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User:Tony Sidaway/BJAODN/1

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The Law of Time is formulated: Suavecito

T(E)=ART Energy factored by Time equals Art.

By Suavecito Productions & Jose Arguelles

“0-19 is my code. In it are all demonstrations of the wisdom that is always close and near, but which comprehends the web of galactic being and all forms of its natural orders in time. Just as nineteen is the power of God’s mercy, so zero is the fullness and emptiness all at once which characterize the nature of mind and all it can know.” Storm of Non-Ego,” Section 15, Verse 97 Telektonon of Pacal Votan

This is why there is no such thing as an ugly sunset, and why nature is a harmony.

Did you know that time is a frequency?

The Law of Time is a discovery that has been occurring over the past decade. The key to this discovery is that time is a frequency. The natural timing frequency is expressed as a ratio 13:20. All of the universe is governed by this ratio which establishes the synchronic or fourth-dimensional order of reality.

The combination of the Gregorian Calendar and the mechanical clock has created the artificial 12:60 timing frequency. It is this unconscious frequency that drives modern civilization in an accelerating pace that is devouring our environment.

Law of Time, making conscious what was unconscious

The 13:20 timing frequency was known by the ancient civilization of the Maya. It is encoded as a 260-unit matrix known as the Tzolkin (Sacred Count). Its essence is kept by a continuous set of permutations of 20 icons - Solar Seals - and 13 numbers -Galactic Tones.

The new Thirteen Moon Calendar is perfectly synchronized with the 260-unit Tzolkin. The synchronization date is July 26 - a galactic date which coincides with Sirius rising. The day before, July 25th, 2002 is the 365th day of the Thirteen Moon Calendar year - it is no day of the week or month and is known as the Day Out of Time.

Friends of the Foundation for the Law of Time is organized for the purpose of creating funds for the growing PAN World Thirteen Moon Calendar Change Peace Movement and to meet the Foundation's most immediate goal - universal calendar reform. Through funding the Foundation you are funding the Campaign for the New Time.

Your funds will be used for:

Production, promulgation, and propagation of Thirteen Moon Calendars Production of tools and educational literature about the Law of Time - Investing in educational media projects Developing a public awareness campaign Convening of educational seminars and Congresses Developing a library and archive of the Law and Science of Time Creation of educational caravans for more information e-mail: suavecito.productions@gmail.com

The Return to Natural Time through the Thirteen Moon Calendar is the only hope humanity has of avoiding wide scale environmental destruction and total biospheric collapse, the end of life as we know it on Earth.

Because the Thirteen Moon Calendar is mathematically perfect, it is perpetual and harmonic throughout. By adopting this calendar humanity will truly be able to enter a new millennium of harmony, hope, and prosperity. This is the goal. To attain this goal requires many hands. The Foundation for the Law of Time is calling upon people everywhere to join in this great Campaign. The Foundation is also enlisting the support of affiliate organizations to join in this effort. Already the White Land Global Energy Program of Russia has joined ranks with the Foundation. Won't you join us, too?

It is also clear that in light of the 2012 end-point of the cycle of history, that a change in time must be made before the cycle closes. The Campaign for the New Time, established through the Foundation for the Law of Time, is intended to marshal all of the information and strategies necessary to propagate a major planetary consciousness shift regarding the absolute need to make the change in time now - any later than 2004-05 will be too late. To carry out the Campaign there are two levels of activity, outer and inner. The outer level calls for the activation of apostles of the new time, members of the World Thirteen Moon Calendar Change Peace Movement operating under the Banner of Peace through the network of world wide PAN nodes. These apostles of the new time will be charged to carry out the consciousness raising through a variety of educational strategies, from the popular to the diplomatic, including the creation of “time is art caravans,” and the establishment of an alliance uniting all kindred groups and organizations drawn from all cultures and spiritual traditions worldwide. This activity, a global “synchronization for peace force,” will culminate in an all out media-alert and a popular referendum mandating the calendar change, July 25-26, 2004.

The inner level of the Campaign for the New Time, complementing the action oriented outer level, consists of the application of the law of time through a dedicated cadre of individuals and groups totally committed to embodying the principles of the synchronic order and bringing about the manifestation of a new transformative planetary culture of harmony in time. The telepathic-synchronic programs for bringing about this cultural transformation have already been established through the law of time and are being practiced by increasing numbers of people throughout the world. The ultimate goal will be the creation of natural time communities which will be operational - living the scientific experiment in world peace -by the year 2004-05.

The goal of the Campaign is to establish and celebrate the calendar change by the day out of time, 2004, July 25, White Spectral Mirror, and the next day, the first day of the solar galactic year, Blue Crystal Storm, to fully implement the change. This will be the world year of trial for the great transition to be made using the Thirteen Moon 28-day calendar as the new global civil standard. By the end of that year, Blue Crystal Night, day out of time, 2005, the world will fully celebrate universal forgiveness in the new time of peace on Earth. The transition will have been made, emerging from a time of chaos into a time of cosmic harmony. It will be hard to imagine ever wanting to go back to the old time. New meaning will invest the life of the people of planet Earth: sacred earth, sacred order, sacred time. The mythic return of the second creation will be genuine and realizable as the creation of a culture of peace on Earth. A new heroic age will dawn

Welcome to Heven on Earth.

Suavecito Productions is the new information format reflecting the radical break in human evolution that is now occurring as a result of the unprecedented impact of human thought and machinery upon the biosphere itself. Suavecito Productions recognizes that the Earth is in a condition of evolutionary transition technically referred to as the Biosphere-Noosphere transition. This evolutionary transition is a test of the survival and evolution of human intelligence, will, and spirit. Suavecito Productions is education for evolution and it is evolutionary education.

The purpose of Suavecito Productions is to create a self-instructional format for learning about the new time and the biosphere. The law of time and the principles governing the fourth dimension have only recently been discovered and formulated. The law of time functions as a self-referenced radial matrix capable of an infinite number of fractal sequences. This simple, whole systems matrix functions by means of a fifth force informational biology.

The fifth force is the four-plus-one chromatic factor of the circulation of galactic time. The immutable process of this fifth force information biology maintains the biosphere as the region of the transformation of cosmic energy on planet Earth. The information biology of the fifth force consists of five time cells: input, store, process, output, and matrix. All information in Suavecito Productions is arranged and cross-referenced according to the self-existing, self-circulating order of the five time cells.

The five time cells that govern and moderate the information flow of the Invisible College were first presented in the Dreamspell, Journey of Timeship Earth 2013 (1991). The Dreamspell is the set of tools and proofs of the law and principles of fourth- dimensional time which are also the blue-prints for comprehensive human social reorganization. A "Dreamspell" refers to any agreed upon consensus reality. The Invisible College is the Dreamspell of the Home School, which is the heart or matrix of the Invisible College learning program. Home School is the methodology of human life no longer defined by jobs or money.The Invisible College redefines life as evolutionary learning. But why "The Invisible College?" Five Time Cells

The self-existing order of intelligence and the capacity to learn inherent in the evolving field of life on Earth are "invisible" because mind cannot be seen or grasped by the senses. Mind is informed by invisible structures of intelligence which are not limited to individuals or generations. These structures of intelligence are part of the genetic inheritance of humans. It is through collectives of humans that structures of intelligence take on different qualities of coherence from generation to generation.

The structures of intelligence are the codes of time mathematically constructed as the order of the universe in which we all participate, consciously or unconsciously. It is our nature as humans to self-reflectively come to know these structures of intelligence and the underlying mathematical order whence they originated. Once we come to know and intuitively recognize a structure of intelligence, effort is made to articulate, express and even manifest into concrete form any one of these structures. This is known as making the invisible visible.

A college refers to a gathering or coming together for mutual learning and discourse concerning structures of intelligence. As colleges take on specific third-dimensional physical forms they tend to institutionalize the structures of intelligence into coherent patterns of communication and expression which give form to a generation or many generations of humans.

The physical plant of the contemporary college or university and the institutionalization of the structures of intelligence, reduced to convenient patterns of learning and behavior, may actually obstruct genetic need and disposition. What was originally an invisible, intuitive knowing over several generations may become a rote cliche. On the other hand, when the rate of technological change reaches its exponential curve, the opposite effect occurs: information overload increases lack of discrimination while rate of change relegates genuine structures of intelligence to the dust-bin even before they have had a chance to be properly formed and experienced.

The Invisible College of the Congress of Biospheric Rights exists precisely to offset the detriments to genuine learning that now exist as a consequence of the rate of technological change and information over-load. Its purpose is to present structures of intelligence demanded by the Earth’s life-support system, the biosphere.

The structures of intelligence presented by the Invisible College are inseparable from and based upon the laws and principles of time that guide life in the biosphere. The life of the biosphere is a whole system. The sum of life in the biosphere is the sum of all the species. The continuum of life of all of the species is inseparable from certain inviolable processes that govern the entire biosphere. The sum of these processes which maintain the biosphere over eons of change are referred to as biogeochemical. Bio mean life, geo means earth, and chemical to the molecular dynamics of atomic existence, whether organic or inorganic.

The biogeochemical process governs the continuum of life and acquires all of its meaning and value from the law of time. The law of time moderates the value of the biogeochemical process in proportion to the advent of self-reflective consciousness. The biogeochemical continuum becomes exponential as the cumulative impact of self-reflective thought manifests its ultimate projection, the machine. The machine process engenders a temporary geological condition: the creation of the technosphere. As the global mechanization of human biological functions, the technosphere provides the tinder for the ultimate crisis of the biosphere: biogeochemical combustion. Biogeochemical combustion is the sum of the effects of environmental degradation, including: global warming, depleted ozone, species extinction, human population explosion, radioactive waste, decreasing resources such as drinking water, petroleum, etc.

The human species holds the smoking industrial gun of biogeochemical combustion in its hands. The biosphere-noosphere transition has commenced. What was once unconscious--the law of time--is now conscious. The Invisible College is the manifestation of the law of time within the electronic mental order of the technosphere at the final moment preceding its dissolution. If the human species can intelligently and consciously grasp the opportunity presented by this irrevocable moment of biogeochemical combustion it will inaugurate the biosphere's transition to the noosphere: the telepathically unified human species in symbiotic union with the biosphere.

Dynamics of Time, 1.6: “Biological evolution tends toward states of being capable of sustaining conscious moments in time. Evolved biological entities capable of sustaining conscious moments in time trigger self-reflective consciousness or naive experiences of time. These naive experiences of time are categorically referred to as mystical experiences. Mystical experience is predisposed to the naive experience of time because of the intent to approximate God "Allah, Ometeotl & Hunab Ku", the center and director of all intelligence.”

Sixteen Principles

1. Human beings can transform their world (Dragon) The web of our relationships with others and the natural world, which has given rise to the problems we face as a human family, can be changed.

2. Development comes from within (Wind ) The process of human and community development unfolds from within each person, relationship, family, organization, community, or nation.

3. Healing is a necessary part of development (Night) Healing the past, closing up old wounds and learning healthy habits of thought and action to replace dysfunctional thinking and disruptive patterns of human relations is a necessary part of the process of sustainable development.

4. Justice (Seed) Every person (regardless of gender, race, age, culture, religion) must be accorded equal opportunity to participate in the process of healing and development and to receive a fair share of the benefits.

5. No vision, no development (Serpent) A vision of who we can become, and what a sustainable world would be like, works as a powerful magnet, drawing us to our potential.

6. Authentic development is culturally based (World-bridger) Healing and development must be rooted in the wisdom, knowledge and living processes of the culture of the people.

7. Interconnectedness (Hand) Everything is connected to everything else. Therefore, any aspect of our healing and development is related to all the others (personal, social, cultural, political, economic, etc.). When we work on any one part, the whole circle is affected.

8. No unity, no development (Star) Unity means oneness. Without unity, the common oneness that makes (seemingly) separate human beings into "community" is impossible. Disunity is the primary disease of community.

9. No participation, no development (Moon) Participation is the active engagement of the minds, hearts and energy of the people in the process of their own healing and development.

10. The hurt of one is the hurt of all; the honour of one is the honour of all. (Dog) The basic fact of our oneness as a human family means that development for some at the expense of well-being for others is not acceptable or sustainable.

11. Spirit (Monkey) Human beings are both material and spiritual in nature. It is therefore inconceivable that human community could become whole and sustainable without bringing our lives into balance with the requirements of our spiritual nature.

12. Morals and ethics (Human) Sustainable human and community development requires a moral foundation. When morals decline and basic ethical principles are violated, development stops.

13. Learning (Skywalker) Human beings are learning beings. We begin learning while we are still in our mother's wombs, and unless something happens to close off our minds and paralyze our capacities, we keep on learning throughout our entire lives. Learning is at the core of healing and development.

14. Sustainability (Wizard) To sustain something means to enable it to continue for a long time. Authentic development does not use up or undermine what it needs to keep on going.

15. Move to the positive (Eagle) Solving the critical problems in our lives and communities is best approached by visualizing and moving into the positive alternative that we wish to create, and by building on the strengths we already have, rather than on giving away our energy fighting the negative.

16. Be the change you want to see (Warrior) The most powerful strategies for change always involve positive role modeling and the creation of living examples of the solutions we are proposing. By walking the path, we make the path visible.

These sixteen principles are summarized as four "guiding principles" essential for the formation and functioning of any community. Adopted to our needs, these principles are:

1. "Starting from Within" - Development comes from within; take responsibility yourself for your relationships; vision is the basis of development; culture is the basis of all healing and development. To make culture real practice time is art, learn from your elders and from nature.

2. "Working in a Circle" - All community, like the path of nature, forms a circle. Make a daily circle and dissolve into one. A circle is a whole system. All approaches must be used and balanced. A circle is unity. A circle means we all share and participate. A circle means we are all equal and maintains the justice of our equality, regardless of age, sex, race, relgiion, etc.; make decisions from consensus - move the circle, and keep the circle moving.

3. "In a Sacred Manner" - Spirituality is the center of healing and development. Practice daily salat prayer and/or vipassana meditation; make ceremony that integrates the natural elements in natural time with our mind, prayers, and needs. Connect with the Creator. Cultivate a heart-centered approach in all matters. Listen to spirit. Know with whom you are speaking and act and behave accordingly. Walk in balance. Do not violate ethical or moral boundaries. Think before you do anything. Work from principle. Let your principles reflect the order and plan of the universe. Do not sacrifice principle, but remain flexible.

4. "We heal and develop Ourselves, our Relationships and World." - Learn to live in ways that promote life and uplift others in your environment. Practice sustainability and non-codependence. Do not be afraid to be humble. Seek help when you need it. Respect all living systems and relations. Move to the positive. Be the change you want to see!

If we begin to learn and practice these principles in our communities and integrate them with our Earth Wizards practices, we will become successful and attractive to others dissatisfied with the 12:60 world. Community thrives on intimacy of all as one together. Let us learn to practice intimacy with self-respect!

In sum, as Earth Wizards, we wish to develop an ethic that can be characterized as:

Whole Person - that we are each committed to the care and maintenance of our own autonomy in mutual respect of the autonomy of others. Whole Family - that we recognize that our family, clan or group bonding will become whole only as each one of us becomes whole Whole Earth - the wholeness you attain as a person extends to the wholeness we attain as a family which then reflects the wholeness of our relation to the Earth, for it is the Earth which needs us to be whole.

Do not be afraid to admit your weaknesses. If you are not participating in the circle and extending the circle into all you do, then the community is not functioning.

Drugs, stimulants or alcohol are no substitute for true community sharing and love in the Circle. Be aware before you indulge. The world will be watching our communities. The use of drugs - even marijuana - in a a public manner can destroy our work. Let us be sensitive and discrete. Let us free ourselves, and free ourselves more every day! Seek nothing and let the truth know you.

Once we have understood the ethical principles and know the circle is One, than we can turn to the other two factors, Economics and Ecology. Of course, these cannot be separated from our ethical community values. Ideally and ultimately the community is based on absolute autonomy. Everyone needs their own space. And everyone needs a space in which they can be a community. Eating and meeting determine the communal space. The garden is in common, and all craft and artistic activities are best executed autonomously and anonymously as a collective whole. We each breathe and live in the same common space. Who is to say where the inspiration comes from? The cook in the kitchen cooks the beets which make the soul of the poet come alive. Was the poem in the beet and the love of the cook before it became a song in the mind? Give thanks to all beings and take credit for nothing. The Creator sustains the flow. Barter and exchange are better than money and help cultivate our ethical character and resourcefulness.

To have something to barter we must all tend the garden together. To sustain ourselves we must learn permaculture, biodynamics, greenhouses. Study your environment. Know your local flora and fauna and what is possible where you live - what are the growing seasons? Learn about dry compost toilets, lime for latrines. Learn about solar panels, alternative energy, and building techniques that manifest energy conservation. Zero residue in energy consumption! Waste free is Earth way.

There is much to learn. But if we are not ethically attuned, nothing will matter. If we learn and live by such principles as are herein enumerated, nothing will sway us from our path. Let the circle grow. Let the Circle move us. Love is vast, everywhere, and in everything - but belongs to no one. Let the circle move us. We are ONE.

The Galactic Federation Comes In Peace

title: User:Tony Sidaway/BJAODN/1


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license: Creative Commons - Attribution Share-Alike - https://creativecommons.org/licenses/by-sa/4.0/

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Wikipedia:Articles for deletion/Florida State Road 300

 This page is an archive of the proposed deletion of the article below. Further comments should be made on the appropriate discussion page (such as the article's talk page or on a Votes for Undeletion nomination). No further edits should be made to this page.

The result of the debate was NO CONSENSUS, which defaults to KEEP Paul August ☎ 20:32, September 2, 2005 (UTC)

Florida State Road 300
I'm unsure if this should be deleted or expanded. What is the Wiki policy on roads? Is this particular road notable in any way? (I'm new to Wiki, please excuse me.) Fang Aili 01:15, 26 August 2005 (UTC)
 * Keep for merge to St. George Island. I believe the prevailing opinion is to keep national roads per se, and others according to significance. This isn't significant but we might as well merge it. Gazpacho 01:33, 26 August 2005 (UTC)
 * Keep all Interstate, U.S. and state numbered highways. FCYTravis 02:06, 26 August 2005 (UTC)
 * You noticed, I hope, that it is four miles long. Gazpacho
 * Certainly. But if every single one of the hundreds of thousands of schools in America is notable, I fail to see how any of the far-smaller number of state, U.S. and Interstate highways can be deemed non-notable. Deleting articles on state-designated and maintained highways which link communities together while keeping articles on elementary schools that are notable for "teaching things" makes no sense. FCYTravis 02:51, 26 August 2005 (UTC)
 * Just because there's a bunch of people who want all American roads and schools included doesn't mean they should be. Wikipedia is not a list of indiscriminate information. - Mgm|(talk) 09:19, August 26, 2005 (UTC)
 * Keep EdwinHJ | Talk 03:03, 26 August 2005 (UTC)
 * Delete. Wiki policy, as you can perhaps gather, is very contentious on the issue of articles about roads that just describe their geography. It seems to come in phases -- sometimes inclusion, sometimes deletion wins. Sdedeo 03:05, 26 August 2005 (UTC)
 * Which is why we should keep them all, or we'll have a patchwork of some articles that have been kept and others about equally "notable" roads that have been deleted. --SPUI (talk) 08:25, 26 August 2005 (UTC)
 * No, what it means is that people who want to include individual pages for otherwise non-notable highways, as we do for schools, should try to hammer out a consensus among wikipedians before going ahead and creating thousands of articles. Sdedeo 20:33, 27 August 2005 (UTC)
 * Delete. Unexpandable; there's nothing encyclopedic to say on the topic. Fernando Rizo T/C 04:01, 26 August 2005 (UTC)
 * Delete; And for the love of God - let's reach some consensus on the matter as a whole | Celcius 04:51, 26 August 2005 (UTC)
 * Delete. Road systems (networks) are encyclopedic. Individual roads are not. -maclean25 06:03, 26 August 2005 (UTC)
 * Keep all roadcruft. Especially this one, as it's a long bridge, and such bridges are certainly "notable". --SPUI (talk) 08:02, 26 August 2005 (UTC)
 * Keep Passes the thousands of people test. Klonimus 20:18, 28 August 2005 (UTC)
 * Delete. Not notable. --GraemeL (talk) 10:01, 26 August 2005 (UTC)
 * Brrrrrmmmmmm brrrrrrmmmm delete all roadcruft Proto t c 10:03, 26 August 2005 (UTC)
 * Comment - I suggest you all visit Category:California state highways and examine the work done there. Do people wish to VFD all those informative articles because "individual roads are unencyclopedic?" FCYTravis 11:48, 26 August 2005 (UTC)
 * As much as I can appreciate this sentiment, it has nothing to do with the matter at hand. If someone spent 100 hours working on an article about his belly button lint, I would feel bad about the wasted effort, but that would not change the validity of the article. How much time and effort has been spent should have no bearing on an editor's decision WRT the encyclopedic nature of the subject. Fernando Rizo T/C 16:41, 26 August 2005 (UTC)
 * They *are* encyclopedic, in the views of a goodly number of editors. This isn't like an article on some fan forum or a crufty screed on a Star Wars character who got 5 seconds of screen time. These are articles on important links in the transportation network of the United States, which are encyclopedic for being (relatively) permanent, publicly-constructed, widely used and verifiable. I would argue that these roads have far more impact on the nation at large than any Star Wars vs. Star Trek debate forum ever created, or any band which released two albums, sold five copies of each and then disappeared into the mists of time. FCYTravis 16:53, 26 August 2005 (UTC)
 * I'm not arguing about whether or not they're encyclopedic in this case; all I'm trying to get at is that if an article is unencyclopedic, the fact that a large amount of work has been put into it should not merit its inclusion. Fernando Rizo T/C 00:21, 27 August 2005 (UTC)
 * This is not the Overseas Highway serving the Florida Keys but a short stretch of road serving St. George Island, which is all but deserted in the winter. I'm afraid that it doesn't pass the bar. Delete, failing that, merge into the community that it serves. Pilatus 11:56, 26 August 2005 (UTC)
 * Keep. as per SPUI's arguments. Roodog2k 13:34, 26 August 2005 (UTC)
 * Does the road have a Florida state route marker on it? If so, keep. -- Grev -- Talk 16:02, August 26, 2005 (UTC)
 * Keep This is verifiable and factual. Trollderella 16:42, 26 August 2005 (UTC)
 * Keep. --Tony Sidaway Talk  17:03, 26 August 2005 (UTC)
 * delete tarmac, about as notable as sand. --TimPope 17:59, 26 August 2005 (UTC)
 * So you should vote to keep as Sand is notable. :-) Roby Wayne  Talk •  Hist 03:28, 27 August 2005 (UTC)
 * Keep and expand. Gateman1997 19:17, 26 August 2005 (UTC)
 * Keep. Numbered state highways are a noted precedent.  Roby Wayne  Talk •  Hist 19:24, 26 August 2005 (UTC)
 * Delete per the minor-roads-don't-deserve-an-entry-they're just-asphalt argument. Dottore So 19:53, 26 August 2005 (UTC)
 * Delete. Minor road.  State highways usually are major enough to get a stripe down the middle, but not always. --Carnildo 21:46, 26 August 2005 (UTC)
 * Keep Once we get down into local street level, it's probably going to be nn in most cases, but precedent has been set above for state level roads, which I concur with. Karmafist 21:53, 26 August 2005 (UTC)
 * Delete Yes, we now have to accept schools. This is not an excuse for accepting other pointless information. Wikipedia is not Everything2. Denni ☯ 23:32, 2005 August 26 (UTC)
 * You heard it here! Roads are the new schools.  I remain utterly convinced by the suggestion that institutions that obtain state-level grants for their construction and maintenance can be described as "non-notable".  When we remove neutral, verifiable information from Wikipedia, we degrade it in a small way. If we continue to do so, we end up degrading it in a large way.  We have no noticeable namespace problems, we have no noticeable diskspace problems, so the only real reason for removing something from Wikipedia is the suggestion that the information could be damaging to the project.  In what way does the information that there is a road leading out to St. George Island, designated Florida State Road 300, damage Wikipedia?  Why is this information so toxic to Wikipedia that it must be removed? --Tony Sidaway Talk
 * Data!=information. When irrelevant minutiæ are included the information content of Wikipedia is diluted. Pilatus 12:18, 27 August 2005 (UTC)
 * Because it keeps people from seeing the forest for the trees. It has an adverse effect on the use of categories, of lists,  and of any search engine to find information. Gene Nygaard 12:46, 27 August 2005 (UTC)
 * Wikipedia keeps articles on area codes and zip codes, as well as articles on numbers (one, for example.)--Rschen7754 16:32, August 29, 2005 (UTC)
 * Keep, verifiable. JYolkowski // talk 23:40, 26 August 2005 (UTC)
 * Keep per Karmafist. -- Kjkolb 06:24, August 27, 2005 (UTC)
 * Delete. Gamaliel 07:16, 27 August 2005 (UTC)
 * Delete. Radiant_ >|< 10:34, August 27, 2005 (UTC)
 * Delete. Not notable. - brenneman (t) (c)  12:09, 27 August 2005 (UTC)
 * Delete. Not notable. Possibly make article on the bridge instead (note that it is not now in any bridges category, etc.), and link the numbered highway to that in Florida State Roads; at least describing the bridge will give more interesting reading than describing a road.  Gene Nygaard 12:46, 27 August 2005 (UTC)
 * Keep. This is a useful article and has encyclopedic value. --K1vsr (talk) 15:38, August 27, 2005 (UTC)
 * Keep. As there are articles on schools in US, articles on certain roads should be accepted too. *drew 22:28, 27 August 2005 (UTC)
 * Keep Verifiable. Sam Vimes 22:32, 27 August 2005 (UTC)
 * Delete. Wikipedia is not a road atlas. Nandesuka 22:40, 27 August 2005 (UTC)
 * Keep. Although short, a state numbered road and in a whole category full of state numbered roads. HollyAm 01:54, August 28, 2005 (UTC)
 * Keep. May I point you to WPs on WikiProject California State Highways, WikiProject Washington State Highways, WikiProject Kentucky State Highways, WikiProject California County Routes, WikiProject U.S. Interstate Highways, WikiProject U.S. Highways, and WikiProject Highways? A state highway project for all 50 states is not feasible at this time... leave it be and it will be improved with a routebox and that sort of thing in the near future. There are also over 600 US road stubs alone. And not to mention the nearly 1,000 state highway/ interstate articles in the WPs mentioned alone. You can't just delete 1,000+ articles! They are informative- you can learn about the highway that you commute on to work or a highway that you will travel once on vacation. We keep county routes in CA which are less notable than these.--Rschen7754
 * Merge/Comment - Whereas I believe that state highways should be kept, please take a look at the article. Florida State Road 300 is a 4 mile long road, purely on the St. George Island Bridge.  The article should be about the bridge, and the road should be mentioned within.  This really should be a merge and redirect. - Hahnchen 14:36, 29 August 2005 (UTC)
 * Delete all insignificant and non-notable roads. Quale 14:46, 31 August 2005 (UTC)
 * Meaning you vote keep on this road, right? --SPUI (talk) 17:06, 31 August 2005 (UTC)
 * Weak Keep. Doesn't make sense to me to have articles on all the other Florida state roads, but not this one--keep as part of the overall project. 68.185.16.5 17:19, 1 September 2005 (UTC) {User:Niteowlneils not logged in, editing from an internet cafe in Roseburg, Oregon.}
 * The above discussion is preserved as an archive of the debate. Please do not modify it. Subsequent comments should be made on the appropriate discussion page (such as the article's talk page or in an undeletion request). No further edits should be made to this page.


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Wisconsin tornado outbreak of 2005

The Wisconsin tornado outbreak of 2005 was an outbreak of tornadoes that occurred primarily in southern Wisconsin on August 18, 2005. A system of storms unleashed a total of 28 tornadoes, 27 of which were confirmed in southern Wisconsin, and 1 confirmed in Minnesota. This outbreak set a new record for the most tornadoes observed in the state in a single day, breaking the previous record of 24 tornadoes set on May 8, 1988. The system generating the Stoughton tornado was also accompanied by many reports of severe winds and hail throughout the region. The Stoughton tornado was documented on an episode of The Weather Channel's Storm Stories.

Stoughton, Wisconsin
By far the most significant tornado of the day developed 2.0 mi north of Oregon at 6:15 p.m.. This large, intense multiple-vortex tornado tracked 20.0 mi into Jefferson County from Dane County, devastating the town of Stoughton.

East of Oregon the tornado tore through several farms before impacting residential subdivisions in Stoughton. One person was crushed to death in their basement from fireplace and chimney bricks that crashed through the floor. Numerous homes, businesses, farm buildings, vehicles, power-lines, trees, and other personal effects were either damaged or destroyed along its path that grew to a maximum width of about 600 yards north of Stoughton. As for residential structures, 220 sustained minor damage, 84 had major damage, and 69 were destroyed. As for business structures, 6 sustained minor damage, 1 had major damage, and 1 was destroyed. As for agricultural structures, 5 sustained minor damage, 5 had major damage, and 40 were destroyed. Several vehicles were flipped and tossed as well. Some homes in town were completely leveled, and an F4 rating was considered. Further investigation revealed that the homes were not well-built, and the slow (sometimes nearly stationary) forward movement of the tornado negated a rating higher than F3. After striking Stoughton, the tornado caused damage to trees and crops north of Busseyville before dissipating. Debris from this tornado was lofted by the parent updraft and carried downstream to scattered locations in the counties of Jefferson, Waukesha, Milwaukee, Walworth, Racine, and Kenosha. 23 people were injured.

Ten years later to the day, three tornadoes touched down outside of Lake Geneva, Big Bend, and Waukesha. There were no injuries or fatalities from those tornadoes.

title: Wisconsin tornado outbreak of 2005


text:
Wikipedia:Articles for deletion/Allison Fonte

 This page is an archive of the proposed deletion of the article below. Further comments should be made on the appropriate discussion page (such as the article's talk page or on a Votes for Undeletion nomination). No further edits should be made to this page.

The result of the debate was keep rewritten version. --Tony Sidaway Talk 16:31, 2 September 2005 (UTC)

Allison Fonte
I would have speedied this as vanity, but the article appears to place her on the razor's edge of notability. What say you, brethren? DS 01:16, 26 August 2005 (UTC)

 * Ugh... this defines borderline. Negligibly weak keep. --Tito xd 01:33, 26 August 2005 (UTC)
 * After the Google Test, I remove the "negligibly weak" part. 26,100 Google hits. --Tito xd  01:36, 26 August 2005 (UTC)
 * The Google Test is evil and much misunderstood. Try . 225 hits, you mean. JRM · Talk 01:41, 26 August 2005 (UTC)
 * Comment. Most of the article (as it is) is unverifiable; Wikipedia is not a primary source. It's possible to edit this article down to only the most stringently verifiable facts (Allison Fonte does exist, she did co-found the company mentioned, she was a Mouseketeer ), but if you're talking notability, I'd say no. I still haven't made up my mind about notability, however, so I can't really vote. How annoying. JRM · Talk 01:41, 26 August 2005 (UTC)
 * Keep and Cleanup. Regular actors in notable television shows are notable. Pburka 01:42, August 26, 2005 (UTC)
 * Rewrite. I think information on people who someone might, someday, want to look up is good — I'm just turned off by the way this article appears to have been written as a (kinda creepy, third-person) personal homepage. (Anon editor, intimate knowledge of her own life.) If a registered user rewrites it from available sources, definitely keep; otherwise, I'd rather it be a stub or deleted. --Quuxplusone 02:21, 26 August 2005 (UTC)
 * A Google search for "Allison Fonte" shows 135 hits see However as WP:BIO provides that: "Well known entertainment figures, such as TV/movie producers, directors, writers, and actors who have starring roles, or a series of minor roles, in commercially distributed work watched by a total audience of 5,000 or more" meet the criterion for articles, then she meets it for her role on the New Mousketeers.Keep Capitalistroadster 04:17, 26 August 2005 (UTC)
 * Rewrite for reasons states by Quuxplusone. Too bad the author of the existing article didn't upload a nice picture of Ms. Fonte as a Mousetekeer.Crypticfirefly 04:20, 26 August 2005 (UTC)
 * Rewrite; and keep | Celcius 04:53, 26 August 2005 (UTC)
 * Keep and Cleanup as per Pburka. 23skidoo 05:02, 26 August 2005 (UTC)
 * Keep I rewrote this, it's probably ok now, she meets WP:BIO Rx StrangeLove 05:38, 26 August 2005 (UTC)
 * Keep. I was compelled to add "cast" in the first sentence so it reads as "was a cast member of The New Mickey Mouse Club". Alf 13:11, 26 August 2005 (UTC)
 * Keep Trollderella 16:41, 26 August 2005 (UTC)
 * Keep. *drew 22:31, 27 August 2005 (UTC)
 * The above discussion is preserved as an archive of the debate. Please do not modify it. Subsequent comments should be made on the appropriate discussion page (such as the article's talk page or in an undeletion request). No further edits should be made to this page.


text:
Talk:Doreen Gentzler

Untitled
The sentences in this article are choppy, and poorly done I suggest this aricle should be rewritten.

I agree

What happened to "Goentzler"?
For years, from early in her DC area air-time, she was referred to on-screen as "Goentzler". The "o" was removed some years later. I find it disconcerting this whole page has been scrubbed along with all the popular/online references, too, as if Orwell's Memory Hole is in full-swing. SpookyMike (talk) 03:27, 10 August 2022 (UTC)

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 15:26, 9 November 2007 (UTC)

title: Talk:Doreen Gentzler


text:
Talk:Sophie Gengembre Anderson

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Uyent99. Peer reviewers: Uyent99.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 09:49, 17 January 2022 (UTC)

Untitled
I am looking for a print of a Sophie Anderson painting called Touch and Go to Kiss or Now but can not find it anywhere. - unsigned edit by
 * Maybe because it's called Touch and Go, to Laugh or No? Gordonofcartoon 01:22, 27 August 2007 (UTC)

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title: Talk:Sophie Gengembre Anderson


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WRNO-FM

WRNO-FM (99.5 MHz) – branded News Talk 99.5 WRNO – is a commercial radio station in New Orleans, Louisiana. It airs a news/talk format and is owned by iHeartMedia, Inc. The studios and offices are on Howard Avenue in Downtown New Orleans.

WRNO-FM has an effective radiated power (ERP) of 100,000 watts, the maximum for most FM stations. The transmitter is off Paris Road in the Bayou Bienvenue Central Wetland District near Chalmette. It broadcasts using HD Radio technology. The HD-2 digital subchannel airs "Throwback 96.3," a classic hip-hop format which feeds 250-watt FM translator K242CE at 96.3 MHz in Meraux.

Programming
WRNO-FM's weekday line up is all syndicated talk shows, beginning with Walton & Johnson from KPRC Houston, followed by The Glenn Beck Radio Program (which is also replayed in the evening hours), The Clay Travis and Buck Sexton Show, The Sean Hannity Show, The Michael Berry Show, The Jesse Kelly Show, Coast to Coast AM with George Noory and America in the Morning.

Weekend programming features shows on money, health, law and technology, some of which are paid brokered programming. Syndicated shows include Handel on the Law with Bill Handel, Armstrong & Getty and The Jesus Christ Show. Most hours begin with an update from Fox News Radio.

Early years
On October 17, 1967, WRNO first signed on the air. It was a stand-alone FM station, put on the air by Gulf South Broadcasters, with Joseph Costello III as the owner and general manager. The station had its studios at 3230 Patterson Drive. It was a network affiliate of the Mutual Broadcasting System and aired a Progressive Rock format.

Although its previous slogan was "We're the Rock of New Orleans," the station's call letters actually stand for "Westbank Radio New Orleans." The station operated a popular business selling rock t-shirts, records and other music related items called the WRNO "Rock Shop" on the ground level of the studio. Since its inception in 1967, WRNO moved from Progressive to Album Rock in the 1980s, and switched to Classic Rock in 1997. WRNO was also home to a popular shortwave radio service in the 1980s and 1990s called WRNO Worldwide, now owned by a Christian broadcaster.

In 1998, WRNO was acquired by Centennial Broadcasting. Then in 2002, the station changed hands again, acquired by San Antonio-based Clear Channel Communications, the forerunner to today's owner, iHeartMedia, Inc.

Talk Radio
In early November, 2006, management planned a major change. WRNO began stunting by playing the full album version of Whole Lotta Love by Led Zeppelin for at least a week on 24 hour rotation. On November 13, at 4 AM, after signing off with The Doors' "The End," WRNO flipped from rock music to a talk radio format as "The New 99.5FM.com." As explained in the official mission statement posted at its website, "The station is committed to providing listeners with everything they need to know on the radio at 99.5 FM and on demand at thenew995fm.com." On the same day, sister station 104.3 KHEV became "The Rock of New Orleans," as it flipped from Urban Gospel to Active Rock.

On April 1, 2008, WRNO changed its slogan to "Rush Radio," with all-day repeats of The Rush Limbaugh Show. It also aired a tape loop of Limbaugh's theme song, the instrumental from My City Was Gone by The Pretenders, during times when the show was not playing. The stunt was to celebrate WRNO's acquisition of the show from longtime affiliate 870 WWL. WRNO resumed its regular schedule on April 7, with Limbaugh heard from 11 a.m. to 2 p.m. weekdays plus a repeat on Saturdays. The Limbaugh program had previously aired on WRNO Worldwide, which Limbaugh called "The EIB World Service" on the air (in joking reference to the BBC World Service). The stations are no longer co-owned.

In September 2014, WRNO re-branded as "News Talk 99.5 WRNO."

Past personalities
Notable station alumni include Bill Burkett, E.Alvin Davis, Joe Clark, Bobby Reno (later on WTIX-FM owned by Michael Costello, Joe's brother), Captain Humble, Doug Christian, and Russ Boney.

WRNO alumni also include former PD Michael Costello ("Michael In The Morning" and brother of late WRNO founder/owner Joseph Costello III), Jim White, DJ-turned-actor John Larroquette, Soxless Scott Seagraves, Jeff "JD The DJ" Douglas ("Rock 'n' Roll Flight To Midnight"), Tom Owens, Jimbo Roberts, Mitch McCracken, Johnny Tyler, "Weerd" Wayne Watkins, Mary London, Lyn Taylor and writer-producer Vance DeGeneres. Steve Suter (later on Magic 101.9 WLMG) did the morning show with sidekick Kevin Carlile, as the "Morning Dudes."

title: WRNO-FM


text:
Johnathan Aitken

Johnathan James Aitken (born May 24, 1978) is a Canadian former professional ice hockey defenceman who played in the National Hockey League (NHL) with the Boston Bruins and the Chicago Blackhawks.

Playing career
Aitken was drafted 8th overall in the 1996 NHL Entry Draft by the Boston Bruins. He played in three games over the course of his two-year entry-level contract. For the 2000–01 season he went to the Czech Republic to play for HC Sparta Praha of the Czech Extraliga. He returned to North America after only a year, and made it back to the NHL during the 2003–04 season with the Chicago Blackhawks, playing 41 games, scoring just one assist. He moved to the Austrian Hockey League for Klagenfurt AC for the 2006–07 season before retiring from professional hockey.

title: Johnathan Aitken


text:
Talk:George Weaver (educator)

Untitled
I have emailed the librarians at the Weaver-Bolden Branch Library to try to find out George Weaver's date of death, which was not included by the creator of the article. --DavidConrad 01:20, 26 August 2005 (UTC)

Found birth date (month only) in census; death date in death certificate. --Tusc 01:10, 7 October 2005 (UTC)

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title: Talk:George Weaver (educator)


text:
Talk:Richard Bozulich

Untitled
Once an article has been placed on Wikipedia, it must go through certain processes to be removed. In this case, if Bozulich had no claim to fame, a speedy delete might be possible. However, his extensive work with Go clearly makes him noteworthy. Therefore, the route to take is via Votes for Deletion, which is where I will send this article. Denni ☯ 01:21, 2005 August 26 (UTC)

Huh, was there some notion that Bozulich would prefer that this page not exist? -- 71.141.235.70 00:13, 27 February 2006 (UTC)

 * Seems so. However that is not particularly relevant. Charles Matthews 08:48, 27 February 2006 (UTC)
 * Objection that Mr. Bozulich does not want this page to exist. I am a friend of his, we are in frequent contact, and I frequently visit his office for consulting. He has given his approval for the existence of this page, and I have rewritten some of the articles after he himself asked me to correct some of them. Herohero2jp (talk) 09:34, 8 September 2023 (UTC)

Death
He is alive as of this moment. I confirmed this with a mutual friend and an associate of his. Vincent (talk) 09:54, 12 November 2011 (UTC)
 * It was corrected — Preceding unsigned comment added by Xavier Combelle (talk • contribs) 10:59, 11 January 2012 (UTC)
 * He is alive in Japan. By the way I have added his picture to the article, can someone please keep up appearances? Herohero2jp (talk) 15:26, 29 August 2023 (UTC)

title: Talk:Richard Bozulich


text:
Howard Gordon

Howard Gordon (born March 31, 1961) is an American television writer and producer.

He is well known for his work on the Fox action series 24 alongside the Showtime thriller Homeland, which he co-developed with Alex Gansa and Gideon Raff, and for the FX political drama Tyrant, which he co-developed with Craig Wright. He also produced the NBC science fiction thriller Awake.

Life and career
Gordon was born to a Reform Jewish family  in Queens, New York City and graduated from Roslyn High School. After graduating from Princeton with a major in creative writing in 1984, Gordon came to Los Angeles with fellow filmmaker Alex Gansa to pursue a career in writing for television. Both broke into the industry with single episodes of ABC's Spenser: For Hire. Their Spenser work turned industry heads, and the pair joined the series Beauty and the Beast as staff writers, and were later named producers.

In 1990, the Gansa-Gordon team was signed to a two-year deal with Witt-Thomas Productions, during which they produced several pilots. One was an ABC project called Country Estates, which caught the attention of producer Chris Carter.

Soon after, Carter invited Gordon and Gansa to join The X-Files as supervising producers; Gordon wrote or co-wrote several scripts each season, before departing from the series in 1997 to pursue other projects.

After co-writing one episode of Buffy the Vampire Slayer, Gordon created his own show, the short-lived Strange World in 1999. Strange World went to seed 13 episodes in, but Gordon and Strange World writer Tim Minear's services were quickly snapped up by Buffy creator Joss Whedon on another project: Angel. After two years with Angel, Gordon jumped ship in 2001 for FOX's successful 24, where he would write several episodes in Seasons 1 & 2, then crafted the entire story arcs for Seasons 3 and 4. Gordon temporarily left 24 in the middle of the 2004 season to re-join Minear, this time as co-creator of another FOX series, The Inside. Despite The Inside's cancellation and short run, talk circulated of including the two Minear-Gordon series, Strange World and The Inside, on a special DVD set sometime in 2006.

Beginning in 2006, Gordon became 24's showrunner, a title he held through its final season. The successful deal led up with his continuing deal at Fox. That same year, he was made partner with 24 creators Joel Surnow and Robert Cochran at Real Time Productions to develop projects, until the duo quit in 2008. In 2019, after a stint at Fox through Teakwood Lane Productions, he signed a deal with Sony.

Gordon is also the author of the Gideon Davis novels.

Homeland
In 2010, after finishing 24, Gordon began co-developing (along with Gideon Raff and Alex Gansa) the thriller Homeland for Showtime. Based on the Israeli series Prisoners of War, it centers on a woman (Claire Danes) who works for the CIA and is convinced a recently returned American prisoner of war (Damian Lewis) has been turned by al-Qaeda. The show premiered Sunday, October 2, 2011, at 10/9 central. It has been met with major critical acclaim and maintained a steady viewership rating throughout its first season. Showtime premiered its fourth season on October 5, 2014.

In 2012, he won the Primetime Emmy Award for Outstanding Writing for a Drama Series for writing the "Pilot" of Homeland and the series itself won the Primetime Emmy Award for Outstanding Drama Series.

Awake
In 2011, Gordon signed on to NBC's new Kyle Killen fantasy pilot Awake as an executive producer. When NBC picked the project up to series status, Gordon added writer and showrunner to his occupational duties on the show. The series only ran from March 1 to May 24, 2012, before it was cancelled.

Second Chance
In 2015, Gordon was executive producer on the horror-drama series Second Chance for Fox Television Network. The pilot for Second Chance is based on a script written by Rand Ravich, who also worked as an executive producer on the series.

Accused
In May 2021, Fox ordered an American adaptation of Accused, the International Emmy-winning British series and it was announced that Gordon would act as executive producer and show-runner. It will be co-produced between Sony Pictures Television, All3Media America and Fox Entertainment and scheduled to premiere in the 2022–23 television season. Alex Gansa and David Shore will serve as co-executive producers. It is slated to premiere on January 22, 2023.

Novels

 * Gideon's War (also published in the UK as The Obelisk) - 2011
 * Hard Target (also published in the UK as The Chamber) - 2012

title: Howard Gordon


text:
Talk:Albert Dubout

Untitled
This article is translated from french Albert Dubout. I'm afraid I don't know how to make the images work though! Sbwoodside 01:21, 26 August 2005 (UTC)

WikiProject class rating
This article was automatically assessed because at least one article was rated and this bot brought all the other ratings up to at least that level. BetacommandBot 02:09, 27 August 2007 (UTC)

title: Talk:Albert Dubout


text:
Klotho (biology)

Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β-klotho, and γ-klotho. α-klotho activates FGF23, and β-klotho activates FGF19 and FGF21. When the subfamily is not specified, the word "klotho" typically refers to the α-klotho subfamily, because α-klotho was discovered before the other members.

α-klotho is highly expressed in the brain, liver and kidney. β-klotho is predominantly expressed in the liver. γ-klotho is expressed in the skin.

Klotho can exist in a membrane-bound form or a (hormonal) soluble, circulating form. Proteases can convert the membrane-bound form into the circulating form.

The KL gene encodes a type-I single-pass transmembrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic kidney failure (CKF), and this may be one of the factors underlying degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CKF. Mutations within the family have been associated with ageing, bone loss and alcohol consumption.  Transgenic mice that overexpress Klotho live longer than wild-type mice.

Structure
The α-klotho gene is located on chromosome 13, and is translated into a single-pass integral membrane protein. The intracellular portion of the α-klotho protein is short (11 amino acids), whereas the extracellular portion is long (980 amino acids). The transmembrane portion is also comparatively short (21 amino acids). The extracellular portion contains two repeat sequences, termed the KL1 (about 450 amino acids) and KL2 (about 430 amino acids) domains. In the kidney and the choroid plexus of the brain, the transmembrane protein can be proteolytically cleaved to produce a 130-Kilo-Dalton, soluble form of α-klotho protein, released into the circulation and cerebrospinal fluid, respectively. In humans, the secreted form of klotho is more dominant than the membrane form.

The β-Klotho gene is located on chromosome 4. The protein shares homology (43.1% identity and 60.1% similarity) with α-klotho. It should not be confused with the alpha-cut and beta-cut of alpha-klotho, which releases KL1+KL2 and KL2 domain, respectively.

Function
Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in ageing. Its discovery was documented in 1997 by Makoto Kuro-o et al. The name of the gene comes from Klotho or Clotho, one of the Moirai, or Fates, in Greek mythology, who spins the thread of human life.

The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging, and klotho protein has been shown to be a circulating factor detectable in serum that declines with age.

The binding of the endocrine fibroblast growth factors (FGF's, viz., FGF19 and FGF21) to their fibroblast growth factor receptors, is promoted via their interactions as co-receptors with β-klotho. Loss of β-Klotho abolishes all effects of FGF21.

α-klotho, which binds to the endocrine FGF FGF23 changes cellular calcium homeostasis, by both increasing the expression and activity of TRPV5 (decreasing phosphate reabsorption in the kidney) and decreasing that of TRPC6 (decreasing phosphate absorption from the intestine). α-klotho increases kidney calcium reabsorption by stabilizing TPRV5. About 95% to 98% of Ca2+ filtered from the blood by the kidney is normally reabsorbed by the kidney's renal tubule, which is mediated by TRPV5.

Clinical significance
α-klotho can suppress oxidative stress and inflammation, thereby reducing endothelial dysfunction and atherosclerosis. Blood plasma α-klotho is increased by aerobic exercise, thereby reducing endothelial dysfunction.

β-klotho activation of FGF21 protein has a protective effect on heart muscle cells. Obesity is characterized by FGF21 resistance, believed to be caused by the inhibition of β-klotho by the inflammatory cell signalling protein (cytokine) tumor necrosis factor alpha, but there is evidence against this mechanism.

Klotho is required for oligodendrocyte maturation, myelin integrity, and can protect neurons from toxic effects. Mice deficient in klotho have a reduced number of synapses and cognitive deficits, whereas mice overexpressing klotho have enhanced learning and memory. Research with injections of klotho in primates demonstrates a positive effect on memory that lasts for as long as two weeks.

Reduced klotho expression is seen in the lung macrophages of smokers. An abnormal form of autophagy associated with reduced expression of klotho is linked to the pathogenesis of chronic obstructive pulmonary disease. (Although normal autophagy helps maintain muscle, excessive autophagy causes loss of muscle mass. )

It has been found that the decreased klotho expression may be due to DNA hypermethylation, which may have been induced by the overexpression of DNMT3a. Klotho may be a reliable gene for early detection of methylation changes in oral tissues, and can be used as a target for therapeutic modification in oral cancer during the early stages.

Klotho-deficient mice manifest a syndrome resembling accelerated human ageing and display extensive and accelerated arteriosclerosis. Additionally, they exhibit impaired endothelium dependent vasodilation and impaired angiogenesis, suggesting that klotho protein may protect the cardiovascular system through endothelium-derived nitric oxide production.

Klotho could play a protective role in Alzheimer's disease patients.

Research with injections of α-klotho in primates suggests a positive effect on memory that could have implications for research with humans. Interestingly the cognitive effects in rhesus monkeys were observed even with subcutaneous injection despite previous results showing that klotho protein fails to cross the blood–brain barrier.

Effects on aging
Reduced α-klotho or FGF23 can result in impaired phosphate excretion from the kidney, leading to hyperphosphatemia. In mice, this leads to a phenotype characteristic of premature aging, which can be mitigated by feeding the mice a low phosphate diet.

The plasma (soluble) form of α-klotho is most easily measured, and has been shown to decrease after 40 years of age in humans. Lower plasma levels of α-klotho in older adults is associated with increased frailty and all-cause mortality. Physical activity has been shown to increase plasma α-klotho.

Mice lacking either fibroblast growth factor 23 or the α-klotho enzyme display premature aging due to hyperphosphatemia. Many of these symptoms can be alleviated by feeding the mice a low phosphate diet.

Although the majority of research has explored klotho's absence, it was demonstrated that klotho over-expression in mice extended their average life span between 19% and 31% compared to normal mice. In addition, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations and mice, but only if the gene expression was heterozygous, not homozygous. The cognitive benefits of α-klotho are primarily seen late in life.

Klotho increases membrane expression of the inward rectifier ATP-dependent potassium channel ROMK. Klotho-deficient mice show increased production of vitamin D, and altered mineral-ion homeostasis is suggested to cause premature aging‑like phenotypes, because reduced vitamin D activity from dietary restriction reverses the premature aging‑like phenotypes and prolongs survival in these mutants. These results suggest that aging‑like phenotypes were due to klotho-associated vitamin D metabolic abnormalities (hypervitaminosis).

Klotho is an antagonist of the Wnt signaling pathway, and chronic Wnt stimulation can lead to stem cell depletion and aging. Klotho inhibition of Wnt signaling can inhibit cancer. The anti-aging effects of klotho are also a consequence of increased resistance to inflammation and oxidative stress.

Extracellular vesicles (EV) in young mice carried more copies of klotho-producing mRNA than those from old mice. Transfusing young EVs into older mice helped rebuild their muscles.

The presence of senescent cells decreases α-klotho levels. Senolytic drugs reduce the level of these cells, allowing α-klotho levels to increase.

title: Klotho (biology)


text:
Old English Bulldog

The Old English Bulldog is an extinct breed of dog.

Physical characteristics
The Old English Bulldog was compact, broad and muscular, as reflected in the painting Crib and Rosa. Through John Scott's engraving, this painting became the best-known and most reproduced painting of dogs from that period. As described in the Philo-kuon standard from 1865, the average height was approximately 15 in, and they weighed about 45 lb.

History
The English blood sport of bull-baiting allowed for a specialized breed in the form of the Old English Bulldog. The main locations in London for these exhibitions were the Westminster Pit, Beargarden and Old Conduit Fields.

Breeding
Historians are fairly confident that the Old English Bulldog is derived from ancient war dogs, such as the old Mastiff or the extinct Alaunt dog. Others believe that the true origin of the breed is not entirely clear. Depictions in old prints show that the variety was without doubt a small Mastiff with a comparatively long head. The word 'Mastiff' was eventually dropped when describing these smaller Mastiffs, as the Mastiff proper was found too slow for bull-baiting.

Description
Two other recognized members of the breed can be seen in the 1817 painting Crib and Rosa, with Rosa exemplifying the form and size of the ideal type of Old English Bulldog, albeit deficient in wrinkles about the head and neck and in substance of bone in the limbs.

Many authors bring us descriptions about the extinct bulldog, but this description by William Hamilton Maxwell stands out as one of the most extensive: "BULL-DOG (Canis Molossus), s. A dog of particular form, remarkable for his courage. The bull-dog is low in stature, deep-chested, and strongly made about the shoulders and thighs, the muscles of both of which are extremely developed. His head is broad, his nose short, and the under jaw projects beyond the upper, which gives him a fierce and disagreeable aspect. His eyes are distant and prominent, and have a peculiar suspicious-like leer, which, with the distension of his nostrils, gives him also a contemptuous look; and from his teeth being always seen, he has the constant appearance of grinning, while he is perfectly placid. He is the most ferocious and unrelenting of the canine tribe, and may be considered courageous beyond every other creature in the world, for he will attack any animal, whatever be his magnitude.

The internal changes which determine the external characters of this dog, consist in a great development of the frontal sinuses, a development which elevates the bones of the forehead above the nose, and draws the cerebral cavity in the same direction.

But the most important quality, and that, perhaps, which causes all the others, although we cannot perceive the connexion, is the diminution of the brain. The cerebral capacity of the bull-dog is sensibly smaller than in any other race; and it is doubtless to the decrease of the encephalon that we must attribute its inferiority to all others in every thing relating to intelligence. The bull-dog is scarcely capable of any education, and is fitted for nothing but combat and ferocity.

This animal takes his name from his having been employed, in former times, in assaulting the bull, and he is used for the same purpose at the present day, in those districts where this brutal amusement is still practised.

Nothing can exceed the fury with which the bull-dog falls upon all other animals, and the invincible obstinacy with which he maintains his hold. In attacking the bull, he always assails him in front, and generally fastens upon his lip, tongue, or eye, where he holds and hangs on, in spite of the most desperate efforts of the other to free himself from his antagonist, which affords ample proof of the amazing strength and power of this animal.

Whenever a bull-dog attacks any of the extremities of the body, it is invariably considered a mark of his degeneracy from the original purity of blood. Puppies will assail a bull, and thereby give a decided proof of their breed, when only six months old; and, if permitted, will rather suffer themselves to be destroyed than relinquish the contest.

Although this trial is sometimes made with the whelps of a particular litter, to demonstrate the purity of their descent, and to prove that there has been no improper cross by which the future fame of their posterity may be affected, yet they are seldom entered in a regular ring until from fifteen to eighteen months old. But their ligaments cannot be considered as at their full strength until they are at least two years old. Indeed, amateurs say, that they are not at their prime until they have attained four or five years of age.

The bull-dog is admitted by naturalists to be one of the original and peculiar races of Britain, and may be ranked, in point of originality, with the shepherd’s dog and Irish greyhound. In various districts of England this breed is still preserved in its native purity, by that class of people who delight in bullbaiting and fighting of dogs; both of which amusements, alike inhuman, are now happily on the decline. — Brown."

Decline

In England, the passage of the Cruelty to Animals Act 1835 caused a decline of bull-baiting and dog fighting, leading to a lack of interest in perpetuating the Old English Bulldog. Three dogs from the Duke of Hamilton's strain of Old English Bulldog, Wasp, Child, and Billy, were depicted in a painting and recognized as some of the last known members of the breed before it became extinct.

Despite the laws making dog fighting illegal, it continued for many years. Breeders determined a cross between the Old English Bulldog and Old English Terrier created a superior fighting dog with increased quickness and dexterity. This new breed of dog, called the bull and terrier, was a precursor to the Staffordshire Bull Terrier, Bull Terrier and American Pit Bull Terrier and accelerated the extinction of the Old English Bulldog.

English Bulldog
Often confused with the Old English Bulldog, the English Bulldog is noted for its sweet disposition; it does not have the speed and agility that were the definitive characteristics of the Old English Bulldog.

title: Old English Bulldog