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QuickDraw

QuickDraw was the 2D graphics library and associated application programming interface (API) which is a core part of classic Mac OS. It was initially written by Bill Atkinson and Andy Hertzfeld. QuickDraw still existed as part of the libraries of macOS, but had been largely superseded by the more modern Quartz graphics system. In Mac OS X Tiger, QuickDraw has been officially deprecated. In Mac OS X Leopard applications using QuickDraw cannot make use of the added 64-bit support. In OS X Mountain Lion, QuickDraw header support was removed from the operating system. Applications using QuickDraw still ran under OS X Mountain Lion to macOS High Sierra; however, the current versions of Xcode and the macOS SDK do not contain the header files to compile such programmes.

Principles of QuickDraw
QuickDraw was grounded in the Apple Lisa's LisaGraf of the early 1980s and was designed to fit well with the Pascal-based interfaces and development environments of the early Apple systems. In addition, QuickDraw was a raster graphics system, which defines the pixel as its basic unit of graphical information. This is in contrast to vector graphics systems, where graphics primitives are defined in mathematical terms and rasterized as required to the display resolution. A raster system requires much less processing power however, and was the prevailing paradigm at the time that QuickDraw was developed.

QuickDraw defined a key data structure, the graphics port, or GrafPort. This was a logical drawing area where graphics could be drawn. The most obvious on-screen "object" corresponding to a GrafPort was a window, but the entire desktop view could be a GrafPort, and off-screen ports could also exist.

The GrafPort defined a coordinate system. In QuickDraw, this had a resolution of 16 bits, giving 65,536 unique vertical and horizontal locations. These are numbered from -32,767 on the extreme left (or top), to +32,767 on the extreme right (or bottom). A window was usually set up so that the top, left corner of its content area was located at 0,0 in the associated GrafPort. A window's content area did not include the window's frame, drop shadow or title bar (if any).

QuickDraw coordinates referred to the infinitely thin lines between pixel locations. An actual pixel was drawn in the space to the immediate right and below the coordinate. This made it easier for programmers to avoid graphical glitches caused by off-by-one errors.

On the Macintosh, pixels were square, and a GrafPort had a default resolution of 72 pixels per inch, chosen to match conventions established by the printing industry of having 72 points per inch.

QuickDraw also contained a number of scaling and mapping functions.

QuickDraw maintained a number of global variables per process, chief among these being the current port. This originally simplified the API, since all operations pertained to "the current port," but as the OS developed, this use of global state has also made QuickDraw much harder to integrate with modern design approaches such as multi-threading and pre-emptive multitasking. To address these problems, the Carbon API (a bridge between Mac OS 9 and Mac OS X) added additional parameters to some of the routines, allowing for the (opaque) storage of thread information and a new (non-polled) event structure.

Graphics primitives
Everything seen on a classic Mac OS screen is drawn by QuickDraw, but the library itself is quite low level. The primitive objects it can draw are:
 * Lines
 * Rectangles
 * Rounded (and oval) cornered rectangles
 * Ovals (including circles and ellipses)
 * Arcs (and wedges), both circular and oval
 * Polygons (arbitrary closed shapes built from a list of points joined by lines)
 * Regions (arbitrary sets of pixels—see below)
 * Bitmaps and Pixmaps
 * Text

Each of these objects (except text) may be drawn using a "pen", which can have any rectangular dimensions, pattern or color. Note that, because the pen is rectangular and axis-aligned, diagonal lines will end up thicker than horizontal or vertical ones. Shapes may be drawn filled or framed, using any pattern or color. A filled Arc forms a wedge. Text may be drawn in any installed font, in a variety of stylistic variations, and at any size and color. Depending on how the selected font is stored, text can be scaled in a variety of ways - TrueType fonts will scale smoothly to any size, whereas bitmap fonts do not usually scale well.

An important feature of QuickDraw was support for transfer modes, which governed how a destination pixel value was related to its previous value and the color of the object being drawn.

The set of attributes of the pen and text drawing are associated with the GrafPort.

Regions are a key data structure in QuickDraw. They define an arbitrary set of pixels, rather like a bitmap, but in a compressed form which can be very rapidly manipulated in complex ways. Regions can be combined (union), subtracted (difference), and XORed to form other Regions. They can be used within a GrafPort for clipping, or drawn filled or framed like any other shape. A series of framed shapes and connected lines may be combined into a Region. A Region need not consist of a contiguous set of pixels - disconnected regions are possible and common. Although regions could allow powerful graphic manipulations they are limited by the current implementation that restricts the maximum region data storage size to a sixteen bit value and so are not practical as a general-purpose drawing composition tool and practical use at high resolution is also restricted. Regions underpin the rest of QuickDraw, permitting clipping to arbitrary shapes, essential for the implementation of multiple overlapping windows. Invented by Bill Atkinson, Regions were patented as a separate invention by Apple.

A region is specified (after initial creation) by an opening of the region, drawing various QuickDraw shapes, and closing the region. Hidden routines construct the region as the QuickDraw commands are executed. Bitmaps may also be converted to regions, and bitmaps may be made from regions by "painting" or "filling" the region into a graphics port.

The internal structure of a region, other than the storage length and its bounding rectangle, is opaque - there are no Apple-published documents available, though the mechanism is outlined in the patent. Regions are implemented using both vertical and horizontal compression. A region is stored as a series of horizontal scan lines ("rasters"), each of which contains a vertical coordinate followed by a list of horizontal inversion coordinates. Each inversion point can be thought of as toggling inclusion in the region for all the points after it: the first point turns the region on, the second turns it off, and so on. Further compression is achieved by storing each line differentially: each line contains only the differences from the previous line rather than a full set of inversion points. Finally, identical adjacent scan lines are efficiently encoded by simply skipping them. In this way, a commonly used region, the rounded corner rectangle, is efficiently encoded, and complex operations such as region composition and image clipping may be done without requiring either extensive processor cycles or large amounts of memory. (The original systems executing QuickDraw code used processors operating at 8 megahertz clock rates and systems had but 128 kilobytes of writable memory.)

Because regions are bound to a specific orientation, a ninety degree rotation of a region would require both detailed reverse engineering of the structure and extensive coding. A general rotation is impractical when compared to rotating the original source boundary description and simply creating a new region. However, the API includes conversion routines to and from BitMaps. (Bitmaps may also be rotated using well known methods, but with various degrees of image degradation depending upon angle chosen, the storage and processor cycles available to the operation, and the complexity of the algorithm.)

Apple has recently (in the Carbon API) defined regions as an opaque structure under some program compilation options.

Higher level operations
Any series of graphics calls to QuickDraw can be recorded in a structure called a Picture. This can then be saved in memory and "played back" at any time, reproducing the graphics sequence. At playback time the picture may be placed at new coordinates or scaled without the loss of resolution commonly encountered in bitmap scaling. A picture can be saved to disk in which form it defines the Apple PICT format.

An entire BitMap (or PixMap, when referring to color images) may be copied from one GrafPort to another, with scaling and clipping. Known as blitting, or CopyBits, after the name of the function, this operation is the basis for most animation and sprite-like effects on the Mac.

QuickDraw provides a similar blitting function which is designed to implement scrolling within a GrafPort - the image in the port can be shifted to a new location without scaling (but with clipping if desired).

Each graphics primitive operation is vectored through the StdProcs, a series of function pointers stored in the GrafPort. This limited polymorphism permits individual operations to be overridden or replaced by custom functions, allowing printer drivers to intercept graphics commands and translate them to suitable printer operations. In this way, QuickDraw can be rendered using PostScript, a fact that enabled the Macintosh to practically invent desktop publishing.

Similar to a subclass, the Window data structure began with the associated GrafPort, thus basically making windows exchangeable with any GrafPort. While convenient, this made it easy to write erroneous code that passed an offscreen graphics port into API that expected a full-blown window.

History
QuickDraw started life as Lisa Graf as part of the Apple Lisa development. For the Macintosh it was initially simplified, but then later extended. Originally, QuickDraw GrafPorts only supported a bit depth of 1, that is one bit per pixel, or black and white. This suited the built-in screen of the early Macintosh, with its fixed size of 512×342 pixels. Limited color was supported using a crude planar model, allowing QuickDraw to drive some types of dot-matrix printer that used multi-colored ribbons, but very few applications supported this feature.

In 1987, the Macintosh II was developed and launched, which was designed as a more conventional three-box design - Computer, monitor and keyboard all separate. Because the monitor was separate, and larger than the original Mac, the video architecture had to necessarily change. In addition, the Mac II took the Macintosh from black-and-white to full color. Apple also decided at this time to support a seamless desktop spanning multiple monitors, an industry first. Thus Color QuickDraw, a significant extension of the original QuickDraw, was created. The original architecture lacked much provision for expandability, but using a series of hacks, the Apple developers managed to make the addition of color and the new video architecture virtually seamless to both developers and end users.

Color QuickDraw introduced new data structures, including GDevices to represent each attached video card/monitor, and a new color GrafPort (CGrafPort) structure to handle color, as well as PixMaps instead of BitMaps for multiple bits-per-pixel images. One of the hacks for compatibility used here was that the new structure was exactly the same size as the old one, with most data members in the same place, but with additional handles and pointers to color structures in place of the BitMap fields. The upper two bits of the rowBytes field were pressed into use as flags to distinguish a GrafPort from a CGrafPort (they were always zero on old-style GrafPorts because a BitMap could never feasibly be so wide as to ever set these bits). The use of these two high bits would come back to haunt QuickDraw later, as it forced a maximum row width of just 4,095 on 32-bit PixMaps, which became problematic for high-resolution graphics work. Later development (Carbon) eliminated this limitation but was not fully backward compatible. A Palette Manager was also added in Color QuickDraw which managed the arbitration of colors on indexed video devices. Most graphics primitives operations remained either unchanged (but would operate in color), or else new color versions of the black and white APIs were added.

Initially, Color QuickDraw was only capable of operating with 1, 2, 4 and 8-bit video cards, which were all that was available at the time. Soon after however, 24-bit video cards appeared (so-called true color), and QuickDraw was updated again to support up to 32 bits per pixel (in reality, 24 bits, with 8 unused) of color data ("32-Bit QuickDraw"). The architecture always allowed for this, however, so no new APIs were necessary. The color data structures themselves allowed a color depth of 1, 2, 4, 8, 15 and 24 bits, yielding 2, 4, 16, 256, 32,768 and 16,777,216 colors respectively, or 4, 16 and 256 scales of grey. QuickDraw took care of managing the resampling of colors to the available color depths of the actual video hardware, or transfer between offscreen image buffers, including optionally dithering images down to a lower depth to improve image quality. A set of color sampling utilities were also added so that programmers could generate optimal color palettes for use with indexed video devices.

The architecture of QuickDraw had always allowed the creation of GrafPorts and their associated BitMaps or PixMaps "offscreen", where graphics could be composed in memory without it being visible immediately on the screen. Pixels could be transferred between these offscreen ports and the screen using the QuickDraw blitting function CopyBits. Such offscreen compositing is the workhorse for games and graphics-intensive applications. However, until the advent of 32-Bit QuickDraw, such offscreen worlds had to be created and set up by hand by programmers within their applications. This could be error-prone, as it involved three or more separate and fairly complex data structures (CGrafPort, PixMap and GDevice, and for indexed devices, the color look-up table and its inverse). With 32-Bit QuickDraw, OS support for handling this was added, with the "Offscreen Graphics World" or GWorld. The video buffer (PixMap) of a GWorld could be stored in main memory, or when available in unused parts of video ram where copying to the screen could be optimized for speed by avoiding the need to transfer a large amount of pixel data across the main memory bus.

With the advent of QuickTime, QuickDraw gained the ability to deal with compressed raster data, such as JPEG. The QuickTime Image Compression Manager integrated closely with QuickDraw: in particular, image decompression calls were full-fledged QuickDraw drawing calls, and if a picture was being recorded, the compressed data would be saved as part of the picture, for display when the picture was later drawn. The Image Compression Manager also added integration with ColorSync color matching.

After this, apart from back-end changes to optimize for new processor architectures (PowerPC), QuickDraw remained largely unchanged throughout the rest of the life of the classic Mac OS. QuickDraw GX and QuickDraw 3D shared the QuickDraw name and were able to interoperate with QuickDraw PixMap and picture data structures, but were otherwise completely separate in functionality.

With Mac OS X, QuickDraw became part of the Carbon API. In 2005, with the release of Mac OS X 10.4, QuickDraw was officially deprecated.

In 2010 with MacPaint 1.3's source code release through the Computer History Museum, a historical version of QuickDraw source code became available too.

title: QuickDraw


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Moro Gulf

The Moro Gulf is the largest gulf in the Philippines. It is located off the coast of Mindanao Island, and is part of the Celebes Sea. The gulf is one of the country's tuna fishing grounds.

Geography
The gulf stretches between and is surrounded by the main section of Mindanao on the east, and the Zamboanga Peninsula of Mindanao on the west. The peninsula's major drainage goes towards the gulf.

Sibuguey Bay and Illana Bay are its major bays.

Zamboanga City, which is an international port, is bound by the Gulf and Celebes Sea in the East. Cotabato City, on the eastern coast, is another major port.

Earthquakes
The Moro Gulf is also an area of significant tectonic activity with several fault zones in the region capable of producing major earthquakes and destructive local tsunamis, such as the devastating 1976 Moro Gulf earthquake which killed over 5,000 people and left over 90,000 people homeless as it hit the west coast of Mindanao.

license: Creative Commons - Attribution Share-Alike - https://creativecommons.org/licenses/by-sa/4.0/

title: Moro Gulf


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USS Alliance

Two United States Navy ships have been named Alliance.

 * USS Alliance (1778), was a sailing frigate of the Continental Navy, and notable for firing the last shots of the Revolutionary War.
 * USS Alliance (1875), was a screw gunboat commissioned in 1877 and in service until 1911.

title: USS Alliance


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Pedipalp

Pedipalps (commonly shortened to palps or palpi) are the secondary pair of forward appendages among chelicerates – a group of arthropods including spiders, scorpions, horseshoe crabs, and sea spiders. The pedipalps are lateral to the chelicerae ("jaws") and anterior to the first pair of walking legs.

Overview
Pedipalps are composed of six segments or articles. From the proximal end (where they are attached to the spider) to the distal, they are: the coxa, the trochanter, the femur, the short patella, the tibia, and the tarsus. In spiders, the coxae frequently have extensions called maxillae or gnathobases, which function as mouth parts with or without some contribution from the coxae of the anterior legs. The limbs themselves may be simple tactile organs outwardly resembling the legs, as in spiders, or chelate weapons (pincers) of great size, as in scorpions. The pedipalps of Solifugae are covered in setae, but have not been studied in detail.

Comparative studies of pedipalpal morphology may suggest that leg-like pedipalps are primitive in arachnids. At present, the only reasonable alternative to this view is to assume that xiphosurans reflect the morphology of the primitive arachnid pedipalp and to conclude that this appendage is primitively chelate. Pedipalps are traditionally thought to be homologous with mandibles in crustaceans and insects, although more recent studies (e.g. using Hox genes) suggest they are probably homologous with the crustacean second antennae.

Chelate pedipalps
Chelate or sub-chelate (pincer-like) pedipalps are found in several arachnid groups (Ricinulei, Uropygi, scorpions and pseudoscorpions) but the chelae in most of these groups may not be homologous with those found in Xiphosura. The pedipalps are distinctly raptorial (i.e., modified for seizing prey) in the Amblypygi, Uropygi, Schizomida, and some Opiliones belonging to the laniatorid group.

Spider pedipalps
Pedipalps of spiders have the same segmentation as the legs, but the tarsus is undivided, and the pretarsus has no lateral claws. Pedipalps contain sensitive chemical detectors and function as taste and smell organs, supplementing those on the legs. In sexually mature male spiders, the final segment of the pedipalp, the tarsus, develops a complicated structure (sometimes called the palpal bulb or palpal organ) that is used to transfer sperm to the female seminal receptacles during mating. The details of this structure vary considerably between different groups of spiders and are useful for identifying species. The pedipalps are also used by male spiders in courtship displays, contributing to vibratory patterns in web-shaking, acoustic signals, or visual displays.

The cymbium is a spoon-shaped structure located at the end of the spider pedipalp that supports the palpal organ. The cymbium may also be used as a stridulatory organ in spider courtship.

The embolus is a narrow whip-like or leaf-like extension of the palpal bulb.

title: Pedipalp


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Pasig River

The Pasig River (Ilog Pasig; Río Pásig) is a water body in the Philippines that connects Laguna de Bay to Manila Bay. Stretching for 25.2 km, it bisects the Philippine capital of Manila and its surrounding urban area into northern and southern halves. Its major tributaries are the Marikina River and San Juan River. The total drainage basin of the Pasig River, including the basin of Laguna de Bay, covers 4678 km2.

The Pasig River is technically a tidal estuary, as the flow direction depends upon the water level difference between Manila Bay and Laguna de Bay. During the dry season, the water level in Laguna de Bay is low with the river's flow direction dependent on the tides. During the wet season, when the water level of Laguna de Bay is high, the flow is reversed towards Manila Bay.

The Pasig River used to be an important transport route and source of water for Spanish Manila. Due to negligence and industrial development, the river suffered a rapid decline in the second half of the 20th century and was declared biologically dead in 1990. Two decades after that declaration, however, a renaturation program designed to revive the river has seen the return of life to the river, including eight fish species, 39 species of birds, and 118 species of trees and other vegetation. As a result, the Pasig River received the Asian River Prize by the International River Foundation (IRF) in 2019.

The Pasig River Rehabilitation Commission (PRRC) was a Philippine government agency established to oversee rehabilitation efforts for the river from 1999 until it was abolished in November 2019. Rehabilitation efforts are also aided by private sector organizations, such as the Clean and Green Foundation, Inc., which ran the Piso para sa Pasig (Filipino: "A peso for the Pasig") campaign in the 1990s.

Etymology
The river takes its name from the city of Pasig, which is named after the Tagalog word pasig, meaning "a river that flows into the sea" or "the sandy bank of a river", with the former in reference to the Pasig River's flow from Laguna de Bay towards Manila Bay and out into the South China Sea.

Geography
The Pasig River winds generally northwestward for some 25 km from Laguna de Bay, the largest lake in the Philippines, to Manila Bay, in the southern part of the island of Luzon. From the lake, the river runs between Taguig and Taytay, Rizal, before entering Pasig. This portion of the Pasig River, to the confluence with the Marikina River tributary, is known as the Napindan River or Napindan Channel.

From there, the Pasig forms flows through Pasig until its confluence with the Taguig River. From here, it forms the border between Mandaluyong to the north and Makati to the south. The river then sharply turns northeast, where it has become the border between Mandaluyong and Manila before turning again westward, joining its other major tributary, the San Juan River, and then following a sinuous path through the center of Manila before emptying into the bay.

The whole river and most portions of its tributaries lie entirely within Metro Manila, the metropolitan region of the capital. Isla de Convalecencia, the only island dividing the Pasig River, can be found in Manila and is where the Hospicio de San Jose is located.

Tributaries and canals
One major river that drains Laguna de Bay is the Taguig River, which enters into Taguig before becoming the Pateros River; it is the border between the municipalities of Pateros and Makati. The Pateros River then enters the confluence where the Napindan Channel and Marikina River meet. The Marikina River is the larger of the two major tributaries of the Pasig River, and it flows southward from the mountains of Rizal and cuts through the Marikina Valley. The San Juan River drains the plateau on which Quezon City stands; its major tributary is Diliman Creek.

Within the city of Manila, various esteros (canals) criss-cross through the city and connect with the Tullahan River in the north and the Parañaque River to the west.

Crossings
A total of 20 bridges currently cross the Pasig. The first bridge from the source at Laguna de Bay is the Napindan Bridge, followed by the Arsenio Jimenez Bridge to its west. Crossing the Napindan Channel in Pasig is the Bambang Bridge. It is followed by the Kaunlaran Bridge that connects barangays Buting and Sumilang in Pasig.

The next bridge downstream is the C.P. Garcia Bridge carrying C-5 Road and connecting the cities of Makati and Pasig. It is followed by the Sta. Monica–Lawton Bridge, the newest bridge opened in June 2021 that connects Lawton Avenue in Makati to Fairlane Street in Pineda, Pasig as part of the Bonifacio Global City–Ortigas Link Road project approved in 2015.

The Guadalupe Bridge between Makati and Mandaluyong carries Epifanio de los Santos Avenue, the major artery of Metro Manila, as well as the MRT Line 3 from Guadalupe station to Boni station. The Estrella–Pantaleon and Makati–Mandaluyong Bridges likewise connect the two cities downstream, with the latter forming the end of Makati Avenue.

The easternmost crossing in Manila is Lambingan Bridge in the district of Santa Ana. It is then followed by the Tulay Pangarap Footbridge (Abante Bridge), the newest pedestrian bridge that connects the Punta area and Santa Ana proper. It is followed by the Abante Bridge (Tulay Pangarap Footbridge) in Santa Ana, Skyway Stage 3, and the Padre Zamora (Pandacan) Bridge connecting Pandacan and Santa Mesa districts, and carries the southern line of the Philippine National Railways. The expressway bridge of Skyway Stage 3, serving as a connection road between the North Luzon Expressway and the South Luzon Expressway, is built near the mouth of the San Juan River where most parts of it is built and another bridge parallel to Padre Zamora and PNR bridges will be built to merge with NLEX Connector in Santa Mesa; it will thus serve as a solution to heavy traffic along EDSA. The Mabini Bridge (formerly Nagtahan Bridge) provides a crossing for Nagtahan Street, part of C-2 Road. Ayala Bridge carries Ayala Boulevard, and connects the Isla de Convalecencia to both banks of the Pasig.

Further downstream are the Quezon Bridge from Quiapo to Ermita, the Line 1 bridge from Central Terminal station to Carriedo station, MacArthur Bridge from Santa Cruz to Ermita, and the Jones Bridge from Binondo to Ermita. The last bridge near the mouth of the Pasig is the Roxas Bridge (also known as M. Lopez Bridge and formerly called Del Pan Bridge) from San Nicolas to Port Area and Intramuros.

Landmarks
The growth of Manila along the banks of the Pasig River has made it a focal point for development and historical events. The foremost landmark on the banks of the river is the walled district of Intramuros, located near the mouth of the river on its southern bank. It was built by the Spanish colonial government in the 16th century. Further upstream is the Hospicio de San Jose, an orphanage located on Pasig's sole island, the Isla de Convalescencia. On the northern bank stands the Quinta Market in Quiapo, Manila's central market, and Malacañan Palace, the official residence of the President of the Philippines. Also on the Pasig River's northern bank and within the Manila district of Sta. Mesa is the main campus of the Polytechnic University of the Philippines.

In Makati, along the southern bank of Pasig, are Circuit Makati (the former Santa Ana Race Track), the Poblacion sewage treatment plant and pumping station of Manila Water, and the Rockwell Center, a high-end office and commercial area containing the Power Plant Mall. At the confluence of the Pasig and Marikina rivers is the Napindan Hydraulic Control Structure, which regulates the flow of water from the Napindan Channel.

Geographical landmarks
The third chapter of Jose Rizal's novel El filibusterismo mentions several stories surrounding certain geographical features along the Pasig River during the Spanish colonial era, such as the Buwayang Bato, the Malapad na Bato, and Doña Geromina's Cave.

Doña Geromina's Cave, according to legend, was built by the Archbishop of Manila as a sanctuary for his former lover. The cave is believed to be located in Barangay Pineda, Pasig under the Bagong Ilog Bridge, which carries Circumferential Road 5 between Pasig and Taguig.

Malapad na Bato
In what is now Barangay West Rembo, Taguig, a cliff along the river is known as Malapad-na-bato (lit. '"Wide-rock"'), which was considered to be sacred to the early Tagalog people as a home to spirits. After the Nuestra Señora de Gracia Church was completed in 1630, it eventually became a pilgrimage site for newly converted Christians, resulting in a decline in the importance of Malapad-na-bató as a religious site. It was mentioned in El Filibusterismo that the sacred character of the site disappeared as fears of the spirits living there had disappeared after the cliff was inhabited by bandits.

Buwayang Bato
The Buwayang Bato (lit. '"crocodile rock"') is a rock formation that allegedly resembled a large crocodile. In El Filibusterismo, the legend tells a story of a rich Chinese man who did not believe in Catholicism that boasted of not being afraid of crocodiles. One day, while trading on the river, the man was attacked by a large crocodile. It was said that after the Chinese man prayed to San Nicholas for mercy, the crocodile turned into stone. The rock formation is believed to be located at the southeastern shore of Mandaluyong, in the namesake barangay of Buayang Bato.

Geology
The Pasig River's main watershed is concentrated in the plains between Manila Bay and Laguna de Bay. The watershed of the Marikina River tributary mostly occupies the Marikina Valley, which was formed by the Marikina Fault Line. The Manggahan Floodway is an artificially constructed waterway that aims to reduce the flooding in the Marikina Valley during the rainy season, by bringing excess water to Laguna de Bay.

Tidal flows
The Pasig River is technically considered a tidal estuary. Toward the end of the summer or dry season (April and May), the water level in Laguna de Bay reaches to a minimum of 10.5 m. During times of high tide, the water level in the lake may drop below that of Manila Bay's, resulting in a reverse flow of seawater from the bay into the lake. This results in increased pollution and salinity levels in Laguna de Bay at this time of the year.

Flooding
The Pasig River is vulnerable to flooding in times of very heavy rainfall, with the Marikina River tributary the main source of the floodwater. The Manggahan Floodway was constructed to divert excess floodwater from the Marikina River into Laguna de Bay, which serves as a temporary reservoir. By design, the Manggahan Floodway is capable of handling 2,400 m3 per second of water flow, with the actual flow being about 2,000 m3 per second. To complement the floodway, the Napindan Hydraulic Control System (NHCS) was built in 1983 at the confluence of the Marikina River and the Napindan Channel to regulate the flow of water between the Pasig River and the lake.

Archaeology
A human cranium and mandible was described by D. Sánchez y Sánchez (1929) from under 2.1 - 3 m of Pasig River alluvium. It was discovered during construction of the Church of the Jesuits in 1921 and was partially damaged during excavation, and was noted to be 'primitive' through a loss of Neanderthal characters and mandibular traits (most notably in the teeth and lack of chin), coining the name Homo manillensis. Sánchez y Sánchez classified the species as pre-indigenous using outdated methods based on racial classification. The specimen remains undated (although a Quaternary age has been suggested ), and Romeo (1979) somewhat equates the skull with Homo sapiens in his description. Sarat Chandra (1930) follows suite of Romeo (1979).

History
The Pasig River served as an important means of transport; it was Manila's lifeline and center of economic activity. Some of the most prominent kingdoms in early Philippine history, including the kingdoms of Namayan, Maynila, and Tondo grew up along the banks of the river, drawing their life and source of wealth from it. When the Spanish established Manila as the capital of their colonial properties in the Far East, they built the walled city of Intramuros on the southern bank of the Pasig River near its mouth.

Pollution
After World War II, massive population growth, infrastructure construction, and the dispersal of economic activities to Manila's suburbs left the river neglected. The banks of the river attracted informal settlers and the remaining factories dumped their wastes into the river, making it effectively a huge sewer system. Industrialization had already polluted the river.

In the 1930s, observers noticed the increasing pollution of the river, as fish migration from Laguna de Bay diminished. People ceased using the river's water for laundering in the 1960s, and ferry transport declined. By the 1970s, the river started to emanate offensive smells, and in the 1980s, fishing in the river was prohibited. In 1990, the Pasig River was considered biologically dead by the Danish International Development Agency.

It is estimated that about 60-65 percent of the pollution in the Pasig River comes from household waste disposed into the tributaries of the river. Increasing poverty in the rural areas in Philippines has driven migration to Metro Manila in search of better opportunities. This resulted in rapid urban growth, congestion and overcrowding of land and along the riverbanks, making the river and its tributaries a dumping ground for informal settlers living there. About 30–35 percent of the river pollution is generated from industries locating close to the river (such as tanneries, textile mills, food processing plants, distilleries, and chemical and metal plants), some of which do not have water treatment facilities which are capable of removing heavy metal pollutants. The rest of the pollutants consist of solid waste dumped into the rivers. Metro Manila has been reported to produce as much as 7,000 t of garbage per day. In a study conducted by the researchers from Polytechnic University of the Philippines, the river is also contaminated with microplastics.

Rehabilitation efforts
Efforts to revive the river began in December 1989 with the help of Danish authorities. The Pasig River Rehabilitation Program (PRRP) was established, with the Department of Environment and Natural Resources (DENR) as the main agency with the coordination of the Danish International Development Assistance (DANIDA).

In 1999, President Joseph Estrada signed Executive Order No. 54 establishing the Pasig River Rehabilitation Commission (PRRC) to replace the old PRRP with additional expanded powers such as managing of wastes and resettling of squatters. The PRRC was abolished in November 2019, with its functions and powers being transferred to the Manila Bay Task Force, DENR, Department of Housing and Urban Development, Metropolitan Manila Development Authority (MMDA), and the Department of Public Works and Highways (DPWH).

In 2010, the television network ABS-CBN and PRRC headed by ABS-CBN Foundation-Bantay Kalikasan Director Gina Lopez – currently serving as a chairperson of PRRC – launched a fun run fund-raising activity called "Run for the Pasig River" held every month of October. The proceeds from the fun run will serve as a fund for the "Kapit-bisig para sa Ilog Pasig" (Collaborate for the Pasig River) rehabilitation project of the Pasig River.

In October 2018, the PRRC won the first Asia Riverprize, in recognition of its efforts to rehabilitate the Pasig River. According to the PRRC, aquatic life has returned to the river.

On April 20, 2021, San Miguel Corporation announced that it would initiate a clean-up of the Pasig River in May 2021. SMC will also work with the DENR and the DPWH in this river cleanup. The river cleanup is part of San Miguel Corporation's ₱95 billion Pasig River Expressway project.

Pasig River Esplanade
On January 17, 2024, the Bongbong Marcos administration inaugurated its Pasig Bigyang Buhay Muli (PBBM; lit. 'Give Life to Pasig Again') project, aiming to revitalize the Pasig River through the development of linear parks, walkways, bikeways, and commercial developments. The program also aims to improve the existing Pasig River Ferry System through the addition of more ferry boats and stations.

title: Pasig River


text:
Pseudomonarchia Daemonum

Pseudomonarchia Daemonum, or False Monarchy of Demons, first appears as an Appendix to De praestigiis daemonum (1577) by Johann Weyer. An abridgment of a grimoire similar in nature to the Ars Goetia (first book of The Lesser Key of Solomon), it contains a list of demons, and the appropriate hours and rituals to conjure them.

The Pseudomonarchia predates, and differs somewhat from, Ars Goetia. The Pseudomonarchia lists sixty-nine demons (in contrast to the later seventy-two), and their sequence varies, along with some of their characteristics. The demon Pruflas appears only in Pseudomonarchia, and Pseudomonarchia does not attribute any sigils to the demons.

Weyer referred to his source manuscript as ''Liber officiorum spirituum, seu Liber dictus Empto. Salomonis, de principibus et regibus daemoniorum. (Book of the offices of spirits, or the book called 'Empto'. Solomon, concerning the princes and kings of demons.) This work is likely related to a very similar 1583 manuscript titled The Office of Spirits, both of which appear ultimately be an elaboration on a fifteenth-century manuscript titled Le Livre des Esperitz (of which 30 of its 47 spirits are nearly identical to spirits in the Ars Goetia'').

The 69 demons

 * 1) King Baël
 * 2) Duke Aguarès
 * 3) President Barbas
 * 4) Prince/Duke Pruflas
 * 5) Marquess Amon
 * 6) Duke/Count Barbatos
 * 7) President Buer
 * 8) Duke Gusoyn
 * 9) Count/President Botis
 * 10) Duke Bathym
 * 11) King Pursan
 * 12) Duke Eligos
 * 13) Marquess Loray
 * 14) Duke Valefor
 * 15) Count/President Morax
 * 16) Prince/Count Ipes
 * 17) President Glasya labolas
 * 18) Marquess Naberius
 * 19) Duke Zepar
 * 20) King Byleth
 * 21) Prince Sytry
 * 22) King Paimon
 * 23) King Bélial
 * 24) Duke Bune
 * 25) Marquess Forneus
 * 26) Marquess/Count Roneve
 * 27) Duke Berith
 * 28) Duke Astaroth
 * 29) President Forras
 * 30) Count Furfur
 * 31) Marquess Marchocias
 * 32) President Malphas
 * 33) Duke Vepar
 * 34) Marquess Sabnac
 * 35) King Sidonay
 * 36) Prince/President Gaap
 * 37) Duke/Marquess Chax
 * 38) Duke Pucel
 * 39) Knight Furcas
 * 40) Duke/Count Murmur
 * 41) President Caym
 * 42) Count Raum
 * 43) Count Halphas
 * 44) Duke Focalor
 * 45) King/Count Vine
 * 46) Count Bifrons
 * 47) Marquess Samigina
 * 48) King/President Zagan
 * 49) Marquess Orias
 * 50) President Volac
 * 51) Duke Gomory
 * 52) King/Count Decarabia
 * 53) Duke Amduscias
 * 54) Marquess Andras
 * 55) Marquess Andrealphus
 * 56) President Oze
 * 57) Duke Aym
 * 58) Prince Orobas
 * 59) Duke Vapula
 * 60) Marquess Cimeries
 * 61) President Amy
 * 62) Duke Flauros
 * 63) King Balam
 * 64) Duke Alocer
 * 65) Count Saleos
 * 66) Duke Vuall
 * 67) President Haagenti
 * 68) Marquess Phoenix
 * 69) Prince Stolas

title: Pseudomonarchia Daemonum


text: User talk:Etan

title: User talk:Etan


text:
Babuyan Islands

The Babuyan Islands, also known as the Babuyan Group of Islands, is an archipelago in the Philippines, located in the Luzon Strait north of the main island of Luzon and south of Taiwan via Bashi Channel to Luzon Strait. The archipelago consists of five major islands and their surrounding smaller islands. These main islands are, counterclockwise starting from northeast, Babuyan, Calayan, Dalupiri, Fuga, and Camiguin. The Babuyan Islands are separated from Luzon by the Babuyan Channel, and from the province of Batanes to the north by the Balintang Channel.

Geography
The archipelago, comprising 24 volcanic-coralline islands, has a total area of about 590 km2. The largest of these is Calayan with an area of 196 km2, while the highest peak in the island group is Mount Pangasun (1108 m) on Babuyan Claro.

Islands
The following are the islands of Babuyan and their adjoining islets and rocks, along with land areas and highest elevation:

Geology
The eastern islands of the archipelago are part of the Luzon Volcanic Arc. Three volcanoes from two of the islands have erupted in historical times - Camiguin de Babuyanes on Camiguin Island, Babuyan Claro Volcano and Smith Volcano (also known as Mount Babuyan) on Babuyan Island.

Another small volcanic island located just 22 km NE of Camiguin Island, Didicas Volcano on Didicas Island, became a permanent island only after emerging and rising to over 200. m above sea level in 1952.

Flora and fauna
All of the islands within the island group are classified by Haribon Foundation and BirdLife International as key biodiversity areas, or sites with outstanding universal value due to its geographic and biologic importance. All of the islands within the island group have never been part of any large landmass, and thus have unique flora and fauna, most of which are found nowhere else. A research conducted by the Department of Environment and Natural Resources have found at least 5 faunal regions in the area, one of the highest density of separate faunal regions in the world. The islands are also home to the most critically endangered bird species in the Philippines, the Calayan rail (found only on the small island of Calayan), and the most critically endangered snake species in the Philippines, the Ross' wolf snake (found only on the small island of Dalupiri). The island group is also a congregation site for endangered humpback whales, one of the only few of its kind in Southeast Asia. Due to its immense value to the natural world and Philippine biological diversity, various scientific and conservation groups have been lobbying for its declaration as a national park and its inclusion in the UNESCO World Heritage List.

Humpback whales have re-colonized into the area and the Babuyan became the only wintering ground for the species in the Philippines although historical records among Babuyan Islands have not been confirmed.

Demographics
List of islands by population (as of 2020):
 * 1) Calayan Island - 9,648
 * 2) Camiguin Island - 5,231
 * 3) Fuga Island - 1,939
 * 4) Babuyan Island - 1,910
 * 5) Dalupiri Island - 621
 * 6) Barit Island - 14

Government
The whole archipelago is administered under the province of Cagayan with Babuyan, Calayan, Camiguin, and Dalupiri comprising the municipality of Calayan while Fuga is under the jurisdiction of Aparri.

Babuyan and Dalupiri are themselves individual barangays in Calayan municipality, respectively named Babuyan Claro and Dalupiri, while Fuga Island is also an individual barangay, also named Fuga Island, in Aparri.

title: Babuyan Islands


text:
Frederick III, Elector of Saxony

Frederick III (17 January 1463 – 5 May 1525), also known as Frederick the Wise (German: Friedrich der Weise), was Prince-elector of Saxony from 1486 to 1525, who is mostly remembered for the protection given to his subject Martin Luther, the seminal figure of the Protestant Reformation. Frederick was the son of Ernest, Elector of Saxony and his wife Elisabeth, daughter of Albert III, Duke of Bavaria.

He is notable as being one of the most powerful early defenders of Martin Luther, as the elector successfully protected him from the Holy Roman Emperor, the Pope and other hostile figures. He was ostensibly led, not by religious conviction about the possible truthness of Luther's propositions, but rather by personal belief in a fair trial for any of his subjects (a privilege guaranteed by the imperial statutory law) and the rule of law.

The prince-elector is considered to have remained a Roman Catholic all his life, yet gradually inclining toward doctrines of the Reformation and supposedly converting on his deathbed.

He is held in high regard by Protestants in church history, and is officially commemorated as an exemplary Christian ruler in the Calendar of Saints of the American Lutheran Church – Missouri Synod every 5 May.

Biography
Born in Torgau, he succeeded his father as elector in 1486; in 1502, he founded the University of Wittenberg, where theologians Martin Luther and Philip Melanchthon would teach some time later.

Frederick was among the German princes who pressed the need of reform upon Maximilian I, Holy Roman Emperor, and in 1500, he became president of the newly formed council of regency (Reichsregiment).His court painter from 1504 on was the Renaissance master Lucas Cranach the Elder (1472–1453).

Frederick was Pope Leo X's candidate for Holy Roman Emperor at the 1519 imperial election; thus the Pope had awarded him the Golden Rose of virtue on 3 September 1518 in an effort to persuade him to accept the throne. However, Frederick helped secure the election of Charles V by agreeing to support Charles and to convince his fellow electors to do the same if Charles repaid an outstanding debt to the Saxons dating back to 1497.

Frederick collected many relics in his Castle Church; his inventory of 1518 listed 17,443 items, including a thumb from St. Anne, a twig from Moses' burning bush, hay of the holy manger, and milk from the Virgin Mary. Money was paid in order to venerate these relics and thus escape years in purgatory, according to the current belief in indulgence at that context. Thus, according to some calculations, a diligent and pious person who rendered appropriate devotion to each of these relics at that time would be able to merit 1,902,202 years worth of penance (an earthly equivalent of time otherwise spent in purgatory, removed by indulgences). Two years later, the collection exceeded 19,000 pieces.

The elector's dream
About October 30, 1517, Frederic had a dream which made a deep impression upon his mind, and which foreshadowed the work of the Reformation: "The feast of All-Saints was at hand, and the elector, having retired to rest, lay musing how he should keep the festival, and was praying for the poor souls in purgatory, and beseeching Divine guidance for himself, his counselors, and his people. Thus engaged, he fell asleep, and dreamed that a monk, a true son of the apostle Paul, was sent to him; and that all the saints accompanied him, for the purpose of testifying that he was divinely commissioned. They asked of the elector, that the monk might be allowed to write something on the church door at Wittenberg. The monk began to write, and the characters were so large and brilliant that they could be read at a great distance; and the pen he used was so long that its extremity reached even to Rome, and wounded the ears of a lion which was crouching there, and shook the triple crown on the pope's head. All the cardinals and princes ran to support it; and, as the dreamer himself joined in the effort to support the pope's crown, he awoke in great alarm, and angry with the monk who had used his pen so awkwardly. Presently he fell asleep again, and his strange dream continued; the disturbed lion began to roar, and Rome and all the surrounding States ran to make inquiry; and the pope demanded that the monk be restrained, and demanded this especially of the elector, as the monk dwelt in his dominions.

Once more the elector awoke from his dream, besought God to preserve the holy father, the pope, and slept again. And still his strange dream continued, and he saw all the princes of the empire crowding to Rome, and all striving to break the mysterious pen. Yet the more they endeavored to break it, the stiffer it became; and when they asked the monk where he found it, and why it was so strong, he replied that he secured it from one of his old schoolmasters; that it belonged to a Bohemian goose (John Huss, who proclaimed the truth a century before Luther and whose surname in the Bohemian language signifies 'goose') a hundred years old; and that it was strong because no man could take the pith out of it. Suddenly the dreamer heard an outcry, and lo, a great number of pens had issued from the long pen of the monk!"

The festival of All-Saints was an important day for Wittenberg. The costly relics of the castle church were then displayed before the people, and a full remission of sin was granted to all who visited the church and made confession. Accordingly on this day the people in great numbers flocked to Wittenberg in pilgrimage. On the 31st of October, the day preceding the festival, the monk Martin Luther went boldly to the church, to which a crowd of worshipers was already repairing, and affixed to the door ninety-five propositions against the doctrine of indulgences. He went alone; his closest friends did not know his plan. As he fastened his theses upon the door of the church, he proclaimed himself ready to defend them the next day at the university itself against all opposers.

These propositions attracted universal attention. They were read and re-read and repeated in every direction. Great excitement was created in the university and in the whole city.

By these theses the doctrine of indulgences was fearlessly opposed. Luther argued that the power to grant the pardon of sin, and to remit its penalty, had never been committed to the Pope, or to any other man. The whole scheme was a farce, an artifice to extort money by playing upon the superstitions of the people, a device of Satan to destroy the souls of all who should trust to its lying pretensions. It was also clearly shown that the gospel of Christ was the most valuable treasure of the Church, and that the grace of God, therein revealed, was freely bestowed upon all who should seek it by repentance and faith.

Protection of Martin Luther
Martin Luther, an Augustinian friar, was ordained to the priesthood in 1507, and on the following year, in 1508, he began teaching theology at the University of Wittenberg, which was located in the Electorate of Saxony, i.e., inside the territory ruled by Prince-elector Frederick III. Therefore, Luther was a subject of the elector, by living at his domains.

Luther received two bachelor's degrees, one in biblical studies on 9 March 1508, and another in the Sentences by Peter Lombard in 1509. On 19 October 1512, he was awarded his Doctor of Theology. On 21 October 1512, Luther was received into the senate of the theological faculty of the University of Wittenberg, succeeding von Staupitz as chair of theology. He spent the rest of his career in this position at the University of Wittenberg. In 1515, he was made provincial vicar of Saxony and Thuringia, which required him to visit and oversee eleven monasteries in his province.

From 1510 to 1520, Luther lectured on the Psalms, and on the books of Hebrews, Romans, and Galatians. As he studied these portions of the Bible, he came to view the use of terms such as penance and righteousness by the Catholic Church in new ways. He became convinced that the church was corrupt in its ways and had lost sight of what he saw as several of the central truths of Christianity. The most important for Luther was the doctrine of justification—God's act of declaring a sinner righteous—by faith alone through God's grace. He began to teach that salvation or redemption is a gift of God's grace, attainable only through faith in Jesus as the Messiah. "This one and firm rock, which we call the doctrine of justification", he writes, "is the chief article of the whole Christian doctrine, which comprehends the understanding of all godliness."

After a while, Luther came to reject several teachings and practices of the Roman Catholic Church; in particular, he disputed the view on indulgences. Luther attempted to resolve these differences amicably, first proposing an academic discussion of its practice and efficacy.Luther at the Diet of Worms.jpg, 1877.

]]

In 1516, Johann Tetzel, a Dominican friar, was sent to Germany by the Roman Catholic Church to sell indulgences to raise money in order to rebuild St. Peter's Basilica in Rome.

Then, on 31 October 1517, Luther wrote to his bishop, Albrecht von Brandenburg, protesting against the sale of indulgences. He enclosed in his letter a copy of his "Disputation on the Power and Efficacy of Indulgences", which came to be known as the Ninety-five Theses.

In 1520, Pope Leo X demanded that Luther renounce all of his writings, and when Luther refused to do so, excommunicated him in January 1521.

Then, to give him the right to a fair trial, Elector Frederick ensured that Martin Luther would be heard before the Diet of Worms in 1521; after Holy Roman Emperor Charles V condemned Luther as an outlaw at the Diet, the elector also secured an exemption from the Edict of Worms for Saxony.

The Elector then protected Luther from the Pope's enforcement of the edict by faking a highway attack on Luther's way back to Wittenberg, abducting and then hiding him for several years at Wartburg Castle after the Diet of Worms.

Luther's disappearance during his return to Wittenberg was planned by Frederick III, who had him intercepted on his way home in the forest near Wittenberg by masked horsemen impersonating highway robbers. They escorted Luther to the security of the Wartburg Castle at Eisenach, where he remained desguised as "Junker Jörg".

During his stay at Wartburg, which he referred to as "my Patmos", Luther translated the New Testament from Greek into German and poured out doctrinal and polemical writings. In the summer of 1521, Luther widened his target from individual pieties like indulgences and pilgrimages to doctrines at the heart of Church practice.

In On the Abrogation of the Private Mass, he condemned as idolatry the idea that the mass is a sacrifice, asserting instead that it is a gift, to be received with thanksgiving by the whole congregation. His essay On Confession, Whether the Pope has the Power to Require It rejected compulsory confession and encouraged private confession and absolution, since "every Christian is a confessor." In November, Luther wrote The Judgement of Martin Luther on Monastic Vows. He assured monks and nuns that they could break their vows without sin, because vows were an illegitimate and vain attempt to win salvation.

Last years and Wittenberg happenings

Despite actively protecting Luther from the hostile menaces against him, the elector had little personal contact with the reformer himself, but Frederick's treasurer Degenhart Pfaffinger spoke on his behalf to Luther, as Pfaffinger had supported the elector since their pilgrimage to the Holy Land together.

The pronouncements by Luther from Wartburg Castle were made the context of rapid developments at Wittenberg, of which he was kept fully informed while residing at the fortress. Andreas Karlstadt, supported by the ex-Augustinian Gabriel Zwilling, embarked on a radical programme of reform there in June 1521, exceeding anything envisaged by Luther. The reforms provoked disturbances, including a revolt by the Augustinian friars against their prior, the smashing of statues and images in churches, and denunciations of the magistracy.

After secretly visiting Wittenberg in early December 1521, Luther wrote A Sincere Admonition by Martin Luther to All Christians to Guard Against Insurrection and Rebellion.

Wittenberg became even more volatile after Christmas when a band of visionary zealots, the so-called Zwickau prophets, arrived, preaching revolutionary doctrines such as the absolute equality of man, adult baptism, and Christ's imminent return. When the town council asked Luther to return, he decided it was his duty to act. Luther secretly returned to Wittenberg on 6 March 1522. He wrote to the elector: "During my absence, Satan has entered my sheepfold, and committed ravages which I cannot repair by writing, but only by my personal presence and living word." For eight days in Lent, beginning on Invocavit Sunday, 9 March, Luther preached eight sermons, which became known as the "Invocavit Sermons". In these sermons, he hammered home the primacy of core Christian values such as love, patience, charity, and freedom, and reminded the citizens to trust God's word rather than violence to bring about necessary change.

The effect of Luther's intervention was immediate at the city. After the sixth sermon, the Wittenberg jurist Jerome Schurf wrote to the elector: "Oh, what joy has Dr. Martin's return spread among us! His words, through divine mercy, are bringing back every day misguided people into the way of the truth." Luther next set about reversing or modifying the new church practices. By working alongside the authorities to restore public order, he signaled his reinvention as a conservative force within the Reformation.

Despite his victory in Wittenberg, after banishing the Zwickau prophets, Luther would still have to fight elsewhere against both the established Catholic Church and also the radical reformers who threatened the new order by fomenting social unrest and violence.

Personal faith and issue of conversion
Frederick III was a lifelong Roman Catholic, but he might have converted to Lutheranism on his deathbed in 1525 depending on how his receiving of a Protestant communion is viewed.

The elector leaned heavily towards Lutheranism throughout his later years, guaranteeing safety for his subject and Protestant reformer Martin Luther, so that he would not receive the same fate as of Jan Huss and other pre-reformers, after he was tried for heresy and excommunicated by the Pope.

However, to define what it meant to "convert" to Lutheranism or Protestantism at the time, it must be taken into account that, when he passed away, the Reformation had begun not long before, as the time he died was just eight years after the publication of the Ninety-five Theses, considered the start of the movement, and many important works, were yet to be written at the time of Frederick's death, such as Luther's cathecisms (1529), about Protestant doctrine, and the German Mass (1526), about Lutheran liturgy. Therefore the Protestant doctrine was not yet fully established, and was just beginning to be seen as the autonomous expression of faith it would become, instead of just a correction or a heresy inside the scope of Roman Catholicism.

Death and succession

Frederick died unmarried in 1525, aged 62 years old, at Lochau, a hunting castle near Annaburg (30 km southeast of Wittenberg), and was buried in the Castle Church at Wittenberg, with a grave tomb sculpted by Peter Vischer the Younger.

As he was unmarried and had no offspring, he was succeeded as prince-elector of Saxony by his brother John the Steadfast, as former duke and heir presumptive of his older brother. John had been Lutheran even before succeeding Frederick as elector, and continued with his policies of supporting the Reformation, having made the Lutheran church the official state church in Saxony in 1527.

title: Frederick III, Elector of Saxony


text:
Artificial heart

An artificial heart is an artificial organ device that replaces the heart. Artificial hearts are typically used to bridge the time to complete heart transplantation surgery, but research is ongoing to develop a device that could permanently replace the heart in the case that a heart transplant (from a deceased human or, experimentally, from a deceased genetically engineered pig) is unavailable or not viable. , there are two commercially available full artificial heart devices; in both cases, they are for temporary use, of less than a year, for total heart failure patients awaiting a human heart to be transplanted into their bodies.

Although other similar inventions preceded it from the late 1940s, the first artificial heart to be successfully implanted in a human was the Jarvik-7 in 1982, designed by a team including Willem Johan Kolff, William DeVries and Robert Jarvik.

An artificial heart is distinct from a ventricular assist device (VAD; for either one or both of the ventricles, the heart's lower chambers), which can be a permanent solution also, or the intra-aortic balloon pump – both devices are designed to support a failing heart. It is also distinct from a cardiopulmonary bypass machine, which is an external device used to provide the functions of both the heart and lungs, used only for a few hours at a time, most commonly during cardiac surgery. It is also distinct from a ventilator, used to support failing lungs, or the extracorporeal membrane oxygenation (ECMO), which is used to support those with both inadequate heart and lung function for up to days or weeks, unlike the bypass machine.

Origins
A synthetic replacement for a heart remains a long-sought "holy grail" of modern medicine. The obvious benefit of a functional artificial heart would be to lower the need for heart transplants because the demand for organs always greatly exceeds supply.

Although the heart is conceptually a pump, it embodies subtleties that defy straightforward emulation with synthetic materials and power supplies. Artificial hearts have historically had issues from both a biomedical standpoint, regarding clotting and foreign object rejection, as well as longevity and practicality, regarding the lifespan of the device as well as the equipment required to run it.

Since the inception of the device, artificial hearts have been continually improved as medical technology has. More recent devices, such as the Carmat heart, have sought to improve upon their predecessors by reducing complications resultant from device implant, such as foreign-body rejection and thrombus.

Early development
The first artificial heart was made by the Soviet scientist Vladimir Demikhov in 1938. It was implanted in a dog.

On July 2, 1952, 41-year-old Henry Opitek, suffering from shortness of breath, made medical history at Harper University Hospital at Wayne State University in Michigan. The Dodrill-GMR heart machine, considered to be the first operational mechanical heart, was successfully used while performing heart surgery. Ongoing research was done on calves at Hershey Medical Center, Animal Research Facility, in Hershey, Pennsylvania, during the 1970s.

Forest Dewey Dodrill, working closely with Matthew Dudley, used the machine in 1952 to bypass Henry Opitek's left ventricle for 50 minutes while he opened the patient's left atrium and worked to repair the mitral valve. In Dodrill's post-operative report, he notes, "To our knowledge, this is the first instance of survival of a patient when a mechanical heart mechanism was used to take over the complete body function of maintaining the blood supply of the body while the heart was open and operated on."

A heart–lung machine was first used in 1953 during a successful open heart surgery. John Heysham Gibbon, the inventor of the machine, performed the operation and developed the heart–lung substitute himself.

Following these advances, scientific interest for the development of a solution for heart disease developed in numerous research groups worldwide.

Early designs of total artificial hearts
In 1949, a precursor to the modern artificial heart pump was built by doctors William Sewell and William Glenn of the Yale School of Medicine using an Erector Set, assorted odds and ends, and dime-store toys. The external pump successfully bypassed the heart of a dog for more than an hour.

On December 12, 1957, Willem Johan Kolff, the world's most prolific inventor of artificial organs, implanted an artificial heart into a dog at Cleveland Clinic. The dog lived for 90 minutes.

In 1958, Domingo Liotta initiated the studies of TAH (Total Artificial Heart) replacement at Lyon, France, and in 1959–60 at the National University of Córdoba, Argentina. He presented his work at the meeting of the American Society for Artificial Internal Organs held in Atlantic City in March 1961. At that meeting, Liotta described the implantation of three types of orthotopic (inside the pericardial sac) TAHs in dogs, each of which used a different source of external energy: an implantable electric motor, an implantable rotating pump with an external electric motor, and a pneumatic pump.

Paul Winchell designed a model of artificial heart with the assistance of Henry Heimlich (the inventor of the Heimlich maneuver) and submitted a patent for a mechanically driven artificial heart implementing a cam driven roller mechanism to compress flexible bags containing blood, on February 6, 1961. This is contrary to the popular claim that Winchell submitted the patent in the summer of 1956, as well as contrary to the claim that Winchell "invented" the artificial heart. In fact, two patents existed prior to Winchell's submission. These patents were filed April 10, 1956, and April 17, 1959, respectively. Winchell also claims that the design within his patent was used in later models of the Jarvik hearts, a claim in which Robert Jarvik, the principle designer of those hearts, denies on the basis that his pneumatically driven hearts share little in common with Winchell's mechanically actuated patent.

In 1964, the National Institutes of Health started the Artificial Heart Program, with the goal of putting an artificial heart into a human by the end of the decade. The purpose of the program was to develop an implantable artificial heart, including the power source, to replace a failing heart.

In February 1966, Adrian Kantrowitz rose to international prominence when he performed the world's first permanent implantation of a partial mechanical heart (left ventricular assist device) at Maimonides Medical Center.

In 1967, Kolff left Cleveland Clinic to start the Division of Artificial Organs at the University of Utah and pursue his work on the artificial heart.
 * 1) In 1973, a calf named Tony survived for 30 days on an early Kolff heart.
 * 2) In 1975, a bull named Burk survived 90 days on the artificial heart.
 * 3) In 1976, a calf named Abebe lived for 184 days on the Jarvik 5 artificial heart.
 * 4) In 1981, a calf named Alfred Lord Tennyson lived for 268 days on the Jarvik 5.

Over the years, more than 200 physicians, engineers, students and faculty developed, tested and improved Kolff's artificial heart. To help manage his many endeavors, Kolff assigned project managers. Each project was named after its manager. Graduate student Robert Jarvik was the project manager for the artificial heart projects, for which the Jarvik line of artificial hearts get their name. There, physician-engineer Clifford Kwan-Gett invented two components of an integrated pneumatic artificial heart system: a ventricle with hemispherical diaphragms that did not crush red blood cells (a problem with previous artificial hearts) and an external heart driver that inherently regulated blood flow without needing complex control systems. Jarvik also combined several modifications: an ovoid shape to fit inside the human chest, a more blood-compatible polyurethane developed by biomedical engineer Donald Lyman, and a fabrication method by Kwan-Gett that made the inside of the ventricles smooth and seamless to reduce dangerous stroke-causing blood clots.

First clinical implantation of a total artificial heart
On April 4, 1969, Domingo Liotta and Denton A. Cooley replaced a dying man's heart with a mechanical heart inside the chest at The Texas Heart Institute in Houston as a bridge for a transplant. The man woke up and began to recover. After 64 hours, the pneumatic-powered artificial heart was removed and replaced by a donor heart. However thirty-two hours after transplantation, the man died of what was later proved to be an acute pulmonary infection, extended to both lungs, caused by fungi, most likely caused by an immunosuppressive drug complication.

The original prototype of Liotta-Cooley artificial heart used in this historic operation is prominently displayed in the Smithsonian Institution's National Museum of American History "Treasures of American History" exhibit in Washington, D.C.

First clinical applications of a permanent pneumatic total artificial heart
The first clinical use of an artificial heart designed for permanent implantation rather than a bridge to transplant occurred in 1982 at the University of Utah. In 1981, William DeVries submitted a request to the FDA for permission to implant the Jarvik-7 into a human being. On December 1, 1982, William DeVries implanted the Jarvik-7 artificial heart into Barney Clark, a retired dentist from Seattle who had severe congestive heart failure. Clark's case was highly publicized and received much media attention, garnering attention from television networks, newspapers and periodicals. Clark lived for 112 days tethered to the UtahDrive pneumatic drive console, a device weighing some 400 lb. During that time Clark required several re-operations, suffered seizures, experienced prolonged periods of confusion and a number of instances of bleeding and asked several times to be allowed to die. Clark, however, still believed his being part of the initial experiment was an important contribution to medicine, and maintained an overall positive outlook on his condition. Barney Clark died on March 23, 1983, of multiorgan system failure. Despite the complications, DeVries considered Clark's case a success. DeVries subsequently moved his practice to Humana Hospital Audubon in Louisville, Kentucky to continue studies using the Jarvik-7. DeVries' first artificial heart patient in Louisville was Bill Schroeder. DeVries replaced Schroeder's failing heart with a Jarvik-7 on November 25, 1984. Like Clark, Schroeder suffered from bleeding that required re-operation to resolve. In the first weeks the outlook was good and Schroeder was allowed to have a can of Coors beer and he was given a phone call by President Reagan, in which he famously asked the president for an update on a late Social Security check. However, 19 days after the operation, Schroeder suffered the first of four strokes. Despite this, his recovery continued and was allowed to live in a specially outfitted apartment near the hospital for a period of time, as well as use a newly developed battery-powered portable drive unit for the heart which allowed him to venture out of the hospital for short periods. Schroeder's health continued to decline as three more strokes plagued his time with the artificial heart. He died on August 6, 1986, from complications from a stroke, respiratory failure and sepsis, after 620 days with the artificial heart.

Three more patients received the Jarvik-7 as a permanent heart. Murray Haydon, DeVries' third patient, received a Jarvik-7 on February 17, 1985. Haydon suffered pulmonary issues and was required to be on a mechanical ventilator for the duration of his time with the artificial heart. Haydon died of infection and kidney failure on June 19, 1986, after 488 days with his artificial heart. On April 7, 1985, Dr. Bjarne Semb of Karolinska Hospital in Stockholm Sweden implanted a Jarvik-7 in Swedish businessman Leif Stenberg. Stenberg lived 229 largely-uneventful days with the heart but suffered from a stroke and subsequently died on November 21, 1985. Jack Burcham was DeVries' fourth and final patient to receive a Jarvik-7 as a destination therapy. Burcham received his heart on April 14, 1985, but due to complications from the size of the device, bleeding and kidney failure, Burcham died just 10 days later on April 25, 1985.

In the mid-1980s, artificial hearts were powered by large pneumatic drive consoles. Moreover, two sizable catheters had to cross the body wall to carry the pneumatic pulses to the implanted heart, greatly increasing the risk of infection. To speed development of a new generation of technologies, the National Heart, Lung, and Blood Institute opened a competition for implantable electrically powered artificial hearts. Three groups received funding: Cleveland Clinic in Cleveland, Ohio; the College of Medicine of Pennsylvania State University (Penn State Milton S. Hershey Medical Center) in Hershey, Pennsylvania; and AbioMed, Inc. of Danvers, Massachusetts. Despite considerable progress, the Cleveland program was discontinued after the first five years.

First clinical application of an intrathoracic pump
On July 19, 1963, E. Stanley Crawford and Domingo Liotta implanted the first clinical Left Ventricular Assist Device (LVAD) at The Methodist Hospital in Houston, Texas, in a patient who had a cardiac arrest after surgery. The patient survived for four days under mechanical support but did not recover from the complications of the cardiac arrest; finally, the pump was discontinued, and the patient died.

First clinical application of a paracorporeal pump
On 21 April 1966, Michael DeBakey and Liotta implanted the first clinical LVAD in a paracorporeal position (where the external pump rests at the side of the patient) at The Methodist Hospital in Houston, in a patient experiencing cardiogenic shock after heart surgery. The patient developed neurological and pulmonary complications and died after few days of LVAD mechanical support. In October 1966, DeBakey and Liotta implanted the paracorporeal Liotta-DeBakey LVAD in a new patient who recovered well and was discharged from the hospital after 10 days of mechanical support, thus constituting the first successful use of an LVAD for postcardiotomy shock.

First VAD patient with FDA approved hospital discharge
In 1990, Brian Williams was discharged from the University of Pittsburgh Medical Center (UPMC), becoming the first VAD patient to be discharged with Food and Drug Administration (FDA) approval. The patient was supported in part by bioengineers from the University of Pittsburgh's McGowan Institute.

SynCardia
SynCardia Systems is a company based in Tucson, Arizona, which currently has two separate models of their artificial heart available. It is available in a 70cc and 50cc size. The 70cc model is used for biventricular heart failure in adult men, while the 50cc is for children and women. As of 2014, more than 1,250 patients have received SynCardia artificial hearts.

The device has two drive systems available for patients to use; the Companion 2 in-hospital driver, approved by the FDA in 2012, or the Freedom Driver System, approved in 2014. The Companion 2 replaced the Circulatory Support System Console, which was the original drive system for the heart. The Freedom Driver System is a compact portable driver for greater mobility and can allow some patients to return home. To power the heart, the drivers send pulsed air through the drivelines into the heart. The drivers also monitor blood flow for each ventricle.

In 1991 the rights to the Jarvik-7 were transferred to CardioWest, who resumed testing of the heart. Following good results with the TAH as a bridge to heart transplant, a trial of the CardioWest TAH was initiated in 1993 and completed in 2002. After the completion of this trial, CardioWest became SynCardia. The SynCardia total artificial heart was first approved for use in 2004 by the US Food and Drug Administration.

Though the SynCardia shares its design with the Jarvik-7, improvements have been made throughout its lifespan, reducing the occurrence of stroke and bleeding. Lifespan while being supported by the device has also drastically improved, with one patient being supported by the device for over 1,700 days.

In 2016, SynCardia filed for bankruptcy protection and was later acquired by the private equity firm Versa Capital Management. In 2021, SynCardia was acquired by Hunniwell Lake Ventures under its portfolio company, Picard Medical. In April 2023, SynCardia filed to become a publicly traded company via SPAC.

Carmat Aeson bioprosthetic heart
On October 27, 2008, French professor and leading heart transplant specialist Alain F. Carpentier announced a timeline that a fully implantable artificial heart would be ready for clinical trial by 2011 and for alternative transplant in 2013. It was developed and would be manufactured by his biomedical firm CARMAT SA, and venture capital firm Truffle Capital. The prototype used embedded electronic sensors and was made from chemically treated animal tissues, called "biomaterials", or a "pseudo-skin" of biosynthetic, microporous materials.

According to a press-release by Carmat dated December 20, 2013, the first implantation of its artificial heart in a 75-year-old patient was performed on December 18, 2013, by the Georges Pompidou European Hospital team in Paris (France). The patient died 75 days after the operation.

In Carmat's design, called the Aeson, two chambers are each divided by a membrane that holds hydraulic fluid on one side. A motorized pump moves hydraulic fluid in and out of the chambers. The pumped fluid causes the membrane to move, causing blood to pump through the heart. The blood-facing side of the membrane is made of tissue obtained from a sac that surrounds a cow's heart, to make the device more biocompatible. The Carmat device also uses valves made from cow heart tissue and has sensors to detect increased pressure within the device. Cardiac information is sent to an internal control system that can adjust the flow rate in response to increased demand, such as when a patient is exercising.

The Carmat Aeson is aimed to be used in cases of terminal heart failure, instead of being used as a bridge device while the patient awaits a transplant. At 900 grams it weighs nearly three times the typical heart and is targeted primarily towards obese men. It also requires the patient to carry around an additional Li-Ion battery. The projected lifetime of the artificial heart is around 5 years (230 million beats).

In 2016, trials for the Carmat "fully artificial heart" were banned by the National Agency for Security and Medicine in Europe after short survival rates were confirmed. The ban was lifted in May 2017. At that time, a European report stated that Celyad's C-Cure cell therapy for ischemic heart failure "could only help a subpopulation of Phase III study participants, and Carmat will hope that its artificial heart will be able to treat a higher proportion of heart failure patients".

The Carmat artificial heart was approved for sale in the European Union, receiving a CE marking on December 22, 2020. , the Carmat is only available in Europe as a bridge-to-transplant, for up to 180 days while awaiting a human heart transplant. In the United States it is only available in clinical trials.

Total artificial heart pump
The U.S. Army artificial heart pump was a compact, air-powered unit developed by Kenneth Woodward at Harry Diamond Laboratories in the early to mid-1960s. The Army's heart pump was partially made of plexiglass, and consisted of two valves, a chamber, and a suction flapper. The pump operated without any moving parts under the principle of fluid amplification – providing a pulsating air pressure source resembling a heartbeat.

Jarvik Hearts
The Jarvik line of hearts was developed by the now-defunct medical device company Symbion, by medical device researchers Willem Kolff and Robert Jarvik in conjunction with the University of Utah. These hearts were developed through animal trials and culminated in the Jarvik-7 100, the original model that was used in the first clinical trials of the heart. Jarvik-7 hearts were made primarily of a biocompatible plastics and polymers. These hearts used four Medtronic-Hall valves and consisted of two “ventricles” which contained multi-layer low-stress diaphragms. The Jarvik-7 was powered pneumatically by two transcutaneous drivelines attached to a large compressed-air drive console, originally called the Utahdrive. The drive console contained two independent drive systems for redundancy, data recording devices and backup compressed air cylinders.

The Jarvik-7 was later developed in a smaller 70cc variant so that it would fit better in the chest cavities of more patients. Another development that came to the Jarvik-7 was the introduction of a battery-powered portable drive system the size of a briefcase that later patients took advantage of.

Contrary to popular belief and erroneous articles in several periodicals, the Jarvik-7 heart was not permanently banned for use. After a hostile takeover, Symbion's facilities had lost FDA compliance in 1990 and required that the devices be destroyed. After the rights to the device had been transferred to then CardioWest Technologies, an investigational study was approved in 1993. CardioWest Technologies became SynCardia in 2003 who currently produces the modern version of the Jarvik-7, known as the SynCardia temporary Total Artificial Heart.

POLVAD
Since 1991, the Foundation for Cardiac Surgery Development (FRK) in Zabrze, Poland, has been working on developing an artificial heart. Nowadays, the Polish system for heart support POLCAS consists of the artificial ventricle POLVAD-MEV and the three controllers POLPDU-401, POLPDU-402 and POLPDU-501. Presented devices are designed to handle only one patient. The control units of the 401 and 402 series may be used only in hospital due to its big size, method of control and type of power supply. The control unit of 501 series is the latest product of FRK. Due to its much smaller size and weight, it is significantly more mobile solution. For this reason, it can be also used during supervised treatment conducted outside the hospital.

Phoenix-7
In June 1996, a 46-year-old man received a total artificial heart implantation done by Jeng Wei at Cheng-Hsin General Hospital in Taiwan. This technologically advanced pneumatic Phoenix-7 Total Artificial Heart was manufactured by Taiwanese dentist Kelvin K. Cheng, Chinese physician T. M. Kao, and colleagues at the Taiwan TAH Research Center in Tainan, Taiwan. With this experimental artificial heart, the patient's BP was maintained at 90–100/40–50 mmHg and cardiac output at 4.2–5.8 L/min. The patient then received the world's first successful combined heart and kidney transplantation after bridging with a total artificial heart.

AbioMed hearts
The first AbioCor to be surgically implanted in a patient was on July 3, 2001. The AbioCor is made of titanium and plastic with a weight of 0.9 kg (two pounds), and its internal battery can be recharged with a transduction device that sends power through the skin. The internal battery lasts for half an hour, and a wearable external battery pack lasts for four hours. The FDA announced on September 5, 2006, that the AbioCor could be implanted for humanitarian uses after the device had been tested on 15 patients. It is intended for critically ill patients who cannot receive a heart transplant. Some limitations of the current AbioCor are that its size makes it suitable for less than 50% of the female population and only about 50% of the male population, and its useful life is only 1–2 years.

By combining its valved ventricles with the control technology and roller screw developed at Penn State, AbioMed designed a smaller, more stable heart, the AbioCor II. This pump, which should be implantable in most men and 50% of women with a life span of up to five years, had animal trials in 2005, and the company hoped to get FDA approval for human use in 2008. After a great deal of experimentation, AbioMed has abandoned development of total artificial hearts as of 2015. Abiomed as of 2019 only markets heart pumps, "intended to help pump blood in patients who need short-term support (up to 6 days)", which are not total artificial hearts.

Frazier-Cohn
On March 12, 2011, an experimental artificial heart was implanted in 55-year-old Craig Lewis at The Texas Heart Institute in Houston by O. H. Frazier and William Cohn. The device was a combination of two modified HeartMate II pumps which had undergone bovine trials.

So far, only one person has benefited from Frazier and Cohn's artificial heart. Craig Lewis had amyloidosis in 2011 and sought treatment. After obtaining permission from his family, Frazier and Cohn replaced his heart with their device. Lewis survived for another 5 weeks after the operation; he eventually died from liver and kidney failure due to his amyloidosis, after which his family asked that his artificial heart be unplugged.

Soft artificial heart

On July 10, 2017, Nicholas Cohrs and colleagues presented a new concept of a soft total artificial heart in the Journal of Artificial Organs. The heart was developed in the Functionals Materials Laboratory at ETH Zurich. (Cohrs was listed as a doctoral student in a group led by Professor Wendelin Stark at ETH Zurich.)

The soft artificial heart (SAH) is a silicone monoblock fabricated with the help of 3D bioprinting technology. It weighs 390g, has a volume of 679 cm3, and is operated through pressurized air. "Our goal is to develop an artificial heart that is roughly the same size as the patient's own one and which imitates the human heart as closely as possible in form and function", Cohrs said in an interview. The SAH fundamentally moves and works like a natural heart, but the prototype only performed for 3000 beats (about 30 to 50 minutes at an average heart rate) in a hybrid mock circulation machine before the silicone membrane (2.3 mm thick) between the Left Ventricle and the Air Expansion Chamber ruptured.

The working life of a more recent Cohrs prototype (using various polymers instead of silicone) was still limited, according to reports in early 2018, with that model providing a useful life of 1 million heartbeats, roughly ten days in a human body. At the time, Cohrs and his team were experimenting with CAD software and 3D printing, striving to develop a model that would last up to 15 years. "We cannot really predict when we could have a final working heart which fulfills all requirements and is ready for implantation. This usually takes years", said Cohrs.

BiVACOR Artificial Heart
Founded in 2008, the BiVACOR company has been developing a total artificial heart based on a rotary centrifugal pump. Artificial heart researchers and cardiologists O. H. Frazier and William Cohn are on the board of the BiVACOR company. The BiVACOR heart seeks to improve the artificial heart by using a magnetically levitated impeller which reduces clotting and only has a single moving part. This also reduces size and complexity, as well as only requiring a battery pack to run. The BiVACOR heart is not pulsatile like previous hearts and contains no valves, but is capable of generating “beats” by rapidly changing the speed of the impeller. BiVACOR has been tested as a replacement for a heart in a sheep.

On November 10, 2023, the BiVACOR heart received FDA authorization under the investigational device exemption for use in human trials.

Others
A centrifugal pump or an axial-flow pump  can be used as an artificial heart, resulting in the patient being alive without a pulse.

A centrifugal artificial heart which alternately pumps the pulmonary circulation and the systemic circulation, causing a pulse, has been described.

Researchers have constructed a heart out of foam. The heart is made out of flexible silicone and works with an external pump to push air and fluids through the heart. It currently cannot be implanted into humans, but offers a new concept in artificial hearts.

Hybrid assistive devices
Patients who have some remaining heart function but who can no longer live normally may be candidates for ventricular assist devices (VAD), which do not replace the human heart but complement it by taking up much of the function.

The first Left Ventricular Assist Device (LVAD) system was created by Domingo Liotta at Baylor College of Medicine in Houston in 1962.

Another VAD, the Kantrowitz CardioVad, designed by Adrian Kantrowitz, boosts the native heart by taking up over 50% of its function. Additionally, the VAD can help patients on the wait list for a heart transplant. In a young person, this device could delay the need for a transplant by 10–15 years, or even allow the heart to recover, in which case the VAD can be removed. The artificial heart is powered by a battery that needs to be changed several times while still working.

The first heart assist device was approved by the FDA in 1994, and two more received approval in 1998. While the original assist devices emulated the pulsating heart, newer versions, such as the Heartmate II, developed by The Texas Heart Institute of Houston, provide continuous flow. These pumps (which may be centrifugal or axial flow) are smaller and potentially more durable and last longer than the current generation of total heart replacement pumps. Another major advantage of a VAD is that the patient keeps the natural heart, which may still function for temporary back-up support if the mechanical pump were to stop. This may provide enough support to keep the patient alive until a solution to the problem is implemented.

In August 2006, an artificial heart was implanted into a 15-year-old girl at the Stollery Children's Hospital in Edmonton, Alberta. It was intended to act as a temporary fixture until a donor heart could be found. Instead, the artificial heart (called a Berlin Heart) allowed for natural processes to occur and her heart healed on its own. After 146 days, the Berlin Heart was removed, and the girl's heart functioned properly on its own. On 16 December 2011 the Berlin Heart gained U.S. FDA approval. The device has since been successfully implanted in several children including a 4-year-old Honduran girl at Children's Hospital Boston.

Several continuous-flow ventricular assist devices have been approved for use in the European Union, and, as of August 2007, were undergoing clinical trials for FDA approval.

In 2012, Craig Lewis, a 55-year-old Texan, presented at the Texas Heart Institute with a severe case of cardiac amyloidosis. He was given an experimental continuous-flow artificial heart transplant which saved his life. Lewis died 5 weeks later of liver failure after slipping into a coma due to the amyloidosis.

In 2012, a study published in the New England Journal of Medicine compared the Berlin Heart to extracorporeal membrane oxygenation (ECMO) and concluded that "a ventricular assist device available in several sizes for use in children as a bridge to heart transplantation [such as the Berlin Heart] was associated with a significantly higher rate of survival as compared with ECMO." The study's primary author, Charles D. Fraser Jr., surgeon in chief at Texas Children's Hospital, explained: "With the Berlin Heart, we have a more effective therapy to offer patients earlier in the management of their heart failure. When we sit with parents, we have real data to offer so they can make an informed decision. This is a giant step forward."

Suffering from end-stage heart failure, former Vice President Dick Cheney underwent a procedure at INOVA Fairfax Hospital, in Fairfax Virginia in July 2010, to have a Heartmate II VAD implanted. In 2012, he received a heart transplant at age 71 after 20 months on a waiting list.

General references

 * George B. Griffenhagen and Calvin H. Hughes. The History of the Mechanical Heart. Smithsonian Report for 1955, (Pub. 4241): 339–356, 1956.
 * "Donor saves Detroit pastor living on artificial heart". Fox News. 18 May 2018

title: Artificial heart


text:
Valefar

In demonology, Valefar (also Valefor, Malaphar, Malephar, Valafar ) is a Duke of Hell. He tempts people to steal and is in charge of a good relationship among thieves. Valefar is considered a good familiar by his associates "till they are caught in the trap". He commands ten legions of demons.

He is represented as a lion with the head of a man, or as a lion with the head of a donkey.

title: Valefar