the 1750s "denouncing all of the arguments for slavery, and calling them an execration and ridiculous and 'absurd'," but the King and his son, the Duke of Clarence, supported the efforts of the London Society of West India Planters and Merchants to delay the abolition of the British slave trade for almost 20 years. William Pitt the Younger conversely wished to see slavery abolished but, because the cabinet was divided and the King was in the pro-slavery camp, Pitt decided to refrain from making abolition official government policy. Instead, he worked toward abolition in an individual capacity.

On 7 November 1775, during the American War of Independence, John Murray, Lord Dunmore, issued a proclamation that offered freedom to the slaves of Rebel masters if they enlisted to put down the colonial rebellion. Dunmore was the last Royal Governor of Virginia, appointed by King George III in July 1771. Dunmore's Proclamation inspired slaves to escape from captivity and fight for the British. On 30 June 1779, George III's Commanding General Henry Clinton broadened Dunmore's proclamation with his Philipsburg Proclamation. For all colonial slaves who fled their Rebel masters, Clinton forbade their recapture and resale, giving them protection by the British military. Approximately 20,000 freed slaves joined the British, fighting for George III. In 1783, given British certificates of freedom, 3,000 former slaves, including their families, settled in Nova Scotia.

Between 1791 and 1800, almost 400,000 Africans were shipped to the Americas, by 1,340 slaving voyages, mounted from British ports, including Liverpool and Bristol. On 25 March 1807 George III signed into law An Act for the Abolition of the Slave Trade, under which the transatlantic slave trade was banned in the British Empire.

Legacy
George was succeeded by two of his sons, George IV and William IV in turn, who both died without surviving legitimate children, leaving the throne to Victoria, the only legitimate child of his fourth son Prince Edward.

George III lived for 81 years and 239 days, and reigned for 59 years and 96 days: both his life and his reign were longer than those of any of his predecessors and reigned longer.

George III was dubbed "Farmer George" by satirists, at first to mock his interest in mundane matters rather than politics, but later to portray him as a man of the people, contrasting his homely thrift with his son's grandiosity. Under George III, the British Agricultural Revolution reached its peak and great advances were made in fields such as science and industry. There was unprecedented growth in the rural population, which in turn provided much of the workforce for the concurrent Industrial Revolution. George's collection of mathematical and scientific instruments is now owned by King's College London but housed in the Science Museum, London, to which it has been on long-term loan since 1927. He had the King's Observatory built in Richmond-upon-Thames for his own observations of the 1769 transit of Venus. When William Herschel discovered Uranus in 1781, he at first named it Georgium Sidus (George's Star) after the King, who later funded the construction and maintenance of Herschel's 1785 40-foot telescope, which at the time was the biggest ever built.

George III hoped that "the tongue of malice may not paint my intentions in those colours she admires, nor the sycophant extoll me beyond what I deserve" but, in the popular mind, George III has been both demonised and praised. While very popular at the start of his reign, by the mid-1770s George had lost the loyalty of revolutionary American colonists, though it has been estimated that as many as half of the colonists remained loyal. The grievances in the United States Declaration of Independence were presented as "repeated injuries and usurpations" that he had committed to establish an "absolute Tyranny" over the colonies. The declaration's wording has contributed to the American public's perception of George as a tyrant. Contemporary accounts of George III's life fall into two camps: one demonstrating "attitudes dominant in the latter part of the reign, when the King had become a revered symbol of national resistance to French ideas and French power", while the other "derived their views of the King from the bitter partisan strife of the first two decades of the reign, and they expressed in their works the views of the opposition".

Building on the latter of these two assessments, British historians of the nineteenth and early twentieth centuries, such as Trevelyan and Erskine May, promoted hostile interpretations of George III's life. However, in the mid-twentieth century the work of Lewis Namier, who thought George was "much maligned", started a re-evaluation of the man and his reign. Scholars of the later twentieth century, such as Butterfield and Pares, and Macalpine and Hunter, are inclined to treat George sympathetically, seeing him as a victim of circumstance and illness. Butterfield rejected the arguments of his Victorian predecessors with withering disdain: "Erskine May must be a good example of the way in which an historian may fall into error through an excess of brilliance. His capacity for synthesis, and his ability to dovetail the various parts of the evidence ... carried him into a more profound and complicated elaboration of error than some of his more pedestrian predecessors ... he inserted a doctrinal element into his history which, granted his original aberrations, was calculated to project the lines of his error, carrying his work still further from centrality or truth." In pursuing war with the American colonists, George III believed he was defending the right of an elected Parliament to levy taxes, rather than seeking to expand his own power or prerogatives. In the opinion of modern scholars, during the long reign of George III, the monarchy continued to lose its political power and grew as the embodiment of national morality.

Titles and styles

 * 4 June 1738 – 31 March 1751: His Royal Highness Prince George
 * 31 March 1751 – 20 April 1751: His Royal Highness The Duke of Edinburgh
 * 20 April 1751 – 25 October 1760: His Royal Highness The Prince of Wales
 * 25 October 1760 – 29 January 1820: His Majesty The King

In Great Britain, George III used the official style "George the Third, by the Grace of God, King of Great Britain, France, and Ireland, Defender of the Faith, and so forth". In 1801, when Great Britain united with Ireland, he dropped the title of king of France, which had been used for every English monarch since Edward III's claim to the French throne in the medieval period. His style became "George the Third, by the Grace of God, of the United Kingdom of Great Britain and Ireland King, Defender of the Faith."

In Germany, he was "Duke of Brunswick and Lüneburg, Arch-Treasurer and Prince-elector of the Holy Roman Empire" (Herzog von Braunschweig und Lüneburg, Erzschatzmeister und Kurfürst des Heiligen Römischen Reiches ) until the end of the empire in 1806. He then continued as duke until the Congress of Vienna declared him "King of Hanover" in 1814.

Honours

 * undefined: Royal Knight of the Garter, 22 June 1749
 * Ireland: Founder of the Most Illustrious Order of St. Patrick, 5 February 1783

Arms
Before his succession, George was granted the royal arms differenced by a label of five points Azure, the centre point bearing a fleur-de-lis Or on 27 July 1749. Upon his father's death, and along with the dukedom of Edinburgh and the position of heir-apparent, he inherited his difference of a plain label of three points Argent. In an additional difference, the crown of Charlemagne was not usually depicted on the arms of the heir, only on the Sovereign's.

From his succession until 1800, George bore the royal arms: Quarterly, I Gules three lions passant guardant in pale Or (for England) impaling Or a lion rampant within a tressure flory-counter-flory Gules (for Scotland); II Azure three fleurs-de-lys Or (for France); III Azure a harp Or stringed Argent (for Ireland); IV tierced per pale and per chevron (for Hanover), I Gules two lions passant guardant Or (for Brunswick), II Or a semy of hearts Gules a lion rampant Azure (for Lüneburg), III Gules a horse courant Argent (for Saxony), overall an escutcheon Gules charged with the crown of Charlemagne Or (for the dignity of Archtreasurer of the Holy Roman Empire).

Following the Acts of Union 1800, the royal arms were amended, dropping the French quartering. They became: Quarterly, I and IV England; II Scotland; III Ireland; overall an escutcheon of Hanover surmounted by an electoral bonnet. In 1816, after the Electorate of Hanover became a kingdom, the electoral bonnet was changed to a crown.

title: George III


text:
Laudanum

Laudanum is a tincture of opium containing approximately 10% powdered opium by weight (the equivalent of 1% morphine). Laudanum is prepared by dissolving extracts from the opium poppy (Papaver somniferum) in alcohol (ethanol).

Reddish-brown in color and extremely bitter, laudanum contains several opium alkaloids, including morphine and codeine. Laudanum was historically used to treat a variety of conditions, but its principal use was as a pain medication and cough suppressant. Until the early 20th century, laudanum was sold without a prescription and was a constituent of many patent medicines. Laudanum has since been recognized as addictive and is strictly regulated and controlled as such throughout most of the world. The United States Controlled Substances Act, for example, lists it on Schedule II, the second strictest category.

Laudanum is known as a "whole opium" preparation since it historically contained all the alkaloids found in the opium poppy, which are extracted from the dried latex of ripe seed pods (Papaver somniferum L., succus siccus). However, the modern drug is often processed to remove all or most of the noscapine (also called narcotine) present as this is a strong emetic and does not add appreciably to the analgesic or antipropulsive properties of opium; the resulting solution is called Denarcotized Tincture of Opium or Deodorized Tincture of Opium (DTO).

Laudanum remains available by prescription in the United States (under the generic name "opium tincture") and in the European Union and United Kingdom (under the trade name Dropizol), although the drug's therapeutic indication is generally limited to controlling diarrhea when other medications have failed.

The terms laudanum and tincture of opium are generally interchangeable, but in contemporary medical practice, the latter is used almost exclusively.

Paracelsus's laudanum
Paracelsus, a 16th-century Swiss alchemist, experimented with various opium concoctions, and recommended opium for reducing pain. One of his preparations, a pill which he extolled as his "archanum" or "laudanum", may have contained opium. Paracelsus' laudanum was strikingly different from the standard laudanum of the 17th century and beyond, containing crushed pearls, musk, amber, and other substances.

British laudanum
One researcher has documented that "Laudanum, as listed in the London Pharmacopoeia (1618), was a pill made from opium, saffron, castor, ambergris, musk and nutmeg".

Sydenham's laudanum
In the 1660s English physician Thomas Sydenham (1624–1689) popularized a proprietary opium tincture that he also named laudanum, although it differed substantially from the laudanum of Paracelsus. In 1676 Sydenham published a seminal work, Medical Observations Concerning the History and Cure of Acute Diseases, in which he promoted his brand of opium tincture, and advocated its use for a range of medical conditions.

18th-century
By the 18th century, the medicinal properties of opium and laudanum were well known, and the term "laudanum" came to refer to any combination of opium and alcohol.

In the 18th century several physicians published work about it, including John Jones, who wrote The Mysteries of Opium Revealed (1700), which was described by one commentator as "extraordinary and perfectly unintelligible." The Scottish physician John Brown, creator of the Brunonian system of medicine, recommended opium for what he termed asthenic conditions, but his system was discredited by the time of his death. The most influential work was by George Young, who published a comprehensive medical text entitled Treatise on Opium (1753). Young, an Edinburgh surgeon and physician, wrote this to counter an essay on opium by his contemporary Charles Alston, professor of botany and materia medica at Edinburgh who had recommended the use of opium for a wide variety of conditions. Young countered this by emphasising the risks  '...that I may prevent such mischief as I can, I here give it as my sincere opinion... that opium is a poison by which great numbers are daily destroyed.' Young gives a comprehensive account of the indications for the drug including its complications. He is critical about writers whose knowledge of the drug is based on chemical or animal experiments rather than clinical practice. The treatise is a detailed, balanced and valuable guide to prevailing knowledge and practice. As it gained popularity, opium, and after 1820, morphine, was mixed with a wide variety of agents, drugs and chemicals including mercury, hashish, cayenne pepper, ether, chloroform, belladonna, whiskey, wine and brandy."

During the late 18th and early 19th centuries, patients undergoing surgery were often administered laudanum and alcohol, and had their hands restrained and bodies held down while the operation was performed.

19th-century
By the 19th century, laudanum was used in many patent medicines to "relieve pain ... to produce sleep ... to allay irritation ... to check excessive secretions ... to support the system ... [and] as a soporific". The limited pharmacopoeia of the day meant that opium derivatives were among the most effective of available treatments, so laudanum was widely prescribed for ailments from colds to meningitis to cardiac diseases, in both adults and children. Laudanum was used during the yellow fever epidemic.

Innumerable Victorian women were prescribed the drug for relief of menstrual cramps and vague aches. Nurses also spoon-fed laudanum to infants. The Romantic and Victorian eras were marked by the widespread use of laudanum in Europe and the United States. Mary Todd Lincoln, for example, the wife of the US president Abraham Lincoln, was a laudanum addict, as was the English poet Samuel Taylor Coleridge, who was famously interrupted in the middle of an opium-induced writing session of Kubla Khan by "a person on business from Porlock". Initially a working class drug, laudanum was cheaper than a bottle of gin or wine, because it was treated as a medication for legal purposes and not taxed as an alcoholic beverage.

As one researcher has noted: "To understand the popularity of a medicine that eased—even if only temporarily—coughing, diarrhoea and pain, one only has to consider the living conditions at the time". In the 1850s, "cholera and dysentery regularly ripped through communities, its victims often dying from debilitating diarrhoea", and dropsy, consumption, ague and rheumatism were all too common.

An 1869 article in Scientific American describes a farmer growing and harvesting poppy in Indian Springs, Georgia, and subsequently selling the raw material to a local pharmacist who prepared laudanum.

20th-century
Laudanum was used in home remedies and prescriptions, as well as a single medication. For example, a 1901 medical book published for home health use gave the following two "Simple Remedy Formulas" for "dysenterry" [sic]: (1) Thin boiled starch, 2 ounces; Laudanum, 20 drops; "Use as an injection [meaning as an enema] every six to twelve hours"; (2) Tincture rhubarb, 1 ounce; Laudanum 4 drachms; "Dose: One teaspoonful every three hours." In a section entitled "Professional Prescriptions" is a formula for "diarrhoea (acute)": Tincture opium, deodorized, 15 drops; Subnitrate of bismuth, 2 drachms; Simple syrup, 1⁄2 ounce; Chalk mixture, 11⁄2 ounces, "A teaspoonful every two or three hours to a child one year old." "Diarrhoea (chronic)": Aqueous extract of ergot, 20 grains; Extract of nux vomica, 5 grains; Extract of Opium, 10 grains, "Make 20 pills. Take one pill every three or four hours."

The early 20th century brought increased regulation of all manner of narcotics, including laudanum, as the addictive properties of opium became more widely understood, and "patent medicines came under fire, largely because of their mysterious compositions". In the US, the Food and Drug Act of 1906 required that certain specified drugs, including alcohol, cocaine, heroin, morphine, and cannabis, be accurately labeled with contents and dosage. Previously many drugs had been sold as patent medicines with secret ingredients or misleading labels. Cocaine, heroin, cannabis, and other such drugs continued to be legally available without prescription as long as they were labeled. It is estimated that sale of patent medicines containing opiates decreased by 33% after labeling was mandated. In 1906 in Britain and in 1908 in Canada "laws requiring disclosure of ingredients and limitation of narcotic content were instituted".

The Harrison Narcotics Tax Act of 1914 restricted the manufacture and distribution of opiates, including laudanum, and coca derivatives in the US. This was followed by France's Loi des stupéfiants in 1916, and Britain's Dangerous Drugs Act in 1920.

Laudanum was supplied to druggists and physicians in regular and concentrated versions. For example, in 1915, Frank S. Betz Co., a medical supply company in Hammond, Indiana, advertised Tincture of Opium, U.S.P., for $2.90 per lb., Tincture of Opium Camphorated, U.S.P, for 85 cents per lb., and Tincture of Opium Deodorized, for $2.85 per lb. Four versions of opium as a fluid extract were also offered: (1) Opium, Concentrated (assayed) "For making Tincture Opii (Laudanum) U.S.P. Four times the strength of the regular U.S.P." tincture, for $9.35 per pint; (2) Opium, Camphorated Conc. "1 oz. making 8 ozs. Tr. Opii Camphorated U.S.P (Paregoric)" for $2.00 per pint; (3) Opium, Concentrated (Deodorized and Denarcotized) "Four times the strength of tincture, Used when Tinct. Opii U.S.P. is contraindicated" for $9.50 per pint, and (4) Opium (Aqueous), U.S.P., 1890, "Tr. (assayed) Papaver Somniferum" for $2.25 per pint.

In 1929–30, Parke, Davis & Co., a major US drug manufacturer based in Detroit, Michigan, sold "Opium, U.S.P. (Laudanum)", as Tincture No. 23, for $10.80 per pint (16 fluid ounces), and "Opium Camphorated, U.S.P. (Paregoric)", as Tincture No. 20, for $2.20 per pint. Concentrated versions were available. "Opium Camphorated, for U.S.P. Tincture: Liquid No. 338" was "exactly 8 times the strength of Tincture Opium Camphorated (Paregoric) [italics in original], U.S.P., "designed for preparing the tincture by direct dilution," and cost $7 per pint. Similarly, at a cost of $36 per pint, "Opium Concentrated, for U.S.P. Tincture: Liquid No. 336", was "four times the strength of the official tincture", and "designed for the extemporaneous preparation of the tincture". The catalog also noted: "For quarter-pint bottles add 80c. per pint to the price given for pints."

Toward the middle 20th century, the use of opiates was generally limited to the treatment of pain, and opium was no longer a medically accepted "cure-all". Further, the pharmaceutical industry began synthesizing various opioids, such as propoxyphene, oxymorphone and oxycodone. These synthetic opioids, along with codeine and morphine were preferable to laudanum since a single opioid could be prescribed for different types of pain rather than the "cocktail" of laudanum, which contains nearly all of the opium alkaloids. Consequently, laudanum became mostly obsolete as an analgesic, since its principal ingredient is morphine, which can be prescribed by itself to treat pain. Until now, there has been no medical consensus on which of the two (laudanum or morphine alone) is the better choice for treating pain.

In 1970, the US adopted the Uniform Controlled Substances Act, which regulated opium tincture (Laudanum) as a Schedule II substance (currently DEA #9630), placing even tighter controls on the drug.

By the late 20th century, laudanum's use was almost exclusively confined to treating severe diarrhea.

21st-century
The current prescribing information for laudanum in the US states that opium tincture's sole indication is as an anti-diarrheal, although the drug is occasionally prescribed off-label for treating pain and neonatal withdrawal syndrome.

Historical varieties
Several historical varieties of laudanum exist, including Paracelsus' laudanum, Sydenham's Laudanum (also known as tinctura opii crocata), benzoic laudanum (tinctura opii benzoica), and deodorized tincture of opium (the most common contemporary formulation), among others. Depending on the version, additional amounts of the substances and additional active ingredients (e.g. saffron, sugar, eugenol) are added, modifying its effects (e.g., amount of sedation, or antitussive properties).

There is probably no single reference that lists all the pharmaceutical variations of laudanum that were created and used in different countries during centuries since it was initially formulated. The reasons are that in addition to official variations described in pharmacopeias, pharmacists and drug manufacturers were free to alter such formulas. The alcohol content of Laudanum probably varied substantially; on the labels of turn-of-the-century bottles of Laudanum, alcoholic content is stated as 48%. In contrast, the current version of Laudanum contains about 18% alcohol.

The four variations of laudanum listed here were used in the United States during the late 19th century. The first, from an 1870 publication, is "Best Turkey opium 1 oz., slice, and pour upon it boiling water 1 gill, and work it in a bowl or mortar until it is dissolved; then pour it into the bottle, and with alcohol of 70 percent proof 1⁄2 pt., rinse the dish, adding the alcohol to the preparation, shaking well, and in 24 hours it will be ready for use. Dose—From 10 to 30 drops for adults, according to the strength of the patient, or severity of the pain. Thirty drops of this laudanum will be equal to one grain of opium. And this is a much better way to prepare it than putting the opium into alcohol, or any other spirits alone, for in that case much of the opium does not dissolve." The remaining three formulas are copied from an 1890 publication of the day:
 * 1) Sydenham's Laudanum: "According to the Paris Codex this is prepared as follows: opium, 2 ounces; saffron, 1 ounce; bruised cinnamon and bruised cloves, each 1 drachm; sherry wine, 1 pint. Mix and macerate for 15 days and filter. Twenty drops are equal to one grain of opium."
 * 2) Rousseau's Laudanum: "Dissolve 12 ounces white honey in 3 pounds warm water, and set it aside in a warm place. When fermentation begins add to it a solution of 4 ounces selected opium in 12 ounces water. Let the mixture stand for a month at a temperature of 86° Fahr.; then strain, filter, and evaporate to 10 ounces; finally strain and add 41⁄2 ounces proof alcohol. Seven drops of this preparation contain about 1 grain of opium."
 * 3) Tincture of Opium (Laudanum), U.S.P., attributed to the United States Pharmacoepia of 1863: "Macerate 21⁄2 ounces opium, in moderately fine powder in 1 pint water for 3 days, with frequent agitation. Add 1 pint alcohol, and macerate for 3 days longer. Percolate, and displace 2 pints tincture by adding dilute alcohol in the percolator."

United Kingdom
Opium tincture remains in the British Pharmacopoeia, where it is referred to as Tincture of Opium, B.P., Laudanum, Thebaic Tincture or Tinctura Thebaica, and "adjusted to contain 1% w/v of anhydrous morphine." It is a Class A substance under the Misuse of Drugs Act of 1971. At least one manufacturer (Macfarlan Smith) still produces opium tincture in the UK. "Gee's Linctus" is also available from most UK pharmacies, especially independent stores. This contains "Opium Tincture", at 0.083 mL, per 5 mL.

United States
Tincture of Opium is available by prescription in the United States. It is regulated as a Schedule II drug (No. 9639) under the Controlled Substances Act.

In the United States, opium tincture is marketed and distributed by several pharmaceutical firms, each producing a single formulation of the drug, which is deodorized. Each mL contains 10 mg of anhydrous morphine (the equivalent of 100 mg of powdered opium), other opium alkaloids (except noscapine), and ethanol, 19%. It is available packaged in bottles of 4 USoz and 16 USoz.

Tincture of Opium is known as one of many "unapproved drugs" regulated by the U.S. Food and Drug Administration (FDA); the marketing and distribution of opium tincture prevails only because opium tincture was sold prior to the Federal Food, Drug & Cosmetic Act of 1938. Its "grandfathered" status protects opium tincture from being required to undergo strict FDA drug reviews and subsequent approval processes. However, the FDA closely monitors the labeling of opium tincture. Bottles of opium tincture are required by the FDA to bear a bright red "POISON" label given the potency of the drug and the potential for overdose (see discussion about confusion with Paregoric below). Additionally, in a warning letter to a manufacturer of opium tincture in late 2009, the FDA noted that "we found that your firm is manufacturing and distributing the prescription drug Opium Tincture USP (Deodorized – 10 mg/mL). Based on our information, there are no FDA-approved applications on file for this drug product."

Pharmacology
Opium tincture is useful as an analgesic and antidiarrheal. Opium enhances the tone in the long segments of the longitudinal muscle and inhibits propulsive contraction of circular and longitudinal muscles. The pharmacological effects of opium tincture are due principally to its morphine content. The quantity of the papaverine and codeine alkaloids in opium tincture is too small to have any demonstrable central nervous system effect.

Most modern formulations of opium tincture do not contain the alkaloid narcotine (also known as noscapine), which has antitussive properties. Even modest doses of narcotine can induce profound nausea and vomiting. Since opium tincture is usually prescribed for its antidiarrheal and analgesic properties (rather than as an antitussive), opium tincture without narcotine is generally preferred. This "de-narcotized" or "deodorized" opium tincture is formulated using a petroleum distillate to remove the narcotine.

Oral doses of opium tincture are rapidly absorbed in the gastrointestinal tract and metabolized in the liver. Peak plasma concentrations of the morphine content are reached in about one hour, and nearly 75% of the morphine content of the opium tincture is excreted in the urine within 48 hours after oral administration.

Diarrhea
Opium tincture is indicated for the treatment of severe fulminant (intense, prolific) diarrhea that does not respond to standard therapy (e.g., Imodium or Lomotil). The usual starting dose is 0.3 mL to 0.6 mL (about six to 12 drops) in a glass of water or juice four times a day. Refractory cases (such as diarrhea resulting from the complications of HIV/AIDS) may require higher than normal dosing, for example, 1 to 2 mL every 3 hours, for a total daily dose of up to 16 mL a day. In terminal diseases, there is no ceiling dose for opium tincture; the dose is increased slowly until diarrhea is controlled.

Neonatal abstinence syndrome
Opium tincture is used to treat neonatal opioid withdrawal syndrome (NOWS) when diluted 1:25 (one part opium tincture to 25 parts water). The recommended dose is 0.2 mL of the diluted solution under the tongue every three hours, which may be increased by 0.05 mL every three hours until no objective signs of withdrawal are observed. In no event, however, should the dose exceed 0.7 mL every three hours. The opium tincture is gradually tapered over a 3- to 5-week period, at which point the newborn should be completely free of withdrawal symptoms.

Potency of laudanum
Opium tincture is one of the most potent oral formulations of morphine available by prescription. Accidental or deliberate overdose is common with opium tincture given the highly concentrated nature of the solution. Overdose and death may occur with a single oral dose of between 100 and 150 mg of morphine in a healthy adult who has no tolerance to opiates. This represents the equivalent of between two and three teaspoons (10 - 15 mL) of opium tincture. Suicide by laudanum was common in the mid-19th century. Prudent medical judgment necessitates toward dispensing very small quantities of opium tincture in small dropper bottles or in pre-filled syringes to reduce the risk of intentional or accidental overdose.

Danger of confusion with paregoric
In the United States, opium tincture contains 10 mg per mL of anhydrous morphine. By contrast, opium tincture's weaker cousin, paregoric, also confusingly known as "camphorated tincture of opium", is 1/25th the strength of opium tincture, containing only 0.4 mg of morphine per mL. A 25-fold morphine overdose may occur if opium tincture is used where paregoric is indicated. Opium tincture is almost always dosed in drops, or fractions of a mL, or less commonly, in minims, while paregoric is dosed in teaspoons or tablespoons. Thus, an order for opium tincture containing directions in teaspoons is almost certainly in error. To avoid this potentially fatal outcome, the term "camphorated tincture of opium" is avoided in place of paregoric since the former can easily be mistaken for opium tincture.

In 2004, the FDA issued a "Patient Safety" news bulletin stating that "To help resolve the confusion [between opium tincture and paregoric], FDA will be working with the manufacturers of these two drugs to clarify the labeling on the containers and in the package inserts." Indeed, in 2005, labels for opium tincture began to include the concentration of morphine (10 mg/mL) in large text beneath the words "Opium Tincture". The FDA has also alerted pharmacists and other medical practitioners about the dangers of confusing these drugs, and has recommended that opium tincture not be stocked as a standard item (i.e., that it should not be "on the shelf"), that opium tincture be dispensed in oral syringes, and that pharmacy software alert the dispenser if unusually large doses of opium tincture appear to be indicated.

Despite the FDA's efforts over the past few years, the confusion persists, sometimes with deadly results. The Institute for Safe Medication Practices recommends that opium tincture not be stocked at all in a pharmacy's inventory, and that "It may be time to relegate opium tincture and paregoric to the museum of outmoded opioid therapy." Despite the risk of confusion, opium tincture, like many end-stage medications, is indispensable for intractable diarrhea for terminally ill patients, such as those with AIDS and cancer.

Misinterpretation of "DTO"
The abbreviation "DTO," traditionally used to refer to Deodorized Tincture of Opium, is sometimes also erroneously employed to abbreviate "diluted tincture of opium." Diluted tincture of opium, also known as Camphorated Tincture of Opium (Paregoric) is a 1:25 mixture of opium tincture to water prescribed to treat withdrawal symptoms in newborns whose mothers were using opioids while pregnant. The United States Pharmacopeia and FDA recommend that practitioners refrain from using DTO in prescriptions, given this potential for confusion. In cases where pharmacists have misinterpreted DTO, and given "deodorized tincture of opium" when "diluted tincture of opium" was meant, infants have received a massive 25-fold overdose of morphine, sometimes resulting in fatalities.

Side effects
Side effects of laudanum are generally the same as with morphine, and include euphoria, dysphoria, pruritus, sedation, constipation, reduced tidal volume, respiratory depression, as well as psychological dependence, physical dependence, miosis, and xerostomia. Overdose can result in severe respiratory depression or collapse and death. The ethanol component can also induce adverse effects at higher doses; the side effects are the same as with alcohol. Long-term use of laudanum in nonterminal diseases is discouraged due to the possibility of drug tolerance and addiction. Long-term use can also lead to abnormal liver function tests; specifically, prolonged morphine use can increase ALT and AST blood serum levels.

Treatment for overdose
Life-threatening overdose of opium tincture owes to the preparation's morphine content. Morphine produces a dose-dependent depressive effect on the respiratory system, which can lead to profound respiratory depression, hypoxia, coma and finally respiratory arrest and death. If overdose of opium tincture is suspected, rapid professional intervention is required. The primary concern is re-establishing a viable airway and institution of assisted or controlled ventilation if the patient is unable to breathe on their own. Other supportive measures such as the use of vasopressors and oxygen may be indicated to treat cardiac and/or pulmonary failure. Cardiac arrhythmias or arrest will require advanced life-saving measures.

Intravenous naloxone or nalmefene, quick-acting opioid antagonists, are the first-line treatment to reverse respiratory depression caused by an overdose of opium tincture. Gastric lavage may be of some use in certain cases.

Literature

 * In Mary Shelley's novel Frankenstein (1818), Victor Frankenstein takes laudanum as his only means of sleeping and thus preserving his life while in recovery from months of fever and a series of horrible events.
 * In Charles Dickens's novel Oliver Twist (1837), Nancy gave William "Bill" Sikes laudanum to keep him asleep while she ran away to meet Rose Maylie.
 * In Uncle Tom's Cabin (1852), an anti-slavery novel by Harriet Beecher Stowe, an enslaved woman named Cassy talks about how she killed her newborn by laudanum overdose to spare him from experiencing the horrors of slavery.
 * In the novel Silas Marner: The Weaver of Raveloe by George Eliot (Mary Ann Evans) (1861), Silas finds and adopts a two-year old girl who had wandered into his house. The girl had been abandoned while walking with her opium-addicted mother, Molly Farren, who had fallen asleep in the snow and died. Earlier in the novel, in Chapter 3, it is specified that she uses laudanum.... if Molly should take a drop too much laudanum some day, and make a widower of you.
 * A laudanum-addicted character also appeared in Wilkie Collins' novel Armadale (1864–1866).
 * Wilkie Collins' novel The Moonstone (1868) features laudanum "as an essential ingredient of the plot." Collins based his description of the drug's effects on his own experiences with it.
 * Laudanum appears in Charles Baudelaire's prose poem The Double Room, published in his collection Le Spleen de Paris in 1869.
 * In the novel Anna Karenina (1878) by Leo Tolstoy, the eponymous character becomes addicted to laudanum.
 * The Sherlock Holmes short story The Man with the Twisted Lip by Arthur Conan Doyle (1891) contains a character who is addicted to laudanum.
 * In the novel Red Harvest (1929) by Dashiel Hammett, The Continental Op drinks gin doped with laudanum and has a series of strange dreams before awakening to find himself framed for murder.
 * Laudanum is portrayed as the surgical drug of choice for fifteenth-century physicians in Lawrence Schoonover's novel The Burnished Blade (1948), the plot of which deals in part with the smuggling of expensive raw opium into France from the Empire of Trebizond.
 * In William Faulkner's novel Requiem for a Nun (1951), Compson, Doctor Peabody, and Ratcliffe give whiskey tainted with laudanum to a group of rowdy lynchers and a militia band that had joined together. Upon their falling asleep, they were gathered up and locked in jail while still unconscious.
 * Stephen Maturin, one of the main characters in Patrick O'Brian's Aubrey–Maturin series of novels (1969–2004) about the Napoleonic wars, is a sometime laudanum addict.
 * Laudanum is prescribed in Glendon Swarthout's novel The Shootist (1975) to the character J.B. Books, played by John Wayne in Don Siegel's movie adaptation (1976).
 * In the book series All the Wrong Questions (2012–2015) by Daniel Handler, Who Could That Be at This Hour? (2012) Lemony Snicket's tea had laudanum. Laudanum is mentioned and used throughout the series, mostly by The Inhuman society.
 * In Eleanor Catton's novel The Luminaries (2013), and the subsequent TV adaptation (2020), many characters are addicted to laudanum and it is used to murder Crosbie Wells.
 * In Sara Collins' novel The Confessions of Frannie Langton (2019), and the subsequent TV adaptation (2022), the titular character becomes addicted to laudanum.

Film and television

 * In the movie The Shootist (1976) John Wayne’s gunslinger character, John Books, is prescribed laudanum by the doctor (James Stewart) for his terminal cancer.
 * In the original version of the miniseries Roots (1977), upon Toby's arrival to Virginia and ready for sale, the slave doctor says he'll give laudanum to the wild ones, brandy to the dull ones and "let the buyer beware".
 * In Philippa Gregory's novel Wideacre (1987), the main character Beatrice Lacey nearly becomes addicted to laudanum when her eventual husband Dr. John MacAndrew prescribes it to her after her mother's death.
 * It plays a major role in the plot of James Clavell's historical novel Gai-Jin (1993).
 * In the film Tombstone (1993), Mattie Earp, Wyatt Earp's wife is addicted to laudanum.
 * In the adaptation Interview with the Vampire (1994), which was based on the 1976 novel with the same name, Claudia uses laudanum to try to kill Lestat: Under the pretext of making peace, she offers him some drunk noble-blood twins to feed on, when she actually had them overdose on the drug, and misled Lestat into drinking dead blood which is toxic to vampires.
 * In the film From Hell (2001), Inspector Abberline is a user of laudanum, and Jack the Ripper also uses laudanum for making his victims sleepy.
 * In the TV series Deadwood, (2004–2006) the town doctor recommends laudanum several times, bringing a bottle of it to a patient. Initially in the series, Alma Garrett is an addict to laudanum. Trixie is a former addict.
 * In the TV show American Horror Story: Murder House (2011), laudanum is repeatedly used to drug a main character, leaving him waking up unable to remember what had occurred.
 * In the TV series Outlander (2014), Claire uses laudanum in several episodes throughout the 18th century.
 * In the film Winchester (2018), Doctor Eric Price is addicted to laudanum due to his wife's suicide.
 * In the film The Highwaymen (2019), Bonnie Parker (Emily Brobst) of Bonnie and Clyde fame is addicted to laudanum.
 * In the miniseries The North Water (2021), the main character, a surgeon who takes a job on a whaling ship in the Arctic, is addicted to laudanum.
 * In season two of the series Good Omens (2023), the demon Crowley drinks an entire glass of laudanum to prevent a poor grave robber named Elspeth from killing herself. Due to his demon constitution, he merely becomes extremely drunk from it.
 * In season two of the series Warrior (2020), Officer Lee (Tom Weston-Jones) becomes addicted to laudanum when he uses it to offset his lingering head trauma.

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title: Laudanum